SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bff'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 6bff AMINOGLYCOSIDE
ACETYLTRANSFERASE
(Escherichia
coli) 		3 / 3 ASP A 135
PHE A 152
ASN A 140
 MG  A 201 (-2.7A)
None
None
 0.87A 1sg9B-6bffA:
undetectable		 1sg9B-6bffA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BUE_A_RIOA1201_0
(AAC(6')-IB)		 6bff AMINOGLYCOSIDE
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 11 TYR A  49
GLN A  73
TYR A  75
ASP A  98
ASP A 135
 None
None
None
MG  A 201 (-2.8A)
MG  A 201 (-2.7A)
 0.79A 2bueA-6bffA:
21.0		 2bueA-6bffA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 6bff AMINOGLYCOSIDE
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 12 TYR A  49
GLN A  73
TYR A  75
ASP A  98
ASP A 135
 None
None
None
MG  A 201 (-2.8A)
MG  A 201 (-2.7A)
 0.81A 2vqyA-6bffA:
21.2		 2vqyA-6bffA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 6bff AMINOGLYCOSIDE
ACETYLTRANSFERASE
(Escherichia
coli) 		4 / 5 GLN A  73
ILE A  74
TYR A  75
GLU A  56
 None
 1.22A 4a99D-6bffA:
undetectable		 4a99D-6bffA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_A_VK3A202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 6bff AMINOGLYCOSIDE
ACETYLTRANSFERASE
(Escherichia
coli) 		4 / 5 TYR A  75
TYR A  85
LEU A  81
TRP A  53
 None
 1.15A 4f8yA-6bffA:
undetectable
4f8yB-6bffA:
undetectable		 4f8yA-6bffA:
21.30
4f8yB-6bffA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 6bff AMINOGLYCOSIDE
ACETYLTRANSFERASE
(Escherichia
coli) 		4 / 7 TYR A  75
TYR A  85
LEU A  81
TRP A  53
 None
 1.22A 4f8yC-6bffA:
undetectable
4f8yD-6bffA:
undetectable		 4f8yC-6bffA:
21.30
4f8yD-6bffA:
21.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QC6_A_KANA201_1
(BIFUNCTIONAL AAC/APH)		 6bff AMINOGLYCOSIDE
ACETYLTRANSFERASE
(Escherichia
coli) 		6 / 11 TYR A  33
TYR A  49
GLU A  51
GLN A  73
ASP A  98
ASP A 135
 None
None
None
None
MG  A 201 (-2.8A)
MG  A 201 (-2.7A)
 0.58A 4qc6A-6bffA:
28.3		 4qc6A-6bffA:
59.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QC6_A_KANA201_1
(BIFUNCTIONAL AAC/APH)		 6bff AMINOGLYCOSIDE
ACETYLTRANSFERASE
(Escherichia
coli) 		6 / 11 TYR A  33
TYR A  49
GLU A  51
GLN A  73
ASP A  98
HIS A 164
 None
None
None
None
MG  A 201 (-2.8A)
None
 1.18A 4qc6A-6bffA:
28.3		 4qc6A-6bffA:
59.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QC6_A_KANA201_1
(BIFUNCTIONAL AAC/APH)		 6bff AMINOGLYCOSIDE
ACETYLTRANSFERASE
(Escherichia
coli) 		7 / 11 TYR A  33
TYR A  49
TRP A  53
GLN A  73
ASP A  98
ASP A 135
GLU A 162
 None
None
None
None
MG  A 201 (-2.8A)
MG  A 201 (-2.7A)
None
 0.79A 4qc6A-6bffA:
28.3		 4qc6A-6bffA:
59.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QC6_A_KANA201_1
(BIFUNCTIONAL AAC/APH)		 6bff AMINOGLYCOSIDE
ACETYLTRANSFERASE
(Escherichia
coli) 		6 / 11 TYR A  33
TYR A  49
TRP A  53
GLN A  73
ASP A  98
HIS A 164
 None
None
None
None
MG  A 201 (-2.8A)
None
 1.26A 4qc6A-6bffA:
28.3		 4qc6A-6bffA:
59.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QC6_B_KANB201_1
(BIFUNCTIONAL AAC/APH)		 6bff AMINOGLYCOSIDE
ACETYLTRANSFERASE
(Escherichia
coli) 		7 / 12 TYR A  33
TYR A  49
GLU A  51
ARG A  59
GLN A  73
ASP A  98
ASP A 135
 None
None
None
None
None
MG  A 201 (-2.8A)
MG  A 201 (-2.7A)
 0.57A 4qc6B-6bffA:
28.6		 4qc6B-6bffA:
59.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QC6_B_KANB201_1
(BIFUNCTIONAL AAC/APH)		 6bff AMINOGLYCOSIDE
ACETYLTRANSFERASE
(Escherichia
coli) 		6 / 12 TYR A  33
TYR A  49
GLU A  51
ARG A  59
GLN A  73
HIS A 164
 None
 1.27A 4qc6B-6bffA:
28.6		 4qc6B-6bffA:
59.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QC6_B_KANB201_1
(BIFUNCTIONAL AAC/APH)		 6bff AMINOGLYCOSIDE
ACETYLTRANSFERASE
(Escherichia
coli) 		8 / 12 TYR A  33
TYR A  49
TRP A  53
ARG A  59
GLN A  73
ASP A  98
ASP A 135
GLU A 162
 None
None
None
None
None
MG  A 201 (-2.8A)
MG  A 201 (-2.7A)
None
 0.83A 4qc6B-6bffA:
28.6		 4qc6B-6bffA:
59.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 6bff AMINOGLYCOSIDE
ACETYLTRANSFERASE
(Escherichia
coli) 		3 / 3 TYR A  33
TYR A  75
GLN A  73
 None
 1.06A 5jsdA-6bffA:
undetectable
5jsdB-6bffA:
undetectable		 5jsdA-6bffA:
12.75
5jsdB-6bffA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 6bff AMINOGLYCOSIDE
ACETYLTRANSFERASE
(Escherichia
coli) 		3 / 3 TYR A  33
TYR A  75
GLN A  73
 None
 1.06A 5jsdB-6bffA:
undetectable
5jsdC-6bffA:
undetectable		 5jsdB-6bffA:
12.75
5jsdC-6bffA:
12.75