SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bfn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		4 / 7 GLU A 443
GLU A 440
GLU A 441
GLU A 444
 None
 1.15A 1knyA-6bfnA:
3.8
1knyB-6bfnA:
3.9		 1knyA-6bfnA:
20.29
1knyB-6bfnA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		4 / 8 GLU A 444
GLU A 443
GLU A 440
GLU A 441
 None
 1.15A 1knyA-6bfnA:
3.8
1knyB-6bfnA:
3.9		 1knyA-6bfnA:
20.29
1knyB-6bfnA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		7 / 12 ALA A 237
LYS A 239
GLU A 259
LEU A 286
GLY A 294
LEU A 347
ASP A 358
 DL1  A 601 (-3.4A)
DL1  A 601 ( 4.1A)
None
None
DL1  A 601 (-3.5A)
DL1  A 601 (-3.9A)
DL1  A 601 (-3.1A)
 0.84A 1m17A-6bfnA:
24.6		 1m17A-6bfnA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		8 / 12 VAL A 226
ALA A 237
LYS A 239
GLU A 259
LEU A 263
VAL A 272
GLY A 294
LEU A 347
 None
DL1  A 601 (-3.4A)
DL1  A 601 ( 4.1A)
None
None
DL1  A 601 ( 4.8A)
DL1  A 601 (-3.5A)
DL1  A 601 (-3.9A)
 0.92A 1t46A-6bfnA:
23.9		 1t46A-6bfnA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		3 / 3 LEU A 263
PHE A 359
ARG A 324
 None
 0.81A 1xdkF-6bfnA:
undetectable		 1xdkF-6bfnA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		6 / 12 ALA A 237
GLY A 294
ASP A 298
LEU A 347
ASP A 358
PHE A 359
 DL1  A 601 (-3.4A)
DL1  A 601 (-3.5A)
DL1  A 601 ( 4.9A)
DL1  A 601 (-3.9A)
DL1  A 601 (-3.1A)
None
 1.01A 1xkkA-6bfnA:
23.4		 1xkkA-6bfnA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		9 / 12 GLY A 219
VAL A 226
ALA A 237
LYS A 239
GLU A 259
LEU A 286
GLY A 294
LEU A 347
ASP A 358
 DL1  A 601 ( 4.1A)
None
DL1  A 601 (-3.4A)
DL1  A 601 ( 4.1A)
None
None
DL1  A 601 (-3.5A)
DL1  A 601 (-3.9A)
DL1  A 601 (-3.1A)
 1.00A 2ityA-6bfnA:
25.0		 2ityA-6bfnA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		8 / 12 VAL A 226
ALA A 237
LYS A 239
GLU A 259
GLY A 294
ASP A 298
LEU A 347
ASP A 358
 None
DL1  A 601 (-3.4A)
DL1  A 601 ( 4.1A)
None
DL1  A 601 (-3.5A)
DL1  A 601 ( 4.9A)
DL1  A 601 (-3.9A)
DL1  A 601 (-3.1A)
 1.04A 2itzA-6bfnA:
25.0		 2itzA-6bfnA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		5 / 10 THR A 322
VAL A 413
VAL A 412
ASP A 406
ILE A 326
 None
 1.45A 2qboA-6bfnA:
undetectable		 2qboA-6bfnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		5 / 12 THR A 407
ASP A 404
VAL A 403
SER A 335
SER A 365
 None
 1.22A 2y00B-6bfnA:
2.0		 2y00B-6bfnA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		5 / 12 THR A 407
ASP A 404
VAL A 403
SER A 335
SER A 365
 None
 1.22A 2y01B-6bfnA:
2.1		 2y01B-6bfnA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		5 / 12 THR A 407
ASP A 404
VAL A 403
SER A 335
SER A 365
 None
 1.16A 2y03B-6bfnA:
2.4		 2y03B-6bfnA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y04_B_68HB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		5 / 12 THR A 407
ASP A 404
VAL A 403
SER A 335
SER A 365
 None
 1.23A 2y04B-6bfnA:
undetectable		 2y04B-6bfnA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		6 / 12 ILE A 218
VAL A 226
ALA A 237
GLY A 294
LEU A 347
ASP A 358
 DL1  A 601 (-4.0A)
None
DL1  A 601 (-3.4A)
DL1  A 601 (-3.5A)
DL1  A 601 (-3.9A)
DL1  A 601 (-3.1A)
 0.70A 2y7jA-6bfnA:
23.3		 2y7jA-6bfnA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		6 / 10 ILE A 218
VAL A 226
ALA A 237
GLY A 294
LEU A 347
ASP A 358
 DL1  A 601 (-4.0A)
None
DL1  A 601 (-3.4A)
DL1  A 601 (-3.5A)
DL1  A 601 (-3.9A)
DL1  A 601 (-3.1A)
 0.59A 2y7jB-6bfnA:
23.8		 2y7jB-6bfnA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		6 / 10 ILE A 218
VAL A 226
ALA A 237
GLY A 294
ASP A 298
LEU A 347
 DL1  A 601 (-4.0A)
None
DL1  A 601 (-3.4A)
DL1  A 601 (-3.5A)
DL1  A 601 ( 4.9A)
DL1  A 601 (-3.9A)
 0.69A 2y7jD-6bfnA:
24.1		 2y7jD-6bfnA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		7 / 12 VAL A 226
ALA A 237
LEU A 286
GLY A 294
LEU A 347
ASP A 358
PHE A 359
 None
DL1  A 601 (-3.4A)
None
DL1  A 601 (-3.5A)
DL1  A 601 (-3.9A)
DL1  A 601 (-3.1A)
None
 0.86A 3bbtD-6bfnA:
23.4		 3bbtD-6bfnA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_0
(NEURAMINIDASE)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		5 / 12 ARG A 481
LEU A 310
ARG A 315
ALA A 423
ARG A 422
 None
 1.50A 3k37B-6bfnA:
undetectable		 3k37B-6bfnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		5 / 12 ARG A 517
GLY A 494
GLY A 492
LEU A 489
ALA A 497
 None
 1.17A 3kkzA-6bfnA:
undetectable		 3kkzA-6bfnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		8 / 11 ILE A 218
ALA A 237
LYS A 239
VAL A 272
PHE A 290
GLY A 294
LEU A 347
ASP A 358
 DL1  A 601 (-4.0A)
DL1  A 601 (-3.4A)
DL1  A 601 ( 4.1A)
DL1  A 601 ( 4.8A)
DL1  A 601 (-4.3A)
DL1  A 601 (-3.5A)
DL1  A 601 (-3.9A)
DL1  A 601 (-3.1A)
 0.61A 3miyA-6bfnA:
25.0		 3miyA-6bfnA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		6 / 9 ILE A 218
ALA A 237
LYS A 239
PHE A 290
GLY A 294
LEU A 347
 DL1  A 601 (-4.0A)
DL1  A 601 (-3.4A)
DL1  A 601 ( 4.1A)
DL1  A 601 (-4.3A)
DL1  A 601 (-3.5A)
DL1  A 601 (-3.9A)
 0.57A 3miyB-6bfnA:
24.8		 3miyB-6bfnA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		6 / 12 ILE A 218
VAL A 226
ALA A 237
LYS A 239
LEU A 263
PHE A 359
 DL1  A 601 (-4.0A)
None
DL1  A 601 (-3.4A)
DL1  A 601 ( 4.1A)
None
None
 1.27A 3og7A-6bfnA:
24.6		 3og7A-6bfnA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		8 / 12 GLY A 219
VAL A 226
ALA A 237
LEU A 286
GLY A 294
ASP A 298
LEU A 347
ASP A 358
 DL1  A 601 ( 4.1A)
None
DL1  A 601 (-3.4A)
None
DL1  A 601 (-3.5A)
DL1  A 601 ( 4.9A)
DL1  A 601 (-3.9A)
DL1  A 601 (-3.1A)
 0.80A 4i22A-6bfnA:
23.0		 4i22A-6bfnA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		8 / 10 ILE A 218
ALA A 237
VAL A 272
PHE A 290
LEU A 291
GLY A 294
LEU A 347
ASP A 358
 DL1  A 601 (-4.0A)
DL1  A 601 (-3.4A)
DL1  A 601 ( 4.8A)
DL1  A 601 (-4.3A)
DL1  A 601 (-4.4A)
DL1  A 601 (-3.5A)
DL1  A 601 (-3.9A)
DL1  A 601 (-3.1A)
 0.56A 4ks8A-6bfnA:
24.7		 4ks8A-6bfnA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		8 / 12 GLY A 219
GLY A 221
GLY A 224
VAL A 226
ALA A 237
LYS A 239
VAL A 272
ASP A 358
 DL1  A 601 ( 4.1A)
None
None
None
DL1  A 601 (-3.4A)
DL1  A 601 ( 4.1A)
DL1  A 601 ( 4.8A)
DL1  A 601 (-3.1A)
 0.82A 4otiA-6bfnA:
17.1		 4otiA-6bfnA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		6 / 12 ILE A 218
GLY A 219
VAL A 226
ALA A 237
LEU A 291
LEU A 347
 DL1  A 601 (-4.0A)
DL1  A 601 ( 4.1A)
None
DL1  A 601 (-3.4A)
DL1  A 601 (-4.4A)
DL1  A 601 (-3.9A)
 0.49A 4qmzA-6bfnA:
24.0		 4qmzA-6bfnA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		5 / 12 ALA A 466
THR A 417
VAL A 413
LEU A 501
LEU A 518
 None
 1.27A 4qynA-6bfnA:
undetectable		 4qynA-6bfnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		6 / 12 VAL A 226
ALA A 237
LYS A 239
SER A 295
GLY A 357
GLY A 360
 None
DL1  A 601 (-3.4A)
DL1  A 601 ( 4.1A)
DL1  A 601 ( 4.6A)
DL1  A 601 ( 4.8A)
None
 1.10A 4rzvB-6bfnA:
24.6		 4rzvB-6bfnA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		6 / 12 VAL A 226
ALA A 237
LYS A 239
GLY A 357
ASP A 358
PHE A 359
 None
DL1  A 601 (-3.4A)
DL1  A 601 ( 4.1A)
DL1  A 601 ( 4.8A)
DL1  A 601 (-3.1A)
None
 1.01A 4xv2A-6bfnA:
24.4		 4xv2A-6bfnA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		5 / 12 ALA A 237
LYS A 239
GLY A 357
ASP A 358
PHE A 359
 DL1  A 601 (-3.4A)
DL1  A 601 ( 4.1A)
DL1  A 601 ( 4.8A)
DL1  A 601 (-3.1A)
None
 0.96A 4xv2B-6bfnA:
24.8		 4xv2B-6bfnA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		4 / 6 LEU A 501
LEU A 496
ILE A 341
PHE A 410
 None
 1.25A 4y4dA-6bfnA:
undetectable		 4y4dA-6bfnA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		5 / 12 CYH A 498
LEU A 501
LEU A 415
ILE A 469
ALA A 470
 None
 1.02A 5eypB-6bfnA:
undetectable		 5eypB-6bfnA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		5 / 12 ALA A 237
GLY A 294
LEU A 347
GLY A 357
ASP A 358
 DL1  A 601 (-3.4A)
DL1  A 601 (-3.5A)
DL1  A 601 (-3.9A)
DL1  A 601 ( 4.8A)
DL1  A 601 (-3.1A)
 0.57A 5h2uC-6bfnA:
24.1		 5h2uC-6bfnA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		6 / 12 VAL A 226
ALA A 237
GLY A 294
LEU A 347
GLY A 357
ASP A 358
 None
DL1  A 601 (-3.4A)
DL1  A 601 (-3.5A)
DL1  A 601 (-3.9A)
DL1  A 601 ( 4.8A)
DL1  A 601 (-3.1A)
 0.59A 5h2uD-6bfnA:
24.2		 5h2uD-6bfnA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		5 / 7 GLY A 219
GLY A 221
VAL A 226
LYS A 239
LEU A 241
 DL1  A 601 ( 4.1A)
None
None
DL1  A 601 ( 4.1A)
None
 0.69A 5izjA-6bfnA:
20.4		 5izjA-6bfnA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		4 / 7 ASP A 340
GLY A 339
HIS A 338
ASP A 358
 None
None
None
DL1  A 601 (-3.1A)
 1.06A 5nnwD-6bfnA:
undetectable		 5nnwD-6bfnA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		4 / 7 ASP A 340
GLY A 339
HIS A 338
ASP A 358
 None
None
None
DL1  A 601 (-3.1A)
 1.05A 5no9D-6bfnA:
undetectable		 5no9D-6bfnA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		6 / 12 ILE A 218
GLY A 219
ALA A 237
GLU A 259
GLY A 294
ASP A 298
 DL1  A 601 (-4.0A)
DL1  A 601 ( 4.1A)
DL1  A 601 (-3.4A)
None
DL1  A 601 (-3.5A)
DL1  A 601 ( 4.9A)
 0.58A 5vc3A-6bfnA:
24.7		 5vc3A-6bfnA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		5 / 12 GLY A 222
VAL A 272
LEU A 356
GLY A 360
SER A 255
 None
DL1  A 601 ( 4.8A)
None
None
None
 1.13A 5vooE-6bfnA:
undetectable		 5vooE-6bfnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		5 / 12 GLY A 222
VAL A 272
LEU A 356
GLY A 360
SER A 255
 None
DL1  A 601 ( 4.8A)
None
None
None
 1.14A 5vooF-6bfnA:
undetectable		 5vooF-6bfnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		5 / 12 GLY A 222
VAL A 272
LEU A 356
GLY A 360
SER A 255
 None
DL1  A 601 ( 4.8A)
None
None
None
 1.17A 5vopB-6bfnA:
undetectable		 5vopB-6bfnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		6 / 12 GLY A 219
VAL A 226
ALA A 237
LEU A 286
LEU A 347
ASP A 358
 DL1  A 601 ( 4.1A)
None
DL1  A 601 (-3.4A)
None
DL1  A 601 (-3.9A)
DL1  A 601 (-3.1A)
 0.63A 5yu9A-6bfnA:
22.9		 5yu9A-6bfnA:
29.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		6 / 12 GLY A 219
VAL A 226
ALA A 237
LEU A 286
LEU A 347
ASP A 358
 DL1  A 601 ( 4.1A)
None
DL1  A 601 (-3.4A)
None
DL1  A 601 (-3.9A)
DL1  A 601 (-3.1A)
 0.60A 5yu9B-6bfnA:
22.9		 5yu9B-6bfnA:
29.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		5 / 12 VAL A 226
ALA A 237
LEU A 286
GLY A 294
ASP A 358
 None
DL1  A 601 (-3.4A)
None
DL1  A 601 (-3.5A)
DL1  A 601 (-3.1A)
 0.48A 5yu9C-6bfnA:
22.6		 5yu9C-6bfnA:
29.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		5 / 12 VAL A 226
ALA A 237
GLY A 294
LEU A 347
ASP A 358
 None
DL1  A 601 (-3.4A)
DL1  A 601 (-3.5A)
DL1  A 601 (-3.9A)
DL1  A 601 (-3.1A)
 0.49A 5yu9D-6bfnA:
23.1		 5yu9D-6bfnA:
29.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		5 / 12 LEU A 241
HIS A 338
VAL A 272
THR A 258
LEU A 257
 None
None
DL1  A 601 ( 4.8A)
None
None
 1.27A 6djzB-6bfnA:
undetectable		 6djzB-6bfnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNM_A_1N1A1001_1
(-)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		7 / 12 ILE A 218
VAL A 226
ALA A 237
LYS A 239
GLU A 259
GLY A 294
LEU A 347
 DL1  A 601 (-4.0A)
None
DL1  A 601 (-3.4A)
DL1  A 601 ( 4.1A)
None
DL1  A 601 (-3.5A)
DL1  A 601 (-3.9A)
 0.82A 6fnmA-6bfnA:
24.4		 6fnmA-6bfnA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7J_A_5FWA401_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		5 / 12 THR A 407
ASP A 404
VAL A 403
SER A 335
SER A 365
 None
 1.14A 6h7jA-6bfnA:
undetectable		 6h7jA-6bfnA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7J_B_5FWB402_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		5 / 12 THR A 407
ASP A 404
VAL A 403
SER A 335
SER A 365
 None
 1.14A 6h7jB-6bfnA:
undetectable		 6h7jB-6bfnA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		5 / 12 THR A 407
ASP A 404
VAL A 403
SER A 335
SER A 365
 None
 1.09A 6h7lA-6bfnA:
undetectable		 6h7lA-6bfnA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		5 / 12 THR A 407
ASP A 404
VAL A 403
SER A 335
SER A 365
 None
 1.09A 6h7lB-6bfnA:
undetectable		 6h7lB-6bfnA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_A_68HA504_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		5 / 12 THR A 407
ASP A 404
VAL A 403
SER A 335
SER A 365
 None
 1.15A 6h7mA-6bfnA:
undetectable		 6h7mA-6bfnA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens) 		3 / 3 ASP A 404
SER A 335
SER A 365
 None
 0.45A 6mxtA-6bfnA:
1.3		 6mxtA-6bfnA:
undetectable