SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bgz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 6bgz LYSINE-SPECIFIC
DEMETHYLASE 5A,
LINKED KDM5A JMJ
DOMAIN
(Homo
sapiens) 		4 / 8 GLY A 573
THR A 502
GLY A 577
GLN A 576
 None
 0.76A 1jr1B-6bgzA:
undetectable		 1jr1B-6bgzA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_C_DMEC997_1
(ACETYLCHOLINESTERASE)		 6bgz LYSINE-SPECIFIC
DEMETHYLASE 5A,
LINKED KDM5A JMJ
DOMAIN
(Homo
sapiens) 		5 / 12 GLY A 560
PHE A 562
PHE A 422
TYR A 438
HIS A 496
 None
 1.34A 1maaC-6bgzA:
undetectable		 1maaC-6bgzA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)		 6bgz LYSINE-SPECIFIC
DEMETHYLASE 5A,
LINKED KDM5A JMJ
DOMAIN
(Homo
sapiens) 		4 / 6 ASN A 444
TRP A  57
TYR A 494
GLY A 421
 None
 1.48A 1mxdA-6bgzA:
undetectable		 1mxdA-6bgzA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 6bgz LYSINE-SPECIFIC
DEMETHYLASE 5A,
LINKED KDM5A JMJ
DOMAIN
(Homo
sapiens) 		3 / 3 TRP A  26
PHE A  29
TRP A  57
 None
 1.42A 1r15C-6bgzA:
undetectable		 1r15C-6bgzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 6bgz LYSINE-SPECIFIC
DEMETHYLASE 5A,
LINKED KDM5A JMJ
DOMAIN
(Homo
sapiens) 		3 / 3 TRP A  26
PHE A  29
TRP A  57
 None
 1.42A 1r15F-6bgzA:
undetectable		 1r15F-6bgzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 6bgz LYSINE-SPECIFIC
DEMETHYLASE 5A,
LINKED KDM5A JMJ
DOMAIN
(Homo
sapiens) 		3 / 3 TRP A  26
PHE A  29
TRP A  57
 None
 1.43A 1r15G-6bgzA:
undetectable		 1r15G-6bgzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 6bgz LYSINE-SPECIFIC
DEMETHYLASE 5A,
LINKED KDM5A JMJ
DOMAIN
(Homo
sapiens) 		3 / 3 TRP A  26
PHE A  29
TRP A  57
 None
 1.43A 1r15H-6bgzA:
undetectable		 1r15H-6bgzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 6bgz LYSINE-SPECIFIC
DEMETHYLASE 5A,
LINKED KDM5A JMJ
DOMAIN
(Homo
sapiens) 		5 / 10 ALA A 581
TRP A 503
LEU A 495
GLY A 560
PHE A 562
 DNV  A 601 ( 4.8A)
None
None
None
None
 1.34A 1ruaH-6bgzA:
undetectable
1ruaL-6bgzA:
undetectable		 1ruaH-6bgzA:
undetectable
1ruaL-6bgzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 6bgz LYSINE-SPECIFIC
DEMETHYLASE 5A,
LINKED KDM5A JMJ
DOMAIN
(Homo
sapiens) 		5 / 12 ILE A 484
LEU A 545
VAL A 506
GLU A 515
LEU A 514
 None
 1.26A 2bxfB-6bgzA:
undetectable		 2bxfB-6bgzA:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 6bgz LYSINE-SPECIFIC
DEMETHYLASE 5A,
LINKED KDM5A JMJ
DOMAIN
(Homo
sapiens) 		4 / 8 ALA A 569
TRP A 482
GLY A  47
ILE A  48
 None
 0.65A 2zm9A-6bgzA:
undetectable		 2zm9A-6bgzA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 6bgz LYSINE-SPECIFIC
DEMETHYLASE 5A,
LINKED KDM5A JMJ
DOMAIN
(Homo
sapiens) 		3 / 3 PHE A  22
CYH A  49
PHE A 566
 None
 1.09A 3cr5X-6bgzA:
undetectable		 3cr5X-6bgzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 6bgz LYSINE-SPECIFIC
DEMETHYLASE 5A,
LINKED KDM5A JMJ
DOMAIN
(Homo
sapiens) 		5 / 12 GLY A 410
TYR A 361
VAL A 473
GLY A 474
MET A 475
 None
 1.39A 3f8wB-6bgzA:
undetectable		 3f8wB-6bgzA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 6bgz LYSINE-SPECIFIC
DEMETHYLASE 5A,
LINKED KDM5A JMJ
DOMAIN
(Homo
sapiens) 		4 / 6 LEU A  77
VAL A 405
PHE A 373
PHE A 378
 GOL  A 604 (-4.1A)
None
None
None
 1.11A 3soaA-6bgzA:
undetectable		 3soaA-6bgzA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 6bgz LYSINE-SPECIFIC
DEMETHYLASE 5A,
LINKED KDM5A JMJ
DOMAIN
(Homo
sapiens) 		4 / 5 THR A 538
ILE A 539
GLU A  79
PHE A 394
 None
GOL  A 604 (-4.2A)
GOL  A 604 (-3.2A)
None
 1.34A 4ac9C-6bgzA:
undetectable		 4ac9C-6bgzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 6bgz LYSINE-SPECIFIC
DEMETHYLASE 5A,
LINKED KDM5A JMJ
DOMAIN
(Homo
sapiens) 		4 / 5 THR A 538
ILE A 539
GLU A  79
PHE A 394
 None
GOL  A 604 (-4.2A)
GOL  A 604 (-3.2A)
None
 1.34A 4acbC-6bgzA:
undetectable		 4acbC-6bgzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6bgz LYSINE-SPECIFIC
DEMETHYLASE 5A,
LINKED KDM5A JMJ
DOMAIN
(Homo
sapiens) 		4 / 6 TYR A 438
TYR A 494
LEU A 445
PHE A 562
 None
 1.23A 4twdB-6bgzA:
undetectable
4twdC-6bgzA:
undetectable		 4twdB-6bgzA:
13.09
4twdC-6bgzA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6bgz LYSINE-SPECIFIC
DEMETHYLASE 5A,
LINKED KDM5A JMJ
DOMAIN
(Homo
sapiens) 		4 / 6 TYR A 438
TYR A 494
LEU A 445
PHE A 562
 None
 1.17A 4twdD-6bgzA:
undetectable
4twdE-6bgzA:
undetectable		 4twdD-6bgzA:
13.09
4twdE-6bgzA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6bgz LYSINE-SPECIFIC
DEMETHYLASE 5A,
LINKED KDM5A JMJ
DOMAIN
(Homo
sapiens) 		4 / 7 TYR A 494
LEU A 445
PHE A 562
TYR A 438
 None
 1.18A 4twdF-6bgzA:
undetectable
4twdJ-6bgzA:
undetectable		 4twdF-6bgzA:
13.09
4twdJ-6bgzA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6bgz LYSINE-SPECIFIC
DEMETHYLASE 5A,
LINKED KDM5A JMJ
DOMAIN
(Homo
sapiens) 		4 / 6 TYR A 438
TYR A 494
LEU A 445
PHE A 562
 None
 1.20A 4twdF-6bgzA:
undetectable
4twdG-6bgzA:
undetectable		 4twdF-6bgzA:
13.09
4twdG-6bgzA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6bgz LYSINE-SPECIFIC
DEMETHYLASE 5A,
LINKED KDM5A JMJ
DOMAIN
(Homo
sapiens) 		4 / 6 TYR A 438
TYR A 494
LEU A 445
PHE A 562
 None
 1.19A 4twdI-6bgzA:
undetectable
4twdJ-6bgzA:
undetectable		 4twdI-6bgzA:
13.09
4twdJ-6bgzA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 6bgz LYSINE-SPECIFIC
DEMETHYLASE 5A,
LINKED KDM5A JMJ
DOMAIN
(Homo
sapiens) 		5 / 12 ASN A 493
VAL A 564
TYR A 490
SER A 489
THR A 588
 DNV  A 601 ( 4.3A)
None
None
None
None
 1.44A 5v1tA-6bgzA:
undetectable		 5v1tA-6bgzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 6bgz LYSINE-SPECIFIC
DEMETHYLASE 5A,
LINKED KDM5A JMJ
DOMAIN
(Homo
sapiens) 		4 / 5 VAL A 550
PRO A 507
GLY A 505
TYR A 553
 None
 1.44A 5x80A-6bgzA:
undetectable
5x80B-6bgzA:
undetectable		 5x80A-6bgzA:
21.74
5x80B-6bgzA:
21.74