SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bi4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 6bi4 DTDP-GLUCOSE
4,6-DEHYDRATASE
(Bacillus
anthracis) 		4 / 4 ILE A 282
MET A 287
VAL A 121
GLY A 242
 None
 1.03A 1e06B-6bi4A:
undetectable		 1e06B-6bi4A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 6bi4 DTDP-GLUCOSE
4,6-DEHYDRATASE
(Bacillus
anthracis) 		4 / 6 ILE A 267
LYS A 203
ALA A 198
VAL A 253
 None
 1.02A 1hk1A-6bi4A:
undetectable		 1hk1A-6bi4A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 6bi4 DTDP-GLUCOSE
4,6-DEHYDRATASE
(Bacillus
anthracis) 		5 / 11 TYR A 181
PHE A 299
GLU A 251
VAL A 252
ILE A 256
 None
 1.32A 2dg3A-6bi4A:
undetectable		 2dg3A-6bi4A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 6bi4 DTDP-GLUCOSE
4,6-DEHYDRATASE
(Bacillus
anthracis) 		4 / 5 VAL A 252
VAL A 253
THR A 306
THR A 248
 None
 1.26A 3bjwG-6bi4A:
undetectable		 3bjwG-6bi4A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 6bi4 DTDP-GLUCOSE
4,6-DEHYDRATASE
(Bacillus
anthracis) 		3 / 3 ASP A 277
ASN A 212
SER A 148
 None
 0.87A 3lslA-6bi4A:
undetectable
3lslD-6bi4A:
undetectable		 3lslA-6bi4A:
20.83
3lslD-6bi4A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 6bi4 DTDP-GLUCOSE
4,6-DEHYDRATASE
(Bacillus
anthracis) 		3 / 3 SER A 148
ASP A 277
ASN A 212
 None
 0.84A 3lslA-6bi4A:
undetectable
3lslD-6bi4A:
undetectable		 3lslA-6bi4A:
20.83
3lslD-6bi4A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 6bi4 DTDP-GLUCOSE
4,6-DEHYDRATASE
(Bacillus
anthracis) 		5 / 12 GLY A 242
GLY A 243
GLU A 294
ALA A 284
ASN A 240
 None
 1.33A 3t7sC-6bi4A:
6.0		 3t7sC-6bi4A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 6bi4 DTDP-GLUCOSE
4,6-DEHYDRATASE
(Bacillus
anthracis) 		5 / 12 GLY A 242
GLY A 243
GLU A 294
ALA A 284
ASN A 240
 None
 1.32A 3t7sD-6bi4A:
6.2		 3t7sD-6bi4A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 6bi4 DTDP-GLUCOSE
4,6-DEHYDRATASE
(Bacillus
anthracis) 		4 / 8 GLN A 185
ASN A 179
ASN A  15
THR A 220
 None
SO4  A 404 (-3.3A)
None
None
 1.37A 4d1yA-6bi4A:
5.9
4d1yB-6bi4A:
5.5		 4d1yA-6bi4A:
23.25
4d1yB-6bi4A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 6bi4 DTDP-GLUCOSE
4,6-DEHYDRATASE
(Bacillus
anthracis) 		5 / 11 TYR A 181
PHE A 299
GLU A 251
VAL A 252
ILE A 256
 None
 1.34A 4drjA-6bi4A:
undetectable		 4drjA-6bi4A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 6bi4 DTDP-GLUCOSE
4,6-DEHYDRATASE
(Bacillus
anthracis) 		4 / 7 ALA A   9
ALA A  82
ALA A  34
THR A  36
 NAD  A 402 (-3.8A)
NAD  A 402 (-3.5A)
NAD  A 402 (-3.6A)
NAD  A 402 (-3.2A)
 0.91A 4du2B-6bi4A:
undetectable		 4du2B-6bi4A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 6bi4 DTDP-GLUCOSE
4,6-DEHYDRATASE
(Bacillus
anthracis) 		3 / 3 SER A 156
MET A 159
ASP A 126
 None
 0.76A 4mm4B-6bi4A:
undetectable		 4mm4B-6bi4A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT2_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 6bi4 DTDP-GLUCOSE
4,6-DEHYDRATASE
(Bacillus
anthracis) 		5 / 10 TYR A 181
PHE A 299
GLU A 251
VAL A 252
ILE A 256
 None
 1.31A 4qt2A-6bi4A:
undetectable		 4qt2A-6bi4A:
18.54