SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bii'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 6bii GLYOXYLATE REDUCTASE
(Pyrococcus
yayanosii) 		3 / 3 ALA A 164
THR A 101
PHE A 158
 None
 0.65A 2c6nB-6biiA:
undetectable		 2c6nB-6biiA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 6bii GLYOXYLATE REDUCTASE
(Pyrococcus
yayanosii) 		5 / 9 ALA A 166
ALA A 211
GLY A 157
GLY A 159
ILE A 161
 None
None
NAP  A 401 (-3.4A)
NAP  A 401 (-3.3A)
NAP  A 401 (-3.7A)
 1.28A 2v7bA-6biiA:
6.2		 2v7bA-6biiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 6bii GLYOXYLATE REDUCTASE
(Pyrococcus
yayanosii) 		5 / 12 MET A 230
ILE A 259
LEU A 227
LEU A 210
LEU A 264
 None
 1.13A 3a50D-6biiA:
undetectable		 3a50D-6biiA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 6bii GLYOXYLATE REDUCTASE
(Pyrococcus
yayanosii) 		5 / 10 ASN A 282
VAL A 245
ALA A 261
ILE A 259
LEU A 227
 None
 1.21A 3fl9F-6biiA:
undetectable		 3fl9F-6biiA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 6bii GLYOXYLATE REDUCTASE
(Pyrococcus
yayanosii) 		5 / 12 PHE A  23
ALA A  48
GLY A 314
ALA A 310
ILE A  70
 None
 1.40A 3lbdA-6biiA:
undetectable		 3lbdA-6biiA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 6bii GLYOXYLATE REDUCTASE
(Pyrococcus
yayanosii) 		3 / 3 VAL A 126
GLY A 129
LYS A 132
 None
 0.77A 4k50I-6biiA:
undetectable		 4k50I-6biiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 6bii GLYOXYLATE REDUCTASE
(Pyrococcus
yayanosii) 		4 / 6 VAL A 212
VAL A 244
ILE A 222
LEU A 201
 NAP  A 401 (-4.0A)
None
None
None
 0.94A 4l1wB-6biiA:
undetectable		 4l1wB-6biiA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 6bii GLYOXYLATE REDUCTASE
(Pyrococcus
yayanosii) 		5 / 10 VAL A 156
GLY A 157
GLY A 162
ILE A 176
LEU A 177
 None
NAP  A 401 (-3.4A)
None
None
None
 1.02A 5vm8B-6biiA:
2.0		 5vm8B-6biiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6bii GLYOXYLATE REDUCTASE
(Pyrococcus
yayanosii) 		4 / 8 ASP A 246
THR A 247
HIS A 288
LEU A 227
 None
None
MLI  A 402 ( 3.8A)
None
 1.16A 5wauA-6biiA:
undetectable
5wauC-6biiA:
undetectable
5wauc-6biiA:
undetectable		 5wauA-6biiA:
undetectable
5wauC-6biiA:
undetectable
5wauc-6biiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 6bii GLYOXYLATE REDUCTASE
(Pyrococcus
yayanosii) 		5 / 12 LEU A 264
VAL A 283
THR A 247
GLU A 268
HIS A 220
 None
 1.28A 5xipC-6biiA:
undetectable		 5xipC-6biiA:
undetectable