SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bja'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 6bja ACETYL-COA
ACETYLTRANSFERASE A
(Ascaris
suum) 		5 / 10 LEU A 303
VAL A 300
LEU A 369
GLU A 373
LEU A 374
 None
 1.13A 1cqpA-6bjaA:
undetectable
1cqpB-6bjaA:
undetectable		 1cqpA-6bjaA:
23.72
1cqpB-6bjaA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 6bja ACETYL-COA
ACETYLTRANSFERASE A
(Ascaris
suum) 		5 / 9 VAL A  31
GLY A  34
ALA A  76
THR A  38
ILE A  73
 None
 1.20A 1gtnL-6bjaA:
undetectable
1gtnM-6bjaA:
undetectable		 1gtnL-6bjaA:
undetectable
1gtnM-6bjaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 6bja ACETYL-COA
ACETYLTRANSFERASE A
(Ascaris
suum) 		4 / 7 THR A  87
SER A  83
THR A  55
VAL A  57
 None
 0.72A 1ictD-6bjaA:
undetectable		 1ictD-6bjaA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 6bja ACETYL-COA
ACETYLTRANSFERASE A
(Ascaris
suum) 		5 / 12 ARG A 147
ASN A  59
ILE A  69
GLY A  64
PHE A 127
 None
 1.04A 1q8jA-6bjaA:
undetectable		 1q8jA-6bjaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_2
(PROTEASE RETROPEPSIN)		 6bja ACETYL-COA
ACETYLTRANSFERASE A
(Ascaris
suum) 		5 / 11 LEU A 262
ALA A  13
ILE A 361
VAL A 279
ILE A  10
 None
 0.97A 1t3rB-6bjaA:
undetectable		 1t3rB-6bjaA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 6bja ACETYL-COA
ACETYLTRANSFERASE A
(Ascaris
suum) 		4 / 4 GLY A 256
SER A 119
VAL A  36
LEU A  25
 None
 1.36A 1yajB-6bjaA:
undetectable		 1yajB-6bjaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 6bja ACETYL-COA
ACETYLTRANSFERASE A
(Ascaris
suum) 		4 / 7 GLY A  58
ASN A  59
ALA A 257
ILE A  69
 None
 0.74A 3a2qA-6bjaA:
undetectable		 3a2qA-6bjaA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 6bja ACETYL-COA
ACETYLTRANSFERASE A
(Ascaris
suum) 		5 / 12 LEU A 374
GLY A 375
VAL A 341
LEU A 390
LEU A 280
 None
 1.18A 3cjtG-6bjaA:
undetectable		 3cjtG-6bjaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 6bja ACETYL-COA
ACETYLTRANSFERASE A
(Ascaris
suum) 		5 / 12 SER A 251
THR A 252
GLY A 346
GLY A 351
ILE A 361
 COA  A 402 (-2.2A)
None
None
None
None
 1.28A 3fzgA-6bjaA:
undetectable		 3fzgA-6bjaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 6bja ACETYL-COA
ACETYLTRANSFERASE A
(Ascaris
suum) 		5 / 12 ALA A 297
GLY A 327
ILE A 331
VAL A 376
ILE A 319
 None
 1.21A 3n3iA-6bjaA:
undetectable		 3n3iA-6bjaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6bja ACETYL-COA
ACETYLTRANSFERASE A
(Ascaris
suum) 		5 / 10 ILE A  73
ALA A  30
SER A  95
SER A  94
ILE A  88
 None
None
None
CSO  A  92 ( 4.8A)
None
 1.23A 3qgtA-6bjaA:
undetectable		 3qgtA-6bjaA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 6bja ACETYL-COA
ACETYLTRANSFERASE A
(Ascaris
suum) 		4 / 7 PRO A 296
LEU A 334
LEU A 336
ILE A 319
 None
 1.03A 3u5jA-6bjaA:
undetectable		 3u5jA-6bjaA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 6bja ACETYL-COA
ACETYLTRANSFERASE A
(Ascaris
suum) 		5 / 12 SER A 307
LEU A 304
ILE A 100
ILE A 389
VAL A 376
 None
 1.04A 3w67B-6bjaA:
undetectable		 3w67B-6bjaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6bja ACETYL-COA
ACETYLTRANSFERASE A
(Ascaris
suum) 		5 / 12 ASN A 342
ILE A 319
GLY A 358
ALA A 359
LEU A 365
 None
None
CSO  A  92 ( 4.4A)
None
None
 1.00A 4e1gA-6bjaA:
undetectable		 4e1gA-6bjaA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6bja ACETYL-COA
ACETYLTRANSFERASE A
(Ascaris
suum) 		4 / 5 GLY A 383
GLY A 382
MET A 159
GLU A 385
 None
CSO  A  92 ( 4.1A)
CSO  A  92 (-3.0A)
None
 1.29A 4fglC-6bjaA:
undetectable		 4fglC-6bjaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 6bja ACETYL-COA
ACETYLTRANSFERASE A
(Ascaris
suum) 		4 / 8 GLN A  84
ASN A  68
ALA A  70
GLN A  72
 None
 1.01A 5km8A-6bjaA:
undetectable
5km8B-6bjaA:
undetectable		 5km8A-6bjaA:
22.07
5km8B-6bjaA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 6bja ACETYL-COA
ACETYLTRANSFERASE A
(Ascaris
suum) 		5 / 12 ARG A 344
ILE A 331
PHE A 330
ILE A 314
ALA A 315
 None
 1.09A 5vc0A-6bjaA:
undetectable		 5vc0A-6bjaA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 6bja ACETYL-COA
ACETYLTRANSFERASE A
(Ascaris
suum) 		3 / 3 PRO A  80
SER A  82
SER A  83
 None
 0.68A 6bpyA-6bjaA:
undetectable		 6bpyA-6bjaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 6bja ACETYL-COA
ACETYLTRANSFERASE A
(Ascaris
suum) 		5 / 10 SER A 184
ASP A 178
ILE A 331
SER A 324
GLY A 327
 None
 1.21A 6dm0B-6bjaA:
undetectable
6dm0C-6bjaA:
undetectable		 6dm0B-6bjaA:
21.25
6dm0C-6bjaA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 6bja ACETYL-COA
ACETYLTRANSFERASE A
(Ascaris
suum) 		4 / 7 ASP A 219
ARG A 360
GLU A 200
GLU A 318
 None
 1.15A 6mn5E-6bjaA:
undetectable		 6mn5E-6bjaA:
26.37