SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bk5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 6bk5 UBIQUITIN LIGASE CBL
(Salpingoeca
rosetta) 		5 / 12 THR A 113
ALA A 112
LEU A 134
ILE A  44
LEU A  60
 None
 1.14A 1errB-6bk5A:
undetectable		 1errB-6bk5A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 6bk5 UBIQUITIN LIGASE CBL
(Salpingoeca
rosetta) 		4 / 6 LEU A 134
ASP A 118
LEU A  73
HIS A 108
 None
 1.26A 1errB-6bk5A:
undetectable		 1errB-6bk5A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 6bk5 UBIQUITIN LIGASE CBL
(Salpingoeca
rosetta) 		4 / 5 LEU A 134
ASP A 118
LEU A  73
HIS A 108
 None
 1.25A 2jfaA-6bk5A:
undetectable		 2jfaA-6bk5A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2MJI_A_KTRA201_1
(FATTY ACID-BINDING
PROTEIN, INTESTINAL)		 6bk5 UBIQUITIN LIGASE CBL
(Salpingoeca
rosetta) 		5 / 12 ILE A 166
THR A 226
LEU A 235
LEU A 195
ARG A 174
 None
 1.24A 2mjiA-6bk5A:
undetectable		 2mjiA-6bk5A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 6bk5 UBIQUITIN LIGASE CBL
(Salpingoeca
rosetta) 		4 / 5 LEU A 134
ASP A 118
LEU A  73
HIS A 108
 None
 1.29A 2qxsA-6bk5A:
undetectable		 2qxsA-6bk5A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 6bk5 UBIQUITIN LIGASE CBL
(Salpingoeca
rosetta) 		4 / 5 LEU A 134
ASP A 118
LEU A  73
HIS A 108
 None
 1.28A 2qxsB-6bk5A:
undetectable		 2qxsB-6bk5A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 6bk5 UBIQUITIN LIGASE CBL
(Salpingoeca
rosetta) 		4 / 6 LEU A 330
LEU A 328
ILE A 334
ARG A 332
 None
 0.79A 2rlfA-6bk5A:
undetectable
2rlfB-6bk5A:
undetectable		 2rlfA-6bk5A:
20.78
2rlfB-6bk5A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 6bk5 UBIQUITIN LIGASE CBL
(Salpingoeca
rosetta) 		3 / 3 ASP A  27
PHE A  29
LEU A 100
 None
 0.69A 2zi9A-6bk5A:
undetectable		 2zi9A-6bk5A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 6bk5 UBIQUITIN LIGASE CBL
(Salpingoeca
rosetta) 		5 / 11 GLN A 206
LEU A 205
ALA A 168
LEU A 281
PHE A 225
 None
 1.48A 3jwqA-6bk5A:
3.0
3jwqD-6bk5A:
3.2		 3jwqA-6bk5A:
13.83
3jwqD-6bk5A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 6bk5 UBIQUITIN LIGASE CBL
(Salpingoeca
rosetta) 		5 / 12 ALA A 243
LEU A 276
ILE A 211
LEU A 281
LEU A 228
 None
 1.13A 3k2hA-6bk5A:
undetectable		 3k2hA-6bk5A:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 6bk5 UBIQUITIN LIGASE CBL
(Salpingoeca
rosetta) 		3 / 3 ARG A  93
VAL A 102
THR A  40
 None
 0.78A 3ndtA-6bk5A:
undetectable		 3ndtA-6bk5A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 6bk5 UBIQUITIN LIGASE CBL
(Salpingoeca
rosetta) 		5 / 12 LEU A 242
ASP A 336
ASN A 340
PRO A 247
VAL A 241
 None
 1.04A 3ucbA-6bk5A:
undetectable		 3ucbA-6bk5A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 6bk5 UBIQUITIN LIGASE CBL
(Salpingoeca
rosetta) 		4 / 7 LEU A 317
THR A 290
THR A 298
GLY A 287
 None
 0.94A 4eq4A-6bk5A:
undetectable		 4eq4A-6bk5A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 6bk5 UBIQUITIN LIGASE CBL
(Salpingoeca
rosetta) 		4 / 8 LEU A 317
THR A 290
THR A 298
GLY A 287
 None
 0.92A 4eq4B-6bk5A:
undetectable		 4eq4B-6bk5A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 6bk5 UBIQUITIN LIGASE CBL
(Salpingoeca
rosetta) 		4 / 7 LEU A 317
THR A 290
THR A 298
GLY A 287
 None
 0.90A 4eqlA-6bk5A:
undetectable		 4eqlA-6bk5A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 6bk5 UBIQUITIN LIGASE CBL
(Salpingoeca
rosetta) 		4 / 7 LEU A 317
THR A 290
THR A 298
GLY A 287
 None
 0.90A 4eqlB-6bk5A:
undetectable		 4eqlB-6bk5A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6bk5 UBIQUITIN LIGASE CBL
(Salpingoeca
rosetta) 		4 / 7 ARG A 179
VAL A 151
PHE A 161
GLU A 221
 None
None
None
CA  A 401 (-2.2A)
 1.38A 4jseA-6bk5A:
undetectable
4jseB-6bk5A:
3.2		 4jseA-6bk5A:
10.76
4jseB-6bk5A:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6bk5 UBIQUITIN LIGASE CBL
(Salpingoeca
rosetta) 		4 / 7 PHE A 161
GLU A 221
ARG A 179
VAL A 151
 None
CA  A 401 (-2.2A)
None
None
 1.38A 4jseA-6bk5A:
undetectable
4jseB-6bk5A:
3.2		 4jseA-6bk5A:
10.76
4jseB-6bk5A:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 6bk5 UBIQUITIN LIGASE CBL
(Salpingoeca
rosetta) 		3 / 3 ARG A  49
LYS A  50
LYS A  46
 None
 1.30A 4k50A-6bk5A:
undetectable		 4k50A-6bk5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 6bk5 UBIQUITIN LIGASE CBL
(Salpingoeca
rosetta) 		4 / 7 LEU A 317
THR A 290
THR A 298
GLY A 287
 None
 0.91A 4l39B-6bk5A:
undetectable		 4l39B-6bk5A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 6bk5 UBIQUITIN LIGASE CBL
(Salpingoeca
rosetta) 		3 / 3 ARG A 268
HIS A 267
SER A 271
 None
 0.91A 4mjwA-6bk5A:
undetectable
4mjwB-6bk5A:
undetectable		 4mjwA-6bk5A:
undetectable
4mjwB-6bk5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 6bk5 UBIQUITIN LIGASE CBL
(Salpingoeca
rosetta) 		3 / 3 SER A 271
ARG A 268
HIS A 267
 None
 0.88A 4mjwA-6bk5A:
undetectable
4mjwB-6bk5A:
undetectable		 4mjwA-6bk5A:
undetectable
4mjwB-6bk5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_A_FOLA201_0
(FOLATE ECF
TRANSPORTER)		 6bk5 UBIQUITIN LIGASE CBL
(Salpingoeca
rosetta) 		5 / 12 LEU A  62
LYS A  63
SER A  65
ASN A 135
ARG A 131
 None
 1.46A 4z7fA-6bk5A:
undetectable		 4z7fA-6bk5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 6bk5 UBIQUITIN LIGASE CBL
(Salpingoeca
rosetta) 		5 / 11 ALA A 204
ARG A 341
VAL A 344
LEU A 197
TYR A 240
 None
 1.11A 5eb5A-6bk5A:
undetectable		 5eb5A-6bk5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 6bk5 UBIQUITIN LIGASE CBL
(Salpingoeca
rosetta) 		5 / 10 ALA A 204
ARG A 341
VAL A 344
LEU A 197
TYR A 240
 None
 1.08A 5eb5B-6bk5A:
undetectable		 5eb5B-6bk5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 6bk5 UBIQUITIN LIGASE CBL
(Salpingoeca
rosetta) 		4 / 6 LEU A 115
LEU A  51
LEU A  54
HIS A 108
 None
 0.91A 5gs4A-6bk5A:
undetectable		 5gs4A-6bk5A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 6bk5 UBIQUITIN LIGASE CBL
(Salpingoeca
rosetta) 		3 / 3 LYS A 200
GLN A 339
ASN A 340
 None
 0.87A 5l2tA-6bk5A:
undetectable		 5l2tA-6bk5A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M10_A_NCAA603_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 6bk5 UBIQUITIN LIGASE CBL
(Salpingoeca
rosetta) 		4 / 5 LEU A 195
PHE A 222
LEU A 187
TRP A 232
 None
 1.44A 5m10A-6bk5A:
undetectable		 5m10A-6bk5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 6bk5 UBIQUITIN LIGASE CBL
(Salpingoeca
rosetta) 		3 / 3 THR A  30
HIS A 216
ASN A 214
 None
None
CA  A 401 (-3.0A)
 0.85A 5n4tA-6bk5A:
undetectable		 5n4tA-6bk5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 6bk5 UBIQUITIN LIGASE CBL
(Salpingoeca
rosetta) 		5 / 11 MET A 144
PHE A 141
ILE A  72
LEU A  73
ILE A 111
 None
 1.42A 6fgcA-6bk5A:
undetectable		 6fgcA-6bk5A:
17.86