SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bk8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 6bk8 PRE-MRNA-SPLICING
FACTOR SYF1
(Saccharomyces
cerevisiae) 		4 / 6 PHE U 748
GLU U 731
ARG U 760
ILE U 733
 None
 1.27A 1nsiC-6bk8U:
undetectable
1nsiD-6bk8U:
undetectable		 1nsiC-6bk8U:
11.54
1nsiD-6bk8U:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 6bk8 PRE-MRNA-SPLICING
FACTOR SYF1
(Saccharomyces
cerevisiae) 		3 / 3 SER U 783
GLU U 743
ASP U 750
 None
 0.56A 2zthA-6bk8U:
undetectable		 2zthA-6bk8U:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 6bk8 PRE-MRNA-SPLICING
FACTOR SYF1
(Saccharomyces
cerevisiae) 		3 / 3 SER U 783
GLU U 743
ASP U 750
 None
 0.61A 3bwmA-6bk8U:
undetectable		 3bwmA-6bk8U:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 6bk8 PRE-MRNA-SPLICING
FACTOR SYF1
(Saccharomyces
cerevisiae) 		3 / 3 SER U 783
GLU U 743
ASP U 750
 None
 0.55A 3bwyA-6bk8U:
undetectable		 3bwyA-6bk8U:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 6bk8 PRE-MRNA-SPLICING
FACTOR SYF1
(Saccharomyces
cerevisiae) 		4 / 8 PHE U 748
GLU U 731
ARG U 760
ILE U 733
 None
 1.33A 4cx7A-6bk8U:
undetectable
4cx7B-6bk8U:
undetectable		 4cx7A-6bk8U:
11.54
4cx7B-6bk8U:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 6bk8 PRE-MRNA-SPLICING
FACTOR SYF1
(Saccharomyces
cerevisiae) 		4 / 7 PHE U 748
GLU U 731
ARG U 760
ILE U 733
 None
 1.32A 4cx7C-6bk8U:
undetectable
4cx7D-6bk8U:
undetectable		 4cx7C-6bk8U:
11.54
4cx7D-6bk8U:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 6bk8 PRE-MRNA-SPLICING
FACTOR SYF1
(Saccharomyces
cerevisiae) 		3 / 3 SER U 783
GLU U 743
ASP U 750
 None
 0.57A 4xudA-6bk8U:
undetectable		 4xudA-6bk8U:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_1
(PROLINE--TRNA LIGASE)		 6bk8 PRE-MRNA-SPLICING
FACTOR SYF1
(Saccharomyces
cerevisiae) 		4 / 4 THR U 796
GLU U 788
THR U 758
HIS U 791
 None
 1.31A 4ydqA-6bk8U:
undetectable		 4ydqA-6bk8U:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_1
(AMINOACYL-TRNA
SYNTHETASE)		 6bk8 PRE-MRNA-SPLICING
FACTOR SYF1
(Saccharomyces
cerevisiae) 		4 / 4 THR U 796
GLU U 788
THR U 758
HIS U 791
 None
 1.33A 5f9zA-6bk8U:
undetectable		 5f9zA-6bk8U:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_1
(AMINOACYL-TRNA
SYNTHETASE)		 6bk8 PRE-MRNA-SPLICING
FACTOR SYF1
(Saccharomyces
cerevisiae) 		4 / 4 THR U 796
GLU U 788
THR U 758
HIS U 791
 None
 1.33A 5f9zB-6bk8U:
undetectable		 5f9zB-6bk8U:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 6bk8 PRE-MRNA-SPLICING
FACTOR SYF1
(Saccharomyces
cerevisiae) 		3 / 3 THR U 796
GLU U 788
HIS U 791
 None
 0.90A 5xioA-6bk8U:
undetectable		 5xioA-6bk8U:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 6bk8 PRE-MRNA-SPLICING
FACTOR SYF1
(Saccharomyces
cerevisiae) 		3 / 3 THR U 796
GLU U 788
HIS U 791
 None
 0.88A 5xiqB-6bk8U:
undetectable		 5xiqB-6bk8U:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 6bk8 PRE-MRNA-SPLICING
FACTOR SYF1
(Saccharomyces
cerevisiae) 		3 / 3 THR U 796
GLU U 788
HIS U 791
 None
 0.89A 5xiqD-6bk8U:
undetectable		 5xiqD-6bk8U:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 6bk8 PRE-MRNA-SPLICING
FACTOR SYF1
(Saccharomyces
cerevisiae) 		4 / 7 ILE U 735
GLN U 734
GLU U 727
VAL U 692
 None
 1.02A 6j20A-6bk8U:
undetectable		 6j20A-6bk8U:
undetectable