SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bld'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 6bld CYTOCHROME P450
268A2 CYP268A2
(Mycobacterium
marinum) 		5 / 11 LEU A 256
VAL A 259
THR A 264
VAL A 308
VAL A 409
 HEM  A 501 ( 4.8A)
DXJ  A 502 (-4.5A)
HEM  A 501 (-3.4A)
HEM  A 501 ( 4.6A)
None
 0.85A 1akdA-6bldA:
41.2		 1akdA-6bldA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 6bld CYTOCHROME P450
268A2 CYP268A2
(Mycobacterium
marinum) 		5 / 9 ALA A 380
THR A 165
ILE A 133
GLY A 261
THR A 265
 None
None
None
HEM  A 501 (-3.6A)
HEM  A 501 (-3.8A)
 1.17A 1c9sQ-6bldA:
undetectable
1c9sR-6bldA:
undetectable		 1c9sQ-6bldA:
undetectable
1c9sR-6bldA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 6bld CYTOCHROME P450
268A2 CYP268A2
(Mycobacterium
marinum) 		5 / 10 GLY A 261
THR A 265
ALA A 380
THR A 165
ILE A 133
 HEM  A 501 (-3.6A)
HEM  A 501 (-3.8A)
None
None
None
 1.19A 1c9sL-6bldA:
undetectable
1c9sV-6bldA:
undetectable		 1c9sL-6bldA:
undetectable
1c9sV-6bldA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_A_CAMA503_0
(CYTOCHROME P450-CAM)		 6bld CYTOCHROME P450
268A2 CYP268A2
(Mycobacterium
marinum) 		4 / 8 LEU A 256
VAL A 259
THR A 264
VAL A 308
 HEM  A 501 ( 4.8A)
DXJ  A 502 (-4.5A)
HEM  A 501 (-3.4A)
HEM  A 501 ( 4.6A)
 0.53A 1dz9A-6bldA:
42.6		 1dz9A-6bldA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 6bld CYTOCHROME P450
268A2 CYP268A2
(Mycobacterium
marinum) 		5 / 11 LEU A 256
VAL A 259
GLY A 261
THR A 264
VAL A 308
 HEM  A 501 ( 4.8A)
DXJ  A 502 (-4.5A)
HEM  A 501 (-3.6A)
HEM  A 501 (-3.4A)
HEM  A 501 ( 4.6A)
 1.08A 1phgA-6bldA:
42.3		 1phgA-6bldA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_B_RABB646_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 6bld CYTOCHROME P450
268A2 CYP268A2
(Mycobacterium
marinum) 		5 / 9 ARG A 379
GLY A 366
VAL A 362
GLU A 299
ILE A  70
 None
 1.45A 1pw7B-6bldA:
undetectable		 1pw7B-6bldA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 6bld CYTOCHROME P450
268A2 CYP268A2
(Mycobacterium
marinum) 		5 / 11 LEU A 382
LEU A 276
LEU A 273
SER A 270
THR A 268
 None
None
None
None
HEM  A 501 ( 4.7A)
 1.30A 1tz8A-6bldA:
undetectable
1tz8B-6bldA:
undetectable		 1tz8A-6bldA:
22.83
1tz8B-6bldA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_E_TRPE81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6bld CYTOCHROME P450
268A2 CYP268A2
(Mycobacterium
marinum) 		5 / 10 ALA A 380
THR A 165
ILE A 133
GLY A 261
THR A 265
 None
None
None
HEM  A 501 (-3.6A)
HEM  A 501 (-3.8A)
 1.16A 1utdE-6bldA:
undetectable
1utdF-6bldA:
undetectable		 1utdE-6bldA:
undetectable
1utdF-6bldA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_H_TRPH81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6bld CYTOCHROME P450
268A2 CYP268A2
(Mycobacterium
marinum) 		5 / 10 ALA A 380
THR A 165
ILE A 133
GLY A 261
THR A 265
 None
None
None
HEM  A 501 (-3.6A)
HEM  A 501 (-3.8A)
 1.13A 1utdH-6bldA:
undetectable
1utdI-6bldA:
undetectable		 1utdH-6bldA:
undetectable
1utdI-6bldA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 6bld CYTOCHROME P450
268A2 CYP268A2
(Mycobacterium
marinum) 		4 / 8 LEU A 256
VAL A 259
THR A 264
VAL A 308
 HEM  A 501 ( 4.8A)
DXJ  A 502 (-4.5A)
HEM  A 501 (-3.4A)
HEM  A 501 ( 4.6A)
 0.59A 1uyuA-6bldA:
42.3		 1uyuA-6bldA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 6bld CYTOCHROME P450
268A2 CYP268A2
(Mycobacterium
marinum) 		5 / 11 LEU A 256
VAL A 259
GLY A 261
THR A 264
VAL A 308
 HEM  A 501 ( 4.8A)
DXJ  A 502 (-4.5A)
HEM  A 501 (-3.6A)
HEM  A 501 (-3.4A)
HEM  A 501 ( 4.6A)
 1.19A 2a1nA-6bldA:
42.0		 2a1nA-6bldA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 6bld CYTOCHROME P450
268A2 CYP268A2
(Mycobacterium
marinum) 		5 / 11 LEU A 256
VAL A 259
THR A 264
VAL A 308
VAL A 409
 HEM  A 501 ( 4.8A)
DXJ  A 502 (-4.5A)
HEM  A 501 (-3.4A)
HEM  A 501 ( 4.6A)
None
 0.80A 2a1nA-6bldA:
42.0		 2a1nA-6bldA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 6bld CYTOCHROME P450
268A2 CYP268A2
(Mycobacterium
marinum) 		3 / 3 SER A 167
THR A 265
GLN A 381
 None
HEM  A 501 (-3.8A)
HEM  A 501 (-4.2A)
 0.77A 2fk8A-6bldA:
undetectable		 2fk8A-6bldA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 6bld CYTOCHROME P450
268A2 CYP268A2
(Mycobacterium
marinum) 		3 / 3 ASP A 344
ARG A  37
ARG A  66
 None
 1.09A 2j9dA-6bldA:
undetectable
2j9dC-6bldA:
undetectable		 2j9dA-6bldA:
undetectable
2j9dC-6bldA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 6bld CYTOCHROME P450
268A2 CYP268A2
(Mycobacterium
marinum) 		3 / 3 LEU A 212
TYR A 211
GLN A 214
 None
 0.66A 2wekA-6bldA:
undetectable		 2wekA-6bldA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 6bld CYTOCHROME P450
268A2 CYP268A2
(Mycobacterium
marinum) 		4 / 6 LEU A 256
VAL A 259
VAL A 308
VAL A 409
 HEM  A 501 ( 4.8A)
DXJ  A 502 (-4.5A)
HEM  A 501 ( 4.6A)
None
 0.78A 2z97A-6bldA:
42.4		 2z97A-6bldA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAX_A_CAMA422_0
(CYTOCHROME P450-CAM)		 6bld CYTOCHROME P450
268A2 CYP268A2
(Mycobacterium
marinum) 		4 / 7 LEU A 256
VAL A 259
THR A 264
VAL A 308
 HEM  A 501 ( 4.8A)
DXJ  A 502 (-4.5A)
HEM  A 501 (-3.4A)
HEM  A 501 ( 4.6A)
 0.70A 2zaxA-6bldA:
42.0		 2zaxA-6bldA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 6bld CYTOCHROME P450
268A2 CYP268A2
(Mycobacterium
marinum) 		3 / 3 ALA A 260
THR A 264
CYH A 372
 HEM  A 501 ( 3.6A)
HEM  A 501 (-3.4A)
HEM  A 501 (-2.7A)
 0.54A 3e4eA-6bldA:
30.7		 3e4eA-6bldA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 6bld CYTOCHROME P450
268A2 CYP268A2
(Mycobacterium
marinum) 		3 / 3 ALA A 260
THR A 264
CYH A 372
 HEM  A 501 ( 3.6A)
HEM  A 501 (-3.4A)
HEM  A 501 (-2.7A)
 0.43A 3e4eB-6bldA:
30.7		 3e4eB-6bldA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 6bld CYTOCHROME P450
268A2 CYP268A2
(Mycobacterium
marinum) 		4 / 7 LEU A 256
VAL A 259
THR A 264
VAL A 308
 HEM  A 501 ( 4.8A)
DXJ  A 502 (-4.5A)
HEM  A 501 (-3.4A)
HEM  A 501 ( 4.6A)
 0.68A 3fwgB-6bldA:
42.1		 3fwgB-6bldA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWI_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 6bld CYTOCHROME P450
268A2 CYP268A2
(Mycobacterium
marinum) 		4 / 7 LEU A 256
VAL A 259
THR A 264
VAL A 308
 HEM  A 501 ( 4.8A)
DXJ  A 502 (-4.5A)
HEM  A 501 (-3.4A)
HEM  A 501 ( 4.6A)
 0.73A 3fwiA-6bldA:
41.7		 3fwiA-6bldA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 6bld CYTOCHROME P450
268A2 CYP268A2
(Mycobacterium
marinum) 		5 / 12 PHE A  33
ASP A  12
THR A  13
ARG A  37
ALA A  38
 None
 1.01A 3g89A-6bldA:
undetectable		 3g89A-6bldA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 6bld CYTOCHROME P450
268A2 CYP268A2
(Mycobacterium
marinum) 		5 / 11 PHE A  33
ASP A  12
THR A  13
ARG A  37
ALA A  38
 None
 1.01A 3g89B-6bldA:
undetectable		 3g89B-6bldA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 6bld CYTOCHROME P450
268A2 CYP268A2
(Mycobacterium
marinum) 		5 / 12 PHE A  33
ASP A  12
THR A  13
ARG A  37
ALA A  38
 None
 1.09A 3g8bA-6bldA:
undetectable		 3g8bA-6bldA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 6bld CYTOCHROME P450
268A2 CYP268A2
(Mycobacterium
marinum) 		5 / 12 ALA A 186
ALA A 183
LEU A 257
PHE A 253
LEU A 212
 None
 0.94A 3p2kA-6bldA:
undetectable		 3p2kA-6bldA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 6bld CYTOCHROME P450
268A2 CYP268A2
(Mycobacterium
marinum) 		5 / 10 LEU A 187
LEU A 256
ALA A 260
THR A 264
VAL A 308
 DXJ  A 502 (-3.6A)
HEM  A 501 ( 4.8A)
HEM  A 501 ( 3.6A)
HEM  A 501 (-3.4A)
HEM  A 501 ( 4.6A)
 0.77A 3r9cA-6bldA:
39.3		 3r9cA-6bldA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 6bld CYTOCHROME P450
268A2 CYP268A2
(Mycobacterium
marinum) 		5 / 12 SER A  82
ALA A  98
LEU A 113
LEU A 256
LEU A 373
 None
None
None
HEM  A 501 ( 4.8A)
HEM  A 501 (-4.1A)
 0.94A 3r9cA-6bldA:
39.3		 3r9cA-6bldA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 6bld CYTOCHROME P450
268A2 CYP268A2
(Mycobacterium
marinum) 		5 / 10 ARG A 379
GLY A 366
VAL A 362
GLU A 299
ILE A  70
 None
 1.45A 3uayA-6bldA:
undetectable		 3uayA-6bldA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 6bld CYTOCHROME P450
268A2 CYP268A2
(Mycobacterium
marinum) 		5 / 12 ALA A 378
PHE A 121
LEU A 231
LEU A 256
PHE A 102
 HEM  A 501 (-3.4A)
HEM  A 501 (-4.8A)
None
HEM  A 501 ( 4.8A)
HEM  A 501 (-4.6A)
 1.21A 4kykA-6bldA:
undetectable
4kykB-6bldA:
undetectable		 4kykA-6bldA:
20.53
4kykB-6bldA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 6bld CYTOCHROME P450
268A2 CYP268A2
(Mycobacterium
marinum) 		5 / 9 LEU A 256
VAL A 259
THR A 264
VAL A 308
VAL A 409
 HEM  A 501 ( 4.8A)
DXJ  A 502 (-4.5A)
HEM  A 501 (-3.4A)
HEM  A 501 ( 4.6A)
None
 0.83A 5cp4A-6bldA:
42.4		 5cp4A-6bldA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 6bld CYTOCHROME P450
268A2 CYP268A2
(Mycobacterium
marinum) 		5 / 12 SER A  27
TRP A 341
THR A 306
ALA A 337
TYR A 403
 None
 1.43A 5dsgB-6bldA:
1.3		 5dsgB-6bldA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 6bld CYTOCHROME P450
268A2 CYP268A2
(Mycobacterium
marinum) 		5 / 12 PHE A 311
GLY A 367
GLY A 365
VAL A  73
HIS A 370
 HEM  A 501 (-4.6A)
None
HEM  A 501 (-3.9A)
None
HEM  A 501 (-3.8A)
 1.18A 5kocB-6bldA:
undetectable		 5kocB-6bldA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 6bld CYTOCHROME P450
268A2 CYP268A2
(Mycobacterium
marinum) 		4 / 7 LEU A 103
LEU A 256
ALA A 260
THR A 264
 HEM  A 501 ( 4.2A)
HEM  A 501 ( 4.8A)
HEM  A 501 ( 3.6A)
HEM  A 501 (-3.4A)
 0.57A 6a7jA-6bldA:
40.2		 6a7jA-6bldA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 6bld CYTOCHROME P450
268A2 CYP268A2
(Mycobacterium
marinum) 		5 / 12 VAL A 298
LEU A 301
ILE A 269
ALA A 275
LEU A 276
 None
 1.03A 6ajiA-6bldA:
undetectable		 6ajiA-6bldA:
undetectable