SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6blj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 6blj SERINE-TRNA LIGASE
(Naegleria
fowleri) 		5 / 12 LEU A 101
LEU A 104
SER A 100
HIS A  51
ILE A  59
 None
 1.27A 1fmlA-6bljA:
undetectable		 1fmlA-6bljA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 6blj SERINE-TRNA LIGASE
(Naegleria
fowleri) 		3 / 3 GLU A 449
HIS A 183
ASP A 391
 None
 0.79A 1i9gA-6bljA:
undetectable		 1i9gA-6bljA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 6blj SERINE-TRNA LIGASE
(Naegleria
fowleri) 		3 / 3 ARG A 321
ASP A 382
ASN A 367
 None
 0.78A 1nbhA-6bljA:
undetectable		 1nbhA-6bljA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 6blj SERINE-TRNA LIGASE
(Naegleria
fowleri) 		3 / 3 ARG A 321
ASP A 382
ASN A 367
 None
 0.78A 1nbhD-6bljA:
undetectable		 1nbhD-6bljA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 6blj SERINE-TRNA LIGASE
(Naegleria
fowleri) 		3 / 3 ILE A 161
ASP A 382
PHE A 381
 None
 0.63A 1uwjB-6bljA:
1.4		 1uwjB-6bljA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 6blj SERINE-TRNA LIGASE
(Naegleria
fowleri) 		5 / 12 PHE A 355
TYR A 356
ALA A 385
PRO A 460
TYR A 223
 None
 1.03A 2igtA-6bljA:
undetectable		 2igtA-6bljA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 6blj SERINE-TRNA LIGASE
(Naegleria
fowleri) 		5 / 12 PHE A 355
TYR A 356
ALA A 385
PRO A 460
TYR A 223
 None
 1.04A 2igtB-6bljA:
undetectable		 2igtB-6bljA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 6blj SERINE-TRNA LIGASE
(Naegleria
fowleri) 		3 / 3 ARG A   8
ARG A 135
ARG A  43
 None
 1.07A 2jb7A-6bljA:
undetectable
2jb7B-6bljA:
undetectable
2jb7C-6bljA:
undetectable		 2jb7A-6bljA:
undetectable
2jb7B-6bljA:
undetectable
2jb7C-6bljA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 6blj SERINE-TRNA LIGASE
(Naegleria
fowleri) 		3 / 3 ARG A  43
ARG A   8
ARG A 135
 None
 1.09A 2jb7A-6bljA:
undetectable
2jb7B-6bljA:
undetectable
2jb7C-6bljA:
undetectable		 2jb7A-6bljA:
undetectable
2jb7B-6bljA:
undetectable
2jb7C-6bljA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 6blj SERINE-TRNA LIGASE
(Naegleria
fowleri) 		3 / 3 ARG A 135
ARG A  43
ARG A   8
 None
 1.15A 2jb7A-6bljA:
undetectable
2jb7B-6bljA:
undetectable
2jb7C-6bljA:
undetectable		 2jb7A-6bljA:
undetectable
2jb7B-6bljA:
undetectable
2jb7C-6bljA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 6blj SERINE-TRNA LIGASE
(Naegleria
fowleri) 		5 / 9 LEU A 359
ALA A 219
LEU A 220
ALA A 224
PHE A 355
 None
 1.08A 2vcvD-6bljA:
undetectable		 2vcvD-6bljA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 6blj SERINE-TRNA LIGASE
(Naegleria
fowleri) 		5 / 9 LEU A 359
ALA A 219
LEU A 220
ALA A 224
PHE A 355
 None
 1.10A 2vcvH-6bljA:
undetectable		 2vcvH-6bljA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 6blj SERINE-TRNA LIGASE
(Naegleria
fowleri) 		5 / 9 LEU A 359
ALA A 219
LEU A 220
ALA A 224
PHE A 355
 None
 1.11A 2vcvI-6bljA:
undetectable		 2vcvI-6bljA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 6blj SERINE-TRNA LIGASE
(Naegleria
fowleri) 		4 / 8 ASN A 404
SER A 403
PHE A 345
ASN A 367
 None
None
EDO  A 501 ( 4.8A)
None
 1.20A 2wekA-6bljA:
undetectable		 2wekA-6bljA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 6blj SERINE-TRNA LIGASE
(Naegleria
fowleri) 		4 / 8 ASN A 404
SER A 403
PHE A 345
ASN A 367
 None
None
EDO  A 501 ( 4.8A)
None
 1.24A 2wekB-6bljA:
undetectable		 2wekB-6bljA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 6blj SERINE-TRNA LIGASE
(Naegleria
fowleri) 		4 / 6 ILE A 280
TYR A 237
MET A 242
ILE A 273
 None
 1.10A 3eteA-6bljA:
undetectable
3eteE-6bljA:
undetectable		 3eteA-6bljA:
10.23
3eteE-6bljA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 6blj SERINE-TRNA LIGASE
(Naegleria
fowleri) 		4 / 5 ILE A 280
TYR A 237
MET A 242
ILE A 273
 None
 1.11A 3eteB-6bljA:
undetectable
3eteC-6bljA:
undetectable		 3eteB-6bljA:
10.23
3eteC-6bljA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 6blj SERINE-TRNA LIGASE
(Naegleria
fowleri) 		4 / 7 MET A 242
ILE A 273
ILE A 280
TYR A 237
 None
 1.11A 3eteD-6bljA:
undetectable
3eteF-6bljA:
undetectable		 3eteD-6bljA:
10.23
3eteF-6bljA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 6blj SERINE-TRNA LIGASE
(Naegleria
fowleri) 		3 / 3 GLN A 464
THR A 470
LEU A 444
 None
 0.75A 3ondA-6bljA:
undetectable		 3ondA-6bljA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 6blj SERINE-TRNA LIGASE
(Naegleria
fowleri) 		3 / 3 GLN A 464
THR A 470
LEU A 444
 None
 0.76A 3ondB-6bljA:
undetectable		 3ondB-6bljA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 6blj SERINE-TRNA LIGASE
(Naegleria
fowleri) 		5 / 12 SER A  60
ALA A 102
LEU A 104
LEU A 112
LEU A  96
 None
 0.92A 3r9cA-6bljA:
undetectable		 3r9cA-6bljA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 6blj SERINE-TRNA LIGASE
(Naegleria
fowleri) 		4 / 7 ARG A   8
ILE A  18
LEU A   2
ASP A   3
 None
 0.99A 4mmcA-6bljA:
1.2		 4mmcA-6bljA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 6blj SERINE-TRNA LIGASE
(Naegleria
fowleri) 		5 / 12 ALA A 385
PRO A 362
GLY A 360
ALA A 439
GLU A 329
 None
None
None
AMP  A 500 (-3.4A)
None
 0.94A 5c0oE-6bljA:
undetectable		 5c0oE-6bljA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 6blj SERINE-TRNA LIGASE
(Naegleria
fowleri) 		3 / 3 GLU A 449
HIS A 183
ASP A 391
 None
 0.78A 5c0oG-6bljA:
undetectable		 5c0oG-6bljA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSH_B_ACTB401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 6blj SERINE-TRNA LIGASE
(Naegleria
fowleri) 		4 / 5 ARG A  25
LEU A 373
ASN A 144
VAL A 146
 None
 1.21A 5cshB-6bljA:
undetectable		 5cshB-6bljA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_B_ACTB401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 6blj SERINE-TRNA LIGASE
(Naegleria
fowleri) 		4 / 5 ARG A  25
LEU A 373
ASN A 144
VAL A 146
 None
 1.22A 5os7B-6bljA:
undetectable		 5os7B-6bljA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 6blj SERINE-TRNA LIGASE
(Naegleria
fowleri) 		3 / 3 PHE A 227
ASP A 226
LYS A 230
 None
 0.85A 6awtD-6bljA:
undetectable		 6awtD-6bljA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 6blj SERINE-TRNA LIGASE
(Naegleria
fowleri) 		5 / 10 ARG A 306
GLU A 308
PHE A 325
ALA A 439
GLU A 398
 AMP  A 500 (-3.0A)
AMP  A 500 (-3.4A)
AMP  A 500 (-3.6A)
AMP  A 500 (-3.4A)
AMP  A 500 (-3.2A)
 1.08A 6bniA-6bljA:
10.7		 6bniA-6bljA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 6blj SERINE-TRNA LIGASE
(Naegleria
fowleri) 		5 / 10 ARG A 306
GLU A 308
PHE A 325
GLU A 398
ARG A 442
 AMP  A 500 (-3.0A)
AMP  A 500 (-3.4A)
AMP  A 500 (-3.6A)
AMP  A 500 (-3.2A)
AMP  A 500 (-3.9A)
 0.49A 6bniA-6bljA:
10.7		 6bniA-6bljA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 6blj SERINE-TRNA LIGASE
(Naegleria
fowleri) 		5 / 10 ARG A 306
GLU A 308
PHE A 325
ALA A 439
GLU A 398
 AMP  A 500 (-3.0A)
AMP  A 500 (-3.4A)
AMP  A 500 (-3.6A)
AMP  A 500 (-3.4A)
AMP  A 500 (-3.2A)
 1.15A 6bniB-6bljA:
12.3		 6bniB-6bljA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 6blj SERINE-TRNA LIGASE
(Naegleria
fowleri) 		5 / 10 ARG A 306
GLU A 308
PHE A 325
GLU A 398
ARG A 442
 AMP  A 500 (-3.0A)
AMP  A 500 (-3.4A)
AMP  A 500 (-3.6A)
AMP  A 500 (-3.2A)
AMP  A 500 (-3.9A)
 0.50A 6bniB-6bljA:
12.3		 6bniB-6bljA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 6blj SERINE-TRNA LIGASE
(Naegleria
fowleri) 		5 / 12 LEU A 140
GLY A 143
ILE A  18
SER A  21
LEU A  31
 None
 1.05A 6ectA-6bljA:
undetectable		 6ectA-6bljA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_A_ACTA401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 6blj SERINE-TRNA LIGASE
(Naegleria
fowleri) 		4 / 5 ARG A  25
LEU A 373
ASN A 144
VAL A 146
 None
 1.22A 6gmdA-6bljA:
undetectable		 6gmdA-6bljA:
undetectable