SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6blk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 6blk SIGNAL TRANSDUCTION
HISTIDINE-PROTEIN
KINASE/PHOSPHATASE
MPRB
(Mycolicibacteriu
m
hassiacum) 		5 / 9 ASN C 375
ASP C 404
ILE C 409
PRO C 410
THR C 465
 ATP  C 501 ( 2.5A)
ATP  C 501 (-2.6A)
ATP  C 501 ( 4.8A)
None
ATP  C 501 (-3.9A)
 0.91A 1aj6A-6blkC:
5.8		 1aj6A-6blkC:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 6blk SIGNAL TRANSDUCTION
HISTIDINE-PROTEIN
KINASE/PHOSPHATASE
MPRB
(Mycolicibacteriu
m
hassiacum) 		5 / 9 ASP C 454
ILE C 409
GLY C 464
VAL C 372
ILE C 467
 None
ATP  C 501 ( 4.8A)
None
None
None
 1.30A 3ekyB-6blkC:
undetectable		 3ekyB-6blkC:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 6blk SIGNAL TRANSDUCTION
HISTIDINE-PROTEIN
KINASE/PHOSPHATASE
MPRB
(Mycolicibacteriu
m
hassiacum) 		4 / 6 ILE C 393
ILE C 359
GLY C 473
VAL C 444
 None
 0.78A 3n3iA-6blkC:
undetectable		 3n3iA-6blkC:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 6blk SIGNAL TRANSDUCTION
HISTIDINE-PROTEIN
KINASE/PHOSPHATASE
MPRB
(Mycolicibacteriu
m
hassiacum) 		4 / 7 ALA C 466
THR C 465
VAL C 372
HIS C 468
 None
ATP  C 501 (-3.9A)
None
None
 1.15A 5ecnA-6blkC:
undetectable		 5ecnA-6blkC:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_0
(PROTEASE)		 6blk SIGNAL TRANSDUCTION
HISTIDINE-PROTEIN
KINASE/PHOSPHATASE
MPRB
(Mycolicibacteriu
m
hassiacum) 		5 / 12 ASP C 404
GLY C 406
ASP C 457
ILE C 409
ILE C 402
 ATP  C 501 (-2.6A)
None
None
ATP  C 501 ( 4.8A)
None
 0.86A 6dh3A-6blkC:
undetectable		 6dh3A-6blkC:
21.05