SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bm7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 6bm7 INACTIVE
S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROZYME
(Trypanosoma
brucei) 		5 / 12 LEU E 114
ALA E 158
GLY E 162
TYR E 180
PHE E  41
 None
None
None
PGE  E 402 (-4.8A)
None
 1.38A 1brpA-6bm7E:
undetectable		 1brpA-6bm7E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 6bm7 INACTIVE
S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROZYME
(Trypanosoma
brucei) 		3 / 3 GLU E 249
THR E 250
LEU E 266
 None
 0.70A 1v8bC-6bm7E:
undetectable		 1v8bC-6bm7E:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 6bm7 INACTIVE
S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROZYME
(Trypanosoma
brucei) 		3 / 3 ASP E 171
ASP E 173
ASP E 139
 None
 0.63A 2igtA-6bm7E:
undetectable		 2igtA-6bm7E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AMU_A_AG2A422_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 6bm7 INACTIVE
S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROZYME
(Trypanosoma
brucei) 		4 / 5 GLU E  38
ASN E 199
VAL E 200
ARG E  99
 None
 1.27A 3amuA-6bm7E:
2.5		 3amuA-6bm7E:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 6bm7 INACTIVE
S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROZYME
(Trypanosoma
brucei) 		4 / 6 VAL E 275
GLN E 206
PHE E 248
ARG E 274
 None
 1.24A 3bjwF-6bm7E:
undetectable		 3bjwF-6bm7E:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 6bm7 S-ADENOSYLMETHIONINE
DECARBOXYLASE BETA
CHAIN
(Trypanosoma
brucei) 		4 / 7 MET A  13
LEU A  10
ASP A   6
LYS A   5
 None
 1.28A 3lslA-6bm7A:
undetectable
3lslD-6bm7A:
undetectable		 3lslA-6bm7A:
undetectable
3lslD-6bm7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 6bm7 S-ADENOSYLMETHIONINE
DECARBOXYLASE BETA
CHAIN
(Trypanosoma
brucei) 		4 / 7 MET A  13
LEU A  10
ASP A   6
LYS A   5
 None
 1.30A 3lslA-6bm7A:
undetectable
3lslD-6bm7A:
undetectable		 3lslA-6bm7A:
undetectable
3lslD-6bm7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 6bm7 S-ADENOSYLMETHIONINE
DECARBOXYLASE BETA
CHAIN
(Trypanosoma
brucei) 		4 / 6 MET A  13
LEU A  10
ASP A   6
LYS A   5
 None
 1.31A 3lslG-6bm7A:
undetectable		 3lslG-6bm7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 6bm7 INACTIVE
S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROZYME
(Trypanosoma
brucei) 		3 / 3 PHE E  41
THR E 161
LEU E 114
 None
 0.79A 4qztA-6bm7E:
undetectable		 4qztA-6bm7E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 6bm7 INACTIVE
S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROZYME
(Trypanosoma
brucei) 		4 / 8 VAL E 124
ILE E  96
ALA E 109
LEU E 114
 PGE  E 402 (-4.9A)
None
None
None
 0.78A 5og9A-6bm7E:
undetectable		 5og9A-6bm7E:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGG_Z_AG2Z503_0
(TRNA(ILE2)
2-AGMATINYLCYTIDINE
SYNTHETASE TIAS)		 6bm7 INACTIVE
S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROZYME
(Trypanosoma
brucei) 		4 / 5 GLU E  38
ASN E 199
VAL E 200
ARG E  99
 None
 1.34A 6aggZ-6bm7E:
undetectable		 6aggZ-6bm7E:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 6bm7 INACTIVE
S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROZYME
(Trypanosoma
brucei) 		4 / 8 ARG E  86
ARG E 235
VAL E 205
GLN E 197
 None
None
None
PUT  E 401 ( 4.6A)
 1.25A 6fbvD-6bm7E:
undetectable		 6fbvD-6bm7E:
undetectable