SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bo0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 6bo0 MDBA PROTEIN
(Corynebacterium
matruchotii) 		4 / 8 GLN A 162
PHE A  89
ASN A 122
ASP A  88
 CSO  A  91 ( 3.1A)
None
None
CSO  A  91 ( 4.7A)
 1.29A 3n62A-6bo0A:
undetectable		 3n62A-6bo0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 6bo0 MDBA PROTEIN
(Corynebacterium
matruchotii) 		4 / 5 ARG A 155
LEU A  72
VAL A 116
ASP A 102
 None
 1.18A 3ufnA-6bo0A:
undetectable
3ufnB-6bo0A:
undetectable		 3ufnA-6bo0A:
19.81
3ufnB-6bo0A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 6bo0 MDBA PROTEIN
(Corynebacterium
matruchotii) 		4 / 7 ALA A 178
ALA A 192
ALA A 138
THR A 141
 None
 0.93A 4du2B-6bo0A:
undetectable		 4du2B-6bo0A:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 6bo0 MDBA PROTEIN
(Corynebacterium
matruchotii) 		4 / 8 ILE A  85
LYS A 229
ILE A 226
GLY A 215
 None
 0.96A 4hdlA-6bo0A:
undetectable		 4hdlA-6bo0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 6bo0 MDBA PROTEIN
(Corynebacterium
matruchotii) 		5 / 12 GLY A 136
ALA A 135
ILE A 203
SER A  68
ASP A  88
 None
None
None
None
CSO  A  91 ( 4.7A)
 1.09A 4rtpA-6bo0A:
undetectable		 4rtpA-6bo0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6bo0 MDBA PROTEIN
(Corynebacterium
matruchotii) 		3 / 3 ASP A  84
ASN A 117
ASP A  66
 None
 0.85A 5vopA-6bo0A:
undetectable		 5vopA-6bo0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6bo0 MDBA PROTEIN
(Corynebacterium
matruchotii) 		3 / 3 ASP A  84
ASN A 117
ASP A  66
 None
 0.84A 5vopB-6bo0A:
undetectable		 5vopB-6bo0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 6bo0 MDBA PROTEIN
(Corynebacterium
matruchotii) 		5 / 11 ASP A  88
SER A 221
VAL A 116
ILE A 118
THR A 120
 CSO  A  91 ( 4.7A)
CSO  A  91 ( 2.2A)
None
None
None
 1.03A 5y80A-6bo0A:
undetectable		 5y80A-6bo0A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 6bo0 MDBA PROTEIN
(Corynebacterium
matruchotii) 		4 / 7 PHE A  51
ILE A 180
ILE A 165
ALA A 192
 None
 0.85A 6b5vA-6bo0A:
undetectable
6b5vC-6bo0A:
undetectable		 6b5vA-6bo0A:
20.48
6b5vC-6bo0A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 6bo0 MDBA PROTEIN
(Corynebacterium
matruchotii) 		4 / 7 PHE A  51
ILE A 180
ILE A 165
ALA A 192
 None
 0.85A 6b5vC-6bo0A:
undetectable
6b5vD-6bo0A:
undetectable		 6b5vC-6bo0A:
20.48
6b5vD-6bo0A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 6bo0 MDBA PROTEIN
(Corynebacterium
matruchotii) 		4 / 7 ALA A 192
PHE A  51
ILE A 180
ILE A 165
 None
 0.85A 6b5vB-6bo0A:
undetectable
6b5vD-6bo0A:
undetectable		 6b5vB-6bo0A:
20.48
6b5vD-6bo0A:
20.48