SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bp2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_E_H4BE1004_1
(HYPOTHETICAL PROTEIN
PH0634)		 6bp2 ENVELOPE
GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN GP2
(Marburg
marburgvirus) 		5 / 11 LEU B 559
HIS A 175
VAL A 170
THR A  84
GLU A  85
 None
 1.48A 2dttD-6bp2B:
undetectable
2dttE-6bp2B:
undetectable		 2dttD-6bp2B:
25.24
2dttE-6bp2B:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 6bp2 ENVELOPE
GLYCOPROTEIN
(Marburg
marburgvirus) 		4 / 7 ASN A  80
SER A 151
TYR A 155
THR A 153
 None
 0.98A 2uz2A-6bp2A:
undetectable		 2uz2A-6bp2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6bp2 ENVELOPE
GLYCOPROTEIN
MR191 FAB HEAVY
CHAIN
(Marburg
marburgvirus;
Homo
sapiens) 		5 / 11 THR A 152
SER A 151
TYR A 146
VAL A  97
PHE H 106
 None
 1.45A 3u9fN-6bp2A:
undetectable
3u9fO-6bp2A:
undetectable		 3u9fN-6bp2A:
undetectable
3u9fO-6bp2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 6bp2 MR191 FAB HEAVY
CHAIN
(Homo
sapiens) 		4 / 8 SER H  81
GLY H  57
THR H  59
GLY H  37
 None
 0.88A 4fo4B-6bp2H:
undetectable		 4fo4B-6bp2H:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 6bp2 ENVELOPE
GLYCOPROTEIN
(Marburg
marburgvirus) 		4 / 5 SER A 104
LYS A 103
ARG A 156
LEU A 106
 None
None
NAG  A 302 ( 4.4A)
None
 1.30A 4ifxA-6bp2A:
undetectable		 4ifxA-6bp2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 6bp2 ENVELOPE
GLYCOPROTEIN
(Marburg
marburgvirus) 		4 / 5 SER A 104
LYS A 103
ARG A 156
LEU A 106
 None
None
NAG  A 302 ( 4.4A)
None
 1.33A 4ig1A-6bp2A:
undetectable		 4ig1A-6bp2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 6bp2 ENVELOPE
GLYCOPROTEIN
MR191 FAB HEAVY
CHAIN
(Homo
sapiens;
Marburg
marburgvirus) 		5 / 12 GLY A 127
GLN A 128
TYR H  61
LEU H 110
SER H  56
 None
 1.19A 4pb1A-6bp2A:
undetectable		 4pb1A-6bp2A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 6bp2 ENVELOPE
GLYCOPROTEIN
MR191 FAB HEAVY
CHAIN
(Homo
sapiens;
Marburg
marburgvirus) 		5 / 12 GLY A 127
GLN A 128
TYR H  61
LEU H 110
SER H  56
 None
 1.15A 4pd5A-6bp2A:
undetectable		 4pd5A-6bp2A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 6bp2 ENVELOPE
GLYCOPROTEIN
MR191 FAB HEAVY
CHAIN
(Homo
sapiens;
Marburg
marburgvirus) 		5 / 12 GLY A 127
GLN A 128
TYR H  61
LEU H 110
SER H  56
 None
 1.17A 4pd9A-6bp2A:
undetectable		 4pd9A-6bp2A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 6bp2 ENVELOPE
GLYCOPROTEIN
(Marburg
marburgvirus) 		5 / 12 THR A 161
GLY A 163
ASN A 164
LEU A  54
THR A  91
 None
None
NAG  B 704 (-2.9A)
None
None
 1.35A 4pooA-6bp2A:
undetectable		 4pooA-6bp2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6bp2 ENVELOPE
GLYCOPROTEIN
(Marburg
marburgvirus) 		3 / 3 ALA A 150
TYR A 146
PRO A  78
 None
 0.70A 4zdyA-6bp2A:
undetectable		 4zdyA-6bp2A:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 6bp2 ENVELOPE
GLYCOPROTEIN
(Marburg
marburgvirus) 		5 / 12 ASP A  61
SER A  55
GLN A  57
ALA A 142
TYR A  93
 None
None
NAG  B 704 (-3.9A)
NAG  B 704 ( 4.2A)
None
 1.33A 5cxvA-6bp2A:
undetectable		 5cxvA-6bp2A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6bp2 MR191 FAB HEAVY
CHAIN
(Homo
sapiens) 		4 / 5 GLY H 203
GLN H 205
VAL H 197
SER H 200
 None
 1.37A 5vunA-6bp2H:
undetectable		 5vunA-6bp2H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 6bp2 ENVELOPE
GLYCOPROTEIN GP2
(Marburg
marburgvirus) 		4 / 7 ALA B 546
THR B 545
TYR B 544
TRP B 519
 None
 0.82A 6cduA-6bp2B:
undetectable
6cduE-6bp2B:
undetectable		 6cduA-6bp2B:
undetectable
6cduE-6bp2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 6bp2 ENVELOPE
GLYCOPROTEIN GP2
(Marburg
marburgvirus) 		4 / 7 TRP B 519
ALA B 546
THR B 545
TYR B 544
 None
 0.85A 6cduH-6bp2B:
undetectable
6cduI-6bp2B:
undetectable		 6cduH-6bp2B:
undetectable
6cduI-6bp2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 6bp2 MR191 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 THR H  88
VAL H 124
VAL H 122
VAL H  69
TYR H  95
 None
 1.42A 6iblB-6bp2H:
undetectable		 6iblB-6bp2H:
undetectable