SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bpa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 6bpa MONOCLONAL ANTIBODY
3E9 FAB HEAVY CHAIN
(Mus
musculus) 		5 / 12 ALA B 127
LEU B  23
GLN B  22
VAL B  21
ILE B  48
 None
 1.19A 3datA-6bpaB:
undetectable		 3datA-6bpaB:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6bpa MONOCLONAL ANTIBODY
3E9 FAB HEAVY CHAIN
(Mus
musculus) 		4 / 7 PHE B  52
GLU B  73
ARG B  69
VAL B 121
 None
 1.49A 3jt5A-6bpaB:
undetectable
3jt5B-6bpaB:
undetectable		 3jt5A-6bpaB:
11.64
3jt5B-6bpaB:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 6bpa MONOCLONAL ANTIBODY
3E9 FAB HEAVY CHAIN
(Mus
musculus) 		3 / 3 ALA B  61
ARG B  59
LYS B  57
 None
 1.00A 3kp5B-6bpaB:
undetectable		 3kp5B-6bpaB:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTW_B_H4BB1720_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6bpa MONOCLONAL ANTIBODY
3E9 FAB HEAVY CHAIN
(Mus
musculus) 		4 / 7 PHE B  52
GLU B  73
ARG B  69
VAL B 121
 None
 1.49A 4ctwA-6bpaB:
undetectable
4ctwB-6bpaB:
undetectable		 4ctwA-6bpaB:
11.64
4ctwB-6bpaB:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTX_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6bpa MONOCLONAL ANTIBODY
3E9 FAB HEAVY CHAIN
(Mus
musculus) 		4 / 7 ARG B  69
VAL B 121
PHE B  52
GLU B  73
 None
 1.47A 4ctxA-6bpaB:
undetectable
4ctxB-6bpaB:
undetectable		 4ctxA-6bpaB:
11.64
4ctxB-6bpaB:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6bpa MONOCLONAL ANTIBODY
3E9 FAB HEAVY CHAIN
(Mus
musculus) 		4 / 7 ARG B  69
VAL B 121
PHE B  52
GLU B  73
 None
 1.50A 4cx5A-6bpaB:
undetectable
4cx5B-6bpaB:
undetectable		 4cx5A-6bpaB:
11.64
4cx5B-6bpaB:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1N_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6bpa MONOCLONAL ANTIBODY
3E9 FAB HEAVY CHAIN
(Mus
musculus) 		4 / 7 ARG B  69
VAL B 121
PHE B  52
GLU B  73
 None
 1.50A 4d1nA-6bpaB:
undetectable
4d1nB-6bpaB:
undetectable		 4d1nA-6bpaB:
10.48
4d1nB-6bpaB:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1N_C_H4BC760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6bpa MONOCLONAL ANTIBODY
3E9 FAB HEAVY CHAIN
(Mus
musculus) 		4 / 7 ARG B  69
VAL B 121
PHE B  52
GLU B  73
 None
 1.50A 4d1nC-6bpaB:
undetectable
4d1nD-6bpaB:
undetectable		 4d1nC-6bpaB:
10.48
4d1nD-6bpaB:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 6bpa MONOCLONAL ANTIBODY
3E9 FAB HEAVY CHAIN
(Mus
musculus) 		3 / 3 ARG B 117
HIS B  51
TYR B 128
 None
 1.29A 4fu9A-6bpaB:
undetectable		 4fu9A-6bpaB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 6bpa MONOCLONAL ANTIBODY
3E9 FAB HEAVY CHAIN
(Mus
musculus) 		4 / 7 ALA B 111
THR B 110
VAL B 135
GLU B 108
 None
 0.84A 5ecoD-6bpaB:
undetectable		 5ecoD-6bpaB:
undetectable