SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bq1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 THR A1074
THR A1076
PRO A1073
 None
 0.78A 1a7yA-6bq1A:
undetectable		 1a7yA-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 THR A1074
THR A1076
PRO A1073
 None
 0.83A 1a7yB-6bq1A:
undetectable		 1a7yB-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		4 / 7 LEU A1014
THR A1104
ASN A1089
TYR A1083
 None
 1.38A 1afsA-6bq1A:
undetectable		 1afsA-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		4 / 7 LEU A1014
THR A1104
ASN A1089
TYR A1083
 None
 1.38A 1afsB-6bq1A:
undetectable		 1afsB-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 THR A1074
THR A1076
PRO A1073
 None
 0.80A 1dscC-6bq1A:
undetectable		 1dscC-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		4 / 5 ARG A1856
ALA A1888
ASP A1854
GLY A1892
 None
 1.10A 1e7bA-6bq1A:
undetectable		 1e7bA-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		5 / 12 VAL A2027
LEU A1952
GLY A2023
SER A1947
PHE A1872
 None
 1.36A 1fdsA-6bq1A:
undetectable		 1fdsA-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 THR A1074
THR A1076
PRO A1073
 None
 0.87A 1fjaC-6bq1A:
undetectable		 1fjaC-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 THR A1074
THR A1076
PRO A1073
 None
 0.88A 1fjaD-6bq1A:
undetectable		 1fjaD-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 THR A1076
PRO A1073
THR A1074
 None
 0.80A 1i3wE-6bq1A:
undetectable		 1i3wE-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 THR A1074
THR A1076
PRO A1073
 None
 0.81A 1i3wE-6bq1A:
undetectable		 1i3wE-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 THR A1074
THR A1076
PRO A1073
 None
 0.80A 1i3wF-6bq1A:
undetectable		 1i3wF-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 THR A1076
PRO A1073
THR A1074
 None
 0.84A 1i3wG-6bq1A:
undetectable		 1i3wG-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 THR A1074
THR A1076
PRO A1073
 None
 0.81A 1i3wG-6bq1A:
undetectable		 1i3wG-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_H_DVAH8_0
(ACTINOMYCIN D)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 THR A1074
THR A1076
PRO A1073
 None
 0.81A 1i3wH-6bq1A:
undetectable		 1i3wH-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI3_B_PE2B2_1
(THYMIDINE KINASE)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		5 / 12 HIS A1079
GLU A 965
ILE A1308
GLN A1316
ARG A1305
 None
 1.44A 1ki3B-6bq1A:
undetectable		 1ki3B-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 THR A1076
PRO A1073
THR A1074
 None
 0.81A 1mnvD-6bq1A:
undetectable		 1mnvD-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 THR A1074
THR A1076
PRO A1073
 None
 0.76A 1mnvD-6bq1A:
undetectable		 1mnvD-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 THR A1076
PRO A1073
THR A1074
 None
 0.82A 1ovfB-6bq1A:
undetectable		 1ovfB-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 THR A1074
THR A1076
PRO A1073
 None
 0.78A 1qfiA-6bq1A:
undetectable		 1qfiA-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 THR A1074
THR A1076
PRO A1073
 None
 0.81A 1qfiB-6bq1A:
undetectable		 1qfiB-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 THR A1076
PRO A1073
THR A1074
 None
 0.85A 1unjF-6bq1A:
undetectable		 1unjF-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 THR A1074
THR A1076
PRO A1073
 None
 0.81A 1unjF-6bq1A:
undetectable		 1unjF-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 THR A1076
PRO A1073
THR A1074
 None
 0.82A 1unjL-6bq1A:
undetectable		 1unjL-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 THR A1074
THR A1076
PRO A1073
 None
 0.78A 1unjL-6bq1A:
undetectable		 1unjL-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 THR A1076
PRO A1073
THR A1074
 None
 0.84A 1unjR-6bq1A:
undetectable		 1unjR-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 THR A1074
THR A1076
PRO A1073
 None
 0.79A 1unjR-6bq1A:
undetectable		 1unjR-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 THR A1074
THR A1076
PRO A1073
 None
 0.75A 1unjW-6bq1A:
undetectable		 1unjW-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 THR A1076
PRO A1073
THR A1074
 None
 0.81A 1unjX-6bq1A:
undetectable		 1unjX-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 THR A1074
THR A1076
PRO A1073
 None
 0.77A 1unjX-6bq1A:
undetectable		 1unjX-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE2_0
(7-AMINOACTINOMYCIN D)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 THR A1076
PRO A1073
THR A1074
 None
 0.80A 1unmE-6bq1A:
undetectable		 1unmE-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 THR A1074
THR A1076
PRO A1073
 None
 0.74A 1unmE-6bq1A:
undetectable		 1unmE-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 THR A1076
PRO A1073
THR A1074
 None
 0.83A 1unmF-6bq1A:
undetectable		 1unmF-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 THR A1074
THR A1076
PRO A1073
 None
 0.78A 1unmF-6bq1A:
undetectable		 1unmF-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 6bq1 PROTEIN FAM126A
(Homo
sapiens) 		4 / 6 TYR C 109
GLY C 235
PHE C 236
SER C 233
 None
 1.06A 2a3cA-6bq1C:
undetectable		 2a3cA-6bq1C:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 6bq1 PROTEIN FAM126A
(Homo
sapiens) 		4 / 6 TYR C 109
GLY C 235
PHE C 236
SER C 233
 None
 1.09A 2a3cB-6bq1C:
undetectable		 2a3cB-6bq1C:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 6bq1 PROTEIN FAM126A
(Homo
sapiens) 		4 / 5 ILE C 230
PRO C 231
PHE C 236
ILE C  83
 None
 1.03A 2hjhA-6bq1C:
undetectable		 2hjhA-6bq1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		4 / 6 ARG A1662
ASP A2043
THR A2044
ASP A1705
 None
 1.24A 2j2pE-6bq1A:
undetectable
2j2pF-6bq1A:
undetectable		 2j2pE-6bq1A:
0.00
2j2pF-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		5 / 12 LEU A1214
ALA A1255
TRP A1298
MET A1193
PHE A1248
 None
 0.99A 2oaxC-6bq1A:
undetectable		 2oaxC-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		5 / 12 LEU A1214
ALA A1255
TRP A1298
MET A1193
PHE A1248
 None
 1.09A 2oaxD-6bq1A:
undetectable		 2oaxD-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		5 / 12 PHE A1807
LEU A1776
ALA A1847
ALA A1805
VAL A1744
 None
 0.98A 3cwkA-6bq1A:
undetectable		 3cwkA-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		5 / 12 PHE A1807
ILE A1787
ASN A1743
VAL A1851
THR A1889
 None
 1.30A 3em0B-6bq1A:
undetectable		 3em0B-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		4 / 8 SER A1766
ASP A1786
LEU A1804
PRO A1794
 None
 0.99A 3jq7B-6bq1A:
undetectable		 3jq7B-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_B_P77B204_1
(PROTEIN S100-A4)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		4 / 6 MET A2019
CYH A2020
GLU A2018
PHE A1872
 None
 1.24A 3m0wB-6bq1A:
0.9
3m0wJ-6bq1A:
0.5		 3m0wB-6bq1A:
0.00
3m0wJ-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		4 / 5 PHE A1735
ILE A1741
ASN A1690
PHE A1737
 None
 1.40A 3octA-6bq1A:
3.8		 3octA-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		5 / 12 LEU A1177
ALA A1230
GLY A1226
GLY A1217
MET A1221
 None
 1.14A 3ou6A-6bq1A:
undetectable		 3ou6A-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		5 / 12 LEU A1177
ALA A1230
GLY A1226
GLY A1217
MET A1221
 None
 1.16A 3ou6B-6bq1A:
undetectable		 3ou6B-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		5 / 12 LEU A1177
ALA A1230
GLY A1226
GLY A1217
MET A1221
 None
 1.15A 3ou7A-6bq1A:
undetectable		 3ou7A-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		5 / 12 LEU A1177
ALA A1230
GLY A1226
GLY A1217
MET A1221
 None
 1.13A 3ou7B-6bq1A:
undetectable		 3ou7B-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		5 / 12 LEU A1177
ALA A1230
GLY A1226
GLY A1217
MET A1221
 None
 1.16A 3ou7D-6bq1A:
undetectable		 3ou7D-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 ASP A1300
GLU A1235
SER A1405
 None
 0.85A 3p2kA-6bq1A:
undetectable		 3p2kA-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		5 / 11 PRO A1706
THR A2044
GLY A2045
ARG A1856
ASP A1707
 None
 1.10A 3t8nD-6bq1A:
undetectable
3t8nF-6bq1A:
undetectable		 3t8nD-6bq1A:
undetectable
3t8nF-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 ASN A1117
ALA A1130
ARG A1128
 None
 0.66A 3tj7C-6bq1A:
undetectable
3tj7D-6bq1A:
undetectable		 3tj7C-6bq1A:
undetectable
3tj7D-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_2
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		4 / 4 PRO A1247
LEU A1238
HIS A1079
LEU A1007
 None
 1.21A 3vw7A-6bq1A:
1.8		 3vw7A-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		4 / 5 GLU A1376
PHE A1383
TYR A1485
HIS A1482
 None
 1.49A 4a97J-6bq1A:
undetectable		 4a97J-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 THR A1076
PRO A1073
THR A1074
 None
 0.88A 4hivD-6bq1A:
undetectable		 4hivD-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOW_A_CFXA204_1
(UNCHARACTERIZED
PROTEIN)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		5 / 12 PHE A1737
GLY A1894
SER A1778
PHE A1738
LEU A1776
 None
 1.45A 4kowA-6bq1A:
undetectable		 4kowA-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		4 / 6 GLU A1397
ARG A1401
ARG A2022
GLU A2018
 None
 1.43A 4kr3A-6bq1A:
undetectable		 4kr3A-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		5 / 10 LEU A1231
ARG A1305
MET A1249
ALA A1253
PHE A1320
 None
 1.48A 4la0A-6bq1A:
undetectable		 4la0A-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		5 / 12 ILE A1034
ASP A 987
ARG A1060
LEU A1017
ILE A1041
 None
 1.01A 4m2xA-6bq1A:
undetectable		 4m2xA-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		5 / 12 ILE A1034
ASP A 987
ARG A1060
LEU A1017
ILE A1041
 None
 0.97A 4m2xE-6bq1A:
undetectable		 4m2xE-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		4 / 5 TYR A1532
THR A1381
LEU A1353
THR A1412
 None
 1.41A 4mbsB-6bq1A:
undetectable		 4mbsB-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 ARG A1326
HIS A1257
SER A1322
 None
 0.91A 4mjwA-6bq1A:
undetectable
4mjwB-6bq1A:
undetectable		 4mjwA-6bq1A:
undetectable
4mjwB-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 SER A1322
ARG A1326
HIS A1257
 None
 0.97A 4mjwA-6bq1A:
undetectable
4mjwB-6bq1A:
undetectable		 4mjwA-6bq1A:
undetectable
4mjwB-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		5 / 12 PHE A1872
GLY A2023
ILE A2074
LEU A1949
ILE A1972
 None
 0.84A 4pd4C-6bq1A:
1.7		 4pd4C-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 6bq1 PROTEIN FAM126A
(Homo
sapiens) 		5 / 12 GLY C 107
ASN C 110
ILE C 101
HIS C  58
LEU C 106
 None
 1.24A 4pooA-6bq1C:
undetectable		 4pooA-6bq1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		5 / 9 ILE A1657
LEU A1862
VAL A2038
LEU A2037
ILE A1864
 None
 1.10A 4r38C-6bq1A:
undetectable		 4r38C-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		4 / 7 PRO A1289
GLU A1291
ASP A1518
THR A1119
 None
 1.22A 4uacA-6bq1A:
undetectable		 4uacA-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		4 / 8 HIS A1702
GLU A1699
ASP A1698
PRO A1891
 None
 1.12A 4uhxA-6bq1A:
undetectable		 4uhxA-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		4 / 8 HIS A1702
GLU A1699
ASP A1698
PRO A1891
 None
 1.12A 4uhxA-6bq1A:
undetectable		 4uhxA-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 ARG A1662
ASN A1694
ASP A1698
 None
 0.93A 5gwxA-6bq1A:
undetectable		 5gwxA-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		5 / 12 ALA A2033
THR A2053
PHE A1980
ILE A1864
GLN A1863
 None
 1.34A 5hgcA-6bq1A:
undetectable		 5hgcA-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		4 / 6 ASP A1602
HIS A1597
ILE A1599
TYR A1628
 None
 1.21A 5ih0A-6bq1A:
6.2		 5ih0A-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 SER A1622
LEU A1860
MET A2041
 None
 0.68A 5ikrB-6bq1A:
undetectable		 5ikrB-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 6bq1 PROTEIN FAM126A
(Homo
sapiens) 		4 / 8 GLN C 218
GLY C 214
ILE C 226
TRP C  84
 None
 1.06A 5vlmD-6bq1C:
1.9		 5vlmD-6bq1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 TYR A1663
ASP A1707
ASP A2043
 None
 0.73A 5x6yA-6bq1A:
2.8		 5x6yA-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		3 / 3 SER A1530
LYS A1531
SER A1534
 None
 0.84A 6az3P-6bq1A:
undetectable		 6az3P-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		5 / 12 ASP A1363
LEU A1360
THR A1369
GLY A1478
LEU A1481
 None
 1.18A 6b0lB-6bq1A:
undetectable		 6b0lB-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		6 / 12 LEU A1621
LEU A2040
ALA A1649
SER A1280
LEU A1642
LEU A1683
 None
 1.45A 6ew0B-6bq1A:
undetectable		 6ew0B-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		6 / 12 LEU A1621
LEU A2040
ALA A1649
SER A1280
LEU A1642
LEU A1683
 None
 1.45A 6ew0D-6bq1A:
undetectable		 6ew0D-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		6 / 12 LEU A1621
LEU A2040
ALA A1649
SER A1280
LEU A1642
LEU A1683
 None
 1.45A 6ew0H-6bq1A:
undetectable		 6ew0H-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens) 		6 / 12 LEU A1621
LEU A2040
ALA A1649
SER A1280
LEU A1642
LEU A1683
 None
 1.45A 6ew0I-6bq1A:
undetectable		 6ew0I-6bq1A:
0.00