SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bq6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 12 VAL A 134
LEU A  68
LEU A  59
TYR A  28
GLU A  30
 None
None
None
None
TER  A 402 ( 3.8A)
 1.46A 1mmkA-6bq6A:
undetectable		 1mmkA-6bq6A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		4 / 6 ASP A 160
GLY A 106
ILE A 104
ILE A 158
 None
TER  A 402 ( 4.1A)
None
None
 0.94A 1n49D-6bq6A:
undetectable		 1n49D-6bq6A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 12 GLY A 106
GLY A 108
THR A 112
ASP A 129
ALA A 161
 TER  A 402 ( 4.1A)
CL  A 401 (-4.6A)
CL  A 401 (-4.3A)
TER  A 402 ( 4.4A)
None
 0.90A 2gluA-6bq6A:
11.9		 2gluA-6bq6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		3 / 3 ASP A 129
ASP A 160
ASP A 178
 TER  A 402 ( 4.4A)
None
TER  A 402 (-4.1A)
 0.75A 2igtA-6bq6A:
12.3		 2igtA-6bq6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 12 GLY A 106
GLY A 108
ILE A 130
ASP A 131
LEU A 179
 TER  A 402 ( 4.1A)
CL  A 401 (-4.6A)
None
None
None
 0.66A 2nxeB-6bq6A:
12.2		 2nxeB-6bq6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 12 GLY A 108
ILE A 130
ASP A 131
LEU A 179
LEU A 191
 CL  A 401 (-4.6A)
None
None
None
None
 1.11A 2zbpA-6bq6A:
11.9		 2zbpA-6bq6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 10 GLY A 108
ASP A 129
ILE A 130
ASP A 160
LEU A 179
 CL  A 401 (-4.6A)
TER  A 402 ( 4.4A)
None
None
None
 1.13A 3ay0B-6bq6A:
10.4		 3ay0B-6bq6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 12 GLN A  75
TYR A  84
HIS A  85
ASP A 178
GLN A 214
 TER  A 402 ( 4.9A)
TER  A 402 (-4.6A)
None
TER  A 402 (-4.1A)
TER  A 402 ( 3.7A)
 0.82A 3b7pA-6bq6A:
35.6		 3b7pA-6bq6A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 12 GLN A  75
TYR A  84
HIS A  85
ASP A 178
TYR A 251
 TER  A 402 ( 4.9A)
TER  A 402 (-4.6A)
None
TER  A 402 (-4.1A)
TER  A 402 (-3.4A)
 0.58A 3b7pA-6bq6A:
35.6		 3b7pA-6bq6A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 12 GLN A 214
HIS A  85
ASP A 178
TYR A 251
ILE A 248
 TER  A 402 ( 3.7A)
None
TER  A 402 (-4.1A)
TER  A 402 (-3.4A)
None
 1.29A 3b7pA-6bq6A:
35.6		 3b7pA-6bq6A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 12 TYR A  84
HIS A  85
ASP A 178
ASP A 181
GLN A 214
 TER  A 402 (-4.6A)
None
TER  A 402 (-4.1A)
None
TER  A 402 ( 3.7A)
 0.87A 3b7pA-6bq6A:
35.6		 3b7pA-6bq6A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 12 TYR A  84
HIS A  85
ASP A 178
ASP A 181
TYR A 251
 TER  A 402 (-4.6A)
None
TER  A 402 (-4.1A)
None
TER  A 402 (-3.4A)
 0.97A 3b7pA-6bq6A:
35.6		 3b7pA-6bq6A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 12 GLN A  75
TYR A  84
HIS A  85
ASP A 178
GLN A 214
 TER  A 402 ( 4.9A)
TER  A 402 (-4.6A)
None
TER  A 402 (-4.1A)
TER  A 402 ( 3.7A)
 0.78A 3b7pB-6bq6A:
35.0		 3b7pB-6bq6A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 12 GLN A  75
TYR A  84
HIS A  85
ASP A 178
TYR A 251
 TER  A 402 ( 4.9A)
TER  A 402 (-4.6A)
None
TER  A 402 (-4.1A)
TER  A 402 (-3.4A)
 0.62A 3b7pB-6bq6A:
35.0		 3b7pB-6bq6A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 12 GLN A 214
HIS A  85
ASP A 178
TYR A 251
ILE A 248
 TER  A 402 ( 3.7A)
None
TER  A 402 (-4.1A)
TER  A 402 (-3.4A)
None
 1.30A 3b7pB-6bq6A:
35.0		 3b7pB-6bq6A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 12 TYR A  84
HIS A  85
ASP A 178
ASP A 181
GLN A 214
 TER  A 402 (-4.6A)
None
TER  A 402 (-4.1A)
None
TER  A 402 ( 3.7A)
 0.85A 3b7pB-6bq6A:
35.0		 3b7pB-6bq6A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 12 TYR A  84
HIS A  85
ASP A 178
ASP A 181
TYR A 251
 TER  A 402 (-4.6A)
None
TER  A 402 (-4.1A)
None
TER  A 402 (-3.4A)
 0.98A 3b7pB-6bq6A:
35.0		 3b7pB-6bq6A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 12 GLN A  75
TYR A  84
HIS A  85
ASP A 178
TYR A 251
 TER  A 402 ( 4.9A)
TER  A 402 (-4.6A)
None
TER  A 402 (-4.1A)
TER  A 402 (-3.4A)
 0.63A 3b7pC-6bq6A:
35.6		 3b7pC-6bq6A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 12 GLN A 214
HIS A  85
ASP A 178
TYR A 251
ILE A 248
 TER  A 402 ( 3.7A)
None
TER  A 402 (-4.1A)
TER  A 402 (-3.4A)
None
 1.28A 3b7pC-6bq6A:
35.6		 3b7pC-6bq6A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 12 TYR A  84
HIS A  85
ASP A 178
ASP A 181
TYR A 251
 TER  A 402 (-4.6A)
None
TER  A 402 (-4.1A)
None
TER  A 402 (-3.4A)
 1.00A 3b7pC-6bq6A:
35.6		 3b7pC-6bq6A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		7 / 12 GLN A  54
TYR A  84
HIS A  85
GLY A 106
ILE A 130
ASP A 131
VAL A 134
 None
TER  A 402 (-4.6A)
None
TER  A 402 ( 4.1A)
None
None
None
 0.72A 3bwcA-6bq6A:
32.0		 3bwcA-6bq6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		7 / 12 TYR A  84
HIS A  85
GLY A 106
ILE A 130
ASP A 131
VAL A 134
ASP A 160
 TER  A 402 (-4.6A)
None
TER  A 402 ( 4.1A)
None
None
None
None
 0.77A 3bwcA-6bq6A:
32.0		 3bwcA-6bq6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		6 / 12 TYR A  84
HIS A  85
GLY A 106
ILE A 130
ASP A 160
GLN A 214
 TER  A 402 (-4.6A)
None
TER  A 402 ( 4.1A)
None
None
TER  A 402 ( 3.7A)
 0.84A 3bwcA-6bq6A:
32.0		 3bwcA-6bq6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_1
(SPERMIDINE SYNTHASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		4 / 4 LEU A  70
GLN A  75
ASP A 129
ASP A 178
 None
TER  A 402 ( 4.9A)
TER  A 402 ( 4.4A)
TER  A 402 (-4.1A)
 0.79A 3bwcA-6bq6A:
32.0		 3bwcA-6bq6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		6 / 12 LEU A  70
TYR A  84
GLY A 107
ASP A 131
VAL A 134
ASP A 178
 None
TER  A 402 (-4.6A)
CL  A 401 (-3.7A)
None
None
TER  A 402 (-4.1A)
 1.21A 3bwcB-6bq6A:
31.6		 3bwcB-6bq6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		8 / 12 LEU A  70
TYR A  84
HIS A  85
GLY A 106
ILE A 130
ASP A 131
VAL A 134
ASP A 178
 None
TER  A 402 (-4.6A)
None
TER  A 402 ( 4.1A)
None
None
None
TER  A 402 (-4.1A)
 0.71A 3bwcB-6bq6A:
31.6		 3bwcB-6bq6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 12 TYR A  84
HIS A  85
GLY A 106
ASP A 178
GLN A 214
 TER  A 402 (-4.6A)
None
TER  A 402 ( 4.1A)
TER  A 402 (-4.1A)
TER  A 402 ( 3.7A)
 0.67A 3bwcB-6bq6A:
31.6		 3bwcB-6bq6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_A_SPMA501_1
(SPERMINE SYNTHASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 11 TYR A  84
ASP A 178
GLN A 214
TYR A 251
TRP A 255
 TER  A 402 (-4.6A)
TER  A 402 (-4.1A)
TER  A 402 ( 3.7A)
TER  A 402 (-3.4A)
TER  A 402 (-3.9A)
 0.61A 3c6mA-6bq6A:
23.0		 3c6mA-6bq6A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_B_SPMB501_1
(SPERMINE SYNTHASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 9 TYR A  84
ASP A 178
GLN A 214
TYR A 251
TRP A 255
 TER  A 402 (-4.6A)
TER  A 402 (-4.1A)
TER  A 402 ( 3.7A)
TER  A 402 (-3.4A)
TER  A 402 (-3.9A)
 0.55A 3c6mB-6bq6A:
22.9		 3c6mB-6bq6A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_C_SPMC501_1
(SPERMINE SYNTHASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 10 TYR A  84
ASP A 178
GLN A 214
TYR A 251
TRP A 255
 TER  A 402 (-4.6A)
TER  A 402 (-4.1A)
TER  A 402 ( 3.7A)
TER  A 402 (-3.4A)
TER  A 402 (-3.9A)
 0.59A 3c6mC-6bq6A:
22.9		 3c6mC-6bq6A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_D_SPMD501_1
(SPERMINE SYNTHASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 10 TYR A  84
ASP A 178
GLN A 214
TYR A 251
TRP A 255
 TER  A 402 (-4.6A)
TER  A 402 (-4.1A)
TER  A 402 ( 3.7A)
TER  A 402 (-3.4A)
TER  A 402 (-3.9A)
 0.60A 3c6mD-6bq6A:
23.0		 3c6mD-6bq6A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		6 / 12 GLY A 106
ASP A 129
ILE A 130
ASP A 131
LEU A 179
LEU A 191
 TER  A 402 ( 4.1A)
TER  A 402 ( 4.4A)
None
None
None
None
 1.11A 3cjtC-6bq6A:
12.2		 3cjtC-6bq6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 12 GLY A 106
GLY A 108
ASP A 131
LEU A 179
LEU A 191
 TER  A 402 ( 4.1A)
CL  A 401 (-4.6A)
None
None
None
 1.17A 3cjtG-6bq6A:
12.1		 3cjtG-6bq6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 12 GLY A 106
GLY A 108
ILE A 130
ASP A 131
LEU A 179
 TER  A 402 ( 4.1A)
CL  A 401 (-4.6A)
None
None
None
 0.71A 3cjtG-6bq6A:
12.1		 3cjtG-6bq6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 12 GLY A 106
GLY A 108
ASP A 131
ASP A 160
ALA A 161
 TER  A 402 ( 4.1A)
CL  A 401 (-4.6A)
None
None
None
 0.83A 3fuuA-6bq6A:
10.4		 3fuuA-6bq6A:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		6 / 11 GLY A 106
GLY A 108
ILE A 130
ASP A 131
ASP A 160
ALA A 161
 TER  A 402 ( 4.1A)
CL  A 401 (-4.6A)
None
None
None
None
 1.07A 3grvA-6bq6A:
11.3		 3grvA-6bq6A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		6 / 12 GLY A 106
GLY A 108
ILE A 130
ASP A 131
ASP A 160
ALA A 161
 TER  A 402 ( 4.1A)
CL  A 401 (-4.6A)
None
None
None
None
 1.13A 3gryA-6bq6A:
11.2		 3gryA-6bq6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 12 VAL A  89
LEU A  88
LEU A  93
GLY A 110
ALA A 113
 None
None
None
CL  A 401 (-3.5A)
CL  A 401 (-3.8A)
 1.12A 3kk6A-6bq6A:
undetectable		 3kk6A-6bq6A:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 12 GLY A 209
PHE A 211
ALA A  92
ASP A 173
VAL A 174
 None
 1.19A 3nvkF-6bq6A:
undetectable
3nvkJ-6bq6A:
11.8		 3nvkF-6bq6A:
undetectable
3nvkJ-6bq6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 11 VAL A  89
LEU A  88
LEU A  93
GLY A 110
ALA A 113
 None
None
None
CL  A 401 (-3.5A)
CL  A 401 (-3.8A)
 1.09A 3pghB-6bq6A:
undetectable		 3pghB-6bq6A:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 12 VAL A  89
LEU A  88
LEU A  93
GLY A 110
ALA A 113
 None
None
None
CL  A 401 (-3.5A)
CL  A 401 (-3.8A)
 1.10A 3pghD-6bq6A:
undetectable		 3pghD-6bq6A:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_A_QMRA1214_1
(CAPITELLA TELETA
ACHBP)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 9 VAL A 212
TYR A 197
ILE A 210
ILE A 175
PHE A 196
 None
 1.35A 4afgA-6bq6A:
undetectable
4afgB-6bq6A:
undetectable		 4afgA-6bq6A:
17.11
4afgB-6bq6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		4 / 8 VAL A 212
TYR A 197
ILE A 210
ILE A 175
 None
 0.93A 4afgD-6bq6A:
undetectable
4afgE-6bq6A:
undetectable		 4afgD-6bq6A:
17.11
4afgE-6bq6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_D_QMRD1214_1
(CAPITELLA TELETA
ACHBP)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 9 VAL A 212
TYR A 197
ILE A 210
ILE A 175
PHE A 196
 None
 1.31A 4afgC-6bq6A:
undetectable
4afgD-6bq6A:
undetectable		 4afgC-6bq6A:
17.11
4afgD-6bq6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_E_QMRE1214_1
(CAPITELLA TELETA
ACHBP)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 9 VAL A 212
TYR A 197
ILE A 210
ILE A 175
PHE A 196
 None
 1.25A 4afgB-6bq6A:
undetectable
4afgC-6bq6A:
undetectable		 4afgB-6bq6A:
17.11
4afgC-6bq6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		4 / 8 ASP A 151
ARG A 153
ASN A 145
GLU A 115
 None
 1.14A 4gkhF-6bq6A:
undetectable		 4gkhF-6bq6A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 12 GLY A 106
GLY A 108
ASP A 129
ILE A 130
ASP A 160
 TER  A 402 ( 4.1A)
CL  A 401 (-4.6A)
TER  A 402 ( 4.4A)
None
None
 0.72A 4iv8A-6bq6A:
11.2		 4iv8A-6bq6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 12 SER A 222
GLY A 256
LEU A  88
PHE A 211
ILE A 230
 None
 1.14A 4pghD-6bq6A:
10.5		 4pghD-6bq6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 9 VAL A  89
LEU A  88
LEU A  93
GLY A 110
ALA A 113
 None
None
None
CL  A 401 (-3.5A)
CL  A 401 (-3.8A)
 1.12A 4rs0A-6bq6A:
undetectable		 4rs0A-6bq6A:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 12 GLY A 110
GLU A 109
GLY A 108
ALA A 148
ALA A 113
 CL  A 401 (-3.5A)
None
CL  A 401 (-4.6A)
None
CL  A 401 (-3.8A)
 0.96A 4uciA-6bq6A:
6.8		 4uciA-6bq6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 12 GLY A 110
GLU A 109
GLY A 108
ALA A 148
ALA A 113
 CL  A 401 (-3.5A)
None
CL  A 401 (-4.6A)
None
CL  A 401 (-3.8A)
 0.97A 4uciB-6bq6A:
5.8		 4uciB-6bq6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		3 / 3 GLU A 109
ILE A 248
ALA A  67
 None
 0.63A 4wnwB-6bq6A:
undetectable		 4wnwB-6bq6A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 11 ASP A 253
VAL A 302
GLY A 216
PHE A 227
SER A 222
 None
 1.27A 4xp4A-6bq6A:
undetectable		 4xp4A-6bq6A:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 10 ASP A 253
VAL A 302
GLY A 216
PHE A 227
SER A 222
 None
 1.44A 4xpbA-6bq6A:
undetectable		 4xpbA-6bq6A:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 12 VAL A 102
PRO A  91
ALA A  92
VAL A 174
LEU A 201
 None
 1.07A 5hv1A-6bq6A:
undetectable		 5hv1A-6bq6A:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		5 / 12 VAL A  89
LEU A  88
LEU A  93
GLY A 110
ALA A 113
 None
None
None
CL  A 401 (-3.5A)
CL  A 401 (-3.8A)
 1.07A 5ikrB-6bq6A:
undetectable		 5ikrB-6bq6A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		3 / 3 LYS A 100
ASP A 173
ARG A 279
 None
 0.63A 5jwaA-6bq6A:
3.5
5jwaH-6bq6A:
3.6		 5jwaA-6bq6A:
undetectable
5jwaH-6bq6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		4 / 8 GLU A  33
GLY A 216
PRO A 217
ASP A 181
 None
 1.12A 5kgpA-6bq6A:
undetectable		 5kgpA-6bq6A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		4 / 8 GLU A  33
GLY A 216
PRO A 217
ASP A 181
 None
 1.11A 5kgpB-6bq6A:
1.5		 5kgpB-6bq6A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		6 / 12 GLY A 106
GLY A 108
ASP A 129
ILE A 130
LEU A 179
LEU A 191
 TER  A 402 ( 4.1A)
CL  A 401 (-4.6A)
TER  A 402 ( 4.4A)
None
None
None
 1.39A 5wy0A-6bq6A:
11.4		 5wy0A-6bq6A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		12 / 12 GLN A  54
GLY A 106
ASP A 129
ILE A 130
ASP A 131
VAL A 134
ASP A 160
ALA A 161
LEU A 179
ALA A 180
CYH A 188
LEU A 191
 None
TER  A 402 ( 4.1A)
TER  A 402 ( 4.4A)
None
None
None
None
None
None
None
None
None
 0.47A 6bq4A-6bq6A:
50.6		 6bq4A-6bq6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		6 / 12 GLN A  54
GLY A 107
ASP A 129
ASP A 131
VAL A 134
ALA A 180
 None
CL  A 401 (-3.7A)
TER  A 402 ( 4.4A)
None
None
None
 1.14A 6bq4A-6bq6A:
50.6		 6bq4A-6bq6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		8 / 12 GLY A 106
ASP A 129
ILE A 130
VAL A 135
ASP A 160
ALA A 161
LEU A 179
LEU A 191
 TER  A 402 ( 4.1A)
TER  A 402 ( 4.4A)
None
None
None
None
None
None
 1.43A 6bq4A-6bq6A:
50.6		 6bq4A-6bq6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		11 / 12 GLN A  54
GLY A 106
ASP A 129
ILE A 130
ASP A 131
VAL A 134
ASP A 160
ALA A 161
LEU A 179
ALA A 180
CYH A 188
 None
TER  A 402 ( 4.1A)
TER  A 402 ( 4.4A)
None
None
None
None
None
None
None
None
 0.60A 6bq4B-6bq6A:
50.0		 6bq4B-6bq6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		6 / 12 GLN A  54
GLY A 107
ASP A 129
ASP A 131
VAL A 134
ALA A 180
 None
CL  A 401 (-3.7A)
TER  A 402 ( 4.4A)
None
None
None
 1.14A 6bq4B-6bq6A:
50.0		 6bq4B-6bq6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		11 / 12 GLY A 106
ASP A 129
ILE A 130
ASP A 131
VAL A 134
ASP A 160
ALA A 161
LEU A 179
ALA A 180
PRO A 187
CYH A 188
 TER  A 402 ( 4.1A)
TER  A 402 ( 4.4A)
None
None
None
None
None
None
None
None
None
 0.63A 6bq4B-6bq6A:
50.0		 6bq4B-6bq6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 6bq6 THERMOSPERMINE
SYNTHASE
(Medicago
truncatula) 		7 / 12 GLY A 106
ASP A 129
ILE A 130
VAL A 135
ASP A 160
ALA A 161
LEU A 179
 TER  A 402 ( 4.1A)
TER  A 402 ( 4.4A)
None
None
None
None
None
 1.41A 6bq4B-6bq6A:
50.0		 6bq4B-6bq6A:
100.00