SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bq9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 6bq9 DNA TOPOISOMERASE 4
SUBUNIT A
(Pseudomonas
putida) 		5 / 11 THR A 185
LEU A 341
ASP A  43
GLY A  44
ALA A 162
 CL  A 502 (-4.1A)
None
None
None
None
 1.13A 1b02A-6bq9A:
undetectable		 1b02A-6bq9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 6bq9 DNA TOPOISOMERASE 4
SUBUNIT A
(Pseudomonas
putida) 		5 / 10 GLY A  44
LEU A 139
TYR A 135
LEU A 106
TYR A 102
 None
 1.41A 1pbcA-6bq9A:
undetectable		 1pbcA-6bq9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 6bq9 DNA TOPOISOMERASE 4
SUBUNIT A
(Pseudomonas
putida) 		5 / 9 GLU A 194
HIS A 216
ALA A 196
LEU A 472
LEU A 350
 None
 1.20A 2azqA-6bq9A:
undetectable		 2azqA-6bq9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 6bq9 DNA TOPOISOMERASE 4
SUBUNIT A
(Pseudomonas
putida) 		3 / 3 ARG A  36
VAL A 187
THR A 176
 CL  A 502 (-4.1A)
None
None
 0.83A 3cyxA-6bq9A:
undetectable		 3cyxA-6bq9A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6bq9 DNA TOPOISOMERASE 4
SUBUNIT A
(Pseudomonas
putida) 		5 / 12 TYR A 102
GLY A 109
ALA A 130
THR A  73
ILE A  52
 None
 1.27A 3ld6A-6bq9A:
undetectable		 3ld6A-6bq9A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6bq9 DNA TOPOISOMERASE 4
SUBUNIT A
(Pseudomonas
putida) 		5 / 12 TYR A 102
GLY A 109
ALA A 130
THR A  73
ILE A  52
 None
 1.27A 3ld6B-6bq9A:
undetectable		 3ld6B-6bq9A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 6bq9 DNA TOPOISOMERASE 4
SUBUNIT A
(Pseudomonas
putida) 		3 / 3 LEU A 318
MET A 288
ASP A 294
 None
 0.75A 4j7xB-6bq9A:
undetectable		 4j7xB-6bq9A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 6bq9 DNA TOPOISOMERASE 4
SUBUNIT A
(Pseudomonas
putida) 		3 / 3 ARG A 361
ASP A 475
ARG A 368
 None
 0.95A 4mx0A-6bq9A:
undetectable		 4mx0A-6bq9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 6bq9 DNA TOPOISOMERASE 4
SUBUNIT A
(Pseudomonas
putida) 		5 / 12 HIS A  40
ILE A 171
LEU A  38
LEU A 172
THR A 185
 None
None
None
None
CL  A 502 (-4.1A)
 1.16A 5bykA-6bq9A:
undetectable		 5bykA-6bq9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 6bq9 DNA TOPOISOMERASE 4
SUBUNIT A
(Pseudomonas
putida) 		3 / 3 TRP A 357
ARG A 361
LEU A 203
 None
 0.94A 5dbyA-6bq9A:
undetectable		 5dbyA-6bq9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 6bq9 DNA TOPOISOMERASE 4
SUBUNIT A
(Pseudomonas
putida) 		5 / 12 TYR A 135
ALA A  97
THR A 177
ILE A 171
LEU A  45
 None
 1.24A 6aybA-6bq9A:
undetectable		 6aybA-6bq9A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 6bq9 DNA TOPOISOMERASE 4
SUBUNIT A
(Pseudomonas
putida) 		5 / 12 ILE A 228
GLY A 219
ILE A 217
VAL A 187
VAL A 334
 None
 0.96A 6dh0A-6bq9A:
undetectable		 6dh0A-6bq9A:
21.11