SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bqc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A 175
GLY A 177
GLY A 180
ASP A 221
MET A 237
 None
 0.81A 2b25A-6bqcA:
13.4		 2b25A-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F10_A_BCZA382_0
(SIALIDASE 2)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		5 / 12 ILE A 268
GLU A 239
TYR A 350
LEU A 351
TYR A 317
 LOP  A 402 ( 3.5A)
LOP  A 402 ( 2.6A)
LOP  A 402 (-4.0A)
None
LOP  A 402 ( 3.7A)
 1.08A 2f10A-6bqcA:
undetectable		 2f10A-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		5 / 12 TYR A 137
ILE A 174
GLY A 175
GLY A 177
HIS A 240
 LOP  A 402 (-2.8A)
None
None
None
LOP  A 402 (-3.2A)
 0.77A 2fk8A-6bqcA:
32.2		 2fk8A-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		3 / 3 SER A 138
THR A 197
GLN A 202
 CO3  A 401 (-4.5A)
None
None
 0.38A 2fk8A-6bqcA:
32.2		 2fk8A-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		5 / 12 ASP A 173
GLY A 175
GLY A 177
GLY A 180
THR A 197
 None
 0.75A 2oxtD-6bqcA:
9.1		 2oxtD-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A 175
GLY A 177
ASP A 221
VAL A 235
GLY A 236
 None
None
None
None
LOP  A 402 ( 3.4A)
 0.64A 2qe6B-6bqcA:
11.8		 2qe6B-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		5 / 11 GLY A 314
TYR A 317
PHE A 358
GLY A 269
HIS A 266
 None
LOP  A 402 ( 3.7A)
LOP  A 402 ( 4.6A)
None
CO3  A 401 (-4.0A)
 1.16A 2y7kA-6bqcA:
undetectable		 2y7kA-6bqcA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A 314
TYR A 317
PHE A 358
GLY A 269
HIS A 266
 None
LOP  A 402 ( 3.7A)
LOP  A 402 ( 4.6A)
None
CO3  A 401 (-4.0A)
 1.25A 2y7kC-6bqcA:
undetectable		 2y7kC-6bqcA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		4 / 7 GLU A  68
ARG A  40
TYR A  62
ARG A 345
 None
 1.28A 2zt7A-6bqcA:
undetectable		 2zt7A-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		4 / 8 LEU A 126
ASP A 121
GLU A 341
SER A 340
 None
 1.07A 2zw9A-6bqcA:
4.2		 2zw9A-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		4 / 8 ARG A  40
ASP A  73
MET A  74
GLU A 326
 None
GOL  A 408 ( 4.3A)
GOL  A 407 (-4.1A)
None
 1.38A 3dh0A-6bqcA:
14.8		 3dh0A-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW1_A_STIA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		5 / 10 PHE A  76
GLY A  57
GLY A  59
TYR A 349
GLU A  53
 LOP  A 402 ( 3.8A)
None
None
None
None
 1.50A 3fw1A-6bqcA:
2.3		 3fw1A-6bqcA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		4 / 8 SER A 128
ASP A 125
ASP A 121
TYR A 350
 GOL  A 409 ( 4.9A)
None
None
LOP  A 402 (-4.0A)
 1.05A 3havA-6bqcA:
undetectable		 3havA-6bqcA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		4 / 6 SER A 234
PHE A 238
TYR A 249
PRO A 292
 None
 1.50A 3jqaA-6bqcA:
5.4		 3jqaA-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		4 / 6 SER A 234
PHE A 238
TYR A 249
PRO A 292
 None
 1.47A 3jqaC-6bqcA:
5.8		 3jqaC-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		4 / 6 SER A 234
PHE A 238
TYR A 249
PRO A 292
 None
 1.47A 3jqaD-6bqcA:
5.4		 3jqaD-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A  54
GLY A  57
PRO A 279
LEU A  51
LEU A  96
 LOP  A 402 ( 4.2A)
None
None
None
None
 1.06A 3p2kB-6bqcA:
10.7		 3p2kB-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A  54
GLY A  57
PRO A 279
LEU A  51
LEU A  96
 LOP  A 402 ( 4.2A)
None
None
None
None
 1.07A 3p2kD-6bqcA:
10.5		 3p2kD-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		5 / 10 PHE A 250
PHE A 263
VAL A 368
PHE A 370
PHE A 238
 None
 1.42A 3t3qA-6bqcA:
undetectable		 3t3qA-6bqcA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		3 / 3 GLN A 153
PHE A 134
TYR A 184
 None
 0.89A 3ucjB-6bqcA:
undetectable		 3ucjB-6bqcA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		3 / 3 GLN A 153
PHE A 134
TYR A 184
 None
 0.92A 3ucjA-6bqcA:
undetectable		 3ucjA-6bqcA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A 175
GLY A 177
VAL A 196
THR A 197
GLN A 202
 None
 0.48A 4f84A-6bqcA:
23.7		 4f84A-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A  58
PHE A  75
ALA A 357
GLY A  83
LEU A  80
 LOP  A 402 (-4.0A)
None
LOP  A 402 (-3.3A)
None
LOP  A 402 ( 4.4A)
 1.24A 4j7xB-6bqcA:
undetectable		 4j7xB-6bqcA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A 175
GLY A 177
ILE A 198
SER A 199
HIS A 240
 None
None
None
None
LOP  A 402 (-3.2A)
 0.79A 4qdjA-6bqcA:
16.6		 4qdjA-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		3 / 3 GLN A 367
HIS A 311
ARG A 382
 None
 1.21A 4qyqA-6bqcA:
undetectable		 4qyqA-6bqcA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		3 / 3 GLN A 367
HIS A 311
ARG A 382
 None
 1.25A 4qyqB-6bqcA:
undetectable		 4qyqB-6bqcA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_B_ACTB201_0
(RETINOL-BINDING
PROTEIN 2)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		4 / 5 TYR A 325
TYR A  62
GLU A  68
LEU A  72
 GOL  A 403 (-4.5A)
None
None
GOL  A 403 (-3.1A)
 0.95A 4qztB-6bqcA:
undetectable		 4qztB-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVX_A_GMRA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A 321
TRP A 324
SER A 138
LEU A 131
PHE A 286
 LOP  A 402 ( 4.3A)
None
CO3  A 401 (-4.5A)
None
LOP  A 402 (-3.0A)
 1.33A 4yvxA-6bqcA:
undetectable		 4yvxA-6bqcA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A  54
GLY A  57
PRO A 279
LEU A  51
LEU A  96
 LOP  A 402 ( 4.2A)
None
None
None
None
 0.96A 5bw4A-6bqcA:
11.3		 5bw4A-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		7 / 12 SER A 138
GLY A 175
GLY A 177
THR A 197
GLN A 202
VAL A 235
HIS A 240
 CO3  A 401 (-4.5A)
None
None
None
None
None
LOP  A 402 (-3.2A)
 0.75A 5kocB-6bqcA:
28.9		 5kocB-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		5 / 12 SER A 138
GLY A 175
GLY A 177
SER A 199
GLN A 202
 CO3  A 401 (-4.5A)
None
None
None
None
 0.85A 5kpcB-6bqcA:
28.7		 5kpcB-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		6 / 12 GLY A 175
GLY A 177
GLY A 180
THR A 197
ASP A 221
ILE A 174
 None
 1.35A 5kqsA-6bqcA:
8.4		 5kqsA-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A 175
GLY A 177
GLY A 180
THR A 197
ASP A 221
 None
 0.90A 5m5bA-6bqcA:
8.4		 5m5bA-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		3 / 3 CYH A 160
MET A 185
ASN A 188
 None
 1.18A 5qh8A-6bqcA:
undetectable		 5qh8A-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		6 / 12 GLY A 175
GLY A 177
GLY A 180
THR A 197
ASP A 221
ILE A 174
 None
 1.34A 5wz1B-6bqcA:
8.6		 5wz1B-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_A_SAMA601_0
(NS5 MTASE)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		6 / 12 GLY A 175
GLY A 177
GLY A 180
THR A 197
ASP A 221
ILE A 174
 None
 1.35A 5wz2A-6bqcA:
8.0		 5wz2A-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)		 6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A 175
GLY A 177
GLY A 180
THR A 197
ASP A 221
 None
 0.88A 5wz2B-6bqcA:
8.0		 5wz2B-6bqcA:
undetectable