SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bqw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 6bqw BACTERIAL ACTIN ALFA
(Bacillus
subtilis) 		5 / 12 ILE A  86
PHE A 122
THR A  14
ILE A   7
LEU A  92
 None
 1.18A 1dhfB-6bqwA:
undetectable		 1dhfB-6bqwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 6bqw BACTERIAL ACTIN ALFA
(Bacillus
subtilis) 		5 / 11 ASP A   8
ASN A  11
GLY A 195
THR A 196
GLY A 225
 ANP  A 301 (-3.7A)
ANP  A 301 (-3.8A)
None
None
ANP  A 301 ( 4.7A)
 1.18A 1jr1A-6bqwA:
undetectable		 1jr1A-6bqwA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 6bqw BACTERIAL ACTIN ALFA
(Bacillus
subtilis) 		5 / 12 SER A 189
VAL A 176
ILE A 215
ASN A 214
PHE A 208
 None
 1.29A 2vdyA-6bqwA:
undetectable		 2vdyA-6bqwA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 6bqw BACTERIAL ACTIN ALFA
(Bacillus
subtilis) 		5 / 12 SER A 189
VAL A 176
ILE A 215
ASN A 214
PHE A 208
 None
 1.30A 2vdyB-6bqwA:
undetectable		 2vdyB-6bqwA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 6bqw BACTERIAL ACTIN ALFA
(Bacillus
subtilis) 		4 / 6 TYR A 255
GLY A  27
GLU A  98
GLU A  46
 ANP  A 301 (-3.4A)
None
None
None
 1.00A 3fpjA-6bqwA:
undetectable		 3fpjA-6bqwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 6bqw BACTERIAL ACTIN ALFA
(Bacillus
subtilis) 		4 / 5 PHE A 126
ALA A  91
THR A  14
LEU A 108
 None
 1.09A 3t3zC-6bqwA:
undetectable		 3t3zC-6bqwA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 6bqw BACTERIAL ACTIN ALFA
(Bacillus
subtilis) 		3 / 3 GLU A  83
TYR A  55
SER A  35
 None
 0.95A 4at0A-6bqwA:
undetectable		 4at0A-6bqwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 6bqw BACTERIAL ACTIN ALFA
(Bacillus
subtilis) 		5 / 12 SER A 189
VAL A 176
ILE A 215
ASN A 214
PHE A 208
 None
 1.34A 4c49B-6bqwA:
undetectable		 4c49B-6bqwA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 6bqw BACTERIAL ACTIN ALFA
(Bacillus
subtilis) 		5 / 12 SER A 189
VAL A 176
ILE A 215
ASN A 214
PHE A 208
 None
 1.27A 4c49C-6bqwA:
undetectable		 4c49C-6bqwA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 6bqw BACTERIAL ACTIN ALFA
(Bacillus
subtilis) 		5 / 12 SER A 189
VAL A 176
ILE A 215
ASN A 214
PHE A 208
 None
 1.36A 4c49D-6bqwA:
undetectable		 4c49D-6bqwA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 6bqw BACTERIAL ACTIN ALFA
(Bacillus
subtilis) 		4 / 5 SER A 171
GLY A 170
THR A  77
ASP A 168
 ANP  A 301 (-2.5A)
ANP  A 301 (-3.1A)
None
ANP  A 301 ( 3.8A)
 1.09A 4eohA-6bqwA:
undetectable		 4eohA-6bqwA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 6bqw BACTERIAL ACTIN ALFA
(Bacillus
subtilis) 		5 / 12 ILE A  86
PHE A 122
THR A  14
ILE A   7
LEU A  92
 None
 1.09A 4kebB-6bqwA:
undetectable		 4kebB-6bqwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6bqw BACTERIAL ACTIN ALFA
(Bacillus
subtilis) 		5 / 12 ILE A  86
PHE A 122
THR A  14
ILE A   7
LEU A  92
 None
 1.09A 4m6kA-6bqwA:
undetectable		 4m6kA-6bqwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 6bqw BACTERIAL ACTIN ALFA
(Bacillus
subtilis) 		4 / 4 GLY A 194
ARG A  78
ASN A 193
LEU A 174
 None
 1.31A 6b58A-6bqwA:
undetectable		 6b58A-6bqwA:
undetectable