SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6brd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 10 ALA A 455
LEU A 387
MET A 392
LEU A 395
GLU A 434
None
1.47A 1a29A-6brdA:
undetectable
1a29A-6brdA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
3 / 3 GLN A 288
HIS A 282
PRO A 284
None
None
FAD  A 501 (-4.8A)
0.83A 1d8cA-6brdA:
undetectable
1d8cA-6brdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IHI_A_IU5A326_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 10 VAL A 157
VAL A 147
ILE A   5
GLU A  31
LEU A 136
None
None
None
FAD  A 501 (-2.5A)
None
1.47A 1ihiA-6brdA:
1.1
1ihiA-6brdA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 12 VAL A 132
LEU A  16
PHE A 273
LEU A 300
ARG A  21
None
1.08A 1jffB-6brdA:
undetectable
1jffB-6brdA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
4 / 8 ALA A 106
GLU A 102
LEU A  30
VAL A  29
None
0.77A 2bxgA-6brdA:
undetectable
2bxgA-6brdA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 12 PHE A 246
LEU A 238
ALA A 242
VAL A 195
VAL A 214
None
1.14A 2g78A-6brdA:
undetectable
2g78A-6brdA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 12 VAL A 132
LEU A  16
PHE A 273
LEU A 300
ARG A  21
None
1.07A 2hxfB-6brdA:
undetectable
2hxfB-6brdA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 12 VAL A 132
LEU A  16
PHE A 273
LEU A 300
ARG A  21
None
1.07A 2hxhB-6brdA:
undetectable
2hxhB-6brdA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 12 VAL A 132
LEU A  16
PHE A 273
LEU A 300
ARG A  21
None
1.07A 2p4nB-6brdA:
undetectable
2p4nB-6brdA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 12 HIS A 325
TYR A 267
LEU A 274
VAL A 157
LEU A 332
None
1.40A 2prgB-6brdA:
undetectable
2prgB-6brdA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 12 LEU A  86
PRO A  83
THR A  80
GLY A  72
GLY A  73
None
1.18A 2uvnA-6brdA:
undetectable
2uvnA-6brdA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 12 VAL A 132
LEU A  16
PHE A 273
LEU A 300
ARG A  21
None
1.07A 2wbeB-6brdA:
undetectable
2wbeB-6brdA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 10 VAL A 148
LEU A  20
ARG A  21
GLY A  18
ALA A 109
None
1.00A 2xf3A-6brdA:
undetectable
2xf3A-6brdA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
3 / 3 VAL A 377
ASN A 299
TRP A 302
None
0.89A 2y00B-6brdA:
undetectable
2y00B-6brdA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 12 VAL A 132
LEU A  16
PHE A 273
LEU A 300
ARG A  21
None
1.07A 3dcoB-6brdA:
undetectable
3dcoB-6brdA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 12 VAL A 132
LEU A  16
PHE A 273
LEU A 300
ARG A  21
None
1.06A 3edlB-6brdA:
undetectable
3edlB-6brdA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 12 VAL A 132
LEU A  16
PHE A 273
LEU A 300
ARG A  21
None
1.05A 3iz0B-6brdA:
undetectable
3iz0B-6brdA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 11 GLY A   9
GLN A  98
GLU A 102
THR A  37
GLY A 152
FAD  A 501 ( 4.9A)
FAD  A 501 (-3.4A)
None
None
FAD  A 501 (-3.2A)
1.49A 3wg7A-6brdA:
0.6
3wg7B-6brdA:
undetectable
3wg7T-6brdA:
undetectable
3wg7A-6brdA:
undetectable
3wg7B-6brdA:
undetectable
3wg7T-6brdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 11 GLY A  10
GLN A  98
GLU A 102
THR A  37
GLY A 152
FAD  A 501 (-3.2A)
FAD  A 501 (-3.4A)
None
None
FAD  A 501 (-3.2A)
1.37A 3wg7A-6brdA:
0.6
3wg7B-6brdA:
undetectable
3wg7T-6brdA:
undetectable
3wg7A-6brdA:
undetectable
3wg7B-6brdA:
undetectable
3wg7T-6brdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 11 GLY A   9
GLN A  98
GLU A 102
THR A  37
GLY A 152
FAD  A 501 ( 4.9A)
FAD  A 501 (-3.4A)
None
None
FAD  A 501 (-3.2A)
1.43A 3x2qA-6brdA:
0.5
3x2qB-6brdA:
undetectable
3x2qT-6brdA:
undetectable
3x2qA-6brdA:
undetectable
3x2qB-6brdA:
undetectable
3x2qT-6brdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
3 / 3 ARG A 158
PHE A 165
PRO A 166
CL  A 504 (-4.0A)
None
None
0.85A 3zoaB-6brdA:
undetectable
3zoaB-6brdA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
3 / 3 TYR A 379
HIS A 451
ARG A 447
None
1.02A 4e7bC-6brdA:
undetectable
4e7bC-6brdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
4 / 6 ASP A 259
SER A 170
ARG A 171
GLU A 168
None
1.14A 4eysA-6brdA:
undetectable
4eysA-6brdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 12 HIS A  46
ASP A 296
LEU A 292
GLY A 293
VAL A 327
RFP  A 502 (-3.9A)
None
None
None
None
1.23A 4fqsB-6brdA:
undetectable
4fqsB-6brdA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
4 / 6 GLU A 173
THR A 174
THR A 335
HIS A 282
None
1.10A 4pgfA-6brdA:
undetectable
4pgfA-6brdA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 9 HIS A 282
GLY A 293
VAL A 327
VAL A 331
LEU A 332
None
1.01A 4qd3A-6brdA:
undetectable
4qd3A-6brdA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 11 GLY A   9
GLN A  98
GLU A 102
THR A  37
GLY A 152
FAD  A 501 ( 4.9A)
FAD  A 501 (-3.4A)
None
None
FAD  A 501 (-3.2A)
1.48A 5b1aA-6brdA:
0.6
5b1aB-6brdA:
undetectable
5b1aT-6brdA:
undetectable
5b1aA-6brdA:
undetectable
5b1aB-6brdA:
undetectable
5b1aT-6brdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 11 GLY A  10
GLN A  98
GLU A 102
THR A  37
GLY A 152
FAD  A 501 (-3.2A)
FAD  A 501 (-3.4A)
None
None
FAD  A 501 (-3.2A)
1.36A 5b1aA-6brdA:
0.6
5b1aB-6brdA:
undetectable
5b1aT-6brdA:
undetectable
5b1aA-6brdA:
undetectable
5b1aB-6brdA:
undetectable
5b1aT-6brdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 11 GLY A   9
GLN A  98
GLU A 102
THR A  37
GLY A 152
FAD  A 501 ( 4.9A)
FAD  A 501 (-3.4A)
None
None
FAD  A 501 (-3.2A)
1.48A 5b1bA-6brdA:
0.1
5b1bB-6brdA:
undetectable
5b1bT-6brdA:
undetectable
5b1bA-6brdA:
undetectable
5b1bB-6brdA:
undetectable
5b1bT-6brdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 11 GLY A   9
GLN A  98
GLU A 102
THR A  37
GLY A 152
FAD  A 501 ( 4.9A)
FAD  A 501 (-3.4A)
None
None
FAD  A 501 (-3.2A)
1.49A 5b3sA-6brdA:
0.0
5b3sB-6brdA:
undetectable
5b3sT-6brdA:
undetectable
5b3sA-6brdA:
undetectable
5b3sB-6brdA:
undetectable
5b3sT-6brdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 11 GLY A  10
GLN A  98
GLU A 102
THR A  37
GLY A 152
FAD  A 501 (-3.2A)
FAD  A 501 (-3.4A)
None
None
FAD  A 501 (-3.2A)
1.34A 5b3sA-6brdA:
0.0
5b3sB-6brdA:
undetectable
5b3sT-6brdA:
undetectable
5b3sA-6brdA:
undetectable
5b3sB-6brdA:
undetectable
5b3sT-6brdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
4 / 6 SER A 436
GLU A 437
GLY A 450
ARG A 391
None
0.92A 5cdnR-6brdA:
undetectable
5cdnS-6brdA:
undetectable
5cdnR-6brdA:
11.09
5cdnS-6brdA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 12 VAL A 132
LEU A  16
PHE A 273
LEU A 300
ARG A  21
None
1.03A 5hnwB-6brdA:
undetectable
5hnwB-6brdA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 12 VAL A 132
LEU A  16
PHE A 273
LEU A 300
ARG A  21
None
1.08A 5hnyB-6brdA:
undetectable
5hnyB-6brdA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 12 TYR A 403
HIS A  90
THR A  68
ILE A 294
MET A  15
None
1.26A 5iwuA-6brdA:
undetectable
5iwuA-6brdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
8 / 12 GLY A  44
PHE A  74
ARG A 196
GLY A 203
PHE A 257
THR A 285
GLY A 286
GLY A 287
RFP  A 502 ( 4.4A)
RFP  A 502 (-4.5A)
RFP  A 502 (-3.4A)
RFP  A 502 ( 4.7A)
FAD  A 501 (-4.3A)
RFP  A 502 (-4.1A)
RFP  A 502 (-3.5A)
FAD  A 501 (-3.3A)
0.60A 5koxA-6brdA:
63.4
5koxA-6brdA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
4 / 7 TYR A 267
ASP A 296
LEU A 292
VAL A 377
None
1.13A 5ov9A-6brdA:
undetectable
5ov9A-6brdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
3 / 3 GLU A 426
HIS A 431
VAL A 422
None
0.69A 5trqB-6brdA:
undetectable
5trqB-6brdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
4 / 5 GLY A 258
ARG A 256
ASP A 259
GLN A 340
None
1.32A 5ubbA-6brdA:
undetectable
5ubbA-6brdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 12 LEU A 292
GLY A 276
GLY A 152
LEU A 290
GLY A 293
None
FAD  A 501 ( 3.9A)
FAD  A 501 (-3.2A)
FAD  A 501 (-3.7A)
None
0.99A 5wyqA-6brdA:
undetectable
5wyqA-6brdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 11 GLY A   9
GLN A  98
GLU A 102
THR A  37
GLY A 152
FAD  A 501 ( 4.9A)
FAD  A 501 (-3.4A)
None
None
FAD  A 501 (-3.2A)
1.47A 5x19A-6brdA:
0.1
5x19B-6brdA:
undetectable
5x19T-6brdA:
undetectable
5x19A-6brdA:
undetectable
5x19B-6brdA:
undetectable
5x19T-6brdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 11 GLY A  10
GLN A  98
GLU A 102
THR A  37
GLY A 152
FAD  A 501 (-3.2A)
FAD  A 501 (-3.4A)
None
None
FAD  A 501 (-3.2A)
1.35A 5x19A-6brdA:
0.1
5x19B-6brdA:
undetectable
5x19T-6brdA:
undetectable
5x19A-6brdA:
undetectable
5x19B-6brdA:
undetectable
5x19T-6brdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 11 GLY A   9
GLN A  98
GLU A 102
THR A  37
GLY A 152
FAD  A 501 ( 4.9A)
FAD  A 501 (-3.4A)
None
None
FAD  A 501 (-3.2A)
1.49A 5xdqA-6brdA:
undetectable
5xdqB-6brdA:
undetectable
5xdqT-6brdA:
undetectable
5xdqA-6brdA:
undetectable
5xdqB-6brdA:
undetectable
5xdqT-6brdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 11 GLY A  10
GLN A  98
GLU A 102
THR A  37
GLY A 152
FAD  A 501 (-3.2A)
FAD  A 501 (-3.4A)
None
None
FAD  A 501 (-3.2A)
1.35A 5xdxA-6brdA:
0.2
5xdxB-6brdA:
undetectable
5xdxT-6brdA:
undetectable
5xdxA-6brdA:
undetectable
5xdxB-6brdA:
undetectable
5xdxT-6brdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 11 GLY A   9
GLN A  98
GLU A 102
THR A  37
GLY A 152
FAD  A 501 ( 4.9A)
FAD  A 501 (-3.4A)
None
None
FAD  A 501 (-3.2A)
1.47A 5z84A-6brdA:
0.0
5z84B-6brdA:
undetectable
5z84T-6brdA:
undetectable
5z84A-6brdA:
undetectable
5z84B-6brdA:
undetectable
5z84T-6brdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 11 GLY A  10
GLN A  98
GLU A 102
THR A  37
GLY A 152
FAD  A 501 (-3.2A)
FAD  A 501 (-3.4A)
None
None
FAD  A 501 (-3.2A)
1.31A 5z84A-6brdA:
0.0
5z84B-6brdA:
undetectable
5z84T-6brdA:
undetectable
5z84A-6brdA:
undetectable
5z84B-6brdA:
undetectable
5z84T-6brdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 11 GLY A   9
GLN A  98
GLU A 102
THR A  37
GLY A 152
FAD  A 501 ( 4.9A)
FAD  A 501 (-3.4A)
None
None
FAD  A 501 (-3.2A)
1.49A 5z86A-6brdA:
0.6
5z86B-6brdA:
undetectable
5z86T-6brdA:
undetectable
5z86A-6brdA:
undetectable
5z86B-6brdA:
undetectable
5z86T-6brdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 11 GLY A  10
GLN A  98
GLU A 102
THR A  37
GLY A 152
FAD  A 501 (-3.2A)
FAD  A 501 (-3.4A)
None
None
FAD  A 501 (-3.2A)
1.32A 5z86A-6brdA:
0.6
5z86B-6brdA:
undetectable
5z86T-6brdA:
undetectable
5z86A-6brdA:
undetectable
5z86B-6brdA:
undetectable
5z86T-6brdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 11 GLY A   9
GLN A  98
GLU A 102
THR A  37
GLY A 152
FAD  A 501 ( 4.9A)
FAD  A 501 (-3.4A)
None
None
FAD  A 501 (-3.2A)
1.49A 5zcoA-6brdA:
0.2
5zcoB-6brdA:
undetectable
5zcoT-6brdA:
undetectable
5zcoA-6brdA:
undetectable
5zcoB-6brdA:
undetectable
5zcoT-6brdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 11 GLY A  10
GLN A  98
GLU A 102
THR A  37
GLY A 152
FAD  A 501 (-3.2A)
FAD  A 501 (-3.4A)
None
None
FAD  A 501 (-3.2A)
1.35A 5zcpA-6brdA:
0.1
5zcpB-6brdA:
undetectable
5zcpT-6brdA:
undetectable
5zcpA-6brdA:
undetectable
5zcpB-6brdA:
undetectable
5zcpT-6brdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
4 / 5 ILE A 369
GLN A 288
THR A 373
THR A  80
None
0.87A 6f3mD-6brdA:
3.4
6f3mD-6brdA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
4 / 5 GLY A 293
LEU A 290
SER A  49
GLN A 295
None
FAD  A 501 (-3.7A)
None
None
1.35A 6ji6A-6brdA:
undetectable
6ji6A-6brdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae)
5 / 9 GLY A   9
GLN A  98
GLU A 102
THR A  37
GLY A 152
FAD  A 501 ( 4.9A)
FAD  A 501 (-3.4A)
None
None
FAD  A 501 (-3.2A)
1.36A 6nmpA-6brdA:
0.0
6nmpB-6brdA:
0.0
6nmpT-6brdA:
undetectable
6nmpA-6brdA:
undetectable
6nmpB-6brdA:
undetectable
6nmpT-6brdA:
undetectable