SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6brk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Mus
musculus) 		5 / 9 ALA A 234
GLU A 266
SER A 334
VAL A 333
GLY A 204
 None
DGT  A 701 (-4.2A)
None
None
None
 1.27A 1bcuH-6brkA:
undetectable		 1bcuH-6brkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Mus
musculus) 		5 / 12 TYR A 205
ILE A 165
ASP A 169
LEU A 201
PHE A 197
 None
 1.21A 2zzmA-6brkA:
undetectable		 2zzmA-6brkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Mus
musculus) 		3 / 3 PRO A 318
PHE A 299
LYS A 320
 None
 1.27A 3bjwG-6brkA:
undetectable		 3bjwG-6brkA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Mus
musculus) 		4 / 6 HIS A 242
HIS A 265
HIS A 247
ASP A 343
 DGT  A 701 (-4.4A)
DGT  A 701 (-3.9A)
DGT  A 701 (-3.7A)
DGT  A 701 (-2.6A)
 1.18A 3nvcA-6brkA:
undetectable		 3nvcA-6brkA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Mus
musculus) 		3 / 3 HIS A 391
SER A 394
ASN A 338
 None
 0.89A 3s8pB-6brkA:
undetectable		 3s8pB-6brkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Mus
musculus) 		4 / 7 ILE A 223
PHE A 299
LYS A 320
GLY A 321
 None
 1.24A 3sj0X-6brkA:
undetectable		 3sj0X-6brkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Mus
musculus) 		5 / 12 ILE A 332
VAL A 342
TYR A 363
ILE A 340
ILE A 392
 None
 1.24A 3vrjA-6brkA:
undetectable
3vrjC-6brkA:
undetectable		 3vrjA-6brkA:
16.06
3vrjC-6brkA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Mus
musculus) 		4 / 7 LEU A 182
TYR A 347
ASP A 351
HIS A 413
 DGT  A 701 (-4.4A)
DGT  A 701 (-3.8A)
DGT  A 701 (-3.2A)
None
 1.32A 4arcA-6brkA:
undetectable		 4arcA-6brkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Mus
musculus) 		4 / 8 ASP A 343
ASP A 426
ASN A 239
GLU A 266
 DGT  A 701 (-2.6A)
DGT  A 701 ( 4.5A)
DGT  A 701 (-3.7A)
DGT  A 701 (-4.2A)
 0.93A 4feuD-6brkA:
undetectable		 4feuD-6brkA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Mus
musculus) 		3 / 3 TYR A 347
ARG A 196
HIS A 247
 DGT  A 701 (-3.8A)
DGT  A 701 (-3.5A)
DGT  A 701 (-3.7A)
 1.18A 4fubA-6brkA:
undetectable		 4fubA-6brkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA302_1
(CHITOSANASE)		 6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Mus
musculus) 		4 / 5 ARG A 252
THR A 430
ASP A 431
TYR A 497
 None
 1.15A 4oltA-6brkA:
0.6		 4oltA-6brkA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Mus
musculus) 		4 / 5 ARG A 252
THR A 430
ASP A 431
TYR A 497
 None
 1.22A 4oltB-6brkA:
0.3		 4oltB-6brkA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Mus
musculus) 		5 / 12 HIS A 247
HIS A 242
GLY A 243
PHE A 249
GLY A 251
 DGT  A 701 (-3.7A)
DGT  A 701 (-4.4A)
None
None
None
 1.13A 4qa2B-6brkA:
undetectable		 4qa2B-6brkA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA302_1
(CHITOSANASE)		 6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Mus
musculus) 		4 / 5 ARG A 252
THR A 430
ASP A 431
TYR A 497
 None
 1.20A 4qwpA-6brkA:
0.4		 4qwpA-6brkA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB306_1
(CHITOSANASE)		 6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Mus
musculus) 		4 / 5 ARG A 252
THR A 430
ASP A 431
TYR A 497
 None
 1.17A 4qwpB-6brkA:
0.5		 4qwpB-6brkA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Mus
musculus) 		5 / 12 GLY A 183
TYR A 186
SER A 422
ILE A 179
ASN A 195
 None
 1.39A 4xueB-6brkA:
undetectable		 4xueB-6brkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Mus
musculus) 		3 / 3 HIS A 391
SER A 394
ASN A 338
 None
 0.83A 5cprB-6brkA:
undetectable		 5cprB-6brkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_A_LBHA2004_1
(HDAC6 PROTEIN)		 6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Mus
musculus) 		5 / 12 HIS A 413
HIS A 242
HIS A 265
ASP A 343
TYR A 347
 None
DGT  A 701 (-4.4A)
DGT  A 701 (-3.9A)
DGT  A 701 (-2.6A)
DGT  A 701 (-3.8A)
 1.49A 5ef8A-6brkA:
undetectable		 5ef8A-6brkA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Mus
musculus) 		5 / 12 LEU A 206
ILE A 367
PHE A 366
ALA A 370
GLY A 339
 None
 1.02A 5veuA-6brkA:
undetectable		 5veuA-6brkA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Mus
musculus) 		5 / 12 LEU A 206
ILE A 367
PHE A 366
ALA A 370
GLY A 339
 None
 1.04A 5veuH-6brkA:
undetectable		 5veuH-6brkA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Mus
musculus) 		5 / 12 PHE A 173
GLY A 202
GLY A 204
ALA A 207
ILE A 154
 None
 1.16A 6b3aA-6brkA:
undetectable		 6b3aA-6brkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Mus
musculus) 		5 / 12 PHE A 173
GLY A 202
GLY A 204
ALA A 207
ILE A 154
 None
 1.16A 6b3bA-6brkA:
undetectable		 6b3bA-6brkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA717_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Mus
musculus) 		5 / 5 SER A 224
ARG A 226
ASP A 227
ARG A 322
LYS A 326
 None
 0.38A 6dwdA-6brkA:
52.2		 6dwdA-6brkA:
undetectable