SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6brr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 12 LEU A 901
GLU A 756
LEU A 703
GLY A 706
PHE A 794
 None
 1.45A 1d4fA-6brrA:
3.5		 1d4fA-6brrA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 12 SER A 638
TYR A 660
PHE A 794
VAL A 895
PHE A 870
 None
 1.45A 1q23D-6brrA:
undetectable
1q23E-6brrA:
undetectable		 1q23D-6brrA:
16.97
1q23E-6brrA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 10 SER A 638
TYR A 660
PHE A 794
VAL A 895
PHE A 870
 None
 1.49A 1q23E-6brrA:
undetectable		 1q23E-6brrA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 11 SER A 638
TYR A 660
PHE A 794
VAL A 895
PHE A 870
 None
 1.43A 1q23G-6brrA:
undetectable		 1q23G-6brrA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 10 SER A 638
TYR A 660
PHE A 794
VAL A 895
PHE A 870
 None
 1.45A 1q23K-6brrA:
undetectable		 1q23K-6brrA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 11 SER A 638
TYR A 660
PHE A 794
VAL A 895
PHE A 870
 None
 1.43A 1q23L-6brrA:
undetectable		 1q23L-6brrA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		6 / 12 PHE A 640
GLY A 642
GLY A 646
ASP A 686
PRO A 709
LEU A 730
 SAH  A1001 (-4.4A)
SAH  A1001 (-3.4A)
None
SAH  A1001 (-3.0A)
SAH  A1001 (-3.7A)
SAH  A1001 (-4.8A)
 1.15A 2hmyB-6brrA:
17.8		 2hmyB-6brrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		4 / 6 THR A 875
ARG A 885
THR A 862
ASP A 811
 None
 1.27A 2okcA-6brrA:
6.6		 2okcA-6brrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		4 / 6 THR A 875
ARG A 885
THR A 862
ASP A 811
 None
 1.27A 2okcB-6brrA:
6.5		 2okcB-6brrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 12 GLY A 642
ASP A 686
VAL A 687
ARG A 688
GLY A 707
 SAH  A1001 (-3.4A)
SAH  A1001 (-3.0A)
SAH  A1001 (-3.7A)
None
SAH  A1001 (-4.4A)
 0.78A 2qe6B-6brrA:
5.5		 2qe6B-6brrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 12 PRO A 709
PHE A 640
GLY A 642
THR A 645
GLU A 664
 SAH  A1001 (-3.7A)
SAH  A1001 (-4.4A)
SAH  A1001 (-3.4A)
SAH  A1001 (-3.5A)
SAH  A1001 (-2.7A)
 0.55A 2zifA-6brrA:
4.0		 2zifA-6brrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 12 PHE A 640
GLY A 642
GLY A 646
PRO A 709
LEU A 730
 SAH  A1001 (-4.4A)
SAH  A1001 (-3.4A)
None
SAH  A1001 (-3.7A)
SAH  A1001 (-4.8A)
 1.09A 3av6A-6brrA:
11.4		 3av6A-6brrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 12 GLY A 728
ASP A 768
ILE A 769
LEU A 713
ARG A 720
 None
 1.21A 3iv6B-6brrA:
7.1		 3iv6B-6brrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 12 GLY A 728
ASP A 768
ILE A 769
LEU A 713
ARG A 720
 None
 1.26A 3iv6D-6brrA:
7.2		 3iv6D-6brrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 12 LEU A 901
LEU A 653
LEU A 905
ILE A 705
GLY A 646
 None
 1.14A 3q95A-6brrA:
undetectable		 3q95A-6brrA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 11 GLY A 642
ASP A 686
VAL A 687
PRO A 709
LEU A 730
 SAH  A1001 (-3.4A)
SAH  A1001 (-3.0A)
SAH  A1001 (-3.7A)
SAH  A1001 (-3.7A)
SAH  A1001 (-4.8A)
 0.87A 3v8vB-6brrA:
7.2		 3v8vB-6brrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		3 / 3 GLN A 886
THR A 835
THR A 834
 None
 0.71A 4fu9A-6brrA:
undetectable		 4fu9A-6brrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		3 / 3 GLN A 886
THR A 835
THR A 834
 None
 0.72A 4fufA-6brrA:
undetectable		 4fufA-6brrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 12 GLY A 890
ARG A 831
ILE A 833
LEU A 888
ILE A 840
 None
 0.97A 4uw0A-6brrA:
6.9		 4uw0A-6brrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		4 / 5 TYR A 660
GLY A 642
TYR A 683
GLY A 685
 None
SAH  A1001 (-3.4A)
None
None
 1.02A 5ayfA-6brrA:
undetectable		 5ayfA-6brrA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		3 / 3 VAL A 872
THR A 862
ARG A 866
 None
 0.71A 5b2sB-6brrA:
undetectable		 5b2sB-6brrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		3 / 3 VAL A 872
THR A 862
ARG A 866
 None
 0.75A 5b2tB-6brrA:
undetectable		 5b2tB-6brrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		6 / 12 ASP A 686
PRO A 709
PHE A 640
GLY A 642
THR A 645
GLU A 664
 SAH  A1001 (-3.0A)
SAH  A1001 (-3.7A)
SAH  A1001 (-4.4A)
SAH  A1001 (-3.4A)
SAH  A1001 (-3.5A)
SAH  A1001 (-2.7A)
 0.48A 5hfjA-6brrA:
undetectable		 5hfjA-6brrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 12 ASP A 686
PRO A 709
PHE A 640
GLY A 642
THR A 645
 SAH  A1001 (-3.0A)
SAH  A1001 (-3.7A)
SAH  A1001 (-4.4A)
SAH  A1001 (-3.4A)
SAH  A1001 (-3.5A)
 0.48A 5hfjC-6brrA:
2.4		 5hfjC-6brrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		6 / 12 ASP A 686
PRO A 709
PHE A 640
GLY A 642
THR A 645
GLU A 664
 SAH  A1001 (-3.0A)
SAH  A1001 (-3.7A)
SAH  A1001 (-4.4A)
SAH  A1001 (-3.4A)
SAH  A1001 (-3.5A)
SAH  A1001 (-2.7A)
 0.56A 5hfjD-6brrA:
2.6		 5hfjD-6brrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 12 ASP A 686
PHE A 640
GLY A 642
THR A 645
GLU A 664
 SAH  A1001 (-3.0A)
SAH  A1001 (-4.4A)
SAH  A1001 (-3.4A)
SAH  A1001 (-3.5A)
SAH  A1001 (-2.7A)
 0.60A 5hfjE-6brrA:
2.5		 5hfjE-6brrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 12 ASP A 686
PRO A 709
PHE A 640
GLY A 642
THR A 645
 SAH  A1001 (-3.0A)
SAH  A1001 (-3.7A)
SAH  A1001 (-4.4A)
SAH  A1001 (-3.4A)
SAH  A1001 (-3.5A)
 0.55A 5hfjH-6brrA:
2.1		 5hfjH-6brrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		6 / 11 PHE A 640
GLY A 642
GLU A 664
ASP A 686
VAL A 687
PRO A 709
 SAH  A1001 (-4.4A)
SAH  A1001 (-3.4A)
SAH  A1001 (-2.7A)
SAH  A1001 (-3.0A)
SAH  A1001 (-3.7A)
SAH  A1001 (-3.7A)
 0.57A 5hjiA-6brrA:
2.0		 5hjiA-6brrA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 12 VAL A 687
LEU A 738
PHE A 755
LEU A 773
ARG A 729
 SAH  A1001 (-3.7A)
None
None
None
None
 1.37A 5hnxB-6brrA:
undetectable		 5hnxB-6brrA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 12 ASP A 686
ARG A 688
PRO A 709
LEU A 730
PHE A 640
 SAH  A1001 (-3.0A)
None
SAH  A1001 (-3.7A)
SAH  A1001 (-4.8A)
SAH  A1001 (-4.4A)
 0.79A 5il1A-6brrA:
undetectable		 5il1A-6brrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		5 / 12 ASP A 686
ARG A 688
PRO A 709
LEU A 730
PHE A 640
 SAH  A1001 (-3.0A)
None
SAH  A1001 (-3.7A)
SAH  A1001 (-4.8A)
SAH  A1001 (-4.4A)
 0.73A 5k7uA-6brrA:
undetectable		 5k7uA-6brrA:
undetectable