SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bs7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		4 / 6 LEU A 316
GLU A  15
THR A 331
LEU A 407
 None
 1.27A 1etb2-6bs7A:
undetectable		 1etb2-6bs7A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		5 / 10 VAL A   5
TYR A 262
VAL A 263
ILE A 320
LEU A   8
 None
 1.11A 1fe2A-6bs7A:
undetectable		 1fe2A-6bs7A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		5 / 10 LEU A 336
VAL A 287
TYR A 270
GLY A 288
LEU A 342
 None
 1.44A 1fkoA-6bs7A:
undetectable		 1fkoA-6bs7A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		5 / 11 ASN A 323
GLY A 265
THR A 267
GLY A  13
GLN A  11
 None
 1.35A 1jr1A-6bs7A:
undetectable		 1jr1A-6bs7A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SS4_A_ACTA411_0
(GLYOXALASE FAMILY
PROTEIN)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		4 / 5 VAL A 330
THR A 267
GLN A  11
ILE A 344
 None
 1.33A 1ss4A-6bs7A:
undetectable		 1ss4A-6bs7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		5 / 12 PHE A 158
GLY A 150
HIS A 111
LEU A  75
TYR A 110
 None
 1.30A 1zgyA-6bs7A:
undetectable		 1zgyA-6bs7A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		5 / 12 PHE A 158
HIS A 111
LEU A 198
LEU A 165
TYR A 110
 None
 1.45A 1zgyA-6bs7A:
undetectable		 1zgyA-6bs7A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		5 / 12 GLY A 150
SER A 101
ASP A 151
ARG A 157
ASP A 156
 None
 1.28A 2bm9B-6bs7A:
undetectable		 2bm9B-6bs7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		4 / 6 GLY A 265
ILE A 411
GLY A 327
TYR A 262
 None
 0.87A 2jklB-6bs7A:
undetectable		 2jklB-6bs7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		4 / 7 GLY A 265
ILE A 411
GLY A 327
TYR A 262
 None
 0.87A 2jklC-6bs7A:
undetectable		 2jklC-6bs7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		4 / 6 PRO A 280
ASP A 352
ASP A 350
TYR A 348
 None
 1.38A 2lh8A-6bs7A:
undetectable		 2lh8A-6bs7A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		5 / 12 PHE A 158
GLY A 150
HIS A 111
LEU A  75
TYR A 110
 None
 1.38A 2prgA-6bs7A:
undetectable		 2prgA-6bs7A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		5 / 12 PHE A 158
HIS A 111
LEU A  75
LEU A 187
TYR A 110
 None
 1.32A 2prgB-6bs7A:
undetectable		 2prgB-6bs7A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		4 / 8 ASP A 140
LEU A 166
HIS A 111
LEU A 147
 None
 1.13A 2q0iA-6bs7A:
undetectable		 2q0iA-6bs7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		4 / 4 LEU A 108
PRO A 109
LEU A 187
ARG A 155
 None
 1.31A 2qd2A-6bs7A:
undetectable		 2qd2A-6bs7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_2
(PROTEASE RETROPEPSIN)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		5 / 12 GLY A  72
ILE A 100
VAL A 149
ILE A 107
ILE A  69
 None
 0.80A 2rkgB-6bs7A:
undetectable		 2rkgB-6bs7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		3 / 3 ARG A 306
GLU A 297
SER A 319
 None
 0.70A 2xctD-6bs7A:
undetectable		 2xctD-6bs7A:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		3 / 3 ARG A 148
ASP A 204
ASN A  71
 None
 0.76A 2zzmA-6bs7A:
2.1		 2zzmA-6bs7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		4 / 4 LEU A 108
PRO A 109
LEU A 187
ARG A 155
 None
 1.42A 3hcoA-6bs7A:
undetectable		 3hcoA-6bs7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		5 / 12 ASP A  27
GLY A 223
GLY A  18
ASP A  22
ILE A 266
 None
 1.16A 3prsA-6bs7A:
undetectable		 3prsA-6bs7A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		4 / 4 ALA A 345
VAL A 314
ASP A 312
LEU A 369
 None
 1.13A 4e7gA-6bs7A:
1.0		 4e7gA-6bs7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		4 / 6 ILE A 291
VAL A 335
LYS A 268
LEU A 336
 None
 1.03A 4em2A-6bs7A:
undetectable		 4em2A-6bs7A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		4 / 4 LEU A  80
PRO A  77
LEU A  75
ILE A  69
 None
 0.96A 4f4dB-6bs7A:
undetectable		 4f4dB-6bs7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		4 / 5 LEU A  80
PRO A  77
LEU A  75
ILE A  69
 None
 0.87A 4klrA-6bs7A:
undetectable		 4klrA-6bs7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		4 / 8 LEU A   8
VAL A 263
LEU A 315
LEU A 316
 None
 0.98A 4l1xA-6bs7A:
undetectable		 4l1xA-6bs7A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		4 / 7 VAL A  31
ALA A  28
PHE A 430
TYR A 262
 None
 1.04A 4lb2A-6bs7A:
undetectable		 4lb2A-6bs7A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		5 / 11 LEU A 147
ARG A 155
LEU A 184
LEU A 106
LEU A 165
 None
 1.19A 4or0A-6bs7A:
undetectable		 4or0A-6bs7A:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		5 / 11 LEU A 147
ARG A 155
LEU A 184
LEU A 106
LEU A 165
 None
 1.17A 4or0B-6bs7A:
undetectable		 4or0B-6bs7A:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLD_A_BRLA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		5 / 12 PHE A 158
GLY A 150
HIS A 111
LEU A  75
TYR A 110
 None
 1.25A 4xldA-6bs7A:
undetectable		 4xldA-6bs7A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		5 / 12 GLY A  72
ILE A 100
VAL A 149
ILE A 107
ILE A  69
 None
 0.80A 5e5jA-6bs7A:
undetectable		 5e5jA-6bs7A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		5 / 12 GLY A  72
ILE A 100
VAL A 149
ILE A 107
ILE A  69
 None
 0.79A 5t8hA-6bs7A:
undetectable		 5t8hA-6bs7A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		5 / 10 PRO A 429
ILE A 325
VAL A   5
LEU A 220
GLU A 222
 None
 1.43A 5tixB-6bs7A:
undetectable		 5tixB-6bs7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		4 / 8 TYR A 399
THR A 331
TYR A 270
TRP A 379
 None
 1.38A 6cnjD-6bs7A:
undetectable
6cnjE-6bs7A:
undetectable		 6cnjD-6bs7A:
17.65
6cnjE-6bs7A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		5 / 12 PHE A 158
GLY A 150
HIS A 111
ILE A 100
TYR A 110
 None
 1.49A 6md4A-6bs7A:
undetectable		 6md4A-6bs7A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6bs7 ADENYLOSUCCINATE
SYNTHETASE
(Legionella
pneumophila) 		5 / 12 PHE A 158
GLY A 150
HIS A 111
LEU A  75
TYR A 110
 None
 1.20A 6md4A-6bs7A:
undetectable		 6md4A-6bs7A:
16.85