SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6btm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
ALTERNATIVE COMPLEX
III SUBUNIT D
(Flavobacterium
johnsoniae;
Flavobacterium
johnsoniae) 		3 / 3 GLU B 856
ILE D  84
ARG B 878
 None
 0.63A 1cd2A-6btmB:
undetectable		 1cd2A-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_A_CAMA503_0
(CYTOCHROME P450-CAM)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT F
(Flavobacterium
johnsoniae) 		5 / 9 THR F 298
VAL F 439
GLY F 148
THR F 150
VAL F 124
 None
 1.25A 1dz8A-6btmF:
undetectable		 1dz8A-6btmF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 12 GLY B 180
ALA B 208
HIS B 402
THR B 403
ILE B 405
 None
 1.01A 1gtnL-6btmB:
undetectable
1gtnV-6btmB:
undetectable		 1gtnL-6btmB:
undetectable
1gtnV-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT F
(Flavobacterium
johnsoniae) 		5 / 11 GLY F  22
GLY F  19
ILE F 425
LEU F 429
GLY F  26
 None
 1.12A 1jg3B-6btmF:
undetectable		 1jg3B-6btmF:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		6 / 12 ILE B 478
GLY B 142
ALA B 138
SER B 139
TRP B 574
GLY B 916
 None
 1.31A 1kiaA-6btmB:
undetectable		 1kiaA-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		3 / 3 ASN B 365
PHE B 239
VAL B 349
 None
 0.73A 1kijA-6btmB:
undetectable		 1kijA-6btmB:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT D
(Flavobacterium
johnsoniae) 		3 / 3 ALA D 112
HIS D 113
VAL D 116
 None
 0.43A 1lqtB-6btmD:
undetectable		 1lqtB-6btmD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1874_0
(FPRA)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT C
(Flavobacterium
johnsoniae) 		4 / 5 TRP C 254
ALA C 247
PHE C 263
SER C 243
 None
 1.38A 1lqtB-6btmC:
0.0		 1lqtB-6btmC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT D
(Flavobacterium
johnsoniae) 		3 / 3 ALA D 112
HIS D 113
VAL D 116
 None
 0.42A 1lquB-6btmD:
undetectable		 1lquB-6btmD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1431_0
(FPRA)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT C
(Flavobacterium
johnsoniae) 		4 / 5 TRP C 254
ALA C 247
PHE C 263
SER C 243
 None
 1.38A 1lquB-6btmC:
0.0		 1lquB-6btmC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		6 / 12 ILE B 478
GLY B 142
ALA B 138
SER B 139
TRP B 574
GLY B 916
 None
 1.28A 1nbhB-6btmB:
undetectable		 1nbhB-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		6 / 12 ILE B 478
GLY B 142
ALA B 138
SER B 139
TRP B 574
GLY B 916
 None
 1.28A 1nbiA-6btmB:
undetectable		 1nbiA-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 12 GLY B 142
ALA B 138
SER B 139
TRP B 574
GLY B 916
 None
 1.17A 1nbiC-6btmB:
undetectable		 1nbiC-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 12 GLY B 142
ALA B 138
SER B 139
TRP B 574
GLY B 916
 None
 1.20A 1nbiD-6btmB:
undetectable		 1nbiD-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT A
ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae;
Flavobacterium
johnsoniae) 		4 / 7 LEU A 325
ILE A 258
ALA A 328
ILE B  78
 None
 0.77A 1oniB-6btmA:
undetectable
1oniC-6btmA:
undetectable		 1oniB-6btmA:
undetectable
1oniC-6btmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT C
(Flavobacterium
johnsoniae) 		4 / 7 GLY C 312
GLN C 358
ILE C 310
VAL C 311
 None
 1.06A 1rxcC-6btmC:
undetectable		 1rxcC-6btmC:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT C
(Flavobacterium
johnsoniae) 		4 / 7 GLY C 312
GLN C 358
ILE C 310
VAL C 311
 None
 1.04A 1rxcF-6btmC:
undetectable		 1rxcF-6btmC:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT C
(Flavobacterium
johnsoniae) 		4 / 7 GLY C 312
GLN C 358
ILE C 310
VAL C 311
 None
 1.05A 1rxcL-6btmC:
undetectable		 1rxcL-6btmC:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT E
(Flavobacterium
johnsoniae) 		5 / 12 LEU E 181
LEU E 175
VAL E 174
ILE E 144
SER E 143
 None
None
None
HEC  E 201 ( 4.7A)
HEC  E 201 ( 4.6A)
 1.14A 1s19A-6btmE:
undetectable		 1s19A-6btmE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT A
(Flavobacterium
johnsoniae) 		4 / 7 TYR A 412
GLU A 427
THR A 403
VAL A 367
 None
None
HEC  A1003 (-3.4A)
None
 1.04A 1tv8B-6btmA:
undetectable		 1tv8B-6btmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 7 LEU B 519
ALA B  96
LEU B 470
SER B 469
VAL B 110
 None
 1.32A 1tyrB-6btmB:
undetectable		 1tyrB-6btmB:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 12 HIS B 402
THR B 403
ILE B 405
GLY B 180
ALA B 208
 None
 1.00A 1utdO-6btmB:
undetectable
1utdP-6btmB:
undetectable		 1utdO-6btmB:
undetectable
1utdP-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 11 HIS B 402
THR B 403
ILE B 405
GLY B 180
ALA B 208
 None
 1.04A 1utdP-6btmB:
undetectable
1utdQ-6btmB:
undetectable		 1utdP-6btmB:
undetectable
1utdQ-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT A
(Flavobacterium
johnsoniae) 		4 / 7 HIS A 361
ASP A 355
TYR A 358
HIS A 376
 HEC  A1002 (-3.2A)
None
None
HEC  A1002 (-3.2A)
 1.38A 1v54A-6btmA:
undetectable
1v54C-6btmA:
undetectable		 1v54A-6btmA:
undetectable
1v54C-6btmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT F
(Flavobacterium
johnsoniae) 		5 / 10 LEU F 164
ILE F 163
ALA F 155
LEU F 153
PHE F 160
 None
 1.12A 1xp0A-6btmF:
undetectable		 1xp0A-6btmF:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT C
(Flavobacterium
johnsoniae) 		4 / 8 THR C 277
TRP C  85
SER C 122
GLU C 116
 None
 1.43A 1xr2B-6btmC:
undetectable		 1xr2B-6btmC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
ALTERNATIVE COMPLEX
III SUBUNIT C
(Flavobacterium
johnsoniae) 		3 / 3 PHE B 899
ARG C 136
ASN B 897
 None
 0.94A 1xzxX-6btmB:
undetectable		 1xzxX-6btmB:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT A
ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae;
Flavobacterium
johnsoniae) 		5 / 11 GLY A 440
GLU A 438
GLN B 869
GLN B 871
PHE B 754
 None
 1.49A 2dr2A-6btmA:
undetectable		 2dr2A-6btmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT A
(Flavobacterium
johnsoniae) 		4 / 7 HIS A 361
ASP A 355
TYR A 358
HIS A 376
 HEC  A1002 (-3.2A)
None
None
HEC  A1002 (-3.2A)
 1.37A 2eijA-6btmA:
undetectable
2eijC-6btmA:
undetectable		 2eijA-6btmA:
undetectable
2eijC-6btmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT A
(Flavobacterium
johnsoniae) 		4 / 7 HIS A 361
ASP A 355
TYR A 358
HIS A 376
 HEC  A1002 (-3.2A)
None
None
HEC  A1002 (-3.2A)
 1.33A 2eijN-6btmA:
undetectable
2eijP-6btmA:
undetectable		 2eijN-6btmA:
undetectable
2eijP-6btmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT A
(Flavobacterium
johnsoniae) 		4 / 6 HIS A 361
ASP A 355
TYR A 358
HIS A 376
 HEC  A1002 (-3.2A)
None
None
HEC  A1002 (-3.2A)
 1.40A 2einA-6btmA:
undetectable
2einC-6btmA:
undetectable		 2einA-6btmA:
undetectable
2einC-6btmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT A
(Flavobacterium
johnsoniae) 		4 / 6 HIS A 361
ASP A 355
TYR A 358
HIS A 376
 HEC  A1002 (-3.2A)
None
None
HEC  A1002 (-3.2A)
 1.39A 2einN-6btmA:
undetectable
2einP-6btmA:
undetectable		 2einN-6btmA:
undetectable
2einP-6btmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
ALTERNATIVE COMPLEX
III SUBUNIT C
(Flavobacterium
johnsoniae;
Flavobacterium
johnsoniae) 		4 / 7 TRP C 404
TYR C 342
TYR C 332
GLU B 832
 None
 1.28A 2ha4B-6btmC:
undetectable		 2ha4B-6btmC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT C
(Flavobacterium
johnsoniae) 		5 / 11 LEU C  95
ALA C 115
ILE C 120
ILE C  89
VAL C 235
 None
 1.09A 2o4pA-6btmC:
undetectable		 2o4pA-6btmC:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
ALTERNATIVE COMPLEX
III SUBUNIT C
(Flavobacterium
johnsoniae;
Flavobacterium
johnsoniae) 		4 / 8 PRO B 860
SER C 159
VAL B 880
GLY B 881
 None
None
None
F3S  B1101 ( 4.2A)
 1.03A 2qd3A-6btmB:
undetectable		 2qd3A-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT F
(Flavobacterium
johnsoniae) 		4 / 7 GLN F 131
PHE F 127
ILE F 130
PHE F 287
 None
 1.00A 2qmzA-6btmF:
undetectable
2qmzB-6btmF:
undetectable		 2qmzA-6btmF:
16.16
2qmzB-6btmF:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WB9_A_CYSA301_0
(GLUTATHIONE
TRANSFERASE SIGMA
CLASS)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		4 / 5 GLY B 651
ARG B 652
TYR B 413
TYR B 667
 None
 1.34A 2wb9A-6btmB:
undetectable		 2wb9A-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		3 / 3 GLU B 736
HIS B 999
GLU B1002
 None
 0.83A 2x45B-6btmB:
undetectable		 2x45B-6btmB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		3 / 3 GLU B 736
HIS B 999
GLU B1002
 None
 0.82A 2x45C-6btmB:
undetectable		 2x45C-6btmB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
ALTERNATIVE COMPLEX
III SUBUNIT F
(Flavobacterium
johnsoniae;
Flavobacterium
johnsoniae) 		3 / 3 TRP F 341
VAL F 353
TRP B 743
 None
 1.20A 2xdcC-6btmF:
undetectable
2xdcD-6btmF:
undetectable		 2xdcC-6btmF:
undetectable
2xdcD-6btmF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
ALTERNATIVE COMPLEX
III SUBUNIT F
(Flavobacterium
johnsoniae;
Flavobacterium
johnsoniae) 		3 / 3 TRP F 341
VAL F 353
TRP B 743
 None
 1.16A 2xdcE-6btmF:
undetectable
2xdcF-6btmF:
undetectable		 2xdcE-6btmF:
undetectable
2xdcF-6btmF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT F
(Flavobacterium
johnsoniae) 		3 / 3 VAL F 176
ASN F 104
TRP F 107
 None
 1.13A 2y00B-6btmF:
3.1		 2y00B-6btmF:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
ALTERNATIVE COMPLEX
III SUBUNIT F
(Flavobacterium
johnsoniae;
Flavobacterium
johnsoniae) 		3 / 3 TRP F 341
VAL F 353
TRP B 743
 None
 1.18A 2y5mE-6btmF:
undetectable
2y5mF-6btmF:
undetectable		 2y5mE-6btmF:
undetectable
2y5mF-6btmF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CHDA1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT A
(Flavobacterium
johnsoniae) 		4 / 7 HIS A 361
ASP A 355
TYR A 358
HIS A 376
 HEC  A1002 (-3.2A)
None
None
HEC  A1002 (-3.2A)
 1.36A 2y69A-6btmA:
undetectable
2y69C-6btmA:
undetectable		 2y69A-6btmA:
undetectable
2y69C-6btmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
ALTERNATIVE COMPLEX
III SUBUNIT F
(Flavobacterium
johnsoniae;
Flavobacterium
johnsoniae) 		3 / 3 TRP F 341
VAL F 353
TRP B 743
 None
 1.17A 2y6nC-6btmF:
undetectable
2y6nD-6btmF:
undetectable		 2y6nC-6btmF:
undetectable
2y6nD-6btmF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
ALTERNATIVE COMPLEX
III SUBUNIT F
(Flavobacterium
johnsoniae;
Flavobacterium
johnsoniae) 		3 / 3 TRP F 341
VAL F 353
TRP B 743
 None
 1.19A 2y6nE-6btmF:
undetectable
2y6nF-6btmF:
undetectable		 2y6nE-6btmF:
undetectable
2y6nF-6btmF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT A
ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae;
Flavobacterium
johnsoniae) 		3 / 3 TYR A 424
GLU A 419
ASN B 982
 None
 0.79A 2y7hC-6btmA:
undetectable		 2y7hC-6btmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT A
(Flavobacterium
johnsoniae) 		4 / 6 HIS A 361
ASP A 355
TYR A 358
HIS A 376
 HEC  A1002 (-3.2A)
None
None
HEC  A1002 (-3.2A)
 1.34A 2zxwA-6btmA:
undetectable
2zxwC-6btmA:
undetectable		 2zxwA-6btmA:
undetectable
2zxwC-6btmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT A
(Flavobacterium
johnsoniae) 		4 / 6 HIS A 361
ASP A 355
TYR A 358
HIS A 376
 HEC  A1002 (-3.2A)
None
None
HEC  A1002 (-3.2A)
 1.35A 2zxwN-6btmA:
undetectable
2zxwP-6btmA:
undetectable		 2zxwN-6btmA:
undetectable
2zxwP-6btmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT A
(Flavobacterium
johnsoniae) 		4 / 7 HIS A 361
ASP A 355
TYR A 358
HIS A 376
 HEC  A1002 (-3.2A)
None
None
HEC  A1002 (-3.2A)
 1.32A 3abmN-6btmA:
undetectable
3abmP-6btmA:
undetectable		 3abmN-6btmA:
undetectable
3abmP-6btmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		4 / 8 VAL B 388
ASP B 223
LEU B 222
GLY B 384
 None
 0.99A 3af0A-6btmB:
undetectable		 3af0A-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT E
(Flavobacterium
johnsoniae) 		5 / 11 ALA E 171
LEU E 169
ARG E 167
PHE E 145
SER E  88
 None
 1.49A 3bpxA-6btmE:
undetectable
3bpxB-6btmE:
undetectable		 3bpxA-6btmE:
21.53
3bpxB-6btmE:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
ALTERNATIVE COMPLEX
III SUBUNIT F
(Flavobacterium
johnsoniae) 		4 / 8 HIS F  97
ASP B 731
HIS B 732
GLY F 415
 None
 0.85A 3c0zB-6btmF:
undetectable		 3c0zB-6btmF:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 12 ASP B 580
THR B 583
LEU B 288
GLY B 765
PHE B 578
 None
 1.35A 3ce6D-6btmB:
2.2		 3ce6D-6btmB:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		4 / 5 LYS B 153
SER B 431
LEU B 149
SER B 435
 None
 1.30A 3ijxH-6btmB:
undetectable		 3ijxH-6btmB:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		4 / 4 LYS B 153
SER B 431
LEU B 149
SER B 435
 None
 1.43A 3ik6H-6btmB:
undetectable		 3ik6H-6btmB:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		4 / 5 LYS B 153
SER B 431
LEU B 149
SER B 435
 None
 1.43A 3iluH-6btmB:
undetectable		 3iluH-6btmB:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT C
(Flavobacterium
johnsoniae) 		4 / 6 GLY C 312
GLN C 358
ILE C 310
VAL C 311
 None
 1.05A 3kvvA-6btmC:
undetectable		 3kvvA-6btmC:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT C
(Flavobacterium
johnsoniae) 		4 / 6 GLY C 312
GLN C 358
ILE C 310
VAL C 311
 None
 1.04A 3kvvB-6btmC:
undetectable		 3kvvB-6btmC:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT C
(Flavobacterium
johnsoniae) 		4 / 6 GLY C 312
GLN C 358
ILE C 310
VAL C 311
 None
 1.05A 3kvvC-6btmC:
undetectable		 3kvvC-6btmC:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT C
(Flavobacterium
johnsoniae) 		4 / 6 GLY C 312
GLN C 358
ILE C 310
VAL C 311
 None
 1.03A 3kvvD-6btmC:
undetectable		 3kvvD-6btmC:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT C
(Flavobacterium
johnsoniae) 		4 / 6 GLY C 312
GLN C 358
ILE C 310
VAL C 311
 None
 1.06A 3kvvE-6btmC:
undetectable		 3kvvE-6btmC:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT C
(Flavobacterium
johnsoniae) 		4 / 6 GLY C 312
GLN C 358
ILE C 310
VAL C 311
 None
 1.04A 3kvvF-6btmC:
undetectable		 3kvvF-6btmC:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		3 / 3 SER B 986
ASP B 959
ASN B 963
 None
 1.02A 3lsfB-6btmB:
undetectable
3lsfE-6btmB:
undetectable		 3lsfB-6btmB:
undetectable
3lsfE-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT D
(Flavobacterium
johnsoniae) 		5 / 10 PHE D 160
ALA D  19
THR D  23
ILE D  30
VAL D  33
 None
 0.91A 3me6A-6btmD:
undetectable		 3me6A-6btmD:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 12 ASP B 580
THR B 583
LEU B 288
GLY B 765
PHE B 578
 None
 1.34A 3n58C-6btmB:
2.2		 3n58C-6btmB:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		4 / 8 VAL B 779
VAL B 782
TRP B 795
GLU B 933
 None
 1.18A 3nlqA-6btmB:
undetectable
3nlqB-6btmB:
undetectable		 3nlqA-6btmB:
13.38
3nlqB-6btmB:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 12 ASP B 580
THR B 583
LEU B 288
GLY B 765
PHE B 578
 None
 1.38A 3ondA-6btmB:
undetectable		 3ondA-6btmB:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 12 ASP B 580
THR B 583
LEU B 288
GLY B 765
PHE B 578
 None
 1.38A 3ondB-6btmB:
undetectable		 3ondB-6btmB:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		4 / 8 ILE B 352
GLN B 304
ALA B 307
LEU B 308
 None
 0.52A 3ozwA-6btmB:
2.9		 3ozwA-6btmB:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 12 ILE B 352
GLN B 304
ALA B 307
LEU B 308
HIS B 279
 None
 0.93A 3ozwB-6btmB:
2.9		 3ozwB-6btmB:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT C
ALTERNATIVE COMPLEX
III SUBUNIT D
(Flavobacterium
johnsoniae) 		5 / 10 ALA C 214
LEU D  16
LEU D 144
ILE D 145
ALA D   8
 None
 1.19A 3r9cA-6btmC:
1.3		 3r9cA-6btmC:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT C
ALTERNATIVE COMPLEX
III SUBUNIT F
(Flavobacterium
johnsoniae;
Flavobacterium
johnsoniae) 		3 / 3 PHE F 321
GLN C 105
PHE F 287
 None
 0.78A 3rv5A-6btmF:
0.5		 3rv5A-6btmF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 12 GLY B 974
ASP B 759
ARG B1017
ALA B 266
ALA B 292
 None
 0.94A 3sudA-6btmB:
undetectable		 3sudA-6btmB:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 12 GLY B 974
ASP B 759
ARG B1017
ALA B 266
ALA B 292
 None
 0.91A 3sugA-6btmB:
undetectable		 3sugA-6btmB:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT C
ALTERNATIVE COMPLEX
III SUBUNIT F
(Flavobacterium
johnsoniae) 		5 / 10 THR C 232
THR C 307
VAL C 268
LEU C 236
PHE F 328
 None
 1.47A 3tbgC-6btmC:
undetectable		 3tbgC-6btmC:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT C
ALTERNATIVE COMPLEX
III SUBUNIT D
(Flavobacterium
johnsoniae;
Flavobacterium
johnsoniae) 		3 / 3 ASN D 133
ALA D 131
ARG C 191
 None
 0.83A 3tj7C-6btmD:
undetectable
3tj7D-6btmD:
undetectable		 3tj7C-6btmD:
undetectable
3tj7D-6btmD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT F
(Flavobacterium
johnsoniae) 		4 / 7 ASN F 370
GLN F 336
TYR F 331
PRO F 374
 None
 1.24A 3ugrA-6btmF:
undetectable		 3ugrA-6btmF:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		4 / 8 GLN B 281
HIS B 279
GLY B 290
GLY B 259
 None
 0.80A 3v3nB-6btmB:
undetectable		 3v3nB-6btmB:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		4 / 8 GLN B 281
HIS B 279
GLY B 290
GLY B 259
 None
 0.80A 3v3nC-6btmB:
undetectable		 3v3nC-6btmB:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT F
(Flavobacterium
johnsoniae) 		4 / 8 SER F 259
ILE F 260
PHE F 253
GLU F 258
 None
 1.24A 4cx7C-6btmF:
undetectable
4cx7D-6btmF:
undetectable		 4cx7C-6btmF:
10.33
4cx7D-6btmF:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT C
(Flavobacterium
johnsoniae) 		4 / 7 GLY C 312
GLN C 358
ILE C 310
VAL C 311
 None
 1.01A 4e1vB-6btmC:
undetectable		 4e1vB-6btmC:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT C
(Flavobacterium
johnsoniae) 		4 / 6 GLY C 312
GLN C 358
ILE C 310
VAL C 311
 None
 1.05A 4e1vF-6btmC:
undetectable		 4e1vF-6btmC:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 11 ALA B 215
SER B 407
LEU B 189
VAL B 212
THR B 414
 None
 1.23A 4eilA-6btmB:
2.5		 4eilA-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 10 ALA B 215
SER B 407
LEU B 189
VAL B 212
THR B 414
 None
 1.22A 4eilB-6btmB:
undetectable		 4eilB-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 11 ALA B 215
SER B 407
LEU B 189
VAL B 212
THR B 414
 None
 1.24A 4eilC-6btmB:
undetectable		 4eilC-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 11 ALA B 215
SER B 407
LEU B 189
VAL B 212
THR B 414
 None
 1.21A 4eilE-6btmB:
undetectable		 4eilE-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6btm ALTERNATIVE COMPLEX
III SUBUNIT F
(Flavobacterium
johnsoniae) 		4 / 8 GLN F 131
PHE F 127
ILE F 130
PHE F 287
 None
 0.80A 4fglD-6btmF:
undetectable		 4fglD-6btmF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT F
(Flavobacterium
johnsoniae) 		4 / 8 PRO F 362
MET F 410
PHE F 406
ILE F 420
 None
 0.83A 4j4vC-6btmF:
undetectable		 4j4vC-6btmF:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT F
(Flavobacterium
johnsoniae) 		5 / 11 VAL F 414
PRO F 362
MET F 410
PHE F 406
ILE F 420
 None
 1.19A 4j4vD-6btmF:
0.6
4j4vE-6btmF:
0.4		 4j4vD-6btmF:
14.11
4j4vE-6btmF:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		4 / 6 SER B 247
GLY B 258
ASP B 255
GLY B 260
 None
 0.96A 4koeA-6btmB:
undetectable
4koeB-6btmB:
undetectable
4koeC-6btmB:
2.1		 4koeA-6btmB:
11.51
4koeB-6btmB:
11.51
4koeC-6btmB:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 11 ALA B 215
SER B 407
LEU B 189
VAL B 212
THR B 414
 None
 1.19A 4kyaA-6btmB:
undetectable		 4kyaA-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 12 ALA B 215
SER B 407
LEU B 189
VAL B 212
THR B 414
 None
 1.24A 4kyaB-6btmB:
undetectable		 4kyaB-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 10 ALA B 215
SER B 407
LEU B 189
VAL B 212
THR B 414
 None
 1.22A 4kyaC-6btmB:
undetectable		 4kyaC-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 12 ALA B 215
SER B 407
LEU B 189
VAL B 212
THR B 414
 None
 1.25A 4kyaD-6btmB:
undetectable		 4kyaD-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 11 ALA B 215
SER B 407
LEU B 189
VAL B 212
THR B 414
 None
 1.21A 4kyaE-6btmB:
undetectable		 4kyaE-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 12 ALA B 215
SER B 407
LEU B 189
VAL B 212
THR B 414
 None
 1.24A 4kyaF-6btmB:
undetectable		 4kyaF-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 11 ALA B 215
SER B 407
LEU B 189
VAL B 212
THR B 414
 None
 1.19A 4kyaG-6btmB:
undetectable		 4kyaG-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 12 ALA B 215
SER B 407
LEU B 189
VAL B 212
THR B 414
 None
 1.26A 4kyaH-6btmB:
undetectable		 4kyaH-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT C
(Flavobacterium
johnsoniae) 		5 / 9 ARG C 458
GLY C 449
LEU C 447
VAL C  14
VAL C 443
 None
 1.04A 4mjrA-6btmC:
undetectable		 4mjrA-6btmC:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		4 / 4 ASN B 187
GLY B 102
ASP B 145
ASP B 566
 None
 1.22A 4n49A-6btmB:
undetectable		 4n49A-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		4 / 6 THR B 583
GLN B 677
LEU B 556
GLU B 555
 None
 1.07A 4nc3A-6btmB:
undetectable		 4nc3A-6btmB:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT C
ALTERNATIVE COMPLEX
III SUBUNIT F
(Flavobacterium
johnsoniae) 		4 / 6 LEU F 332
GLU F 258
VAL C 313
ALA C 314
 None
 1.19A 4nkvC-6btmF:
undetectable		 4nkvC-6btmF:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT C
ALTERNATIVE COMPLEX
III SUBUNIT D
(Flavobacterium
johnsoniae;
Flavobacterium
johnsoniae) 		3 / 3 ASN D  11
ASP D 141
ASP C  22
 None
 0.85A 4obwD-6btmD:
undetectable		 4obwD-6btmD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 12 ASP B 220
ASN B 386
LEU B 234
GLY B 384
ASP B 214
 None
 1.45A 4pevC-6btmB:
undetectable		 4pevC-6btmB:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT C
(Flavobacterium
johnsoniae) 		3 / 3 ILE C  80
ASP C 164
ARG C 387
 None
 0.71A 4pstA-6btmC:
undetectable		 4pstA-6btmC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		4 / 8 ALA B 292
GLY B 254
VAL B 349
SER B 247
 None
 0.84A 4r20A-6btmB:
undetectable		 4r20A-6btmB:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		3 / 3 ARG B 951
GLN B 952
GLU B 948
 None
 0.93A 4tvtA-6btmB:
undetectable		 4tvtA-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT C
(Flavobacterium
johnsoniae) 		4 / 7 THR C 256
GLY C 253
ARG C 337
ILE C 390
 None
 0.96A 4txnC-6btmC:
undetectable		 4txnC-6btmC:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 12 HIS B 279
ALA B 293
GLY B 249
PHE B 252
GLY B 254
 None
 1.24A 4uilH-6btmB:
undetectable
4uilL-6btmB:
undetectable		 4uilH-6btmB:
undetectable
4uilL-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT F
(Flavobacterium
johnsoniae) 		4 / 7 ASN F 360
PHE F 363
TRP F 418
PHE F 406
 None
 1.31A 4v32C-6btmF:
undetectable		 4v32C-6btmF:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT F
(Flavobacterium
johnsoniae) 		5 / 12 LEU F 443
SER F 446
LEU F 301
ARG F 144
LEU F 142
 None
 1.07A 4x1gA-6btmF:
undetectable		 4x1gA-6btmF:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 12 LEU B 488
THR B 186
VAL B 182
ALA B 208
ILE B 405
 None
 1.05A 4x1yD-6btmB:
undetectable		 4x1yD-6btmB:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT F
(Flavobacterium
johnsoniae) 		5 / 11 ILE F 149
THR F 292
SER F 293
GLY F 290
THR F 150
 None
 1.49A 4xt7A-6btmF:
undetectable		 4xt7A-6btmF:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		4 / 6 GLY B 258
ASP B 255
GLY B 260
SER B 247
 None
 0.95A 4z53A-6btmB:
undetectable
4z53B-6btmB:
undetectable		 4z53A-6btmB:
8.53
4z53B-6btmB:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		4 / 5 ALA B 969
HIS B 137
ALA B 772
GLU B 121
 None
 1.18A 5a06C-6btmB:
undetectable
5a06D-6btmB:
undetectable		 5a06C-6btmB:
undetectable
5a06D-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		4 / 5 LEU B 519
ALA B  96
LEU B 470
VAL B 110
 None
 1.21A 5cr1A-6btmB:
undetectable		 5cr1A-6btmB:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
ALTERNATIVE COMPLEX
III SUBUNIT E
(Flavobacterium
johnsoniae;
Flavobacterium
johnsoniae) 		3 / 3 ASN B 123
ALA B  96
ARG E  65
 None
 0.74A 5cvtB-6btmB:
3.4		 5cvtB-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT A
ALTERNATIVE COMPLEX
III SUBUNIT E
(Flavobacterium
johnsoniae;
Flavobacterium
johnsoniae) 		4 / 8 ALA E 154
HIS E 158
ASN A 296
HIS E 112
 HEC  E 201 ( 3.8A)
HEC  E 201 ( 4.2A)
None
HEC  E 201 (-3.2A)
 1.17A 5db5A-6btmE:
undetectable
5db5B-6btmE:
undetectable		 5db5A-6btmE:
undetectable
5db5B-6btmE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT E
(Flavobacterium
johnsoniae) 		5 / 9 ASP E 172
LEU E 169
GLY E 100
LEU E 103
LEU E 162
 None
 0.97A 5dqfA-6btmE:
2.2		 5dqfA-6btmE:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT C
ALTERNATIVE COMPLEX
III SUBUNIT F
(Flavobacterium
johnsoniae) 		5 / 11 ASP F 317
ARG C 104
PHE C 103
ILE F 325
LEU F 318
 None
 1.44A 5huaA-6btmF:
undetectable		 5huaA-6btmF:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT C
ALTERNATIVE COMPLEX
III SUBUNIT D
(Flavobacterium
johnsoniae) 		5 / 12 VAL C 177
ALA D 111
ALA D 112
MET D 115
VAL D 116
 None
 0.96A 5igjA-6btmC:
undetectable		 5igjA-6btmC:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT C
(Flavobacterium
johnsoniae) 		3 / 3 VAL C 311
SER C 270
MET C 300
 None
 0.82A 5ikqA-6btmC:
undetectable		 5ikqA-6btmC:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		3 / 3 LEU B 502
TYR B 468
SER B 191
 None
 0.76A 5iktA-6btmB:
undetectable		 5iktA-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT F
(Flavobacterium
johnsoniae) 		3 / 3 VAL F 288
SER F 326
TRP F 329
 None
 0.90A 5jwaA-6btmF:
undetectable		 5jwaA-6btmF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 12 LEU B 646
GLY B 649
ASN B 665
ASN B 630
LYS B 627
 None
 1.32A 5kbwA-6btmB:
undetectable		 5kbwA-6btmB:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 12 LEU B 646
GLY B 649
ASN B 665
ASN B 630
LYS B 627
 None
 1.25A 5kbwB-6btmB:
undetectable		 5kbwB-6btmB:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 12 LEU B 646
GLY B 649
ASN B 665
ASN B 630
LYS B 627
 None
 1.33A 5kc0A-6btmB:
undetectable		 5kc0A-6btmB:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 12 LEU B 646
GLY B 649
ASN B 665
ASN B 630
LYS B 627
 None
 1.19A 5kc4E-6btmB:
undetectable		 5kc4E-6btmB:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
ALTERNATIVE COMPLEX
III SUBUNIT E
(Flavobacterium
johnsoniae) 		4 / 8 GLU E  36
PRO E  32
GLY B  72
PRO B  73
 None
None
E87  B1103 (-4.0A)
None
 1.07A 5kf8A-6btmE:
undetectable		 5kf8A-6btmE:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
ALTERNATIVE COMPLEX
III SUBUNIT C
ALTERNATIVE COMPLEX
III SUBUNIT F
(Flavobacterium
johnsoniae;
Flavobacterium
johnsoniae;
Flavobacterium
johnsoniae) 		4 / 7 HIS B1003
ILE F 345
VAL C 250
TYR C 399
 None
 1.19A 5kkzC-6btmB:
undetectable
5kkzE-6btmB:
undetectable		 5kkzC-6btmB:
undetectable
5kkzE-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
ALTERNATIVE COMPLEX
III SUBUNIT C
ALTERNATIVE COMPLEX
III SUBUNIT F
(Flavobacterium
johnsoniae;
Flavobacterium
johnsoniae;
Flavobacterium
johnsoniae) 		4 / 7 ILE F 345
VAL C 250
TYR C 399
HIS B1003
 None
 1.18A 5kkzK-6btmF:
3.2
5kkzQ-6btmF:
undetectable		 5kkzK-6btmF:
undetectable
5kkzQ-6btmF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
ALTERNATIVE COMPLEX
III SUBUNIT C
ALTERNATIVE COMPLEX
III SUBUNIT F
(Flavobacterium
johnsoniae;
Flavobacterium
johnsoniae;
Flavobacterium
johnsoniae) 		4 / 7 HIS B1003
ILE F 345
VAL C 250
TYR C 399
 None
 1.27A 5kkzM-6btmB:
undetectable
5kkzO-6btmB:
undetectable		 5kkzM-6btmB:
undetectable
5kkzO-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8O_B_CHDB1001_0
(GASTROTROPIN)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT F
(Flavobacterium
johnsoniae) 		5 / 12 ILE F 291
PHE F 287
LEU F 142
GLN F 131
SER F 139
 None
 0.94A 5l8oB-6btmF:
undetectable		 5l8oB-6btmF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 12 ASP B 580
THR B 583
LEU B 288
GLY B 765
PHE B 578
 None
 1.36A 5m66A-6btmB:
undetectable		 5m66A-6btmB:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 12 ASP B 580
THR B 583
LEU B 288
GLY B 765
PHE B 578
 None
 1.39A 5m66C-6btmB:
2.4		 5m66C-6btmB:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		4 / 6 PHE B 373
LEU B 348
SER B 370
GLY B 346
 None
 1.06A 5o4yF-6btmB:
undetectable		 5o4yF-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT C
ALTERNATIVE COMPLEX
III SUBUNIT D
(Flavobacterium
johnsoniae) 		5 / 12 LEU C 234
VAL D 108
ALA D  57
ALA D 111
GLY D  61
 None
 1.16A 5tzoB-6btmC:
undetectable		 5tzoB-6btmC:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT A
(Flavobacterium
johnsoniae) 		4 / 6 HIS A 361
ASP A 355
TYR A 358
HIS A 376
 HEC  A1002 (-3.2A)
None
None
HEC  A1002 (-3.2A)
 1.33A 5x19N-6btmA:
undetectable
5x19P-6btmA:
undetectable		 5x19N-6btmA:
undetectable
5x19P-6btmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT A
(Flavobacterium
johnsoniae) 		4 / 7 HIS A 361
ASP A 355
TYR A 358
HIS A 376
 HEC  A1002 (-3.2A)
None
None
HEC  A1002 (-3.2A)
 1.36A 5x1fN-6btmA:
undetectable
5x1fP-6btmA:
undetectable		 5x1fN-6btmA:
undetectable
5x1fP-6btmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT C
ALTERNATIVE COMPLEX
III SUBUNIT D
(Flavobacterium
johnsoniae;
Flavobacterium
johnsoniae) 		3 / 3 LYS D  87
ASN C 158
SER D  98
 None
 1.25A 5yw0A-6btmD:
undetectable		 5yw0A-6btmD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
ALTERNATIVE COMPLEX
III SUBUNIT C
(Flavobacterium
johnsoniae;
Flavobacterium
johnsoniae) 		5 / 12 ILE C  57
THR C  67
ILE C  65
ARG B 883
THR C 420
 None
 1.25A 5z6fA-6btmC:
undetectable		 5z6fA-6btmC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_0
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 12 THR B  97
THR B  98
TYR B 468
LEU B 502
SER B 457
 None
 1.44A 6ak3B-6btmB:
0.0		 6ak3B-6btmB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
ALTERNATIVE COMPLEX
III SUBUNIT E
(Flavobacterium
johnsoniae;
Flavobacterium
johnsoniae) 		4 / 6 GLU E  41
LYS B  76
GLU E  45
ALA E  46
 None
 1.24A 6an0A-6btmE:
undetectable		 6an0A-6btmE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT C
(Flavobacterium
johnsoniae) 		5 / 12 VAL C 238
LEU C 144
VAL C 143
GLY C 127
MET C 134
 None
 1.38A 6brdA-6btmC:
1.4		 6brdA-6btmC:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 12 SER B 131
LEU B 234
GLY B 259
ASP B 255
ILE B 136
 None
 1.38A 6dwnA-6btmB:
undetectable		 6dwnA-6btmB:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_B_ADNB505_1
(-)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT B
(Flavobacterium
johnsoniae) 		5 / 12 ASP B 580
THR B 583
LEU B 288
GLY B 765
PHE B 578
 None
 1.41A 6f3nB-6btmB:
undetectable		 6f3nB-6btmB:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT F
(Flavobacterium
johnsoniae) 		4 / 6 ILE F 149
LEU F 120
VAL F 124
SER F 293
 None
 1.23A 6f6jA-6btmF:
undetectable		 6f6jA-6btmF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT C
(Flavobacterium
johnsoniae) 		5 / 9 ASN C 301
ILE C 377
ILE C 374
TRP C  85
MET C 360
 None
 1.42A 6hloA-6btmC:
5.0		 6hloA-6btmC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT A
(Flavobacterium
johnsoniae) 		4 / 6 HIS A 361
ASP A 355
TYR A 358
HIS A 376
 HEC  A1002 (-3.2A)
None
None
HEC  A1002 (-3.2A)
 1.29A 6nknA-6btmA:
undetectable
6nknC-6btmA:
undetectable		 6nknA-6btmA:
undetectable
6nknC-6btmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6btm ALTERNATIVE COMPLEX
III SUBUNIT A
(Flavobacterium
johnsoniae) 		4 / 7 HIS A 361
ASP A 355
TYR A 358
HIS A 376
 HEC  A1002 (-3.2A)
None
None
HEC  A1002 (-3.2A)
 1.28A 6nmpN-6btmA:
undetectable
6nmpP-6btmA:
undetectable		 6nmpN-6btmA:
undetectable
6nmpP-6btmA:
undetectable