SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bvd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 6bvd LIGHT CHAIN
(Clostridium
botulinum) 		5 / 12 HIS A 226
GLU A 227
HIS A 230
GLU A 264
TYR A 366
 ZN  A 503 ( 3.3A)
ACT  A 502 (-2.6A)
ZN  A 503 (-3.3A)
ZN  A 503 ( 2.6A)
None
 0.86A 1j36A-6bvdA:
undetectable		 1j36A-6bvdA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 6bvd LIGHT CHAIN
(Clostridium
botulinum) 		5 / 12 HIS A 226
GLU A 227
HIS A 230
GLU A 264
TYR A 366
 ZN  A 503 ( 3.3A)
ACT  A 502 (-2.6A)
ZN  A 503 (-3.3A)
ZN  A 503 ( 2.6A)
None
 0.87A 1j36B-6bvdA:
undetectable		 1j36B-6bvdA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 6bvd LIGHT CHAIN
(Clostridium
botulinum) 		5 / 11 HIS A 226
GLU A 227
HIS A 230
GLU A 264
TYR A 366
 ZN  A 503 ( 3.3A)
ACT  A 502 (-2.6A)
ZN  A 503 (-3.3A)
ZN  A 503 ( 2.6A)
None
 0.83A 1j37A-6bvdA:
2.0		 1j37A-6bvdA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 6bvd LIGHT CHAIN
(Clostridium
botulinum) 		5 / 11 HIS A 226
GLU A 227
HIS A 230
GLU A 264
TYR A 366
 ZN  A 503 ( 3.3A)
ACT  A 502 (-2.6A)
ZN  A 503 (-3.3A)
ZN  A 503 ( 2.6A)
None
 0.84A 1j37B-6bvdA:
2.1		 1j37B-6bvdA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 6bvd LIGHT CHAIN
(Clostridium
botulinum) 		5 / 12 HIS A 226
GLU A 227
HIS A 230
GLU A 264
TYR A 366
 ZN  A 503 ( 3.3A)
ACT  A 502 (-2.6A)
ZN  A 503 (-3.3A)
ZN  A 503 ( 2.6A)
None
 0.87A 1o86A-6bvdA:
2.2		 1o86A-6bvdA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 6bvd LIGHT CHAIN
(Clostridium
botulinum) 		5 / 12 LEU A 342
SER A 348
PHE A 349
ILE A 106
GLU A 110
 None
 1.13A 1rnrB-6bvdA:
undetectable		 1rnrB-6bvdA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 6bvd LIGHT CHAIN
(Clostridium
botulinum) 		5 / 12 HIS A 226
GLU A 227
HIS A 230
GLU A 264
TYR A 366
 ZN  A 503 ( 3.3A)
ACT  A 502 (-2.6A)
ZN  A 503 (-3.3A)
ZN  A 503 ( 2.6A)
None
 0.82A 2c6nA-6bvdA:
2.6		 2c6nA-6bvdA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 6bvd LIGHT CHAIN
(Clostridium
botulinum) 		5 / 12 HIS A 226
GLU A 227
HIS A 230
GLU A 264
TYR A 366
 ZN  A 503 ( 3.3A)
ACT  A 502 (-2.6A)
ZN  A 503 (-3.3A)
ZN  A 503 ( 2.6A)
None
 0.90A 2c6nB-6bvdA:
undetectable		 2c6nB-6bvdA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 6bvd LIGHT CHAIN
(Clostridium
botulinum) 		4 / 7 PHE A 268
ASP A 272
ALA A 368
ARG A 363
 None
 1.19A 2e5dA-6bvdA:
undetectable
2e5dB-6bvdA:
undetectable		 2e5dA-6bvdA:
undetectable
2e5dB-6bvdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 6bvd LIGHT CHAIN
(Clostridium
botulinum) 		5 / 12 ILE A  45
ILE A  46
ALA A  36
ALA A 151
ILE A 190
 None
 0.93A 2h79A-6bvdA:
undetectable		 2h79A-6bvdA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 6bvd LIGHT CHAIN
(Clostridium
botulinum) 		5 / 12 ALA A 355
GLU A 351
LEU A 354
LEU A 222
GLY A 390
 None
 1.01A 2jfaB-6bvdA:
undetectable		 2jfaB-6bvdA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 6bvd LIGHT CHAIN
(Clostridium
botulinum) 		5 / 11 HIS A 226
GLU A 227
HIS A 230
GLU A 264
TYR A 366
 ZN  A 503 ( 3.3A)
ACT  A 502 (-2.6A)
ZN  A 503 (-3.3A)
ZN  A 503 ( 2.6A)
None
 0.82A 2x8zA-6bvdA:
undetectable		 2x8zA-6bvdA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 6bvd LIGHT CHAIN
(Clostridium
botulinum) 		5 / 12 HIS A 226
GLU A 227
HIS A 230
GLU A 264
TYR A 366
 ZN  A 503 ( 3.3A)
ACT  A 502 (-2.6A)
ZN  A 503 (-3.3A)
ZN  A 503 ( 2.6A)
None
 0.84A 2x91A-6bvdA:
2.1		 2x91A-6bvdA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 6bvd LIGHT CHAIN
(Clostridium
botulinum) 		5 / 12 ILE A  45
ILE A  46
ALA A  36
ALA A 151
ILE A 190
 None
 0.93A 3gwsX-6bvdA:
undetectable		 3gwsX-6bvdA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 6bvd LIGHT CHAIN
(Clostridium
botulinum) 		3 / 3 THR A  80
LYS A  66
GLU A  83
 None
 0.79A 3ijdB-6bvdA:
undetectable		 3ijdB-6bvdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 6bvd LIGHT CHAIN
(Clostridium
botulinum) 		3 / 3 HIS A 226
GLU A 227
HIS A 230
 ZN  A 503 ( 3.3A)
ACT  A 502 (-2.6A)
ZN  A 503 (-3.3A)
 0.17A 3kecB-6bvdA:
undetectable		 3kecB-6bvdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3007_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 6bvd LIGHT CHAIN
(Clostridium
botulinum) 		5 / 9 THR A 306
ALA A 307
GLN A 148
SER A 136
ASN A 132
 None
 1.38A 3kp6B-6bvdA:
0.4		 3kp6B-6bvdA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 6bvd LIGHT CHAIN
(Clostridium
botulinum) 		4 / 8 ILE A 360
TYR A 385
LEU A 379
PHE A 391
 None
 1.06A 3rqwI-6bvdA:
undetectable
3rqwJ-6bvdA:
undetectable		 3rqwI-6bvdA:
undetectable
3rqwJ-6bvdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 6bvd LIGHT CHAIN
(Clostridium
botulinum) 		5 / 11 ILE A  98
PHE A 195
ILE A 155
ALA A 221
VAL A 231
 None
 0.98A 3tmzA-6bvdA:
undetectable		 3tmzA-6bvdA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 6bvd LIGHT CHAIN
(Clostridium
botulinum) 		5 / 11 HIS A 226
GLU A 227
HIS A 230
GLU A 264
TYR A 366
 ZN  A 503 ( 3.3A)
ACT  A 502 (-2.6A)
ZN  A 503 (-3.3A)
ZN  A 503 ( 2.6A)
None
 0.86A 4c2pA-6bvdA:
2.3		 4c2pA-6bvdA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 6bvd LIGHT CHAIN
(Clostridium
botulinum) 		5 / 12 ILE A  39
ARG A  97
PHE A  95
LEU A 228
VAL A  43
 None
 1.04A 4kfjB-6bvdA:
undetectable		 4kfjB-6bvdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 6bvd LIGHT CHAIN
(Clostridium
botulinum) 		5 / 12 HIS A 226
GLU A 227
HIS A 230
GLU A 264
TYR A 366
 ZN  A 503 ( 3.3A)
ACT  A 502 (-2.6A)
ZN  A 503 (-3.3A)
ZN  A 503 ( 2.6A)
None
 0.46A 4r7lA-6bvdA:
2.0		 4r7lA-6bvdA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 6bvd LIGHT CHAIN
(Clostridium
botulinum) 		4 / 6 LEU A 228
ILE A 229
LEU A 107
GLU A 110
 None
 0.88A 4w5nA-6bvdA:
2.2		 4w5nA-6bvdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 6bvd LIGHT CHAIN
(Clostridium
botulinum) 		4 / 8 TYR A 292
GLY A 186
ILE A 190
GLY A 234
 None
 0.85A 5alcL-6bvdA:
undetectable		 5alcL-6bvdA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 6bvd LIGHT CHAIN
(Clostridium
botulinum) 		4 / 4 HIS A 230
HIS A 226
TYR A 366
GLU A 264
 ZN  A 503 (-3.3A)
ZN  A 503 ( 3.3A)
None
ZN  A 503 ( 2.6A)
 1.45A 5pahA-6bvdA:
undetectable		 5pahA-6bvdA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 6bvd LIGHT CHAIN
(Clostridium
botulinum) 		5 / 10 ILE A  22
ILE A 154
LEU A 153
ILE A  19
ASN A  17
 None
 1.45A 5vkqA-6bvdA:
undetectable
5vkqD-6bvdA:
undetectable		 5vkqA-6bvdA:
undetectable
5vkqD-6bvdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 6bvd LIGHT CHAIN
(Clostridium
botulinum) 		5 / 10 ILE A  19
ASN A  17
ILE A  22
ILE A 154
LEU A 153
 None
 1.44A 5vkqC-6bvdA:
undetectable
5vkqD-6bvdA:
undetectable		 5vkqC-6bvdA:
undetectable
5vkqD-6bvdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 6bvd LIGHT CHAIN
(Clostridium
botulinum) 		4 / 8 PRO A 158
LYS A 166
THR A 163
TYR A  77
 None
 1.16A 5x2sI-6bvdA:
undetectable
5x2sJ-6bvdA:
undetectable
5x2sK-6bvdA:
undetectable		 5x2sI-6bvdA:
17.73
5x2sJ-6bvdA:
17.81
5x2sK-6bvdA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_C_9F2C302_1
(BETA-LACTAMASE)		 6bvd LIGHT CHAIN
(Clostridium
botulinum) 		5 / 10 GLN A 149
ILE A  22
PRO A  24
TYR A  27
ASP A  16
 None
 1.50A 6b68C-6bvdA:
undetectable
6b68D-6bvdA:
undetectable		 6b68C-6bvdA:
19.15
6b68D-6bvdA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		 6bvd LIGHT CHAIN
(Clostridium
botulinum) 		5 / 9 THR A 238
GLY A 237
GLY A 186
TYR A 347
GLU A 110
 None
 1.37A 6gnfA-6bvdA:
undetectable		 6gnfA-6bvdA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		 6bvd LIGHT CHAIN
(Clostridium
botulinum) 		5 / 9 THR A 238
GLY A 237
TYR A 347
VAL A 334
GLU A 110
 None
 1.38A 6gnfA-6bvdA:
undetectable		 6gnfA-6bvdA:
10.41