SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bwc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 6bwc POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
CAPD
(Bacillus
thuringiensis) 		5 / 12 PHE A 167
ILE A  17
VAL A 165
ALA A 215
ILE A 148
 None
NAP  A 401 (-3.8A)
None
None
None
 1.00A 1epbA-6bwcA:
undetectable		 1epbA-6bwcA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 6bwc POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
CAPD
(Bacillus
thuringiensis) 		5 / 9 GLY A 106
ALA A  85
THR A 107
ILE A  64
THR A 140
 None
NAP  A 401 (-3.2A)
None
NAP  A 401 (-4.1A)
None
 1.40A 1gtnS-6bwcA:
undetectable
1gtnT-6bwcA:
undetectable		 1gtnS-6bwcA:
undetectable
1gtnT-6bwcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 6bwc POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
CAPD
(Bacillus
thuringiensis) 		4 / 8 SER A 197
ASN A 235
ASP A 236
GLU A 243
 None
 1.20A 1mxgA-6bwcA:
2.2		 1mxgA-6bwcA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 6bwc POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
CAPD
(Bacillus
thuringiensis) 		4 / 4 LEU A  60
PRO A  30
ILE A  10
LEU A   9
 None
 1.14A 1ya4B-6bwcA:
1.2		 1ya4B-6bwcA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 6bwc POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
CAPD
(Bacillus
thuringiensis) 		4 / 4 LEU A  60
PRO A  30
ILE A  10
LEU A   9
 None
 1.18A 1ya4C-6bwcA:
1.5		 1ya4C-6bwcA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 6bwc POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
CAPD
(Bacillus
thuringiensis) 		5 / 12 ILE A  11
GLY A  12
GLY A  15
GLY A  62
ALA A  84
 None
NAP  A 401 (-3.4A)
NAP  A 401 (-3.5A)
None
NAP  A 401 (-3.5A)
 0.92A 2fk8A-6bwcA:
6.3		 2fk8A-6bwcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 6bwc POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
CAPD
(Bacillus
thuringiensis) 		4 / 8 GLU A 278
ILE A 291
ILE A 226
GLU A 145
 None
 0.91A 2j9dJ-6bwcA:
undetectable
2j9dK-6bwcA:
undetectable
2j9dL-6bwcA:
undetectable		 2j9dJ-6bwcA:
undetectable
2j9dK-6bwcA:
undetectable
2j9dL-6bwcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 6bwc POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
CAPD
(Bacillus
thuringiensis) 		5 / 12 PRO A 286
MET A 288
ILE A 290
ILE A 218
ALA A 219
 None
 1.08A 3a50A-6bwcA:
undetectable		 3a50A-6bwcA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 6bwc POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
CAPD
(Bacillus
thuringiensis) 		5 / 12 PRO A 286
MET A 288
ILE A 290
ILE A 218
ALA A 219
 None
 1.11A 3a50D-6bwcA:
undetectable		 3a50D-6bwcA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 6bwc POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
CAPD
(Bacillus
thuringiensis) 		5 / 10 LEU A 237
ILE A 178
PRO A 179
SER A 173
GLY A 172
 None
None
None
NAP  A 401 ( 2.8A)
None
 1.35A 3ik6B-6bwcA:
undetectable
3ik6E-6bwcA:
undetectable		 3ik6B-6bwcA:
17.49
3ik6E-6bwcA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 6bwc POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
CAPD
(Bacillus
thuringiensis) 		5 / 12 ILE A  17
GLY A  18
GLY A  15
ALA A  84
VAL A  83
 NAP  A 401 (-3.8A)
None
NAP  A 401 (-3.5A)
NAP  A 401 (-3.5A)
NAP  A 401 (-4.5A)
 1.01A 3jb2A-6bwcA:
3.4		 3jb2A-6bwcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 6bwc POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
CAPD
(Bacillus
thuringiensis) 		4 / 8 VAL A 165
VAL A 170
MET A 203
ILE A  17
 None
NAP  A 401 (-4.0A)
None
NAP  A 401 (-3.8A)
 0.99A 3remB-6bwcA:
undetectable		 3remB-6bwcA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 6bwc POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
CAPD
(Bacillus
thuringiensis) 		5 / 12 ILE A 290
PHE A 283
ILE A 218
ALA A 215
THR A 163
 None
 1.18A 3s79A-6bwcA:
undetectable		 3s79A-6bwcA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6bwc POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
CAPD
(Bacillus
thuringiensis) 		5 / 11 VAL A  25
PHE A  50
GLY A  13
GLY A  15
ILE A  17
 None
None
NAP  A 401 ( 4.5A)
NAP  A 401 (-3.5A)
NAP  A 401 (-3.8A)
 1.40A 4zvmA-6bwcA:
5.7
4zvmB-6bwcA:
6.3		 4zvmA-6bwcA:
18.18
4zvmB-6bwcA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 6bwc POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
CAPD
(Bacillus
thuringiensis) 		3 / 3 GLU A 272
ARG A 313
TYR A 270
 None
 0.46A 5trqB-6bwcA:
undetectable		 5trqB-6bwcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 6bwc POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
CAPD
(Bacillus
thuringiensis) 		3 / 3 HIS A  88
SER A 176
ARG A 174
 UD1  A 402 ( 3.9A)
UD1  A 402 (-4.3A)
NAP  A 401 (-3.8A)
 1.01A 5u63A-6bwcA:
3.7		 5u63A-6bwcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		 6bwc POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
CAPD
(Bacillus
thuringiensis) 		5 / 9 THR A  14
GLY A  13
GLY A  18
VAL A 170
GLU A  49
 NAP  A 401 (-3.5A)
NAP  A 401 ( 4.5A)
None
NAP  A 401 (-4.0A)
None
 1.41A 6gnfA-6bwcA:
3.5		 6gnfA-6bwcA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 6bwc POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
CAPD
(Bacillus
thuringiensis) 		4 / 6 SER A 164
ALA A 144
THR A 140
ALA A 129
 None
None
None
UD1  A 402 (-3.6A)
 1.17A 6ma6A-6bwcA:
undetectable		 6ma6A-6bwcA:
20.99