SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bwf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 6bwf -
(-) 		4 / 5 LEU A 397
VAL A 388
TYR A 770
THR A 393
 None
 1.37A 1nw3A-6bwfA:
undetectable		 1nw3A-6bwfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 6bwf -
(-) 		4 / 6 ARG A 385
ASP A 576
ASN A 579
ASP A 582
 None
 0.99A 2okcA-6bwfA:
undetectable		 2okcA-6bwfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6bwf -
(-) 		4 / 6 TYR A 517
TRP A 626
TYR A 550
ILE A 547
 None
 1.41A 2pgzD-6bwfA:
undetectable
2pgzE-6bwfA:
undetectable		 2pgzD-6bwfA:
undetectable
2pgzE-6bwfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6bwf -
(-) 		4 / 7 TYR A 517
TYR A 524
TYR A 550
ILE A 586
 None
 1.26A 2ph9A-6bwfA:
undetectable
2ph9B-6bwfA:
undetectable		 2ph9A-6bwfA:
undetectable
2ph9B-6bwfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 6bwf -
(-) 		3 / 3 LEU A 279
TRP A 282
GLY A 196
 None
 0.67A 3l35A-6bwfA:
3.7
3l35H-6bwfA:
undetectable		 3l35A-6bwfA:
undetectable
3l35H-6bwfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 6bwf -
(-) 		3 / 3 LEU A 279
TRP A 282
GLY A 196
 None
 0.63A 3l35B-6bwfA:
3.7
3l35K-6bwfA:
undetectable		 3l35B-6bwfA:
undetectable
3l35K-6bwfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 6bwf -
(-) 		3 / 3 PHE A 593
TYR A 524
TYR A 619
 None
 1.08A 4ffwA-6bwfA:
undetectable		 4ffwA-6bwfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 6bwf -
(-) 		4 / 7 ASN A 622
ALA A 585
VAL A 628
ARG A 629
 None
 0.88A 4ijiH-6bwfA:
undetectable		 4ijiH-6bwfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 6bwf -
(-) 		5 / 12 LEU A 634
ILE A 647
GLY A 648
ARG A 629
ALA A 635
 None
 1.09A 5h5fA-6bwfA:
undetectable		 5h5fA-6bwfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 6bwf -
(-) 		3 / 3 GLY A 299
GLN A 297
LYS A 305
 None
 0.86A 5imsB-6bwfA:
undetectable		 5imsB-6bwfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHG_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 6bwf -
(-) 		4 / 4 ARG A 596
GLN A 539
PHE A 597
LEU A 523
 None
 1.43A 5uhgC-6bwfA:
0.0		 5uhgC-6bwfA:
undetectable