SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bwm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 6bwm TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Oryctolagus
cuniculus) 		4 / 7 GLY A 443
GLY A 442
GLN A 477
TYR A 401
 None
 0.98A 1ekjE-6bwmA:
undetectable
1ekjF-6bwmA:
undetectable		 1ekjE-6bwmA:
undetectable
1ekjF-6bwmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 6bwm TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Oryctolagus
cuniculus) 		4 / 6 ALA A 165
LEU A 138
ASP A 141
LEU A 104
 None
 0.86A 1mt1D-6bwmA:
undetectable
1mt1E-6bwmA:
undetectable		 1mt1D-6bwmA:
17.24
1mt1E-6bwmA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 6bwm TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Oryctolagus
cuniculus) 		5 / 11 LEU A 324
PHE A 317
GLY A 276
LEU A 228
LEU A 285
 None
 1.07A 1mx1A-6bwmA:
undetectable		 1mx1A-6bwmA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 6bwm TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Oryctolagus
cuniculus) 		4 / 8 ARG A 700
SER A 345
LEU A 248
LEU A 324
 None
 1.01A 2bfpA-6bwmA:
undetectable		 2bfpA-6bwmA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 6bwm TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Oryctolagus
cuniculus) 		5 / 9 GLY A 276
LEU A 273
TYR A 269
LEU A 251
THR A 246
 None
 1.08A 2npnA-6bwmA:
undetectable		 2npnA-6bwmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLO_A_TESA1920_1
(ANDROGEN RECEPTOR)		 6bwm TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Oryctolagus
cuniculus) 		5 / 12 LEU A 505
LEU A 508
THR A 481
PHE A 405
MET A 402
 None
 1.40A 2yloA-6bwmA:
undetectable		 2yloA-6bwmA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 6bwm TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Oryctolagus
cuniculus) 		3 / 3 LEU A 447
TRP A 452
TYR A 445
 None
 1.00A 3aicH-6bwmA:
undetectable		 3aicH-6bwmA:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 6bwm TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Oryctolagus
cuniculus) 		4 / 7 VAL A 151
VAL A 188
ASN A 184
GLY A 185
 None
 1.03A 3kmoB-6bwmA:
undetectable		 3kmoB-6bwmA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 6bwm TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Oryctolagus
cuniculus) 		3 / 3 THR A 329
SER A 339
ARG A 337
 None
 0.74A 3phnA-6bwmA:
undetectable		 3phnA-6bwmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 6bwm TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Oryctolagus
cuniculus) 		5 / 12 SER A 502
GLN A 477
PHE A 405
GLY A 443
ALA A 478
 None
 1.09A 3tegA-6bwmA:
undetectable		 3tegA-6bwmA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 6bwm TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Oryctolagus
cuniculus) 		5 / 9 LEU A 721
LEU A 340
GLN A 322
GLU A 316
GLU A 707
 None
 1.09A 3tmzA-6bwmA:
1.9		 3tmzA-6bwmA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 6bwm TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Oryctolagus
cuniculus) 		3 / 3 LYS A 383
LEU A 379
ALA A 382
 None
 0.73A 4ikiA-6bwmA:
undetectable		 4ikiA-6bwmA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 6bwm TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Oryctolagus
cuniculus) 		4 / 8 GLY A 506
THR A 406
LEU A 499
PHE A 405
 None
 1.23A 4m5mA-6bwmA:
undetectable		 4m5mA-6bwmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 6bwm TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Oryctolagus
cuniculus) 		4 / 7 GLU A 209
LEU A 299
ASN A 290
SER A 213
 None
 1.15A 4pfjA-6bwmA:
undetectable		 4pfjA-6bwmA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 6bwm TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Oryctolagus
cuniculus) 		4 / 6 ALA A 235
GLN A 233
LEU A 212
LEU A 166
 None
 1.19A 4xoyA-6bwmA:
undetectable		 4xoyA-6bwmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 6bwm TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Oryctolagus
cuniculus) 		5 / 12 LEU A 248
LEU A 251
ALA A 255
SER A 262
LEU A 264
 None
 1.02A 5mwyA-6bwmA:
undetectable		 5mwyA-6bwmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 6bwm TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2
(Oryctolagus
cuniculus) 		5 / 6 LEU A 181
ALA A 169
LEU A 150
SER A 164
THR A 117
 None
 1.48A 6f88B-6bwmA:
undetectable		 6f88B-6bwmA:
20.00