SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bwr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EIL_A_FOLA703_0 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	6bwr	PYRIDINIUM-3,5-BISTH IOCARBOXYLIC ACID MONONUCLEOTIDE NICKEL INSERTION PROTEIN (Lactobacillus plantarum)	5 / 11	VAL A 371 ALA A 389 PHE A 402 LEU A 410 VAL A 373	None	1.34A	4eilA-6bwrA: undetectable	4eilA-6bwrA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EIL_C_FOLC703_0 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	6bwr	PYRIDINIUM-3,5-BISTH IOCARBOXYLIC ACID MONONUCLEOTIDE NICKEL INSERTION PROTEIN (Lactobacillus plantarum)	5 / 11	VAL A 371 ALA A 389 PHE A 402 LEU A 410 VAL A 373	None	1.34A	4eilC-6bwrA: undetectable	4eilC-6bwrA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EIL_E_FOLE703_0 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	6bwr	PYRIDINIUM-3,5-BISTH IOCARBOXYLIC ACID MONONUCLEOTIDE NICKEL INSERTION PROTEIN (Lactobacillus plantarum)	5 / 11	VAL A 371 ALA A 389 PHE A 402 LEU A 410 VAL A 373	None	1.34A	4eilE-6bwrA: undetectable	4eilE-6bwrA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KYA_D_FOLD703_0 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	6bwr	PYRIDINIUM-3,5-BISTH IOCARBOXYLIC ACID MONONUCLEOTIDE NICKEL INSERTION PROTEIN (Lactobacillus plantarum)	5 / 12	VAL A 371 ALA A 389 PHE A 402 LEU A 410 VAL A 373	None	1.31A	4kyaD-6bwrA: undetectable	4kyaD-6bwrA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KYA_F_FOLF703_0 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	6bwr	PYRIDINIUM-3,5-BISTH IOCARBOXYLIC ACID MONONUCLEOTIDE NICKEL INSERTION PROTEIN (Lactobacillus plantarum)	5 / 12	VAL A 371 ALA A 389 PHE A 402 LEU A 410 VAL A 373	None	1.32A	4kyaF-6bwrA: undetectable	4kyaF-6bwrA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KYA_H_FOLH703_0 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	6bwr	PYRIDINIUM-3,5-BISTH IOCARBOXYLIC ACID MONONUCLEOTIDE NICKEL INSERTION PROTEIN (Lactobacillus plantarum)	5 / 12	VAL A 371 ALA A 389 PHE A 402 LEU A 410 VAL A 373	None	1.30A	4kyaH-6bwrA: undetectable	4kyaH-6bwrA: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4EIL_A_FOLA703_0","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","6bwr","PYRIDINIUM-3,5-BISTHIOCARBOXYLIC ACID MONONUCLEOTIDE NICKEL INSERTION PROTEIN","Lactobacillus plantarum",5,"VAL A 371;ALA A 389;PHE A 402;LEU A 410;VAL A 373","None","1.34A","4eilA-6bwrA:undetectable","4eilA-6bwrA:undetectable"],["4EIL_C_FOLC703_0","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","6bwr","PYRIDINIUM-3,5-BISTHIOCARBOXYLIC ACID MONONUCLEOTIDE NICKEL INSERTION PROTEIN","Lactobacillus plantarum",5,"VAL A 371;ALA A 389;PHE A 402;LEU A 410;VAL A 373","None","1.34A","4eilC-6bwrA:undetectable","4eilC-6bwrA:undetectable"],["4EIL_E_FOLE703_0","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","6bwr","PYRIDINIUM-3,5-BISTHIOCARBOXYLIC ACID MONONUCLEOTIDE NICKEL INSERTION PROTEIN","Lactobacillus plantarum",5,"VAL A 371;ALA A 389;PHE A 402;LEU A 410;VAL A 373","None","1.34A","4eilE-6bwrA:undetectable","4eilE-6bwrA:undetectable"],["4KYA_D_FOLD703_0","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","6bwr","PYRIDINIUM-3,5-BISTHIOCARBOXYLIC ACID MONONUCLEOTIDE NICKEL INSERTION PROTEIN","Lactobacillus plantarum",5,"VAL A 371;ALA A 389;PHE A 402;LEU A 410;VAL A 373","None","1.31A","4kyaD-6bwrA:undetectable","4kyaD-6bwrA:undetectable"],["4KYA_F_FOLF703_0","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","6bwr","PYRIDINIUM-3,5-BISTHIOCARBOXYLIC ACID MONONUCLEOTIDE NICKEL INSERTION PROTEIN","Lactobacillus plantarum",5,"VAL A 371;ALA A 389;PHE A 402;LEU A 410;VAL A 373","None","1.32A","4kyaF-6bwrA:undetectable","4kyaF-6bwrA:undetectable"],["4KYA_H_FOLH703_0","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","6bwr","PYRIDINIUM-3,5-BISTHIOCARBOXYLIC ACID MONONUCLEOTIDE NICKEL INSERTION PROTEIN","Lactobacillus plantarum",5,"VAL A 371;ALA A 389;PHE A 402;LEU A 410;VAL A 373","None","1.30A","4kyaH-6bwrA:undetectable","4kyaH-6bwrA:undetectable"]]