SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bwt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 6bwt THIOREDOXIN
REDUCTASE
(Francisella
tularensis) 		5 / 12 ILE A 109
ILE A 108
GLY A 283
ALA A 281
ALA A 293
 None
None
SO4  A 402 (-3.5A)
None
None
 0.96A 2yvlA-6bwtA:
5.0		 2yvlA-6bwtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 6bwt THIOREDOXIN
REDUCTASE
(Francisella
tularensis) 		5 / 12 ILE A 109
ILE A 108
GLY A 283
ALA A 281
ALA A 293
 None
None
SO4  A 402 (-3.5A)
None
None
 0.97A 2yvlB-6bwtA:
5.0		 2yvlB-6bwtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 6bwt THIOREDOXIN
REDUCTASE
(Francisella
tularensis) 		5 / 12 ILE A 109
ILE A 108
GLY A 283
ALA A 281
ALA A 293
 None
None
SO4  A 402 (-3.5A)
None
None
 0.98A 2yvlC-6bwtA:
4.7		 2yvlC-6bwtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 6bwt THIOREDOXIN
REDUCTASE
(Francisella
tularensis) 		5 / 12 ILE A   8
PRO A  30
ALA A  23
ILE A 109
ALA A 110
 None
None
None
None
SO4  A 402 ( 4.9A)
 1.09A 3jb1A-6bwtA:
2.3		 3jb1A-6bwtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 6bwt THIOREDOXIN
REDUCTASE
(Francisella
tularensis) 		4 / 7 VAL A 237
ILE A 239
THR A 205
THR A 204
 None
 0.80A 3tneB-6bwtA:
undetectable		 3tneB-6bwtA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 6bwt THIOREDOXIN
REDUCTASE
(Francisella
tularensis) 		4 / 7 THR A 247
ALA A 113
THR A 114
ALA A 115
 None
 0.68A 4qw0K-6bwtA:
undetectable		 4qw0K-6bwtA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 6bwt THIOREDOXIN
REDUCTASE
(Francisella
tularensis) 		4 / 7 THR A 247
ALA A 113
THR A 114
ALA A 115
 None
 0.67A 4qw0Y-6bwtA:
undetectable		 4qw0Y-6bwtA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 6bwt THIOREDOXIN
REDUCTASE
(Francisella
tularensis) 		4 / 8 ALA A 282
GLY A 300
ALA A  19
GLY A  16
 None
 0.66A 4zjzA-6bwtA:
undetectable		 4zjzA-6bwtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 6bwt THIOREDOXIN
REDUCTASE
(Francisella
tularensis) 		3 / 3 GLY A  97
THR A  82
ASN A  84
 None
 0.56A 5odiG-6bwtA:
18.8		 5odiG-6bwtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 6bwt THIOREDOXIN
REDUCTASE
(Francisella
tularensis) 		5 / 9 GLY A 151
ALA A 240
GLY A 152
LEU A 179
SER A 181
 None
None
SO4  A 404 ( 4.1A)
None
None
 1.01A 5vw4A-6bwtA:
2.3		 5vw4A-6bwtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 6bwt THIOREDOXIN
REDUCTASE
(Francisella
tularensis) 		5 / 9 ALA A 303
ALA A 110
GLY A 300
ALA A 286
GLY A 283
 None
SO4  A 402 ( 4.9A)
None
None
SO4  A 402 (-3.5A)
 1.17A 6bklE-6bwtA:
undetectable
6bklF-6bwtA:
undetectable
6bklG-6bwtA:
undetectable
6bklH-6bwtA:
undetectable		 6bklE-6bwtA:
undetectable
6bklF-6bwtA:
undetectable
6bklG-6bwtA:
undetectable
6bklH-6bwtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 6bwt THIOREDOXIN
REDUCTASE
(Francisella
tularensis) 		5 / 10 LEU A 179
THR A 155
VAL A 149
ALA A 240
LEU A 172
 None
SO4  A 403 (-3.4A)
None
None
None
 1.10A 6czmA-6bwtA:
undetectable
6czmC-6bwtA:
undetectable		 6czmA-6bwtA:
undetectable
6czmC-6bwtA:
undetectable