SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bxa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 6bxa VARIABLE LYMPHOCYTE
RECEPTOR 2
(Petromyzon
marinus) 		5 / 12 LEU C 102
LEU C  78
LEU C  54
LEU C  88
LEU C  85
 None
 1.06A 1sqnB-6bxaC:
undetectable		 1sqnB-6bxaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 6bxa VARIABLE LYMPHOCYTE
RECEPTOR 2
(Petromyzon
marinus) 		5 / 9 LEU C 128
LEU C 112
VAL C  92
LEU C  99
PHE C 117
 None
 1.26A 1tbfA-6bxaC:
undetectable		 1tbfA-6bxaC:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 6bxa VARIABLE LYMPHOCYTE
RECEPTOR 2
(Petromyzon
marinus) 		4 / 5 GLY C  37
PRO C  44
VAL C  43
ILE C  61
 None
 0.78A 2aoiA-6bxaC:
undetectable		 2aoiA-6bxaC:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
(Danio
rerio;
Eptatretus
burgeri) 		4 / 5 LEU A  62
PRO A  43
VAL A  42
ILE A  59
 None
 1.00A 2aoiB-6bxaA:
undetectable		 2aoiB-6bxaA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6bxa VARIABLE LYMPHOCYTE
RECEPTOR 2
(Petromyzon
marinus) 		4 / 8 LEU C 109
LEU C 102
VAL C  92
GLY C  91
 None
 1.00A 2po5A-6bxaC:
undetectable		 2po5A-6bxaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_2
(PROTEASE RETROPEPSIN)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
VARIABLE LYMPHOCYTE
RECEPTOR 2
(Danio
rerio;
Eptatretus
burgeri;
Petromyzon
marinus) 		5 / 12 LEU A  56
ILE A  33
VAL C  53
GLY C  55
ILE A  35
 None
 0.81A 2rkgB-6bxaA:
undetectable		 2rkgB-6bxaA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
VARIABLE LYMPHOCYTE
RECEPTOR 2
(Danio
rerio;
Eptatretus
burgeri;
Petromyzon
marinus) 		4 / 5 PHE C 104
SER A  26
PHE C  93
ILE A  28
 None
 1.28A 2v0mD-6bxaC:
undetectable		 2v0mD-6bxaC:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
(Eptatretus
burgeri;
Danio
rerio) 		4 / 5 PHE A 312
PHE A 315
LEU A 289
PHE A 250
 None
 1.12A 2y69C-6bxaA:
undetectable
2y69J-6bxaA:
undetectable		 2y69C-6bxaA:
undetectable
2y69J-6bxaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 6bxa VARIABLE LYMPHOCYTE
RECEPTOR 2
(Petromyzon
marinus) 		5 / 12 LEU C  54
LEU C 152
ILE C 136
VAL C 116
VAL C  92
 None
 1.05A 2ygnA-6bxaC:
undetectable		 2ygnA-6bxaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
(Eptatretus
burgeri;
Danio
rerio) 		4 / 5 PHE A 312
PHE A 315
LEU A 289
PHE A 250
 None
 1.11A 3abmC-6bxaA:
undetectable
3abmJ-6bxaA:
undetectable		 3abmC-6bxaA:
undetectable
3abmJ-6bxaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
(Eptatretus
burgeri;
Danio
rerio) 		4 / 5 PHE A 312
PHE A 315
LEU A 289
PHE A 250
 None
 1.09A 3abmP-6bxaA:
undetectable
3abmW-6bxaA:
undetectable		 3abmP-6bxaA:
undetectable
3abmW-6bxaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
(Eptatretus
burgeri;
Danio
rerio) 		4 / 5 PHE A 312
PHE A 315
LEU A 289
PHE A 250
 None
 1.17A 3ag3C-6bxaA:
undetectable
3ag3J-6bxaA:
undetectable		 3ag3C-6bxaA:
undetectable
3ag3J-6bxaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
(Eptatretus
burgeri;
Danio
rerio) 		6 / 12 PHE A 116
GLY A 118
GLY A  94
LEU A  95
LEU A 111
ASN A  90
 None
 1.35A 3av6A-6bxaA:
undetectable		 3av6A-6bxaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
(Danio
rerio;
Eptatretus
burgeri) 		5 / 12 PHE A 199
LEU A 137
ILE A 161
LEU A 178
ASP A 177
 None
 1.28A 3ko0G-6bxaA:
undetectable
3ko0H-6bxaA:
undetectable
3ko0I-6bxaA:
undetectable
3ko0J-6bxaA:
undetectable		 3ko0G-6bxaA:
19.39
3ko0H-6bxaA:
19.39
3ko0I-6bxaA:
19.39
3ko0J-6bxaA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
(Danio
rerio;
Eptatretus
burgeri) 		5 / 12 LEU A 145
LEU A 127
GLY A 114
ALA A 115
LEU A 111
 None
None
NAG  A 802 ( 3.8A)
None
None
 1.08A 3nt1A-6bxaA:
undetectable		 3nt1A-6bxaA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
(Danio
rerio;
Eptatretus
burgeri) 		5 / 12 LEU A 145
LEU A 127
GLY A 114
ALA A 115
LEU A 111
 None
None
NAG  A 802 ( 3.8A)
None
None
 1.08A 3nt1B-6bxaA:
undetectable		 3nt1B-6bxaA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_2
(PROTEASE)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
VARIABLE LYMPHOCYTE
RECEPTOR 2
(Danio
rerio;
Eptatretus
burgeri;
Petromyzon
marinus) 		5 / 10 LEU A  56
ILE A  33
VAL C  53
GLY C  55
ILE A  35
 None
 0.72A 3s43B-6bxaA:
undetectable		 3s43B-6bxaA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
(Eptatretus
burgeri;
Danio
rerio) 		3 / 3 GLN A 415
GLU A 367
LYS A 391
 None
 1.10A 3su9A-6bxaA:
undetectable		 3su9A-6bxaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
(Danio
rerio;
Eptatretus
burgeri) 		4 / 5 PHE A 250
ALA A 246
THR A 285
LEU A 299
 None
 1.21A 3t3zC-6bxaA:
undetectable		 3t3zC-6bxaA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
(Eptatretus
burgeri;
Danio
rerio) 		4 / 5 SER A 427
ASP A 405
ASP A 409
ILE A 407
 None
 1.31A 3uj7B-6bxaA:
undetectable		 3uj7B-6bxaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
(Eptatretus
burgeri;
Danio
rerio) 		4 / 7 PHE A 166
PHE A 167
THR A 146
PHE A 173
 None
 1.13A 3vnsA-6bxaA:
undetectable		 3vnsA-6bxaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
VARIABLE LYMPHOCYTE
RECEPTOR 2
(Eptatretus
burgeri;
Danio
rerio;
Petromyzon
marinus) 		4 / 7 THR C 130
HIS C 183
ASN A  36
LEU A  56
 None
 1.22A 4awuA-6bxaC:
undetectable		 4awuA-6bxaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
(Eptatretus
burgeri;
Danio
rerio) 		5 / 10 ILE A 258
LEU A 234
THR A 256
GLY A 255
GLY A 288
 None
 1.17A 4bwlC-6bxaA:
undetectable		 4bwlC-6bxaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
VARIABLE LYMPHOCYTE
RECEPTOR 2
(Eptatretus
burgeri;
Danio
rerio;
Petromyzon
marinus) 		5 / 10 ILE A  35
LEU A  56
ASP C  34
GLY C  55
SER C  36
 None
 1.23A 4bwlC-6bxaA:
undetectable		 4bwlC-6bxaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
(Danio
rerio;
Eptatretus
burgeri) 		4 / 7 PHE A 249
PHE A 250
PHE A 226
LEU A 263
 None
 1.01A 4ejgA-6bxaA:
undetectable		 4ejgA-6bxaA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 6bxa VARIABLE LYMPHOCYTE
RECEPTOR 2
(Petromyzon
marinus) 		5 / 11 SER C 135
ILE C 136
LEU C 147
ASP C 118
GLY C 115
 None
 1.39A 4fogA-6bxaC:
undetectable		 4fogA-6bxaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2F_A_ADNA601_1
(5'-NUCLEOTIDASE)		 6bxa VARIABLE LYMPHOCYTE
RECEPTOR 2
(Petromyzon
marinus) 		5 / 9 ASN C 179
GLY C 184
GLY C 185
GLY C 182
PHE C 153
 None
 1.50A 4h2fA-6bxaC:
undetectable		 4h2fA-6bxaC:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
(Danio
rerio;
Eptatretus
burgeri) 		6 / 11 PRO A 225
LEU A 289
LEU A 261
LEU A 263
ILE A 186
PHE A 241
 None
 1.32A 4odrA-6bxaA:
undetectable
4odrB-6bxaA:
undetectable		 4odrA-6bxaA:
22.22
4odrB-6bxaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
VARIABLE LYMPHOCYTE
RECEPTOR 2
(Eptatretus
burgeri;
Danio
rerio;
Petromyzon
marinus) 		3 / 3 SER C  58
TYR A 105
ASP C  34
 None
 0.88A 4rp8C-6bxaC:
undetectable		 4rp8C-6bxaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
(Danio
rerio;
Eptatretus
burgeri) 		5 / 12 ILE A 161
MET A 212
LEU A 236
LEU A 234
LEU A 202
 None
 1.09A 4xumA-6bxaA:
undetectable		 4xumA-6bxaA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6bxa VARIABLE LYMPHOCYTE
RECEPTOR 2
(Petromyzon
marinus) 		5 / 12 PHE C  93
ILE C  47
LEU C  64
LEU C  80
LEU C  56
 None
 1.28A 4xumA-6bxaC:
undetectable		 4xumA-6bxaC:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
VARIABLE LYMPHOCYTE
RECEPTOR 2
(Danio
rerio;
Eptatretus
burgeri;
Petromyzon
marinus) 		5 / 12 LEU A  56
ILE A  33
VAL C  53
GLY C  55
ILE A  35
 None
 0.79A 5e5jA-6bxaA:
undetectable		 5e5jA-6bxaA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
(Danio
rerio;
Eptatretus
burgeri) 		5 / 12 LEU A 145
PHE A 166
GLY A 139
LEU A 111
PHE A  92
 None
 1.21A 5fsaA-6bxaA:
undetectable		 5fsaA-6bxaA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
VARIABLE LYMPHOCYTE
RECEPTOR 2
(Eptatretus
burgeri;
Danio
rerio;
Petromyzon
marinus) 		3 / 3 ASP A  53
SER C  57
TYR C  81
 None
 0.80A 5glmA-6bxaA:
undetectable		 5glmA-6bxaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
VARIABLE LYMPHOCYTE
RECEPTOR 2
(Danio
rerio;
Eptatretus
burgeri;
Petromyzon
marinus) 		4 / 8 ILE A  35
GLY C  55
LEU C  75
LEU C  99
 None
 0.83A 5hs1A-6bxaA:
undetectable		 5hs1A-6bxaA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
(Eptatretus
burgeri;
Danio
rerio) 		4 / 7 LEU A 345
GLU A 392
ASN A 374
ILE A 376
 None
 0.93A 5jh7C-6bxaA:
undetectable		 5jh7C-6bxaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
(Danio
rerio;
Eptatretus
burgeri) 		5 / 12 LEU A 145
LEU A 127
GLY A 114
ALA A 115
LEU A 111
 None
None
NAG  A 802 ( 3.8A)
None
None
 1.10A 5jvzB-6bxaA:
undetectable		 5jvzB-6bxaA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
VARIABLE LYMPHOCYTE
RECEPTOR 2
(Eptatretus
burgeri;
Danio
rerio;
Petromyzon
marinus) 		3 / 3 SER C  36
SER C  57
PHE A  75
 None
 0.83A 5mugA-6bxaC:
undetectable		 5mugA-6bxaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
VARIABLE LYMPHOCYTE
RECEPTOR 2
(Danio
rerio;
Eptatretus
burgeri;
Petromyzon
marinus) 		5 / 12 LEU A  56
ILE A  33
VAL C  53
GLY C  55
ILE A  35
 None
 0.73A 5t8hA-6bxaA:
undetectable		 5t8hA-6bxaA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
(Eptatretus
burgeri;
Danio
rerio) 		5 / 12 LEU A 263
GLY A 238
LYS A 301
LEU A 261
SER A 260
 None
 1.01A 5twjC-6bxaA:
undetectable		 5twjC-6bxaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
VARIABLE LYMPHOCYTE
RECEPTOR 2
(Danio
rerio;
Eptatretus
burgeri;
Petromyzon
marinus) 		4 / 7 LEU A  54
VAL C  53
TYR C 103
GLU C 101
 None
 1.24A 5umwA-6bxaA:
undetectable
5umwF-6bxaA:
undetectable		 5umwA-6bxaA:
21.59
5umwF-6bxaA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
(Eptatretus
burgeri;
Danio
rerio) 		4 / 5 PHE A 312
PHE A 315
LEU A 289
PHE A 250
 None
 1.16A 5wauC-6bxaA:
undetectable
5wauJ-6bxaA:
undetectable		 5wauC-6bxaA:
undetectable
5wauJ-6bxaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
(Eptatretus
burgeri;
Danio
rerio) 		4 / 5 PHE A 312
PHE A 315
LEU A 289
PHE A 250
 None
 1.15A 5wauc-6bxaA:
undetectable
5wauj-6bxaA:
undetectable		 5wauc-6bxaA:
undetectable
5wauj-6bxaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
(Eptatretus
burgeri;
Danio
rerio) 		4 / 5 PHE A 312
PHE A 315
LEU A 289
PHE A 250
 None
 1.12A 5xdqC-6bxaA:
undetectable
5xdqJ-6bxaA:
undetectable		 5xdqC-6bxaA:
undetectable
5xdqJ-6bxaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
(Eptatretus
burgeri;
Danio
rerio) 		4 / 5 PHE A 312
PHE A 315
LEU A 289
PHE A 250
 None
 1.13A 5xdqP-6bxaA:
undetectable
5xdqW-6bxaA:
undetectable		 5xdqP-6bxaA:
undetectable
5xdqW-6bxaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
(Eptatretus
burgeri;
Danio
rerio) 		4 / 8 PHE A 250
SER A 266
PHE A 286
LEU A 261
 None
 0.99A 5y2tB-6bxaA:
undetectable		 5y2tB-6bxaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 6bxa VARIABLE LYMPHOCYTE
RECEPTOR 2
(Petromyzon
marinus) 		5 / 9 LEU C  72
SER C  71
PRO C  23
VAL C  33
ILE C  47
 None
 1.17A 6ef6A-6bxaC:
undetectable		 6ef6A-6bxaC:
undetectable