SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bxn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2
(Candidatus
Methanoperedens
nitroreducens) 		4 / 7 GLN A 302
ARG A 214
PHE A 210
PHE A 161
 None
 1.11A 1e71M-6bxnA:
undetectable		 1e71M-6bxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E73_M_ASCM995_0
(MYROSINASE MA1)		 6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2
(Candidatus
Methanoperedens
nitroreducens) 		4 / 6 GLN A 302
ARG A 214
PHE A 210
PHE A 161
 None
 1.11A 1e73M-6bxnA:
undetectable		 1e73M-6bxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2
(Candidatus
Methanoperedens
nitroreducens) 		5 / 9 LEU A  12
ILE A  15
VAL A  50
GLY A  24
ALA A  48
 None
 0.97A 1e7aA-6bxnA:
undetectable		 1e7aA-6bxnA:
7.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2
(Candidatus
Methanoperedens
nitroreducens) 		3 / 3 ASP A 263
GLU A  29
ARG A 293
 None
 0.56A 1wopA-6bxnA:
undetectable		 1wopA-6bxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2
(Candidatus
Methanoperedens
nitroreducens) 		5 / 12 ALA A  35
ILE A  38
ILE A  52
VAL A  50
ILE A  73
 None
 1.07A 1xozA-6bxnA:
undetectable		 1xozA-6bxnA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2
(Candidatus
Methanoperedens
nitroreducens) 		4 / 8 LYS A  32
THR A 233
SER A  53
GLU A  29
 None
 1.10A 1xr2B-6bxnA:
undetectable		 1xr2B-6bxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2
(Candidatus
Methanoperedens
nitroreducens) 		5 / 10 ALA A 221
ALA A 296
ALA A 277
VAL A 307
GLY A 216
 None
 0.94A 2f16K-6bxnA:
undetectable
2f16L-6bxnA:
undetectable		 2f16K-6bxnA:
17.50
2f16L-6bxnA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2
(Candidatus
Methanoperedens
nitroreducens) 		5 / 10 ALA A 221
ALA A 296
ALA A 277
VAL A 307
GLY A 216
 None
 0.94A 2f16Y-6bxnA:
undetectable
2f16Z-6bxnA:
undetectable		 2f16Y-6bxnA:
17.50
2f16Z-6bxnA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2
(Candidatus
Methanoperedens
nitroreducens) 		4 / 7 THR A 266
ILE A 286
PHE A  58
GLN A 237
 None
SAM  A 901 (-4.7A)
SAM  A 901 ( 3.5A)
SAM  A 901 (-3.0A)
 0.71A 2jc9A-6bxnA:
undetectable		 2jc9A-6bxnA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2
(Candidatus
Methanoperedens
nitroreducens) 		4 / 5 ILE A 230
ARG A 214
THR A 287
GLU A 303
 None
 1.41A 3ny4A-6bxnA:
undetectable		 3ny4A-6bxnA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2
(Candidatus
Methanoperedens
nitroreducens) 		4 / 5 PHE A 294
PRO A 297
VAL A 298
ALA A 291
 None
 1.08A 4w5oA-6bxnA:
4.0		 4w5oA-6bxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2
(Candidatus
Methanoperedens
nitroreducens) 		4 / 5 PHE A 294
PRO A 297
VAL A 298
ALA A 291
 None
 1.12A 4z4cA-6bxnA:
4.0		 4z4cA-6bxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2
(Candidatus
Methanoperedens
nitroreducens) 		4 / 5 PHE A 294
PRO A 297
VAL A 298
ALA A 291
 None
 1.11A 4z4dA-6bxnA:
undetectable		 4z4dA-6bxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2
(Candidatus
Methanoperedens
nitroreducens) 		4 / 5 PHE A 294
PRO A 297
VAL A 298
ALA A 291
 None
 1.08A 4z4eA-6bxnA:
4.0		 4z4eA-6bxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2
(Candidatus
Methanoperedens
nitroreducens) 		5 / 12 GLY A 177
ILE A  63
GLY A  81
LEU A 157
HIS A 180
 None
None
None
SAM  A 901 (-3.8A)
SAM  A 901 (-4.2A)
 0.82A 4ze2A-6bxnA:
undetectable		 4ze2A-6bxnA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2
(Candidatus
Methanoperedens
nitroreducens) 		4 / 7 ILE A 174
VAL A 103
ILE A 100
GLU A 129
 None
 1.00A 4zzbC-6bxnA:
undetectable
4zzbD-6bxnA:
undetectable		 4zzbC-6bxnA:
undetectable
4zzbD-6bxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2
(Candidatus
Methanoperedens
nitroreducens) 		4 / 5 HIS A 123
ILE A  99
SER A 176
ALA A 102
 None
 1.25A 5msdA-6bxnA:
2.6		 5msdA-6bxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2
(Candidatus
Methanoperedens
nitroreducens) 		3 / 3 LYS A 126
HIS A 125
HIS A 123
 None
 1.48A 5oexB-6bxnA:
undetectable		 5oexB-6bxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2
(Candidatus
Methanoperedens
nitroreducens) 		4 / 6 PHE A 294
PRO A 297
VAL A 298
ALA A 291
 None
 1.08A 5t7bA-6bxnA:
4.0		 5t7bA-6bxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2
(Candidatus
Methanoperedens
nitroreducens) 		5 / 10 LEU A 246
ILE A 229
GLY A 257
LEU A 299
VAL A 279
 None
 1.16A 5twjB-6bxnA:
undetectable		 5twjB-6bxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2
(Candidatus
Methanoperedens
nitroreducens) 		5 / 12 LEU A 246
ILE A 229
GLY A 257
LEU A 299
VAL A 279
 None
 1.16A 5twjC-6bxnA:
undetectable		 5twjC-6bxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_A_SAMA401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2
(Candidatus
Methanoperedens
nitroreducens) 		8 / 12 LEU A 157
GLY A 158
HIS A 180
SER A 232
LYS A 234
GLN A 237
CYH A 283
ASP A 289
 SAM  A 901 (-3.8A)
SF4  A 900 ( 3.6A)
SAM  A 901 (-4.2A)
SAM  A 901 ( 3.9A)
SAM  A 901 (-4.9A)
SAM  A 901 (-3.0A)
SF4  A 900 ( 2.2A)
SAM  A 901 (-3.9A)
 0.53A 6bxlA-6bxnA:
19.3		 6bxlA-6bxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2
(Candidatus
Methanoperedens
nitroreducens) 		10 / 12 LEU A 157
GLY A 158
HIS A 180
SER A 232
LYS A 234
GLN A 237
VAL A 265
CYH A 283
ARG A 285
ASP A 289
 SAM  A 901 (-3.8A)
SF4  A 900 ( 3.6A)
SAM  A 901 (-4.2A)
SAM  A 901 ( 3.9A)
SAM  A 901 (-4.9A)
SAM  A 901 (-3.0A)
SAM  A 901 (-4.0A)
SF4  A 900 ( 2.2A)
SAM  A 901 (-4.1A)
SAM  A 901 (-3.9A)
 0.54A 6bxlB-6bxnA:
13.6		 6bxlB-6bxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2
(Candidatus
Methanoperedens
nitroreducens) 		12 / 12 PHE A  58
LEU A 157
GLY A 158
SER A 232
LYS A 234
GLN A 237
LEU A 264
VAL A 265
CYH A 283
ARG A 285
ILE A 286
ASP A 289
 SAM  A 901 ( 3.5A)
SAM  A 901 (-3.8A)
SF4  A 900 ( 3.6A)
SAM  A 901 ( 3.9A)
SAM  A 901 (-4.9A)
SAM  A 901 (-3.0A)
SAM  A 901 (-4.5A)
SAM  A 901 (-4.0A)
SF4  A 900 ( 2.2A)
SAM  A 901 (-4.1A)
SAM  A 901 (-4.7A)
SAM  A 901 (-3.9A)
 0.22A 6bxmA-6bxnA:
41.7		 6bxmA-6bxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2
(Candidatus
Methanoperedens
nitroreducens) 		5 / 12 HIS A 180
VAL A 298
ARG A 285
ASP A 289
ASP A 290
 SAM  A 901 (-4.2A)
None
SAM  A 901 (-4.1A)
SAM  A 901 (-3.9A)
SAM  A 901 (-3.2A)
 1.45A 6bxnA-6bxnA:
47.0		 6bxnA-6bxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2
(Candidatus
Methanoperedens
nitroreducens) 		12 / 12 PHE A  58
LEU A 157
HIS A 180
SER A 232
LYS A 234
GLN A 237
VAL A 265
CYH A 283
ARG A 285
ILE A 286
ASP A 289
ASP A 290
 SAM  A 901 ( 3.5A)
SAM  A 901 (-3.8A)
SAM  A 901 (-4.2A)
SAM  A 901 ( 3.9A)
SAM  A 901 (-4.9A)
SAM  A 901 (-3.0A)
SAM  A 901 (-4.0A)
SF4  A 900 ( 2.2A)
SAM  A 901 (-4.1A)
SAM  A 901 (-4.7A)
SAM  A 901 (-3.9A)
SAM  A 901 (-3.2A)
 0.00A 6bxnA-6bxnA:
47.0		 6bxnA-6bxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2
(Candidatus
Methanoperedens
nitroreducens) 		12 / 12 PHE A  58
LEU A 157
GLY A 158
HIS A 180
SER A 232
LYS A 234
GLN A 237
VAL A 265
CYH A 283
ARG A 285
ILE A 286
ASP A 290
 SAM  A 901 ( 3.5A)
SAM  A 901 (-3.8A)
SF4  A 900 ( 3.6A)
SAM  A 901 (-4.2A)
SAM  A 901 ( 3.9A)
SAM  A 901 (-4.9A)
SAM  A 901 (-3.0A)
SAM  A 901 (-4.0A)
SF4  A 900 ( 2.2A)
SAM  A 901 (-4.1A)
SAM  A 901 (-4.7A)
SAM  A 901 (-3.2A)
 0.18A 6bxnB-6bxnA:
43.0		 6bxnB-6bxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2
(Candidatus
Methanoperedens
nitroreducens) 		4 / 6 GLN A 269
VAL A 265
ALA A 282
THR A 281
 None
SAM  A 901 (-4.0A)
SAM  A 901 ( 4.4A)
None
 1.00A 6cduB-6bxnA:
undetectable
6cduC-6bxnA:
undetectable		 6cduB-6bxnA:
undetectable
6cduC-6bxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2
(Candidatus
Methanoperedens
nitroreducens) 		5 / 10 GLY A 257
VAL A 279
VAL A 307
ALA A 221
LEU A 308
 None
 1.09A 6czmA-6bxnA:
undetectable
6czmC-6bxnA:
undetectable		 6czmA-6bxnA:
undetectable
6czmC-6bxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2
(Candidatus
Methanoperedens
nitroreducens) 		5 / 12 GLY A 177
ILE A  63
GLY A  81
LEU A 157
HIS A 180
 None
None
None
SAM  A 901 (-3.8A)
SAM  A 901 (-4.2A)
 0.79A 6e8qA-6bxnA:
undetectable		 6e8qA-6bxnA:
16.67