SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6by9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 6by9 HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1
(Homo
sapiens) 		4 / 6 ALA A 927
LEU A 910
GLU A 923
LEU A 957
 None
 1.00A 1mt1D-6by9A:
undetectable
1mt1E-6by9A:
undetectable		 1mt1D-6by9A:
28.16
1mt1E-6by9A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6by9 HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1
(Homo
sapiens) 		4 / 4 ALA A 813
VAL A 822
ALA A 821
HIS A 785
 None
 1.12A 1q23A-6by9A:
undetectable		 1q23A-6by9A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 6by9 HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1
(Homo
sapiens) 		4 / 7 ILE A 878
LEU A 925
ASN A 907
ASP A 903
 None
 0.85A 1yc2E-6by9A:
undetectable		 1yc2E-6by9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 6by9 HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1
(Homo
sapiens) 		5 / 12 LEU A 925
ALA A 913
THR A 881
ASN A 907
ILE A 878
 None
 1.16A 3a3bA-6by9A:
undetectable		 3a3bA-6by9A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 6by9 HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1
(Homo
sapiens) 		4 / 7 ASP A 805
SER A 803
GLU A 782
HIS A 778
 None
 1.31A 4aq7A-6by9A:
undetectable		 4aq7A-6by9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 6by9 HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1
(Homo
sapiens) 		4 / 8 LEU A 891
LEU A 843
HIS A 844
ILE A 878
 None
 0.97A 4ok1A-6by9A:
undetectable		 4ok1A-6by9A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 6by9 HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1
(Homo
sapiens) 		3 / 3 ASP A 903
GLY A 872
ASP A 870
 None
 0.47A 4xdtA-6by9A:
undetectable		 4xdtA-6by9A:
undetectable