SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6byn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 6byn WDR5-BINDING
MONOBODY, MB(S4)
(Homo
sapiens) 		5 / 10 LEU M  62
VAL M  66
TYR M  68
TYR M  94
GLY M  65
 None
 1.29A 1fkoA-6bynM:
undetectable		 1fkoA-6bynM:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 6byn WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 8 GLY W 147
HIS W 128
ALA W 169
THR W 166
 None
 0.83A 1gtfN-6bynW:
undetectable
1gtfO-6bynW:
undetectable		 1gtfN-6bynW:
undetectable
1gtfO-6bynW:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 6byn WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 7 ASN W  34
TYR W  35
LEU W 297
GLN W 295
 None
 1.10A 1qzrB-6bynW:
undetectable		 1qzrB-6bynW:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 6byn WDR5-BINDING
MONOBODY, MB(S4)
(Homo
sapiens) 		5 / 12 VAL M  45
ILE M  59
ILE M  70
ILE M  90
ILE M  20
 None
 1.36A 1r5lA-6bynM:
undetectable		 1r5lA-6bynM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 6byn WD REPEAT-CONTAINING
PROTEIN 5
WDR5-BINDING
MONOBODY, MB(S4)
(Homo
sapiens) 		5 / 12 ASP W 107
PHE W 133
GLY M  79
GLY W 147
VAL W 177
 None
 1.31A 2fqyA-6bynW:
undetectable		 2fqyA-6bynW:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_B_ETSB303_1
(CARBONIC ANHYDRASE 4)		 6byn WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 12 HIS W 170
ILE W 229
VAL W 220
LEU W 209
THR W 208
 None
 1.02A 3fw3B-6bynW:
undetectable		 3fw3B-6bynW:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6byn WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 10 ILE W 285
PHE W 219
SER W 189
LEU W 230
ALA W 232
 None
 1.35A 3lw5B-6bynW:
undetectable		 3lw5B-6bynW:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 6byn WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 7 ASP W 280
ILE W 316
SER W 278
TYR W 284
 None
 0.87A 3pglA-6bynW:
undetectable		 3pglA-6bynW:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 6byn WDR5-BINDING
MONOBODY, MB(S4)
(Homo
sapiens) 		5 / 12 ILE M  70
VAL M  72
TYR M  32
TYR M  36
ILE M  59
 None
 1.12A 3vrjA-6bynM:
4.7
3vrjC-6bynM:
undetectable		 3vrjA-6bynM:
15.85
3vrjC-6bynM:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 6byn WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 10 SER W  96
ALA W  94
ILE W 144
VAL W 158
ILE W 113
 None
 1.06A 4lbgA-6bynW:
undetectable		 4lbgA-6bynW:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 6byn WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 5 PHE W 263
PHE W 219
LEU W 234
PRO W 216
 None
 1.45A 4o8zA-6bynW:
undetectable		 4o8zA-6bynW:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6byn WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 11 ALA W 317
ALA W 308
GLY W  77
GLY W  73
ALA W  74
 None
 0.96A 4qvlK-6bynW:
undetectable
4qvlL-6bynW:
undetectable		 4qvlK-6bynW:
20.11
4qvlL-6bynW:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6byn WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 11 ALA W 317
ALA W 308
GLY W  77
GLY W  73
ALA W  74
 None
 0.95A 4qvlY-6bynW:
undetectable
4qvlZ-6bynW:
undetectable		 4qvlY-6bynW:
20.11
4qvlZ-6bynW:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6byn WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 9 ALA W 317
ALA W 308
GLY W  77
GLY W  73
ALA W  74
 None
 0.95A 4qvmK-6bynW:
undetectable
4qvmL-6bynW:
undetectable		 4qvmK-6bynW:
20.11
4qvmL-6bynW:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6byn WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 10 ALA W 317
ALA W 308
GLY W  77
GLY W  73
ALA W  74
 None
 0.96A 4qvmY-6bynW:
undetectable
4qvmZ-6bynW:
undetectable		 4qvmY-6bynW:
20.11
4qvmZ-6bynW:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6byn WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 10 ALA W 317
ALA W 308
GLY W  77
GLY W  73
ALA W  74
 None
 0.96A 4qvpK-6bynW:
undetectable
4qvpL-6bynW:
undetectable		 4qvpK-6bynW:
20.11
4qvpL-6bynW:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6byn WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 10 ALA W 317
ALA W 308
GLY W  77
GLY W  73
ALA W  74
 None
 0.96A 4qvpY-6bynW:
undetectable
4qvpZ-6bynW:
undetectable		 4qvpY-6bynW:
20.11
4qvpZ-6bynW:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6byn WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 11 ALA W 317
ALA W 308
GLY W  77
GLY W  73
ALA W  74
 None
 0.97A 4qw1K-6bynW:
undetectable
4qw1L-6bynW:
undetectable		 4qw1K-6bynW:
20.11
4qw1L-6bynW:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6byn WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 10 ALA W 317
ALA W 308
GLY W  77
GLY W  73
ALA W  74
 None
 0.97A 4qw1Y-6bynW:
undetectable
4qw1Z-6bynW:
undetectable		 4qw1Y-6bynW:
20.11
4qw1Z-6bynW:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6byn WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 10 ALA W 317
ALA W 308
GLY W  77
GLY W  73
ALA W  74
 None
 0.96A 4qw3K-6bynW:
undetectable
4qw3L-6bynW:
undetectable		 4qw3K-6bynW:
20.11
4qw3L-6bynW:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6byn WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 10 ALA W 317
ALA W 308
GLY W  77
GLY W  73
ALA W  74
 None
 0.95A 4qw3Y-6bynW:
undetectable
4qw3Z-6bynW:
undetectable		 4qw3Y-6bynW:
20.11
4qw3Z-6bynW:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6byn WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 11 ALA W 317
ALA W 308
GLY W  77
GLY W  73
ALA W  74
 None
 0.95A 5bxnK-6bynW:
undetectable
5bxnL-6bynW:
undetectable		 5bxnK-6bynW:
20.11
5bxnL-6bynW:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6byn WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 11 ALA W 317
ALA W 308
GLY W  77
GLY W  73
ALA W  74
 None
 0.95A 5bxnY-6bynW:
undetectable
5bxnZ-6bynW:
undetectable		 5bxnY-6bynW:
20.11
5bxnZ-6bynW:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6byn WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 9 ALA W 317
ALA W 308
GLY W  77
GLY W  73
ALA W  74
 None
 0.94A 5d0xK-6bynW:
undetectable
5d0xL-6bynW:
undetectable		 5d0xK-6bynW:
20.11
5d0xL-6bynW:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6byn WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 9 ALA W 317
ALA W 308
GLY W  77
GLY W  73
ALA W  74
 None
 0.95A 5d0xY-6bynW:
undetectable
5d0xZ-6bynW:
undetectable		 5d0xY-6bynW:
20.11
5d0xZ-6bynW:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6byn WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 8 GLY W 147
HIS W 128
ALA W 169
THR W 166
 None
 0.82A 5eevL-6bynW:
undetectable
5eevV-6bynW:
undetectable		 5eevL-6bynW:
undetectable
5eevV-6bynW:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6byn WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 8 GLY W 147
HIS W 128
ALA W 169
THR W 166
 None
 0.82A 5eewL-6bynW:
undetectable
5eewV-6bynW:
undetectable		 5eewL-6bynW:
undetectable
5eewV-6bynW:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6byn WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 8 GLY W 147
HIS W 128
ALA W 169
THR W 166
 None
 0.82A 5eezL-6bynW:
undetectable
5eezV-6bynW:
undetectable		 5eezL-6bynW:
undetectable
5eezV-6bynW:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6byn WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 8 GLY W 147
HIS W 128
ALA W 169
THR W 166
 None
 0.82A 5ef2L-6bynW:
undetectable
5ef2V-6bynW:
undetectable		 5ef2L-6bynW:
undetectable
5ef2V-6bynW:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6byn WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 8 GLY W 147
HIS W 128
ALA W 169
THR W 166
 None
 0.82A 5ef3L-6bynW:
undetectable
5ef3V-6bynW:
undetectable		 5ef3L-6bynW:
undetectable
5ef3V-6bynW:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6byn WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 8 LEU W 249
LEU W 209
GLY W 246
SER W 244
 None
 0.72A 5f1aA-6bynW:
undetectable		 5f1aA-6bynW:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 6byn WDR5-BINDING
MONOBODY, MB(S4)
WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY M  78
GLY M  77
SER W 175
SER W 218
HIS M  82
 None
 0.88A 5twjA-6bynM:
undetectable		 5twjA-6bynM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 6byn WDR5-BINDING
MONOBODY, MB(S4)
(Homo
sapiens) 		4 / 7 ILE M  70
VAL M  10
ALA M  13
THR M  14
 None
 0.97A 6cduC-6bynM:
undetectable
6cduD-6bynM:
undetectable		 6cduC-6bynM:
undetectable
6cduD-6bynM:
undetectable