SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6byo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		3 / 3 SER A1143
GLU A1144
GLU A1145
 None
 0.61A 1eqbD-6byoA:
undetectable		 1eqbD-6byoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		3 / 3 SER A1143
GLU A1144
GLU A1145
 None
 0.61A 1eqbB-6byoA:
undetectable		 1eqbB-6byoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		5 / 12 ILE A 822
PHE A1306
GLN A1311
ASN A1304
LEU A1294
 None
 1.45A 1u70A-6byoA:
undetectable		 1u70A-6byoA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		3 / 3 GLN A 830
ILE A 831
TYR A 834
 None
 0.73A 1vifA-6byoA:
undetectable		 1vifA-6byoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		5 / 9 VAL A 610
LEU A 611
PHE A 597
PHE A 567
LEU A 644
 None
 1.37A 1wrkA-6byoA:
undetectable
1wrkB-6byoA:
undetectable		 1wrkA-6byoA:
17.58
1wrkB-6byoA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_B_ADNB902_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		5 / 11 PHE A 804
ILE A 805
THR A 799
ALA A 798
VAL A 842
 None
 1.25A 2gl0B-6byoA:
undetectable
2gl0C-6byoA:
undetectable		 2gl0B-6byoA:
19.74
2gl0C-6byoA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		4 / 7 THR A1132
ALA A1250
PHE A1125
LEU A 201
 None
 1.13A 2hzqA-6byoA:
undetectable		 2hzqA-6byoA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		4 / 5 LEU A1237
VAL A1253
LEU A 201
ARG A1249
 None
 1.12A 2oiqA-6byoA:
3.0		 2oiqA-6byoA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		5 / 12 GLY A 613
GLY A1015
THR A 612
LEU A 611
ASP A 615
 None
 1.01A 2oxtC-6byoA:
undetectable		 2oxtC-6byoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y04_B_68HB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		5 / 12 TRP A1016
THR A 612
VAL A 610
VAL A 619
PHE A 597
 None
 1.43A 2y04B-6byoA:
4.9		 2y04B-6byoA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		4 / 8 ALA A 443
ILE A 439
ILE A 538
TYR A 541
 None
 0.95A 2zm8A-6byoA:
undetectable		 2zm8A-6byoA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		4 / 8 ALA A 443
ILE A 439
ILE A 538
TYR A 541
 None
 0.95A 2zmaA-6byoA:
undetectable		 2zmaA-6byoA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		5 / 12 ASN A 654
VAL A 655
GLY A 648
TYR A 650
ILE A 643
 None
 1.36A 3bwmA-6byoA:
undetectable		 3bwmA-6byoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_PNTA901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		5 / 12 TYR A 299
ASP A 303
GLY A 306
SER A 250
ASN A1301
 None
 1.18A 3hiiA-6byoA:
undetectable		 3hiiA-6byoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_PNTB901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		5 / 12 TYR A 299
ASP A 303
GLY A 306
SER A 250
ASN A1301
 None
 1.18A 3hiiB-6byoA:
undetectable		 3hiiB-6byoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		4 / 6 LEU A 471
SER A 473
PHE A 475
ILE A 441
 None
 0.98A 3ko0B-6byoA:
undetectable		 3ko0B-6byoA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		4 / 6 LEU A 471
SER A 473
PHE A 475
ILE A 441
 None
 0.95A 3ko0S-6byoA:
0.0		 3ko0S-6byoA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		4 / 5 TYR A 627
ILE A 572
LEU A 576
PHE A 581
 None
 1.22A 3ls4L-6byoA:
undetectable		 3ls4L-6byoA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		5 / 11 LEU A 186
SER A 177
LEU A 173
LEU A 565
LEU A 568
 None
 1.39A 3ndvA-6byoA:
undetectable
3ndvB-6byoA:
undetectable		 3ndvA-6byoA:
12.78
3ndvB-6byoA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		3 / 3 ASP A 662
GLU A 668
SER A 561
 None
 0.77A 3p2kA-6byoA:
undetectable		 3p2kA-6byoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		5 / 12 LEU A1020
LEU A 604
GLN A 602
PHE A 597
SER A 606
 None
 1.35A 3tbgC-6byoA:
1.8		 3tbgC-6byoA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		4 / 8 PRO A 172
VAL A 176
LEU A 565
ILE A 572
 None
 0.93A 3u5kD-6byoA:
undetectable		 3u5kD-6byoA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		3 / 3 ASP A1196
ARG A1236
ASP A1151
 None
 0.86A 4fp9D-6byoA:
undetectable		 4fp9D-6byoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		3 / 3 ASP A1196
ARG A1236
ASP A1203
 None
 0.88A 4fp9D-6byoA:
undetectable		 4fp9D-6byoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		3 / 3 ARG A 171
GLU A  90
ASN A  64
 None
 0.90A 4ip7D-6byoA:
undetectable		 4ip7D-6byoA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		4 / 8 LEU A 472
ASN A 468
LEU A 512
ILE A 524
 None
 0.99A 4ok1A-6byoA:
1.3		 4ok1A-6byoA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		5 / 9 ALA A 660
ALA A 658
SER A 334
LEU A 333
VAL A 332
 None
 1.24A 4or0A-6byoA:
undetectable		 4or0A-6byoA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		5 / 9 ALA A 660
LEU A 562
SER A 334
LEU A 333
VAL A 332
 None
 1.16A 4or0A-6byoA:
undetectable		 4or0A-6byoA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_ACTA605_0
(SERUM ALBUMIN)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		3 / 3 LYS A1291
LYS A 894
ALA A 824
 None
 1.16A 4ot2A-6byoA:
4.7		 4ot2A-6byoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		5 / 12 ASN A 654
VAL A 655
GLY A 648
TYR A 650
ILE A 643
 None
 1.34A 4xucA-6byoA:
undetectable		 4xucA-6byoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		3 / 3 ARG A 986
LYS A 976
GLU A 984
 None
 0.77A 5d0yA-6byoA:
undetectable		 5d0yA-6byoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		5 / 12 ASN A 654
VAL A 655
GLY A 648
TYR A 650
ILE A 643
 None
 1.36A 5lsaA-6byoA:
undetectable		 5lsaA-6byoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		4 / 7 GLY A 293
GLU A1323
ALA A1324
ASP A 615
 None
 0.81A 5mvsA-6byoA:
undetectable		 5mvsA-6byoA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		3 / 3 ASP A1196
ARG A1236
ASP A1203
 None
 0.87A 5zvgA-6byoA:
undetectable		 5zvgA-6byoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		3 / 3 ASP A1196
ARG A1236
ASP A1203
 None
 0.83A 5zvgB-6byoA:
undetectable		 5zvgB-6byoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		5 / 12 ASN A 797
HIS A 793
PHE A 863
THR A 852
THR A 853
 None
 1.15A 6bbsA-6byoA:
undetectable		 6bbsA-6byoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		4 / 8 HIS A 270
GLU A 591
ASP A 589
GLU A 588
 None
 1.27A 6mn4C-6byoA:
undetectable		 6mn4C-6byoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		4 / 8 TRP A 300
ARG A1318
GLU A1323
GLU A1327
 None
 1.11A 6mn4D-6byoA:
undetectable		 6mn4D-6byoA:
undetectable