SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6byq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 6byq TYROSINE--TRNA
LIGASE
(Helicobacter
pylori) 		5 / 12 ILE A  60
PHE A  45
PHE A 126
ALA A  43
THR A 122
 None
 1.12A 2rlcA-6byqA:
undetectable		 2rlcA-6byqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 6byq TYROSINE--TRNA
LIGASE
(Helicobacter
pylori) 		4 / 7 LEU A  76
TRP A 130
ALA A 184
GLY A 186
 None
 0.90A 2wq5A-6byqA:
undetectable		 2wq5A-6byqA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 6byq TYROSINE--TRNA
LIGASE
(Helicobacter
pylori) 		4 / 6 MET A  83
SER A 128
PRO A  47
GLY A  78
 None
 1.45A 2y7pA-6byqA:
undetectable		 2y7pA-6byqA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 6byq TYROSINE--TRNA
LIGASE
(Helicobacter
pylori) 		3 / 3 ARG A  30
ILE A  12
THR A 273
 None
 0.74A 3ia4D-6byqA:
undetectable		 3ia4D-6byqA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 6byq TYROSINE--TRNA
LIGASE
(Helicobacter
pylori) 		5 / 12 LEU A  76
LEU A  63
TRP A 130
GLY A 186
ALA A 187
 None
 1.09A 3n8xB-6byqA:
undetectable		 3n8xB-6byqA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 6byq TYROSINE--TRNA
LIGASE
(Helicobacter
pylori) 		5 / 11 LEU A  76
LEU A  63
TRP A 130
GLY A 186
ALA A 187
 None
 1.05A 3pghB-6byqA:
undetectable		 3pghB-6byqA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 6byq TYROSINE--TRNA
LIGASE
(Helicobacter
pylori) 		5 / 12 LEU A  76
LEU A  63
TRP A 130
GLY A 186
ALA A 187
 None
 1.05A 3pghD-6byqA:
undetectable		 3pghD-6byqA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 6byq TYROSINE--TRNA
LIGASE
(Helicobacter
pylori) 		5 / 12 LEU A  66
LEU A  63
MET A 221
ILE A  25
ILE A  19
 None
 1.22A 4j24B-6byqA:
undetectable		 4j24B-6byqA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6byq TYROSINE--TRNA
LIGASE
(Helicobacter
pylori) 		5 / 12 LEU A  76
LEU A  63
TRP A 130
GLY A 186
ALA A 187
 None
 1.04A 5ikrB-6byqA:
undetectable		 5ikrB-6byqA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6byq TYROSINE--TRNA
LIGASE
(Helicobacter
pylori) 		5 / 12 LEU A  76
LEU A  63
TRP A 130
GLY A 186
ALA A 187
 None
 0.98A 5jw1B-6byqA:
undetectable		 5jw1B-6byqA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 6byq TYROSINE--TRNA
LIGASE
(Helicobacter
pylori) 		4 / 5 LEU A 206
VAL A 202
MET A 151
CYH A 143
 None
 1.17A 5te0A-6byqA:
undetectable		 5te0A-6byqA:
13.15