SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6bz0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMY_A_AZMA400_1
(MURINE CARBONIC
ANHYDRASE V)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		5 / 11 HIS A  38
VAL A  98
SER A  56
LEU A 174
THR A 171
 None
None
FAD  A 501 ( 3.8A)
None
None
 0.96A 1dmyA-6bz0A:
undetectable		 1dmyA-6bz0A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMY_B_AZMB900_1
(MURINE CARBONIC
ANHYDRASE V)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		5 / 12 HIS A  38
SER A  56
VAL A  98
LEU A 174
THR A 171
 None
FAD  A 501 ( 3.8A)
None
None
None
 1.04A 1dmyB-6bz0A:
undetectable		 1dmyB-6bz0A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		5 / 12 ILE A 147
LYS A 118
VAL A  30
ALA A  24
ILE A 114
 None
 1.04A 1epbB-6bz0A:
undetectable		 1epbB-6bz0A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EVE_A_E20A2001_1
(ACETYLCHOLINESTERASE)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		5 / 10 GLY A 420
GLU A 397
LEU A 216
TYR A 357
HIS A 359
 None
None
None
FAD  A 501 (-4.3A)
None
 1.14A 1eveA-6bz0A:
undetectable		 1eveA-6bz0A:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		5 / 12 GLY A 187
LEU A 183
LEU A 231
LEU A 216
TYR A 227
 None
 1.28A 1fm6D-6bz0A:
undetectable		 1fm6D-6bz0A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		4 / 7 ASP A 425
GLY A 420
ILE A 419
ALA A 460
 None
 0.79A 1n49A-6bz0A:
undetectable		 1n49A-6bz0A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		4 / 4 GLY A 184
VAL A 207
TRP A 199
GLY A 196
 None
 1.26A 1ng8A-6bz0A:
undetectable		 1ng8A-6bz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		4 / 4 GLY A 184
VAL A 207
TRP A 199
GLY A 196
 None
 1.26A 1ng8B-6bz0A:
undetectable		 1ng8B-6bz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		5 / 12 GLY A 172
ASP A 169
ILE A 191
GLY A  52
VAL A 198
 CL  A 503 (-3.5A)
CL  A 503 (-3.5A)
FAD  A 501 (-4.2A)
FAD  A 501 (-3.4A)
None
 1.11A 1sduB-6bz0A:
undetectable		 1sduB-6bz0A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		4 / 5 SER A  63
GLU A 194
TYR A 357
SER A 170
 None
FAD  A 501 ( 4.5A)
FAD  A 501 (-4.3A)
CL  A 502 ( 2.9A)
 1.13A 1vidA-6bz0A:
undetectable		 1vidA-6bz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		4 / 5 GLY A 385
PRO A 421
ALA A 422
ILE A 426
 None
 0.92A 2aofA-6bz0A:
undetectable		 2aofA-6bz0A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		4 / 6 SER A  63
GLU A 194
TYR A 357
SER A 170
 None
FAD  A 501 ( 4.5A)
FAD  A 501 (-4.3A)
CL  A 502 ( 2.9A)
 1.14A 2cl5B-6bz0A:
undetectable		 2cl5B-6bz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		5 / 12 ILE A 157
THR A 171
VAL A 274
VAL A 153
ARG A  36
 None
None
None
None
FAD  A 501 (-3.8A)
 1.10A 2g78A-6bz0A:
undetectable		 2g78A-6bz0A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		5 / 12 ALA A  24
ILE A  21
VAL A 337
ALA A 336
ILE A 316
 None
 1.13A 2h42B-6bz0A:
undetectable		 2h42B-6bz0A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		5 / 12 ALA A 219
VAL A 402
GLY A 400
GLU A 226
THR A 358
 None
 1.07A 3c6gB-6bz0A:
undetectable		 3c6gB-6bz0A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		3 / 3 TYR A 357
ASP A 425
HIS A 327
 FAD  A 501 (-4.3A)
None
FAD  A 501 (-4.5A)
 0.96A 3e23A-6bz0A:
2.9		 3e23A-6bz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		5 / 12 GLY A  11
VAL A 302
GLY A 317
ARG A  36
ILE A 316
 FAD  A 501 (-3.3A)
None
FAD  A 501 (-3.4A)
FAD  A 501 (-3.8A)
None
 1.21A 3k13A-6bz0A:
undetectable		 3k13A-6bz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		5 / 12 TYR A 281
VAL A 129
HIS A 134
ALA A  31
LEU A 117
 FAD  A 501 (-4.8A)
None
None
None
None
 1.02A 3ozuA-6bz0A:
2.1		 3ozuA-6bz0A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		6 / 12 ALA A 392
LEU A 393
HIS A  72
ILE A 426
GLY A 420
PRO A 421
 None
 1.37A 3ozwB-6bz0A:
undetectable		 3ozwB-6bz0A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		4 / 7 GLY A 192
ILE A 238
LEU A 231
PHE A 215
 None
 0.75A 4ejjD-6bz0A:
undetectable		 4ejjD-6bz0A:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		4 / 8 TYR A 227
THR A 358
VAL A 208
ILE A 238
 None
 0.98A 4l4cB-6bz0A:
undetectable		 4l4cB-6bz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		4 / 4 VAL A 405
THR A 368
GLU A 369
GLU A 370
 None
CL  A 504 ( 4.1A)
None
CL  A 504 (-4.1A)
 0.92A 4l78A-6bz0A:
undetectable		 4l78A-6bz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		4 / 7 LEU A 174
PRO A  55
LEU A 195
GLU A 194
 None
None
None
FAD  A 501 ( 4.5A)
 1.03A 4z4fA-6bz0A:
undetectable		 4z4fA-6bz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_A_ACTA202_0
(NITROGEN REGULATORY
PROTEIN P-II)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		4 / 4 VAL A 155
GLY A 277
ARG A 278
VAL A 153
 None
None
FAD  A 501 ( 3.7A)
None
 1.45A 5d4nA-6bz0A:
undetectable
5d4nB-6bz0A:
undetectable		 5d4nA-6bz0A:
undetectable
5d4nB-6bz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		4 / 5 SER A  63
GLU A 194
TYR A 357
SER A 170
 None
FAD  A 501 ( 4.5A)
FAD  A 501 (-4.3A)
CL  A 502 ( 2.9A)
 1.15A 5fhrA-6bz0A:
undetectable		 5fhrA-6bz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		4 / 4 ASP A  68
HIS A  64
HIS A 359
HIS A  72
 None
 1.35A 5ncdD-6bz0A:
undetectable		 5ncdD-6bz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		4 / 7 LEU A 174
PRO A  55
LEU A 195
GLU A 194
 None
None
None
FAD  A 501 ( 4.5A)
 1.07A 5t7bA-6bz0A:
undetectable		 5t7bA-6bz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		5 / 12 LEU A 223
ALA A 219
THR A 232
ILE A 356
ALA A 362
 None
 1.21A 5xiwD-6bz0A:
undetectable		 5xiwD-6bz0A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		5 / 12 VAL A   9
VAL A 320
GLY A 333
ALA A  19
LEU A   7
 None
 1.07A 5xxiA-6bz0A:
undetectable		 5xxiA-6bz0A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		4 / 6 GLY A 203
SER A  63
VAL A 179
TRP A 199
 None
 1.06A 5ysiA-6bz0A:
undetectable		 5ysiA-6bz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		5 / 12 MET A 335
GLY A 317
TYR A 314
ALA A 329
ALA A 326
 None
FAD  A 501 (-3.4A)
None
FAD  A 501 (-3.6A)
FAD  A 501 (-3.5A)
 1.07A 5zw4A-6bz0A:
3.7		 5zw4A-6bz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		4 / 5 LEU A 434
THR A 368
PRO A 323
ARG A 321
 None
CL  A 504 ( 4.1A)
None
None
 1.36A 6ew0B-6bz0A:
undetectable		 6ew0B-6bz0A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		4 / 5 LEU A 434
THR A 368
PRO A 323
ARG A 321
 None
CL  A 504 ( 4.1A)
None
None
 1.36A 6ew0D-6bz0A:
undetectable		 6ew0D-6bz0A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		4 / 5 LEU A 434
THR A 368
PRO A 323
ARG A 321
 None
CL  A 504 ( 4.1A)
None
None
 1.36A 6ew0H-6bz0A:
undetectable		 6ew0H-6bz0A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 6bz0 DIHYDROLIPOYL
DEHYDROGENASE
(Acinetobacter
baumannii) 		4 / 5 LEU A 434
THR A 368
PRO A 323
ARG A 321
 None
CL  A 504 ( 4.1A)
None
None
 1.35A 6ew0I-6bz0A:
undetectable		 6ew0I-6bz0A:
23.33