SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6c0b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 6c0b TOXIN B
(Clostridioides
difficile) 		4 / 7 THR A1543
ASN A1553
THR A1520
ASP A1522
 None
 1.00A 1bu5A-6c0bA:
undetectable		 1bu5A-6c0bA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 6c0b TOXIN B
(Clostridioides
difficile) 		4 / 8 THR A1543
ASN A1553
THR A1520
ASP A1522
 None
 0.99A 1bu5B-6c0bA:
undetectable		 1bu5B-6c0bA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 6c0b TOXIN B
(Clostridioides
difficile) 		3 / 3 LEU A1641
SER A1677
ASN A1734
 None
 0.72A 1bx4A-6c0bA:
undetectable		 1bx4A-6c0bA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 6c0b TOXIN B
(Clostridioides
difficile) 		5 / 9 TYR A1724
LEU A1780
VAL A1731
ILE A1704
ILE A1674
 None
 1.30A 1gebA-6c0bA:
undetectable		 1gebA-6c0bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 6c0b FRIZZLED-2
TOXIN B
(Clostridioides
difficile;
Homo
sapiens) 		4 / 7 LEU B 124
MET A1437
LEU A1433
GLU A1471
 PAM  B 202 ( 4.6A)
PAM  B 202 (-3.6A)
PAM  B 202 (-4.2A)
None
 0.94A 1linA-6c0bB:
undetectable		 1linA-6c0bB:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 6c0b TOXIN B
(Clostridioides
difficile) 		5 / 11 LEU A1647
GLN A1620
ILE A1684
PHE A1623
LEU A1566
 None
 1.19A 2q6hA-6c0bA:
undetectable		 2q6hA-6c0bA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 6c0b TOXIN B
(Clostridioides
difficile) 		5 / 11 LEU A1647
GLN A1620
ILE A1684
PHE A1623
LEU A1566
 None
 1.19A 2qeiA-6c0bA:
undetectable		 2qeiA-6c0bA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 6c0b TOXIN B
(Clostridioides
difficile) 		5 / 11 LEU A1647
GLN A1620
ILE A1684
PHE A1623
LEU A1566
 None
 1.15A 2qjuA-6c0bA:
undetectable		 2qjuA-6c0bA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 6c0b TOXIN B
(Clostridioides
difficile) 		5 / 12 SER A1403
THR A1405
VAL A1348
LEU A1327
ILE A1389
 None
 1.49A 2xrlA-6c0bA:
undetectable		 2xrlA-6c0bA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 6c0b TOXIN B
(Clostridioides
difficile) 		3 / 3 LYS A1521
ILE A1624
PHE A1623
 None
 0.51A 3j7zS-6c0bA:
undetectable
3j7za-6c0bA:
undetectable		 3j7zS-6c0bA:
undetectable
3j7za-6c0bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 6c0b FRIZZLED-2
(Homo
sapiens) 		4 / 6 GLY B 152
ILE B 113
GLN B 153
SER B 112
 None
 1.01A 4d39B-6c0bB:
undetectable		 4d39B-6c0bB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6c0b FRIZZLED-2
(Homo
sapiens) 		4 / 6 GLY B 152
ILE B 113
GLN B 153
SER B 112
 None
 1.09A 4kcnA-6c0bB:
undetectable		 4kcnA-6c0bB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6c0b TOXIN B
(Clostridioides
difficile) 		4 / 6 GLY A1529
PHE A1594
ILE A1593
PHE A1604
 None
 1.08A 4qogA-6c0bA:
undetectable
4qogB-6c0bA:
undetectable		 4qogA-6c0bA:
17.24
4qogB-6c0bA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_A_ASCA501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 6c0b FRIZZLED-2
(Homo
sapiens) 		5 / 11 THR B  55
TYR B  52
ILE B  44
GLN B  66
MET B  57
 None
 1.50A 4rp8A-6c0bB:
undetectable		 4rp8A-6c0bB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP9_A_ASCA501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 6c0b FRIZZLED-2
(Homo
sapiens) 		5 / 12 THR B  55
TYR B  52
ILE B  44
GLN B  66
MET B  57
 None
 1.50A 4rp9A-6c0bB:
undetectable		 4rp9A-6c0bB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 6c0b TOXIN B
(Clostridioides
difficile) 		3 / 3 LYS A1364
ASP A1366
ILE A1357
 None
 0.86A 5kc4E-6c0bA:
undetectable		 5kc4E-6c0bA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 6c0b FRIZZLED-2
TOXIN B
(Clostridioides
difficile;
Homo
sapiens) 		5 / 12 LEU A1488
ASP A1490
LEU A1527
VAL A1518
PHE B 128
 None
None
None
None
PAM  B 202 (-3.9A)
 1.04A 5uxdB-6c0bA:
undetectable		 5uxdB-6c0bA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 6c0b TOXIN B
(Clostridioides
difficile) 		4 / 6 PHE A1782
VAL A1719
LEU A1776
LEU A1780
 None
 0.84A 6e43A-6c0bA:
undetectable		 6e43A-6c0bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 6c0b TOXIN B
(Clostridioides
difficile) 		4 / 6 PHE A1782
VAL A1719
LEU A1776
LEU A1780
 None
 0.82A 6e43B-6c0bA:
undetectable		 6e43B-6c0bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 6c0b TOXIN B
(Clostridioides
difficile) 		4 / 6 PHE A1782
VAL A1719
LEU A1776
LEU A1780
 None
 0.85A 6e43C-6c0bA:
undetectable		 6e43C-6c0bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 6c0b TOXIN B
(Clostridioides
difficile) 		4 / 6 PHE A1782
VAL A1719
LEU A1776
LEU A1780
 None
 0.84A 6e43D-6c0bA:
undetectable		 6e43D-6c0bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 6c0b TOXIN B
(Clostridioides
difficile) 		5 / 11 ASP A1748
PHE A1767
ILE A1750
LEU A1751
LEU A1780
 None
 1.38A 6fgcA-6c0bA:
undetectable		 6fgcA-6c0bA:
21.69