SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6c0e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		5 / 11 HIS A 372
LEU A 134
GLY A 331
PHE A 341
VAL A 132
 None
 1.39A 1axwB-6c0eA:
undetectable		 1axwB-6c0eA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		4 / 8 THR A 396
GLY A 360
ALA A 415
ILE A 363
 None
 0.79A 1c9sI-6c0eA:
undetectable
1c9sJ-6c0eA:
undetectable		 1c9sI-6c0eA:
undetectable
1c9sJ-6c0eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		4 / 8 GLY A 360
ALA A 415
ILE A 363
THR A 396
 None
 0.79A 1c9sU-6c0eA:
undetectable
1c9sV-6c0eA:
undetectable		 1c9sU-6c0eA:
undetectable
1c9sV-6c0eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		4 / 7 GLY A 360
ALA A 415
ILE A 363
THR A 396
 None
 0.79A 1gtnA-6c0eA:
undetectable
1gtnK-6c0eA:
undetectable		 1gtnA-6c0eA:
undetectable
1gtnK-6c0eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		4 / 7 SER A 411
GLY A 327
HIS A 345
THR A 396
 None
EE1  A 501 ( 3.7A)
EE1  A 501 (-3.6A)
None
 0.95A 1gtnJ-6c0eA:
undetectable
1gtnK-6c0eA:
undetectable		 1gtnJ-6c0eA:
undetectable
1gtnK-6c0eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		5 / 12 GLY A 413
ALA A 389
GLY A 360
THR A 396
ILE A 328
 None
 0.99A 1gtnL-6c0eA:
undetectable
1gtnV-6c0eA:
undetectable		 1gtnL-6c0eA:
undetectable
1gtnV-6c0eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		4 / 8 GLY A 360
ALA A 415
ILE A 363
THR A 396
 None
 0.80A 1utdI-6c0eA:
undetectable
1utdJ-6c0eA:
undetectable		 1utdI-6c0eA:
undetectable
1utdJ-6c0eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		5 / 12 SER A 361
ALA A 320
GLY A 324
PHE A 399
VAL A 357
 None
None
None
None
EE1  A 501 (-4.0A)
 1.19A 1vpoH-6c0eA:
undetectable
1vpoL-6c0eA:
undetectable		 1vpoH-6c0eA:
14.98
1vpoL-6c0eA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		5 / 11 ILE A  38
GLY A  42
THR A 347
LEU A 120
GLY A 107
 None
None
EE1  A 501 (-3.6A)
None
None
 1.31A 2fn1A-6c0eA:
undetectable		 2fn1A-6c0eA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		5 / 12 TYR A 351
ILE A  43
HIS A 345
GLY A 325
MET A 368
 EE1  A 501 (-4.4A)
None
EE1  A 501 (-3.6A)
None
None
 1.46A 2nyrB-6c0eA:
undetectable		 2nyrB-6c0eA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		4 / 6 ILE A  19
ILE A  52
LEU A  27
MET A 369
 None
 0.97A 3adsA-6c0eA:
undetectable		 3adsA-6c0eA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		3 / 3 SER A 316
GLU A 342
ASP A 313
 None
EE1  A 501 (-3.4A)
EE1  A 501 (-3.4A)
 0.84A 3bwmA-6c0eA:
2.5		 3bwmA-6c0eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		5 / 11 VAL A 143
PRO A 144
ILE A 383
ILE A 363
PRO A 330
 None
 1.36A 3ganA-6c0eA:
undetectable		 3ganA-6c0eA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		5 / 12 PHE A 414
PHE A 399
GLY A 324
GLY A 360
LEU A 364
 None
 1.00A 3hs6B-6c0eA:
undetectable		 3hs6B-6c0eA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		4 / 6 ALA A  76
ILE A  38
LEU A 109
ALA A 123
 None
 0.82A 3r9sC-6c0eA:
undetectable		 3r9sC-6c0eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		4 / 8 ALA A  76
ILE A  38
LEU A 109
ALA A 123
 None
 0.75A 3r9tA-6c0eA:
undetectable		 3r9tA-6c0eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		5 / 12 VAL A  55
ILE A 105
ILE A 334
MET A 373
LEU A 370
 None
 1.22A 4a84A-6c0eA:
undetectable		 4a84A-6c0eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		4 / 5 ILE A 419
ALA A  58
HIS A 421
MET A 422
 None
 1.33A 4acaB-6c0eA:
2.4
4acaC-6c0eA:
2.5		 4acaB-6c0eA:
undetectable
4acaC-6c0eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		5 / 12 PHE A 414
PHE A 399
GLY A 324
GLY A 360
LEU A 364
 None
 1.10A 4e1gB-6c0eA:
undetectable		 4e1gB-6c0eA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		4 / 7 GLY A 168
GLN A 126
ILE A 169
PRO A 206
 None
 1.08A 4e1vB-6c0eA:
undetectable		 4e1vB-6c0eA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		3 / 3 PRO A  36
MET A  72
TYR A 101
 None
 1.05A 4qa0B-6c0eA:
2.7		 4qa0B-6c0eA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		3 / 3 PRO A  36
MET A  72
TYR A 101
 None
 1.11A 4qa0A-6c0eA:
3.0		 4qa0A-6c0eA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		4 / 8 ARG A  53
ASP A 416
PHE A 414
VAL A  47
 None
 1.09A 4xqgA-6c0eA:
2.5		 4xqgA-6c0eA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		4 / 8 ARG A  53
ASP A 416
PHE A 414
VAL A  47
 None
 1.09A 4xqgB-6c0eA:
undetectable		 4xqgB-6c0eA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		5 / 12 GLY A  40
PHE A 399
ILE A 390
GLY A 324
THR A 347
 None
None
None
None
EE1  A 501 (-3.6A)
 1.29A 5eslA-6c0eA:
undetectable		 5eslA-6c0eA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		5 / 10 TYR A 139
GLY A 402
PHE A 399
GLY A 324
VAL A 395
 None
 1.24A 5i6xA-6c0eA:
undetectable		 5i6xA-6c0eA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		3 / 3 GLY A 115
GLY A 114
GLN A 172
 None
 0.44A 5imsA-6c0eA:
undetectable		 5imsA-6c0eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		5 / 9 VAL A  55
GLY A  44
VAL A  47
MET A  51
GLY A  40
 None
 1.39A 5zniA-6c0eA:
undetectable		 5zniA-6c0eA:
28.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		3 / 3 TRP A 250
GLU A 210
GLU A 163
 None
 0.96A 6fhwA-6c0eA:
undetectable		 6fhwA-6c0eA:
18.07