SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6c2h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_2
(PROTEIN (PROTEASE))		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 166
GLY A 203
ILE A 204
THR A 197
ILE A  56
 PGE  A 409 ( 4.3A)
None
None
PLP  A 401 (-2.9A)
None
 0.85A 1c6yB-6c2hA:
undetectable		 1c6yB-6c2hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  39
ALA A 315
ALA A  41
PHE A 294
ALA A 293
 None
 1.09A 1fbyA-6c2hA:
undetectable		 1fbyA-6c2hA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 ILE A  56
GLY A 199
THR A 200
HIS A 167
GLY A 196
 None
PLP  A 401 (-3.9A)
PLP  A 401 (-3.5A)
None
PLP  A 401 (-3.6A)
 1.09A 1i7qA-6c2hA:
undetectable		 1i7qA-6c2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_C_BEZC1502_0
(ANTHRANILATE
SYNTHASE)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 10 ILE A  56
GLY A 199
THR A 200
HIS A 167
GLY A 196
 None
PLP  A 401 (-3.9A)
PLP  A 401 (-3.5A)
None
PLP  A 401 (-3.6A)
 1.11A 1i7qC-6c2hA:
undetectable		 1i7qC-6c2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 255
ALA A 193
ALA A 195
VAL A 251
GLN A 229
 None
None
PLP  A 401 (-4.3A)
None
None
 1.21A 1kt4A-6c2hA:
undetectable		 1kt4A-6c2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 167
ALA A 166
PHE A 169
GLY A 203
 None
PGE  A 409 ( 4.3A)
PGE  A 409 (-4.2A)
None
 1.08A 1mj2B-6c2hA:
undetectable		 1mj2B-6c2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 167
ALA A 166
PHE A 169
GLY A 203
 None
PGE  A 409 ( 4.3A)
PGE  A 409 (-4.2A)
None
 1.06A 1mj2D-6c2hA:
undetectable		 1mj2D-6c2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 167
ALA A 166
PHE A 169
GLY A 203
 None
PGE  A 409 ( 4.3A)
PGE  A 409 (-4.2A)
None
 1.04A 1mjoB-6c2hA:
undetectable		 1mjoB-6c2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 167
ALA A 166
PHE A 169
GLY A 203
 None
PGE  A 409 ( 4.3A)
PGE  A 409 (-4.2A)
None
 1.02A 1mjoA-6c2hA:
undetectable		 1mjoA-6c2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 167
ALA A 166
PHE A 169
GLY A 203
 None
PGE  A 409 ( 4.3A)
PGE  A 409 (-4.2A)
None
 1.07A 1mjoD-6c2hA:
undetectable		 1mjoD-6c2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 166
GLY A 203
ILE A 204
THR A 197
ILE A  56
 PGE  A 409 ( 4.3A)
None
None
PLP  A 401 (-2.9A)
None
 0.91A 1ohrA-6c2hA:
undetectable		 1ohrA-6c2hA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 10 SER A 289
GLY A 287
GLU A 244
SER A 290
ILE A 321
 PLP  A 401 (-2.6A)
None
None
None
None
 1.42A 1pw7A-6c2hA:
2.8		 1pw7A-6c2hA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 125
ASP A 240
TYR A 241
GLU A 106
 None
 1.33A 1rjdB-6c2hA:
2.1		 1rjdB-6c2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 125
ASP A 240
TYR A 241
GLU A 106
 None
 1.31A 1rjdC-6c2hA:
undetectable		 1rjdC-6c2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 268
PHE A 272
LEU A 334
TRP A 333
 None
None
None
EDO  A 410 (-4.2A)
 0.93A 1rmtD-6c2hA:
2.3		 1rmtD-6c2hA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 9 GLY A  88
ALA A  57
LEU A  89
TYR A  98
LEU A 155
 None
 1.17A 1y7iA-6c2hA:
undetectable		 1y7iA-6c2hA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 7 THR A  81
PRO A  80
HIS A 138
GLY A 245
 ACT  A 402 (-3.5A)
None
None
PLP  A 401 ( 3.9A)
 1.05A 2ddwB-6c2hA:
2.3		 2ddwB-6c2hA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 293
GLN A 157
THR A 197
ILE A  52
ASP A 319
 None
ACT  A 402 (-3.0A)
PLP  A 401 (-2.9A)
None
PLP  A 401 (-3.3A)
 1.05A 2v95A-6c2hA:
undetectable		 2v95A-6c2hA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 260
LEU A 259
GLY A 203
GLY A 198
 None
None
None
PLP  A 401 (-3.3A)
 0.75A 2wd9A-6c2hA:
undetectable		 2wd9A-6c2hA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 260
LEU A 259
GLY A 203
GLY A 198
 None
None
None
PLP  A 401 (-3.3A)
 0.75A 2wd9B-6c2hA:
undetectable		 2wd9B-6c2hA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 247
THR A 236
LEU A 227
ASP A 221
ALA A 228
 None
EDO  A 412 (-3.6A)
None
None
None
 1.29A 3d91A-6c2hA:
undetectable		 3d91A-6c2hA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  39
ALA A 315
ALA A  41
PHE A 294
ALA A 293
 None
 1.01A 3e00A-6c2hA:
undetectable		 3e00A-6c2hA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_1
(PROTEASE)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 166
GLY A 203
ILE A 204
THR A 197
ILE A  56
 PGE  A 409 ( 4.3A)
None
None
PLP  A 401 (-2.9A)
None
 0.93A 3ekxA-6c2hA:
undetectable		 3ekxA-6c2hA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 10 ILE A  39
ALA A 315
ALA A  41
PHE A 294
ALA A 293
 None
 1.04A 3falA-6c2hA:
undetectable		 3falA-6c2hA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 115
ILE A  52
ASN A  47
GLY A  49
 None
 0.85A 3hjoB-6c2hA:
undetectable		 3hjoB-6c2hA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 179
GLN A 178
PHE A 185
ILE A 215
LEU A 208
 None
 1.25A 3ia4C-6c2hA:
2.7		 3ia4C-6c2hA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  90
GLY A  93
GLY A 120
LEU A 116
ALA A  57
 None
None
NA  A 404 (-4.0A)
None
None
 1.15A 3ou6B-6c2hA:
2.3		 3ou6B-6c2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  90
GLY A  93
GLY A 120
LEU A 116
ALA A  57
 None
None
NA  A 404 (-4.0A)
None
None
 1.16A 3ou7B-6c2hA:
2.3		 3ou7B-6c2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_3
(PROTEASE)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 172
ILE A  56
GLY A 199
ILE A 201
PRO A 318
 None
None
PLP  A 401 (-3.9A)
None
PLP  A 401 (-4.0A)
 1.03A 3oxcB-6c2hA:
undetectable		 3oxcB-6c2hA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_1
(PROTEASE)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 166
GLY A 203
ILE A 204
THR A 197
ILE A  56
 PGE  A 409 ( 4.3A)
None
None
PLP  A 401 (-2.9A)
None
 0.84A 3tkgC-6c2hA:
undetectable		 3tkgC-6c2hA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		3 / 3 ASN A  20
GLU A 174
ARG A 177
 None
 0.92A 3wxoA-6c2hA:
undetectable		 3wxoA-6c2hA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 5 PRO A  48
ASP A  54
ILE A  95
VAL A  61
 None
 1.24A 4hytA-6c2hA:
2.3		 4hytA-6c2hA:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_1
(MEMBRANE LIPOPROTEIN
TPN38(B))		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 SER A 225
TYR A 158
ILE A 139
GLY A 247
ASP A 249
 None
 1.43A 4iilA-6c2hA:
undetectable		 4iilA-6c2hA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA207_0
(OXIDOREDUCTASE)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 4 GLU A 174
GLY A 172
HIS A 167
ARG A  55
 None
 1.21A 4r82A-6c2hA:
undetectable
4r82B-6c2hA:
undetectable		 4r82A-6c2hA:
undetectable
4r82B-6c2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 6 LYS A 335
LEU A 334
LEU A 345
VAL A 344
 None
 1.16A 4uswA-6c2hA:
undetectable		 4uswA-6c2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 274
PHE A 317
ILE A  35
LEU A  29
 None
 0.87A 4uymA-6c2hA:
undetectable		 4uymA-6c2hA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 274
PHE A 317
ILE A  35
LEU A  29
 None
 0.83A 4uymB-6c2hA:
undetectable		 4uymB-6c2hA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		3 / 3 ASP A  54
ASN A 163
GLN A 157
 None
PLP  A 401 ( 4.8A)
ACT  A 402 (-3.0A)
 0.75A 5k7uA-6c2hA:
undetectable		 5k7uA-6c2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		3 / 3 THR A  21
GLU A 174
HIS A 167
 None
 0.91A 5xioA-6c2hA:
2.6		 5xioA-6c2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		3 / 3 THR A  21
GLU A 174
HIS A 167
 None
 0.91A 5xiqB-6c2hA:
undetectable		 5xiqB-6c2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		3 / 3 THR A  21
GLU A 174
HIS A 167
 None
 0.93A 5xiqD-6c2hA:
2.6		 5xiqD-6c2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  39
ALA A 315
ALA A  41
PHE A 294
ALA A 293
 None
 1.03A 5z12C-6c2hA:
undetectable		 5z12C-6c2hA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 9 ASP A 319
ILE A 316
SER A 289
GLY A 194
THR A 171
 PLP  A 401 (-3.3A)
None
PLP  A 401 (-2.6A)
None
None
 1.47A 6awpA-6c2hA:
undetectable		 6awpA-6c2hA:
10.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 6c2h CYSTATHIONINE
BETA-SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 SER A 205
GLY A 203
ILE A 204
PHE A 185
ILE A 215
 None
 1.05A 6ebzC-6c2hA:
undetectable		 6ebzC-6c2hA:
36.47