SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6c2j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 6c2j RNAP2
(Escherichia
virus
N4) 		4 / 5 ARG B  91
ALA B  94
ASP B 389
GLY B  89
 None
 1.13A 1e7bA-6c2jB:
undetectable		 1e7bA-6c2jB:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 6c2j RNAP2
(Escherichia
virus
N4) 		4 / 5 ARG B  91
ALA B  94
ASP B 389
GLY B  89
 None
 1.06A 1e7cA-6c2jB:
undetectable		 1e7cA-6c2jB:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK4_A_T44A1008_1
(SERUM ALBUMIN)		 6c2j RNAP1
RNAP2
(Escherichia
virus
N4) 		5 / 10 ASP B 353
GLU A 266
ASN B 349
TYR B   9
VAL B  72
 None
 1.32A 1hk4A-6c2jB:
1.5		 1hk4A-6c2jB:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 6c2j RNAP2
(Escherichia
virus
N4) 		3 / 3 ARG B  91
THR B 399
VAL B 100
 None
 0.93A 1hxbA-6c2jB:
undetectable		 1hxbA-6c2jB:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 6c2j RNAP1
RNAP2
(Escherichia
virus
N4;
Escherichia
virus
N4) 		4 / 4 GLY B 249
LEU B 250
GLY A 239
ARG B 253
 None
 1.18A 1j7kA-6c2jB:
undetectable		 1j7kA-6c2jB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 6c2j RNAP2
(Escherichia
virus
N4) 		4 / 7 ILE B 266
ILE B 269
LYS B 270
THR B 320
 None
 0.98A 1sbrB-6c2jB:
undetectable		 1sbrB-6c2jB:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 6c2j RNAP2
(Escherichia
virus
N4) 		3 / 3 ALA B  54
VAL B  56
TRP B  59
 None
 0.94A 1tkqB-6c2jB:
undetectable		 1tkqB-6c2jB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 6c2j RNAP2
(Escherichia
virus
N4) 		5 / 10 LEU B  87
ALA B 366
ILE B 365
VAL B  99
ALA B 402
 None
 1.16A 1xp0A-6c2jB:
undetectable		 1xp0A-6c2jB:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 6c2j RNAP2
(Escherichia
virus
N4) 		5 / 12 GLY B  89
LEU B  84
ASP B 389
LEU B 392
PRO B 174
 None
 1.09A 2f8lA-6c2jB:
undetectable		 2f8lA-6c2jB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 6c2j RNAP2
(Escherichia
virus
N4) 		3 / 3 ARG B  91
THR B 399
VAL B 100
 None
 0.68A 2q64A-6c2jB:
undetectable		 2q64A-6c2jB:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 6c2j RNAP2
(Escherichia
virus
N4) 		3 / 3 ARG B  91
THR B 399
VAL B 100
 None
 0.74A 2qakA-6c2jB:
undetectable		 2qakA-6c2jB:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 6c2j RNAP2
(Escherichia
virus
N4) 		5 / 12 TYR B 358
LEU B 362
ILE B 365
ALA B  76
THR B 244
 None
 1.40A 2qo4A-6c2jB:
undetectable		 2qo4A-6c2jB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 6c2j RNAP2
(Escherichia
virus
N4) 		5 / 12 LEU B 145
LEU B  87
GLY B  89
VAL B 251
ILE B 247
 None
 1.06A 3c6gA-6c2jB:
undetectable		 3c6gA-6c2jB:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 6c2j RNAP2
(Escherichia
virus
N4) 		4 / 5 ALA B  73
ALA B 402
TYR B 401
MET B   1
 None
 1.23A 3d91A-6c2jB:
undetectable		 3d91A-6c2jB:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 6c2j RNAP2
(Escherichia
virus
N4) 		4 / 7 GLU B  23
TRP B  31
LEU B  42
ASN B  35
 None
 1.10A 3k8mA-6c2jB:
undetectable		 3k8mA-6c2jB:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 6c2j RNAP2
(Escherichia
virus
N4) 		4 / 7 GLU B  23
TRP B  31
LEU B  42
ASN B  35
 None
 1.40A 3k8mB-6c2jB:
undetectable		 3k8mB-6c2jB:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 6c2j RNAP1
(Escherichia
virus
N4) 		4 / 5 LEU A 124
GLY A 245
PHE A 229
ASN A 256
 None
 1.09A 3uq6B-6c2jA:
undetectable		 3uq6B-6c2jA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_2
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 6c2j RNAP1
RNAP2
(Escherichia
virus
N4) 		4 / 4 PRO B 331
LEU B 255
HIS A 163
LEU A 164
 None
 1.40A 3vw7A-6c2jB:
0.9		 3vw7A-6c2jB:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 6c2j RNAP1
RNAP2
(Escherichia
virus
N4) 		4 / 8 SER B 246
ASN B 242
ARG A 238
GLY B  80
 None
 1.02A 4af0A-6c2jB:
undetectable		 4af0A-6c2jB:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 6c2j RNAP2
(Escherichia
virus
N4) 		4 / 5 LEU B 179
LEU B 371
THR B 243
TRP B 196
 None
 1.19A 4do3A-6c2jB:
undetectable		 4do3A-6c2jB:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 6c2j RNAP2
(Escherichia
virus
N4) 		5 / 9 VAL B 100
VAL B 396
GLU B 394
GLY B  89
ALA B  93
 None
 1.07A 4fwdA-6c2jB:
undetectable		 4fwdA-6c2jB:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 6c2j RNAP2
(Escherichia
virus
N4) 		4 / 6 ILE B  12
PHE B   4
ARG B 355
GLU B 400
 None
 1.30A 4zzcA-6c2jB:
undetectable
4zzcB-6c2jB:
undetectable		 4zzcA-6c2jB:
undetectable
4zzcB-6c2jB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 6c2j RNAP2
(Escherichia
virus
N4) 		4 / 6 ILE B  12
PHE B   4
ARG B 355
GLU B 400
 None
 1.31A 4zzcB-6c2jB:
undetectable
4zzcC-6c2jB:
undetectable		 4zzcB-6c2jB:
undetectable
4zzcC-6c2jB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 6c2j RNAP2
(Escherichia
virus
N4) 		3 / 3 TRP B 183
ILE B 247
SER B 246
 None
 0.90A 5gqbA-6c2jB:
undetectable		 5gqbA-6c2jB:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 6c2j RNAP2
(Escherichia
virus
N4) 		5 / 10 ILE B 323
ILE B 269
VAL B 318
THR B 314
ASN B 285
 None
 1.28A 5lg3G-6c2jB:
0.7		 5lg3G-6c2jB:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 6c2j RNAP2
(Escherichia
virus
N4) 		5 / 10 ILE B 323
ILE B 269
VAL B 318
THR B 314
ASN B 285
 None
 1.27A 5lg3H-6c2jB:
undetectable		 5lg3H-6c2jB:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 6c2j RNAP2
(Escherichia
virus
N4) 		4 / 8 PHE B 335
ARG B 355
GLN B 357
ILE B 354
 None
 0.96A 5nzxA-6c2jB:
undetectable		 5nzxA-6c2jB:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 6c2j RNAP1
(Escherichia
virus
N4) 		3 / 3 LYS A 265
LYS A 228
SER A 173
 None
 1.42A 5odiA-6c2jA:
undetectable		 5odiA-6c2jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 6c2j RNAP2
(Escherichia
virus
N4) 		5 / 9 LEU B  81
ALA B  94
VAL B 396
CYH B  86
THR B 244
 None
 1.49A 5w5vA-6c2jB:
undetectable		 5w5vA-6c2jB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 6c2j RNAP1
RNAP2
(Escherichia
virus
N4;
Escherichia
virus
N4) 		5 / 9 VAL A 178
HIS A 180
ASP A 177
LEU B  39
ASP B  61
 None
 1.27A 6c2mB-6c2jA:
undetectable		 6c2mB-6c2jA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 6c2j RNAP1
(Escherichia
virus
N4) 		4 / 7 LEU A 260
TYR A 211
VAL A 259
TRP A 176
 None
 1.38A 6g2pA-6c2jA:
undetectable		 6g2pA-6c2jA:
undetectable