SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6c33'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_2
(PROTEASE)		 6c33 5'-3' EXONUCLEASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A   7
ASP A 148
VAL A 163
VAL A 140
VAL A 142
 None
MN  A 403 ( 1.9A)
None
None
None
 0.88A 2ieoB-6c33A:
undetectable		 2ieoB-6c33A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 6c33 5'-3' EXONUCLEASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ASP A 126
ASP A   9
ASP A  62
 None
MN  A 401 ( 4.1A)
None
 0.70A 2igtA-6c33A:
undetectable		 2igtA-6c33A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 6c33 5'-3' EXONUCLEASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 PHE A  39
ILE A 114
VAL A 141
LEU A  55
LEU A 166
 None
 1.27A 2rctA-6c33A:
undetectable		 2rctA-6c33A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 6c33 5'-3' EXONUCLEASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 PHE A  39
ILE A 114
VAL A 141
LEU A  55
LEU A 170
 None
 1.11A 2rctA-6c33A:
undetectable		 2rctA-6c33A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 6c33 5'-3' EXONUCLEASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 114
LEU A  55
MET A  13
ILE A 105
VAL A 294
 None
 1.18A 3a51C-6c33A:
undetectable		 3a51C-6c33A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 6c33 5'-3' EXONUCLEASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 LEU A 231
VAL A 266
ARG A 268
 None
 0.79A 3b0wB-6c33A:
undetectable		 3b0wB-6c33A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 6c33 5'-3' EXONUCLEASE
(Mycolicibacteriu
m
smegmatis) 		4 / 4 LEU A  55
ARG A 309
LEU A 310
ALA A  42
 None
 1.12A 3b9mA-6c33A:
undetectable		 3b9mA-6c33A:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 6c33 5'-3' EXONUCLEASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ASP A 205
SER A 207
ARG A 147
 MN  A 403 (-2.8A)
None
None
 0.85A 3loqA-6c33A:
3.5		 3loqA-6c33A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_A_URFA521_1
(RNA DEPENDENT RNA
POLYMERASE)		 6c33 5'-3' EXONUCLEASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ARG A  79
ASP A 125
ASP A 146
ASP A   9
 None
MN  A 401 ( 2.7A)
MN  A 402 (-2.7A)
MN  A 401 ( 4.1A)
 1.46A 3naiA-6c33A:
undetectable		 3naiA-6c33A:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_C_URFC521_1
(RNA DEPENDENT RNA
POLYMERASE)		 6c33 5'-3' EXONUCLEASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ARG A  79
ASP A 125
ASP A 146
ASP A   9
 None
MN  A 401 ( 2.7A)
MN  A 402 (-2.7A)
MN  A 401 ( 4.1A)
 1.48A 3naiC-6c33A:
undetectable		 3naiC-6c33A:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 6c33 5'-3' EXONUCLEASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 GLY A 129
ALA A 124
VAL A 269
VAL A 142
CYH A  58
 None
MN  A 401 ( 4.9A)
None
None
None
 1.38A 4c5lB-6c33A:
undetectable		 4c5lB-6c33A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 6c33 5'-3' EXONUCLEASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 GLY A 129
ALA A 124
VAL A 269
VAL A 142
CYH A  58
 None
MN  A 401 ( 4.9A)
None
None
None
 1.30A 4c5lD-6c33A:
undetectable		 4c5lD-6c33A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6c33 5'-3' EXONUCLEASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 ASP A 208
ASP A   9
GLU A  92
ASP A 125
 MN  A 403 (-2.9A)
MN  A 401 ( 4.1A)
None
MN  A 401 ( 2.7A)
 1.10A 4feuB-6c33A:
undetectable		 4feuB-6c33A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 6c33 5'-3' EXONUCLEASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 LEU A 253
LEU A 235
ALA A 238
HIS A 228
LEU A 245
 None
 0.85A 4p65E-6c33A:
undetectable
4p65F-6c33A:
undetectable
4p65J-6c33A:
undetectable
4p65L-6c33A:
undetectable		 4p65E-6c33A:
undetectable
4p65F-6c33A:
undetectable
4p65J-6c33A:
undetectable
4p65L-6c33A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 6c33 5'-3' EXONUCLEASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 PHE A  39
ILE A 114
VAL A 141
LEU A  55
LEU A 166
 None
 1.31A 4qynA-6c33A:
undetectable		 4qynA-6c33A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 6c33 5'-3' EXONUCLEASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 PHE A  39
ILE A 114
VAL A 141
LEU A  55
LEU A 170
 None
 1.20A 4qynA-6c33A:
undetectable		 4qynA-6c33A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 6c33 5'-3' EXONUCLEASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 PHE A  39
ILE A 114
VAL A 141
LEU A  55
LEU A 170
 None
 1.03A 4qzuC-6c33A:
undetectable		 4qzuC-6c33A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 6c33 5'-3' EXONUCLEASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ASP A   9
ALA A 119
ASP A  61
GLY A 129
GLY A 118
 MN  A 401 ( 4.1A)
None
None
None
None
 1.11A 4xnxA-6c33A:
undetectable		 4xnxA-6c33A:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 6c33 5'-3' EXONUCLEASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 ALA A 256
ARG A 203
GLY A 217
GLU A 218
 None
 1.02A 5bs8A-6c33A:
undetectable
5bs8B-6c33A:
undetectable
5bs8C-6c33A:
undetectable		 5bs8A-6c33A:
11.42
5bs8B-6c33A:
15.02
5bs8C-6c33A:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 6c33 5'-3' EXONUCLEASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 ALA A 256
ARG A 203
GLY A 217
GLU A 218
 None
 0.96A 5btdA-6c33A:
undetectable
5btdB-6c33A:
undetectable
5btdC-6c33A:
undetectable		 5btdA-6c33A:
11.42
5btdB-6c33A:
15.02
5btdC-6c33A:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 6c33 5'-3' EXONUCLEASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 ALA A 256
ARG A 203
GLY A 217
GLU A 218
 None
 0.93A 5btdA-6c33A:
undetectable
5btdC-6c33A:
undetectable
5btdD-6c33A:
undetectable		 5btdA-6c33A:
11.42
5btdC-6c33A:
11.42
5btdD-6c33A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 6c33 5'-3' EXONUCLEASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 224
ILE A 234
LEU A 201
ILE A 260
ALA A 261
 None
 1.19A 6qyaB-6c33A:
undetectable		 6qyaB-6c33A:
undetectable