SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6c3b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 6c3b UNCHARACTERIZED
PROTEIN
(Streptomyces
cattleya) 		5 / 12 LEU A 194
MET A 216
SER A 223
VAL A 225
ILE A 197
 None
 1.37A 1uobA-6c3bA:
undetectable		 1uobA-6c3bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_B_ANWB99_0
(PROTEIN S100-A13)		 6c3b UNCHARACTERIZED
PROTEIN
(Streptomyces
cattleya) 		4 / 8 MET A 368
ALA A 323
VAL A 320
THR A 296
 None
 1.02A 2kotB-6c3bA:
undetectable		 2kotB-6c3bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 6c3b UNCHARACTERIZED
PROTEIN
(Streptomyces
cattleya) 		5 / 12 LEU A 370
ALA A 380
LEU A 341
LEU A 306
CYH A 301
 None
 1.37A 2oaxE-6c3bA:
undetectable		 2oaxE-6c3bA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 6c3b UNCHARACTERIZED
PROTEIN
(Streptomyces
cattleya) 		5 / 12 PHE A  73
PHE A 181
LEU A 174
ALA A 202
PHE A 199
 None
 1.34A 3apxA-6c3bA:
undetectable		 3apxA-6c3bA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 6c3b UNCHARACTERIZED
PROTEIN
(Streptomyces
cattleya) 		4 / 6 ILE A 230
ALA A 229
THR A 248
ALA A  82
 None
None
EDO  A 402 (-4.5A)
None
 1.03A 3mdrB-6c3bA:
undetectable		 3mdrB-6c3bA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 6c3b UNCHARACTERIZED
PROTEIN
(Streptomyces
cattleya) 		5 / 12 LEU A 370
ALA A 380
LEU A 341
LEU A 306
CYH A 301
 None
 1.37A 3vhuA-6c3bA:
undetectable		 3vhuA-6c3bA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 6c3b UNCHARACTERIZED
PROTEIN
(Streptomyces
cattleya) 		4 / 6 ASP A 137
ASP A 198
ASN A 166
GLU A 138
 None
LLP  A 235 ( 2.8A)
EDO  A 403 ( 4.7A)
EDO  A 405 ( 4.6A)
 1.29A 3vywA-6c3bA:
2.4		 3vywA-6c3bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 6c3b UNCHARACTERIZED
PROTEIN
(Streptomyces
cattleya) 		4 / 5 ASP A 137
ASP A 198
ASN A 166
GLU A 138
 None
LLP  A 235 ( 2.8A)
EDO  A 403 ( 4.7A)
EDO  A 405 ( 4.6A)
 1.23A 3vywD-6c3bA:
2.2		 3vywD-6c3bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 6c3b UNCHARACTERIZED
PROTEIN
(Streptomyces
cattleya) 		5 / 12 LEU A 195
LEU A 160
LEU A 105
ILE A 253
VAL A 257
 None
None
None
None
EDO  A 402 (-3.7A)
 1.11A 4ok1A-6c3bA:
undetectable		 4ok1A-6c3bA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 6c3b UNCHARACTERIZED
PROTEIN
(Streptomyces
cattleya) 		5 / 12 PHE A 141
ILE A 230
THR A 113
ALA A 202
THR A 205
 EDO  A 403 ( 4.2A)
None
None
None
None
 1.21A 5vcgA-6c3bA:
undetectable		 5vcgA-6c3bA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_1
(STIE PROTEIN)		 6c3b UNCHARACTERIZED
PROTEIN
(Streptomyces
cattleya) 		4 / 5 THR A 296
THR A  35
GLN A  37
ASP A  32
 None
LLP  A 235 ( 4.4A)
None
None
 1.37A 6ectA-6c3bA:
3.5		 6ectA-6c3bA:
undetectable