SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6c3p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1D4F_B_ADNB602_1 (S-ADENOSYLHOMOCYSTEI NE HYDROLASE)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	5 / 12	LEU E 885 LEU E 876 LEU E 875 GLY E 871 PHE E 856	None	1.45A	1d4fB-6c3pE: undetectable	1d4fB-6c3pE: 13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LQT_B_ACTB1873_0 (FPRA)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	3 / 3	ASP E 865 ASP E 860 LYS E 889	None	1.13A	1lqtB-6c3pE: undetectable	1lqtB-6c3pE: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LQU_B_ACTB1430_0 (FPRA)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	3 / 3	ASP E 865 ASP E 860 LYS E 889	None	1.14A	1lquB-6c3pE: undetectable	1lquB-6c3pE: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SBR_A_VIBA501_1 (YKOF)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	4 / 8	PHE E 432 LEU E 387 ILE E 395 ILE E 391	None	0.80A	1sbrA-6c3pE: undetectable	1sbrA-6c3pE: 15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TW4_A_CHDA130_0 (FATTY ACID-BINDING PROTEIN)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	5 / 12	LEU E 364 LEU E 367 LEU E 82 ILE E 89 LEU E1260	None	1.02A	1tw4A-6c3pE: undetectable	1tw4A-6c3pE: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1U70_A_MTXA187_2 (DIHYDROFOLATE REDUCTASE)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	4 / 4	SER E1422 ILE E1423 VAL E1533 THR E1541	None	1.21A	1u70A-6c3pE: undetectable	1u70A-6c3pE: 20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1U72_A_MTXA188_1 (DIHYDROFOLATE REDUCTASE)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	5 / 12	ALA E1152 PRO E 317 LEU E 366 ARG E 370 VAL E1259	None	1.23A	1u72A-6c3pE: undetectable	1u72A-6c3pE: 16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DDW_B_PXLB1005_1 (PYRIDOXINE KINASE)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	4 / 7	SER E 403 THR E 689 PRO E 690 GLY E 410	None	0.74A	2ddwB-6c3pE: undetectable	2ddwB-6c3pE: 14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HYY_C_STIC600_2 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	4 / 6	LEU E1519 VAL E1550 ILE E1535 MET E1524	None	1.17A	2hyyC-6c3pE: undetectable	2hyyC-6c3pE: 14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QBL_A_CAMA517_0 (CYTOCHROME P450-CAM)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	4 / 7	PHE E 613 VAL E1207 THR E1206 VAL E 421	None	0.92A	2qblA-6c3pE: undetectable	2qblA-6c3pE: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ELZ_B_CHDB151_0 (ILEAL BILE ACID-BINDING PROTEIN)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	5 / 10	ILE E 701 ILE E 907 GLY E 905 PRO E 694 LEU E 723	None	1.42A	3elzB-6c3pE: undetectable	3elzB-6c3pE: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KO0_F_TFPF202_1 (PROTEIN S100-A4)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	5 / 11	LEU E 722 SER E 721 PHE E 686 ILE E 699 SER E1482	None ATP E2004 (-2.5A) None None ATP E2004 (-2.2A)	1.49A	3ko0E-6c3pE: 0.9 3ko0F-6c3pE: undetectable 3ko0G-6c3pE: undetectable 3ko0H-6c3pE: 0.9	3ko0E-6c3pE: 20.79 3ko0F-6c3pE: 20.79 3ko0G-6c3pE: 20.79 3ko0H-6c3pE: 20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q1E_C_T44C128_1 (5-HYDROXYISOURATE HYDROLASE)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	4 / 6	LEU E 508 LEU E 509 LEU E1117 LEU E 503	None	0.97A	3q1eA-6c3pE: undetectable 3q1eC-6c3pE: undetectable	3q1eA-6c3pE: 21.19 3q1eC-6c3pE: 21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q1E_C_T44C128_1 (5-HYDROXYISOURATE HYDROLASE)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	4 / 6	LEU E1117 LEU E 503 LEU E 508 LEU E 509	None	1.06A	3q1eA-6c3pE: undetectable 3q1eC-6c3pE: undetectable	3q1eA-6c3pE: 21.19 3q1eC-6c3pE: 21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RUK_A_AERA601_1 (STEROID 17-ALPHA-HYDROXYLASE /17,20 LYASE)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	5 / 12	ALA E1494 PHE E1495 ILE E1511 LEU E1519 VAL E1533	None	1.08A	3rukA-6c3pE: undetectable	3rukA-6c3pE: 11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UCJ_A_AZMA229_2 (CARBONIC ANHYDRASE)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	3 / 3	GLN E 845 PHE E 789 TYR E1218	None	0.87A	3ucjB-6c3pE: undetectable	3ucjB-6c3pE: 15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UCJ_B_AZMB229_1 (CARBONIC ANHYDRASE)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	3 / 3	GLN E 845 PHE E 789 TYR E1218	None	0.87A	3ucjA-6c3pE: undetectable	3ucjA-6c3pE: 15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W67_D_VIVD301_0 (ALPHA-TOCOPHEROL TRANSFER PROTEIN)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	5 / 12	PHE E1392 ILE E1344 ILE E1501 PHE E1495 LEU E1417	None	1.26A	3w67D-6c3pE: undetectable	3w67D-6c3pE: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AZT_A_SAMA1472_1 (METHYLTRANSFERASE WBDD)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	3 / 3	GLN E1483 ASP E1427 GLN E1426	None	0.76A	4aztA-6c3pE: undetectable	4aztA-6c3pE: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K36_A_SAMA504_0 (ANAEROBIC SULFATASE-MATURATING ENZYME)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	5 / 12	TYR E1293 GLN E 444 LEU E 586 ILE E 585 LEU E1288	None	1.45A	4k36A-6c3pE: undetectable	4k36A-6c3pE: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K36_B_SAMB504_0 (ANAEROBIC SULFATASE-MATURATING ENZYME)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	5 / 12	TYR E1293 GLN E 444 LEU E 586 ILE E 585 LEU E1288	None	1.48A	4k36B-6c3pE: undetectable	4k36B-6c3pE: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NX6_A_FOLA201_0 (DIHYDROFOLATE REDUCTASE)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	5 / 12	LEU E 614 PHE E 613 ILE E 399 LEU E 402 ILE E 417	None	1.12A	4nx6A-6c3pE: 2.5	4nx6A-6c3pE: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OBW_D_SAMD601_0 (2-METHOXY-6-POLYPREN YL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	5 / 12	ALA E1472 GLY E1468 ASN E1438 GLY E1433 ASN E1480	None None None None ATP E2004 (-4.4A)	1.14A	4obwD-6c3pE: undetectable	4obwD-6c3pE: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OBW_D_SAMD601_0 (2-METHOXY-6-POLYPREN YL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	5 / 12	ALA E1472 GLY E1468 ILE E1435 ASN E1438 GLY E1433	None	1.23A	4obwD-6c3pE: undetectable	4obwD-6c3pE: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4URN_C_NOVC2000_1 (DNA TOPOISOMERASE IV, B SUBUNIT)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	5 / 11	SER E1125 ASP E1127 ARG E 526 ILE E1104 THR E 499	None	1.42A	4urnC-6c3pE: undetectable	4urnC-6c3pE: 15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XJ7_A_ADNA303_1 (5'/3'-NUCLEOTIDASE SURE)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	5 / 10	GLY E 448 ILE E 455 PRO E 317 LEU E 451 LEU E 452	None	1.22A	4xj7A-6c3pE: undetectable 4xj7B-6c3pE: undetectable	4xj7A-6c3pE: 14.23 4xj7B-6c3pE: 14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZME_A_ADNA1002_1 (MYOSIN HEAVY CHAIN KINASE A)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	5 / 11	PHE E1495 ALA E1494 VAL E1523 LEU E1519 THR E1534	None	1.12A	4zmeA-6c3pE: undetectable	4zmeA-6c3pE: 14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZME_B_ADNB902_1 (MYOSIN HEAVY CHAIN KINASE A)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	5 / 10	PHE E1495 ALA E1494 VAL E1523 LEU E1519 THR E1534	None	1.13A	4zmeB-6c3pE: undetectable	4zmeB-6c3pE: 14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5E72_A_SAMA400_0 (N2, N2-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	5 / 12	ILE E 391 GLY E 384 ILE E 385 ILE E 423 LEU E1200	None	0.98A	5e72A-6c3pE: undetectable	5e72A-6c3pE: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEI_A_SHHA2004_1 (HDAC6 PROTEIN)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	5 / 12	HIS E 888 GLY E 713 ASP E 854 ASP E 853 LEU E 723	None None ATP E2004 ( 4.6A) MG E2002 ( 4.5A) None	1.28A	5eeiA-6c3pE: undetectable	5eeiA-6c3pE: 12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEI_B_SHHB801_1 (HDAC6 PROTEIN)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	5 / 12	HIS E 888 GLY E 713 ASP E 854 ASP E 853 LEU E 723	None None ATP E2004 ( 4.6A) MG E2002 ( 4.5A) None	1.29A	5eeiB-6c3pE: undetectable	5eeiB-6c3pE: 12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JNC_D_ACTD305_0 (CARBONIC ANHYDRASE 4)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	4 / 5	ALA E1262 ALA E1287 ILE E1156 LEU E1153	None	0.82A	5jncD-6c3pE: undetectable	5jncD-6c3pE: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KPC_A_SAMA401_1 (PAVINE N-METHYLTRANSFERASE)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	4 / 5	PHE E 613 SER E 615 ASN E 493 GLN E 416	None	1.41A	5kpcA-6c3pE: undetectable	5kpcA-6c3pE: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MWY_A_YNUA1101_0 (MINERALOCORTICOID RECEPTOR)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	5 / 12	LEU E 318 SER E 581 SER E 579 LEU E 582 LEU E 456	None	1.20A	5mwyA-6c3pE: undetectable	5mwyA-6c3pE: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5N0T_B_SAMB501_0 (PEPTIDE N-METHYLTRANSFERASE)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	5 / 12	ILE E 323 GLY E1281 VAL E1159 ALA E 355 VAL E1264	None	0.91A	5n0tB-6c3pE: undetectable	5n0tB-6c3pE: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_C_PCFC1801_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	4 / 9	LYS E 394 ILE E 395 ILE E 399 LEU E 402	None	0.76A	5vkqB-6c3pE: undetectable 5vkqC-6c3pE: undetectable	5vkqB-6c3pE: undetectable 5vkqC-6c3pE: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X2S_I_PEMI202_1 (HEMOGLOBIN SUBUNIT ALPHA HEMOGLOBIN SUBUNIT BETA)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	4 / 8	PRO E 694 THR E 689 THR E 687 PRO E1467	None	1.29A	5x2sI-6c3pE: undetectable 5x2sJ-6c3pE: undetectable 5x2sK-6c3pE: undetectable	5x2sI-6c3pE: 16.67 5x2sJ-6c3pE: 18.12 5x2sK-6c3pE: 16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6BAA_E_GBME2001_1 (ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	7 / 12	ARG E 306 ILE E 381 MET E 429 PHE E 433 ASN E 437 SER E1237 ARG E1245	None	1.08A	6baaE-6c3pE: 31.0	6baaE-6c3pE: 73.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6BAA_E_GBME2001_1 (ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	6 / 12	ARG E 306 ILE E 381 PHE E 433 ASN E 437 LEU E 592 ARG E1245	None	1.09A	6baaE-6c3pE: 31.0	6baaE-6c3pE: 73.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6BAA_F_GBMF2001_1 (ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	7 / 12	ARG E 306 ILE E 381 MET E 429 PHE E 433 ASN E 437 SER E1237 ARG E1245	None	1.08A	6baaF-6c3pE: 31.0	6baaF-6c3pE: 73.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6BAA_F_GBMF2001_1 (ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	6 / 12	ARG E 306 ILE E 381 PHE E 433 ASN E 437 LEU E 592 ARG E1245	None	1.09A	6baaF-6c3pE: 31.0	6baaF-6c3pE: 73.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6BAA_G_GBMG2001_1 (ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	7 / 12	ARG E 306 ILE E 381 MET E 429 PHE E 433 ASN E 437 SER E1237 ARG E1245	None	1.08A	6baaG-6c3pE: 31.0	6baaG-6c3pE: 73.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6BAA_G_GBMG2001_1 (ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	6 / 12	ARG E 306 ILE E 381 PHE E 433 ASN E 437 LEU E 592 ARG E1245	None	1.09A	6baaG-6c3pE: 31.0	6baaG-6c3pE: 73.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6BAA_H_GBMH2001_1 (ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	7 / 12	ARG E 306 ILE E 381 MET E 429 PHE E 433 ASN E 437 SER E1237 ARG E1245	None	1.07A	6baaH-6c3pE: 31.0	6baaH-6c3pE: 73.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6BAA_H_GBMH2001_1 (ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	6 / 12	ARG E 306 ILE E 381 PHE E 433 ASN E 437 LEU E 592 ARG E1245	None	1.09A	6baaH-6c3pE: 31.0	6baaH-6c3pE: 73.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CB4_A_BEZA501_0 (CANAVALIN)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	4 / 8	LEU E 829 LEU E 814 ILE E 811 ARG E 836	None	0.81A	6cb4A-6c3pE: undetectable	6cb4A-6c3pE: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6F7L_B_ACTB505_0 (AMINE OXIDASE LKCE)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	3 / 3	HIS E 125 ASN E 223 LEU E 225	None	0.90A	6f7lB-6c3pE: undetectable	6f7lB-6c3pE: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	6c3p	ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 (Homo sapiens)	5 / 10	ALA E1302 VAL E1298 ILE E1177 ALA E1184 LEU E1247	None	1.28A	6h1lA-6c3pE: undetectable	6h1lA-6c3pE: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1D4F_B_ADNB602_1","S-ADENOSYLHOMOCYSTEINE HYDROLASE","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",5,"LEU E 885;LEU E 876;LEU E 875;GLY E 871;PHE E 856","None","1.45A","1d4fB-6c3pE:undetectable","1d4fB-6c3pE:13.30"],["1LQT_B_ACTB1873_0","FPRA","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",3,"ASP E 865;ASP E 860;LYS E 889","None","1.13A","1lqtB-6c3pE:undetectable","1lqtB-6c3pE:undetectable"],["1LQU_B_ACTB1430_0","FPRA","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",3,"ASP E 865;ASP E 860;LYS E 889","None","1.14A","1lquB-6c3pE:undetectable","1lquB-6c3pE:undetectable"],["1SBR_A_VIBA501_1","YKOF","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",4,"PHE E 432;LEU E 387;ILE E 395;ILE E 391","None","0.80A","1sbrA-6c3pE:undetectable","1sbrA-6c3pE:15.00"],["1TW4_A_CHDA130_0","FATTY ACID-BINDING PROTEIN","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",5,"LEU E 364;LEU E 367;LEU E  82;ILE E  89;LEU E1260","None","1.02A","1tw4A-6c3pE:undetectable","1tw4A-6c3pE:undetectable"],["1U70_A_MTXA187_2","DIHYDROFOLATE REDUCTASE","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",4,"SER E1422;ILE E1423;VAL E1533;THR E1541","None","1.21A","1u70A-6c3pE:undetectable","1u70A-6c3pE:20.13"],["1U72_A_MTXA188_1","DIHYDROFOLATE REDUCTASE","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",5,"ALA E1152;PRO E 317;LEU E 366;ARG E 370;VAL E1259","None","1.23A","1u72A-6c3pE:undetectable","1u72A-6c3pE:16.22"],["2DDW_B_PXLB1005_1","PYRIDOXINE KINASE","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",4,"SER E 403;THR E 689;PRO E 690;GLY E 410","None","0.74A","2ddwB-6c3pE:undetectable","2ddwB-6c3pE:14.29"],["2HYY_C_STIC600_2","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",4,"LEU E1519;VAL E1550;ILE E1535;MET E1524","None","1.17A","2hyyC-6c3pE:undetectable","2hyyC-6c3pE:14.23"],["2QBL_A_CAMA517_0","CYTOCHROME P450-CAM","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",4,"PHE E 613;VAL E1207;THR E1206;VAL E 421","None","0.92A","2qblA-6c3pE:undetectable","2qblA-6c3pE:undetectable"],["3ELZ_B_CHDB151_0","ILEAL BILE ACID-BINDING PROTEIN","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",5,"ILE E 701;ILE E 907;GLY E 905;PRO E 694;LEU E 723","None","1.42A","3elzB-6c3pE:undetectable","3elzB-6c3pE:undetectable"],["3KO0_F_TFPF202_1","PROTEIN S100-A4;PROTEIN S100-A4;PROTEIN S100-A4;PROTEIN S100-A4","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",5,"LEU E 722;SER E 721;PHE E 686;ILE E 699;SER E1482","None;ATP E2004 (-2.5A);None;None;ATP E2004 (-2.2A)","1.49A","3ko0E-6c3pE:0.9;3ko0F-6c3pE:undetectable;3ko0G-6c3pE:undetectable;3ko0H-6c3pE:0.9","3ko0E-6c3pE:20.79;3ko0F-6c3pE:20.79;3ko0G-6c3pE:20.79;3ko0H-6c3pE:20.79"],["3Q1E_C_T44C128_1","5-HYDROXYISOURATE HYDROLASE;5-HYDROXYISOURATE HYDROLASE","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",4,"LEU E 508;LEU E 509;LEU E1117;LEU E 503","None","0.97A","3q1eA-6c3pE:undetectable;3q1eC-6c3pE:undetectable","3q1eA-6c3pE:21.19;3q1eC-6c3pE:21.19"],["3Q1E_C_T44C128_1","5-HYDROXYISOURATE HYDROLASE;5-HYDROXYISOURATE HYDROLASE","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",4,"LEU E1117;LEU E 503;LEU E 508;LEU E 509","None","1.06A","3q1eA-6c3pE:undetectable;3q1eC-6c3pE:undetectable","3q1eA-6c3pE:21.19;3q1eC-6c3pE:21.19"],["3RUK_A_AERA601_1","STEROID 17-ALPHA-HYDROXYLASE\/17,20 LYASE","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",5,"ALA E1494;PHE E1495;ILE E1511;LEU E1519;VAL E1533","None","1.08A","3rukA-6c3pE:undetectable","3rukA-6c3pE:11.62"],["3UCJ_A_AZMA229_2","CARBONIC ANHYDRASE;CARBONIC ANHYDRASE","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",3,"GLN E 845;PHE E 789;TYR E1218","None","0.87A","3ucjB-6c3pE:undetectable","3ucjB-6c3pE:15.70"],["3UCJ_B_AZMB229_1","CARBONIC ANHYDRASE;CARBONIC ANHYDRASE","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",3,"GLN E 845;PHE E 789;TYR E1218","None","0.87A","3ucjA-6c3pE:undetectable","3ucjA-6c3pE:15.70"],["3W67_D_VIVD301_0","ALPHA-TOCOPHEROL TRANSFER PROTEIN","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",5,"PHE E1392;ILE E1344;ILE E1501;PHE E1495;LEU E1417","None","1.26A","3w67D-6c3pE:undetectable","3w67D-6c3pE:undetectable"],["4AZT_A_SAMA1472_1","METHYLTRANSFERASE WBDD","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",3,"GLN E1483;ASP E1427;GLN E1426","None","0.76A","4aztA-6c3pE:undetectable","4aztA-6c3pE:undetectable"],["4K36_A_SAMA504_0","ANAEROBIC SULFATASE-MATURATING ENZYME","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",5,"TYR E1293;GLN E 444;LEU E 586;ILE E 585;LEU E1288","None","1.45A","4k36A-6c3pE:undetectable","4k36A-6c3pE:undetectable"],["4K36_B_SAMB504_0","ANAEROBIC SULFATASE-MATURATING ENZYME","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",5,"TYR E1293;GLN E 444;LEU E 586;ILE E 585;LEU E1288","None","1.48A","4k36B-6c3pE:undetectable","4k36B-6c3pE:undetectable"],["4NX6_A_FOLA201_0","DIHYDROFOLATE REDUCTASE","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",5,"LEU E 614;PHE E 613;ILE E 399;LEU E 402;ILE E 417","None","1.12A","4nx6A-6c3pE:2.5","4nx6A-6c3pE:undetectable"],["4OBW_D_SAMD601_0","2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",5,"ALA E1472;GLY E1468;ASN E1438;GLY E1433;ASN E1480","None;None;None;None;ATP E2004 (-4.4A)","1.14A","4obwD-6c3pE:undetectable","4obwD-6c3pE:undetectable"],["4OBW_D_SAMD601_0","2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",5,"ALA E1472;GLY E1468;ILE E1435;ASN E1438;GLY E1433","None","1.23A","4obwD-6c3pE:undetectable","4obwD-6c3pE:undetectable"],["4URN_C_NOVC2000_1","DNA TOPOISOMERASE IV, B SUBUNIT","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",5,"SER E1125;ASP E1127;ARG E 526;ILE E1104;THR E 499","None","1.42A","4urnC-6c3pE:undetectable","4urnC-6c3pE:15.11"],["4XJ7_A_ADNA303_1","5'\/3'-NUCLEOTIDASE SURE;5'\/3'-NUCLEOTIDASE SURE","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",5,"GLY E 448;ILE E 455;PRO E 317;LEU E 451;LEU E 452","None","1.22A","4xj7A-6c3pE:undetectable;4xj7B-6c3pE:undetectable","4xj7A-6c3pE:14.23;4xj7B-6c3pE:14.23"],["4ZME_A_ADNA1002_1","MYOSIN HEAVY CHAIN KINASE A","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",5,"PHE E1495;ALA E1494;VAL E1523;LEU E1519;THR E1534","None","1.12A","4zmeA-6c3pE:undetectable","4zmeA-6c3pE:14.24"],["4ZME_B_ADNB902_1","MYOSIN HEAVY CHAIN KINASE A","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",5,"PHE E1495;ALA E1494;VAL E1523;LEU E1519;THR E1534","None","1.13A","4zmeB-6c3pE:undetectable","4zmeB-6c3pE:14.24"],["5E72_A_SAMA400_0","N2, N2-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",5,"ILE E 391;GLY E 384;ILE E 385;ILE E 423;LEU E1200","None","0.98A","5e72A-6c3pE:undetectable","5e72A-6c3pE:undetectable"],["5EEI_A_SHHA2004_1","HDAC6 PROTEIN","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",5,"HIS E 888;GLY E 713;ASP E 854;ASP E 853;LEU E 723","None;None;ATP E2004 ( 4.6A); MG E2002 ( 4.5A);None","1.28A","5eeiA-6c3pE:undetectable","5eeiA-6c3pE:12.54"],["5EEI_B_SHHB801_1","HDAC6 PROTEIN","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",5,"HIS E 888;GLY E 713;ASP E 854;ASP E 853;LEU E 723","None;None;ATP E2004 ( 4.6A); MG E2002 ( 4.5A);None","1.29A","5eeiB-6c3pE:undetectable","5eeiB-6c3pE:12.54"],["5JNC_D_ACTD305_0","CARBONIC ANHYDRASE 4","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",4,"ALA E1262;ALA E1287;ILE E1156;LEU E1153","None","0.82A","5jncD-6c3pE:undetectable","5jncD-6c3pE:undetectable"],["5KPC_A_SAMA401_1","PAVINE N-METHYLTRANSFERASE","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",4,"PHE E 613;SER E 615;ASN E 493;GLN E 416","None","1.41A","5kpcA-6c3pE:undetectable","5kpcA-6c3pE:undetectable"],["5MWY_A_YNUA1101_0","MINERALOCORTICOID RECEPTOR","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",5,"LEU E 318;SER E 581;SER E 579;LEU E 582;LEU E 456","None","1.20A","5mwyA-6c3pE:undetectable","5mwyA-6c3pE:undetectable"],["5N0T_B_SAMB501_0","PEPTIDE N-METHYLTRANSFERASE","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",5,"ILE E 323;GLY E1281;VAL E1159;ALA E 355;VAL E1264","None","0.91A","5n0tB-6c3pE:undetectable","5n0tB-6c3pE:undetectable"],["5VKQ_C_PCFC1801_0","NO MECHANORECEPTOR POTENTIAL C ISOFORM L","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",4,"LYS E 394;ILE E 395;ILE E 399;LEU E 402","None","0.76A","5vkqB-6c3pE:undetectable;5vkqC-6c3pE:undetectable","5vkqB-6c3pE:undetectable;5vkqC-6c3pE:undetectable"],["5X2S_I_PEMI202_1","HEMOGLOBIN SUBUNIT ALPHA;HEMOGLOBIN SUBUNIT BETA;HEMOGLOBIN SUBUNIT ALPHA","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",4,"PRO E 694;THR E 689;THR E 687;PRO E1467","None","1.29A","5x2sI-6c3pE:undetectable;5x2sJ-6c3pE:undetectable;5x2sK-6c3pE:undetectable","5x2sI-6c3pE:16.67;5x2sJ-6c3pE:18.12;5x2sK-6c3pE:16.67"],["6BAA_E_GBME2001_1","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",7,"ARG E 306;ILE E 381;MET E 429;PHE E 433;ASN E 437;SER E1237;ARG E1245","None","1.08A","6baaE-6c3pE:31.0","6baaE-6c3pE:73.15"],["6BAA_E_GBME2001_1","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",6,"ARG E 306;ILE E 381;PHE E 433;ASN E 437;LEU E 592;ARG E1245","None","1.09A","6baaE-6c3pE:31.0","6baaE-6c3pE:73.15"],["6BAA_F_GBMF2001_1","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",7,"ARG E 306;ILE E 381;MET E 429;PHE E 433;ASN E 437;SER E1237;ARG E1245","None","1.08A","6baaF-6c3pE:31.0","6baaF-6c3pE:73.15"],["6BAA_F_GBMF2001_1","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",6,"ARG E 306;ILE E 381;PHE E 433;ASN E 437;LEU E 592;ARG E1245","None","1.09A","6baaF-6c3pE:31.0","6baaF-6c3pE:73.15"],["6BAA_G_GBMG2001_1","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",7,"ARG E 306;ILE E 381;MET E 429;PHE E 433;ASN E 437;SER E1237;ARG E1245","None","1.08A","6baaG-6c3pE:31.0","6baaG-6c3pE:73.15"],["6BAA_G_GBMG2001_1","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",6,"ARG E 306;ILE E 381;PHE E 433;ASN E 437;LEU E 592;ARG E1245","None","1.09A","6baaG-6c3pE:31.0","6baaG-6c3pE:73.15"],["6BAA_H_GBMH2001_1","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",7,"ARG E 306;ILE E 381;MET E 429;PHE E 433;ASN E 437;SER E1237;ARG E1245","None","1.07A","6baaH-6c3pE:31.0","6baaH-6c3pE:73.15"],["6BAA_H_GBMH2001_1","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",6,"ARG E 306;ILE E 381;PHE E 433;ASN E 437;LEU E 592;ARG E1245","None","1.09A","6baaH-6c3pE:31.0","6baaH-6c3pE:73.15"],["6CB4_A_BEZA501_0","CANAVALIN","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",4,"LEU E 829;LEU E 814;ILE E 811;ARG E 836","None","0.81A","6cb4A-6c3pE:undetectable","6cb4A-6c3pE:undetectable"],["6F7L_B_ACTB505_0","AMINE OXIDASE LKCE","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",3,"HIS E 125;ASN E 223;LEU E 225","None","0.90A","6f7lB-6c3pE:undetectable","6f7lB-6c3pE:undetectable"],["6H1L_A_FJQA501_0","BIFUNCTIONAL CYTOCHROME P450\/NADPH--P450 REDUCTASE","6c3p","ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8","Homo sapiens",5,"ALA E1302;VAL E1298;ILE E1177;ALA E1184;LEU E1247","None","1.28A","6h1lA-6c3pE:undetectable","6h1lA-6c3pE:undetectable"]]