SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6c43'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE
(Salmonella
enterica) 		5 / 12 LEU A 438
PHE A 436
ALA A 407
GLU A 246
ASP A 279
 None
 1.27A 1a4lB-6c43A:
undetectable		 1a4lB-6c43A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE
(Salmonella
enterica) 		6 / 11 PHE A 192
ALA A 188
LEU A 184
LEU A  70
ILE A 104
ALA A 156
 None
 1.39A 1ha2A-6c43A:
undetectable		 1ha2A-6c43A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE
(Salmonella
enterica) 		5 / 12 THR A 281
ASP A 279
GLY A 277
ALA A 303
GLN A 266
 None
 1.17A 1oltA-6c43A:
undetectable		 1oltA-6c43A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE
(Salmonella
enterica) 		5 / 12 ILE A 386
LEU A 296
GLY A 301
ASN A 302
ILE A 347
 None
 1.18A 2e7fB-6c43A:
undetectable		 2e7fB-6c43A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE
(Salmonella
enterica) 		4 / 6 SER A 402
SER A 450
LEU A 406
GLY A 405
 None
 1.01A 2j2pA-6c43A:
undetectable
2j2pC-6c43A:
undetectable		 2j2pA-6c43A:
18.05
2j2pC-6c43A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE
(Salmonella
enterica) 		4 / 6 SER A 402
SER A 450
LEU A 406
GLY A 405
 None
 1.00A 2j2pD-6c43A:
undetectable
2j2pF-6c43A:
undetectable		 2j2pD-6c43A:
18.05
2j2pF-6c43A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE
(Salmonella
enterica) 		5 / 10 GLY A 204
THR A 212
ILE A 232
LEU A 222
THR A 228
 None
 1.45A 3bexE-6c43A:
undetectable
3bexF-6c43A:
undetectable		 3bexE-6c43A:
undetectable
3bexF-6c43A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE
(Salmonella
enterica) 		5 / 11 LEU A 364
ALA A 282
LEU A 322
PHE A 273
THR A 348
 None
 1.25A 3jwqB-6c43A:
undetectable
3jwqC-6c43A:
undetectable		 3jwqB-6c43A:
12.42
3jwqC-6c43A:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE
(Salmonella
enterica) 		5 / 12 ASP A 279
GLY A 267
LEU A 307
ILE A 386
ILE A 286
 None
 1.09A 3pwwA-6c43A:
undetectable		 3pwwA-6c43A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE
(Salmonella
enterica) 		3 / 3 HIS A 235
HIS A 231
ILE A 232
 None
 0.81A 3u52A-6c43A:
undetectable
3u52C-6c43A:
undetectable		 3u52A-6c43A:
undetectable
3u52C-6c43A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE
(Salmonella
enterica) 		5 / 12 SER A 409
LEU A 300
VAL A 304
PHE A 273
VAL A 384
 None
 1.47A 3u9fH-6c43A:
undetectable
3u9fI-6c43A:
undetectable		 3u9fH-6c43A:
undetectable
3u9fI-6c43A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE
(Salmonella
enterica) 		4 / 6 PRO A 194
GLY A 195
ASN A 198
ASN A  50
 None
 1.01A 3zqtA-6c43A:
undetectable		 3zqtA-6c43A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE
(Salmonella
enterica) 		4 / 7 ALA A 165
PRO A 138
LEU A 118
LEU A 461
 None
 1.06A 4iomA-6c43A:
undetectable		 4iomA-6c43A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE
(Salmonella
enterica) 		4 / 7 MET A 153
VAL A 107
TRP A 157
GLU A 100
 None
 1.42A 4jseA-6c43A:
undetectable
4jseB-6c43A:
1.4		 4jseA-6c43A:
14.75
4jseB-6c43A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE
(Salmonella
enterica) 		4 / 7 GLU A 100
MET A 153
VAL A 107
TRP A 157
 None
 1.42A 4jseA-6c43A:
undetectable
4jseB-6c43A:
1.4		 4jseA-6c43A:
14.75
4jseB-6c43A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE
(Salmonella
enterica) 		5 / 10 SER A  37
VAL A  12
ALA A  43
ALA A  44
ILE A   7
 None
 1.06A 4lbgA-6c43A:
3.1		 4lbgA-6c43A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE
(Salmonella
enterica) 		5 / 12 LEU A 159
ILE A  74
GLU A 100
ILE A 101
ALA A 103
 None
 1.07A 4ltwA-6c43A:
undetectable		 4ltwA-6c43A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE
(Salmonella
enterica) 		3 / 3 GLY A 320
PRO A 321
GLN A 278
 None
 0.37A 4oltB-6c43A:
undetectable		 4oltB-6c43A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE
(Salmonella
enterica) 		3 / 3 GLY A 320
PRO A 321
GLN A 278
 None
 0.26A 4qwpB-6c43A:
undetectable		 4qwpB-6c43A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE
(Salmonella
enterica) 		5 / 11 ALA A 155
ALA A 181
VAL A 199
LEU A 184
LEU A  70
 None
 1.19A 5eb5A-6c43A:
undetectable		 5eb5A-6c43A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE
(Salmonella
enterica) 		5 / 12 ASN A 149
MET A 154
TRP A 157
CYH A 280
THR A 281
 None
 0.82A 5fhzA-6c43A:
57.3		 5fhzA-6c43A:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE
(Salmonella
enterica) 		6 / 12 ASN A 149
MET A 154
TRP A 157
GLU A 246
CYH A 280
THR A 281
 None
 1.04A 5fhzD-6c43A:
54.4		 5fhzD-6c43A:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE
(Salmonella
enterica) 		6 / 12 ASN A 149
MET A 154
TRP A 157
GLU A 246
THR A 281
LEU A 438
 None
 0.82A 5fhzD-6c43A:
54.4		 5fhzD-6c43A:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_A_SALA503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE
(Salmonella
enterica) 		4 / 7 THR A 281
HIS A 444
MET A 153
THR A 223
 None
 1.29A 5u6mA-6c43A:
5.5		 5u6mA-6c43A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE
(Salmonella
enterica) 		3 / 3 THR A 223
MET A 245
HIS A 244
 None
 1.02A 5uunA-6c43A:
undetectable		 5uunA-6c43A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE
(Salmonella
enterica) 		6 / 12 ALA A 164
PRO A 138
GLY A  56
ALA A 114
PRO A 161
PHE A 111
 None
 1.33A 5zvgA-6c43A:
undetectable		 5zvgA-6c43A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE
(Salmonella
enterica) 		6 / 12 ALA A 164
PRO A 138
GLY A  56
ALA A 114
PRO A 161
PHE A 111
 None
 1.34A 5zvgB-6c43A:
undetectable		 5zvgB-6c43A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE
(Salmonella
enterica) 		5 / 11 PHE A 108
LEU A  67
SER A  73
ILE A  74
ILE A 191
 None
 0.88A 6ebzC-6c43A:
undetectable		 6ebzC-6c43A:
19.05