SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6c49'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 6c49 ALCOHOL
DEHYDROGENASE
(Acinetobacter
baumannii) 		5 / 9 MET A 212
ALA A 198
LEU A 237
ILE A 184
HIS A 183
 None
 1.47A 1ereC-6c49A:
undetectable		 1ereC-6c49A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 6c49 ALCOHOL
DEHYDROGENASE
(Acinetobacter
baumannii) 		5 / 12 MET A 212
LEU A 237
ILE A 184
GLY A 180
HIS A 183
 None
None
None
GOL  A 406 ( 3.6A)
None
 1.21A 1g50B-6c49A:
undetectable		 1g50B-6c49A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 6c49 ALCOHOL
DEHYDROGENASE
(Acinetobacter
baumannii) 		4 / 6 LEU A  50
ASP A  46
LEU A  42
GLY A  41
 None
 0.73A 1mt1G-6c49A:
undetectable
1mt1J-6c49A:
undetectable		 1mt1G-6c49A:
23.53
1mt1J-6c49A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 6c49 ALCOHOL
DEHYDROGENASE
(Acinetobacter
baumannii) 		4 / 5 LEU A 237
VAL A 173
CYH A 194
ALA A 169
 None
 1.12A 1mz9D-6c49A:
undetectable		 1mz9D-6c49A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 6c49 ALCOHOL
DEHYDROGENASE
(Acinetobacter
baumannii) 		4 / 4 LEU A 237
VAL A 173
CYH A 194
ALA A 169
 None
 1.05A 1mz9E-6c49A:
undetectable		 1mz9E-6c49A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 6c49 ALCOHOL
DEHYDROGENASE
(Acinetobacter
baumannii) 		4 / 6 LEU A  50
ASP A  46
LEU A  42
GLY A  41
 None
 0.78A 1n13H-6c49A:
undetectable
1n13K-6c49A:
undetectable		 1n13H-6c49A:
22.45
1n13K-6c49A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 6c49 ALCOHOL
DEHYDROGENASE
(Acinetobacter
baumannii) 		4 / 7 LEU A  50
ASP A  46
LEU A  42
GLY A  41
 None
 0.74A 1n13G-6c49A:
undetectable
1n13J-6c49A:
undetectable		 1n13G-6c49A:
23.53
1n13J-6c49A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 6c49 ALCOHOL
DEHYDROGENASE
(Acinetobacter
baumannii) 		5 / 11 GLY A 132
ALA A 131
ILE A  67
GLY A  88
ILE A 137
 None
 0.89A 1n49B-6c49A:
undetectable		 1n49B-6c49A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 6c49 ALCOHOL
DEHYDROGENASE
(Acinetobacter
baumannii) 		5 / 11 GLY A 132
ALA A 131
ILE A  67
GLY A  88
ILE A 137
 None
 0.88A 1n49C-6c49A:
undetectable		 1n49C-6c49A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 6c49 ALCOHOL
DEHYDROGENASE
(Acinetobacter
baumannii) 		5 / 9 LEU A  81
VAL A  72
ILE A  68
VAL A  33
ILE A  71
 None
 1.01A 1ohrB-6c49A:
undetectable		 1ohrB-6c49A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 6c49 ALCOHOL
DEHYDROGENASE
(Acinetobacter
baumannii) 		5 / 10 GLY A 132
ALA A 131
ILE A  67
GLY A  88
ILE A 137
 None
 0.96A 1t7iA-6c49A:
undetectable		 1t7iA-6c49A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6c49 ALCOHOL
DEHYDROGENASE
(Acinetobacter
baumannii) 		6 / 12 ILE A 156
TRP A 192
LEU A 163
LEU A 294
ALA A 292
LEU A 188
 None
 1.37A 1xlsA-6c49A:
undetectable		 1xlsA-6c49A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6c49 ALCOHOL
DEHYDROGENASE
(Acinetobacter
baumannii) 		6 / 12 ILE A 156
TRP A 192
LEU A 163
LEU A 294
ALA A 292
LEU A 188
 None
 1.37A 1xlsB-6c49A:
undetectable		 1xlsB-6c49A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6c49 ALCOHOL
DEHYDROGENASE
(Acinetobacter
baumannii) 		6 / 12 ILE A 156
TRP A 192
LEU A 163
LEU A 294
ALA A 292
LEU A 188
 None
 1.37A 1xlsC-6c49A:
undetectable		 1xlsC-6c49A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6c49 ALCOHOL
DEHYDROGENASE
(Acinetobacter
baumannii) 		6 / 12 ILE A 156
TRP A 192
LEU A 163
LEU A 294
ALA A 292
LEU A 188
 None
 1.37A 1xlsD-6c49A:
undetectable		 1xlsD-6c49A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 6c49 ALCOHOL
DEHYDROGENASE
(Acinetobacter
baumannii) 		4 / 6 ALA A 321
GLU A 320
TYR A   9
LEU A 336
 None
 0.77A 1xvaA-6c49A:
7.5
1xvaB-6c49A:
7.9		 1xvaA-6c49A:
undetectable
1xvaB-6c49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 6c49 ALCOHOL
DEHYDROGENASE
(Acinetobacter
baumannii) 		5 / 12 MET A 212
LEU A 237
ILE A 184
GLY A 180
HIS A 183
 None
None
None
GOL  A 406 ( 3.6A)
None
 1.29A 2j7xA-6c49A:
undetectable		 2j7xA-6c49A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 6c49 ALCOHOL
DEHYDROGENASE
(Acinetobacter
baumannii) 		5 / 12 ALA A 116
GLY A  64
GLY A  90
TRP A  91
ALA A  63
 None
 1.08A 2plwA-6c49A:
8.0		 2plwA-6c49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 6c49 ALCOHOL
DEHYDROGENASE
(Acinetobacter
baumannii) 		4 / 8 LEU A  50
ASP A  46
LEU A  42
GLY A  41
 None
 0.66A 2qqdB-6c49A:
undetectable
2qqdC-6c49A:
undetectable		 2qqdB-6c49A:
22.45
2qqdC-6c49A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 6c49 ALCOHOL
DEHYDROGENASE
(Acinetobacter
baumannii) 		4 / 8 ILE A 184
GLY A 155
LEU A 297
LEU A 298
 None
 0.93A 2vctC-6c49A:
undetectable		 2vctC-6c49A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 6c49 ALCOHOL
DEHYDROGENASE
(Acinetobacter
baumannii) 		6 / 12 MET A 212
ALA A 198
LEU A 237
ILE A 184
GLY A 180
HIS A 183
 None
None
None
None
GOL  A 406 ( 3.6A)
None
 1.39A 2yjaB-6c49A:
undetectable		 2yjaB-6c49A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 6c49 ALCOHOL
DEHYDROGENASE
(Acinetobacter
baumannii) 		4 / 7 ILE A 186
PHE A 233
PHE A 199
GLY A 179
 None
None
None
SO4  A 407 (-3.3A)
 0.91A 3em0B-6c49A:
undetectable		 3em0B-6c49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 6c49 ALCOHOL
DEHYDROGENASE
(Acinetobacter
baumannii) 		4 / 6 MET A 212
ILE A 178
ILE A 184
LEU A 188
 None
 0.80A 3hegA-6c49A:
undetectable		 3hegA-6c49A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA303_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 6c49 ALCOHOL
DEHYDROGENASE
(Acinetobacter
baumannii) 		4 / 4 GLN A 107
GLN A 134
GLY A 132
HIS A  31
 None
 1.41A 3huoA-6c49A:
undetectable		 3huoA-6c49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 6c49 ALCOHOL
DEHYDROGENASE
(Acinetobacter
baumannii) 		5 / 12 ILE A 118
GLY A 123
GLY A 124
ALA A   8
ILE A  89
 None
 1.11A 3jayA-6c49A:
undetectable		 3jayA-6c49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 6c49 ALCOHOL
DEHYDROGENASE
(Acinetobacter
baumannii) 		5 / 12 MET A 212
LEU A 237
ILE A 184
GLY A 180
HIS A 183
 None
None
None
GOL  A 406 ( 3.6A)
None
 1.28A 4j26A-6c49A:
undetectable		 4j26A-6c49A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 6c49 ALCOHOL
DEHYDROGENASE
(Acinetobacter
baumannii) 		5 / 12 GLU A  38
TYR A  39
ALA A 148
GLY A 149
LEU A 152
 PEG  A 409 (-4.5A)
None
None
None
None
 1.13A 4oadA-6c49A:
undetectable		 4oadA-6c49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 6c49 ALCOHOL
DEHYDROGENASE
(Acinetobacter
baumannii) 		3 / 3 ARG A 130
LYS A 128
GLU A  34
 None
 0.76A 5d0yA-6c49A:
undetectable		 5d0yA-6c49A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 6c49 ALCOHOL
DEHYDROGENASE
(Acinetobacter
baumannii) 		6 / 11 MET A 212
ALA A 198
LEU A 237
ILE A 184
GLY A 180
HIS A 183
 None
None
None
None
GOL  A 406 ( 3.6A)
None
 1.37A 5dxbB-6c49A:
undetectable		 5dxbB-6c49A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 6c49 ALCOHOL
DEHYDROGENASE
(Acinetobacter
baumannii) 		5 / 12 LEU A  50
THR A  57
ASP A  46
HIS A  65
GLY A 120
 None
None
None
ZN  A 402 (-3.5A)
None
 1.35A 5hm8A-6c49A:
5.4		 5hm8A-6c49A:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 6c49 ALCOHOL
DEHYDROGENASE
(Acinetobacter
baumannii) 		6 / 12 VAL A  35
ILE A  71
ALA A  73
VAL A  87
GLY A  88
ILE A  67
 None
 1.49A 5j2tC-6c49A:
undetectable		 5j2tC-6c49A:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6c49 ALCOHOL
DEHYDROGENASE
(Acinetobacter
baumannii) 		6 / 11 ILE A 156
TRP A 192
LEU A 163
LEU A 294
ALA A 292
LEU A 188
 None
 1.39A 5ji0A-6c49A:
undetectable		 5ji0A-6c49A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6c49 ALCOHOL
DEHYDROGENASE
(Acinetobacter
baumannii) 		5 / 12 ALA A 136
ILE A 322
THR A  57
HIS A 121
THR A  92
 None
 1.18A 5jlcA-6c49A:
undetectable		 5jlcA-6c49A:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 6c49 ALCOHOL
DEHYDROGENASE
(Acinetobacter
baumannii) 		5 / 12 GLY A 289
ALA A 292
ASP A 160
PRO A 161
THR A 288
 None
 1.35A 5x6yC-6c49A:
undetectable		 5x6yC-6c49A:
undetectable