SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6c4g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		3 / 3 GLU A 141
TYR A 139
PHE A 180
 EQG  A 504 (-2.0A)
EQG  A 504 (-3.2A)
EQG  A 504 (-3.1A)
 0.96A 1eqbB-6c4gA:
undetectable		 1eqbB-6c4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		3 / 3 GLU A 141
TYR A 139
PHE A 180
 EQG  A 504 (-2.0A)
EQG  A 504 (-3.2A)
EQG  A 504 (-3.1A)
 0.96A 1eqbA-6c4gA:
undetectable		 1eqbA-6c4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		3 / 3 GLU A 141
TYR A 139
PHE A 180
 EQG  A 504 (-2.0A)
EQG  A 504 (-3.2A)
EQG  A 504 (-3.1A)
 0.96A 1eqbD-6c4gA:
undetectable		 1eqbD-6c4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		3 / 3 GLU A 141
TYR A 139
PHE A 180
 EQG  A 504 (-2.0A)
EQG  A 504 (-3.2A)
EQG  A 504 (-3.1A)
 0.97A 1eqbC-6c4gA:
undetectable		 1eqbC-6c4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		4 / 7 VAL A 277
ASN A 280
ASP A 453
LYS A 456
 None
NAG  A 503 (-1.8A)
None
None
 1.33A 1hwiC-6c4gA:
undetectable		 1hwiC-6c4gA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		4 / 7 VAL A 277
ASN A 280
ASP A 453
LYS A 456
 None
NAG  A 503 (-1.8A)
None
None
 1.33A 1hwiD-6c4gA:
undetectable		 1hwiD-6c4gA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		4 / 5 SER A 155
THR A 165
GLU A  72
GLY A  69
 None
 1.10A 1icrA-6c4gA:
undetectable
1icrB-6c4gA:
undetectable		 1icrA-6c4gA:
16.29
1icrB-6c4gA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		4 / 5 GLU A  72
GLY A  69
SER A 155
THR A 165
 None
 1.08A 1icrA-6c4gA:
undetectable
1icrB-6c4gA:
undetectable		 1icrA-6c4gA:
16.29
1icrB-6c4gA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		4 / 6 SER A 155
THR A 165
GLU A  72
GLY A  69
 None
 1.07A 1icuA-6c4gA:
undetectable
1icuB-6c4gA:
undetectable		 1icuA-6c4gA:
16.29
1icuB-6c4gA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		4 / 6 GLU A  72
GLY A  69
SER A 155
THR A 165
 None
 1.09A 1icuA-6c4gA:
undetectable
1icuB-6c4gA:
undetectable		 1icuA-6c4gA:
16.29
1icuB-6c4gA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		4 / 5 SER A 155
THR A 165
GLU A  72
GLY A  69
 None
 1.11A 1icvC-6c4gA:
undetectable
1icvD-6c4gA:
undetectable		 1icvC-6c4gA:
16.29
1icvD-6c4gA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		4 / 5 GLU A  72
GLY A  69
SER A 155
THR A 165
 None
 1.10A 1icvC-6c4gA:
undetectable
1icvD-6c4gA:
undetectable		 1icvC-6c4gA:
16.29
1icvD-6c4gA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		4 / 6 TYR A  50
VAL A 216
ILE A 454
LEU A 189
 None
 1.21A 1j96A-6c4gA:
undetectable		 1j96A-6c4gA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		4 / 6 SER A 155
THR A 165
GLU A  72
GLY A  69
 None
 1.08A 1kqbA-6c4gA:
undetectable
1kqbB-6c4gA:
undetectable		 1kqbA-6c4gA:
undetectable
1kqbB-6c4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		4 / 5 GLU A  72
GLY A  69
SER A 155
THR A 165
 None
 1.08A 1kqbA-6c4gA:
undetectable
1kqbB-6c4gA:
undetectable		 1kqbA-6c4gA:
undetectable
1kqbB-6c4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		4 / 6 SER A 155
THR A 165
GLU A  72
GLY A  69
 None
 1.09A 1kqbC-6c4gA:
undetectable
1kqbD-6c4gA:
undetectable		 1kqbC-6c4gA:
undetectable
1kqbD-6c4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		4 / 6 GLU A  72
GLY A  69
SER A 155
THR A 165
 None
 1.08A 1kqbC-6c4gA:
undetectable
1kqbD-6c4gA:
undetectable		 1kqbC-6c4gA:
undetectable
1kqbD-6c4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		5 / 11 LEU A 401
ASN A 380
ILE A 375
LEU A 336
PHE A 297
 None
 1.44A 1tw4A-6c4gA:
undetectable		 1tw4A-6c4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		5 / 12 ASN A 209
VAL A 164
TYR A  50
LEU A 193
ALA A 230
 None
 1.38A 2iyfB-6c4gA:
undetectable		 2iyfB-6c4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		7 / 12 ASP A  80
GLY A  82
SER A  83
TYR A 139
VAL A 188
ASP A 313
GLY A 315
 EQG  A 504 (-2.5A)
EQG  A 504 (-3.0A)
EQG  A 504 (-4.3A)
EQG  A 504 (-3.2A)
None
EQG  A 504 (-2.1A)
EQG  A 504 (-3.5A)
 0.45A 2v0zC-6c4gA:
33.8		 2v0zC-6c4gA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		5 / 12 ASP A 313
GLY A 315
ASP A  80
GLY A  82
SER A  84
 EQG  A 504 (-2.1A)
EQG  A 504 (-3.5A)
EQG  A 504 (-2.5A)
EQG  A 504 (-3.0A)
EDO  A 506 (-3.1A)
 0.86A 2v0zC-6c4gA:
33.8		 2v0zC-6c4gA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		6 / 12 ASP A 313
GLY A 315
SER A 316
ASP A  80
GLY A  82
SER A 192
 EQG  A 504 (-2.1A)
EQG  A 504 (-3.5A)
EQG  A 504 (-3.3A)
EQG  A 504 (-2.5A)
EQG  A 504 (-3.0A)
EDO  A 506 (-3.0A)
 1.31A 2v0zC-6c4gA:
33.8		 2v0zC-6c4gA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		5 / 12 ASP A  80
GLY A  82
VAL A 188
ASP A 313
GLY A 315
 EQG  A 504 (-2.5A)
EQG  A 504 (-3.0A)
None
EQG  A 504 (-2.1A)
EQG  A 504 (-3.5A)
 0.33A 2v0zO-6c4gA:
34.1		 2v0zO-6c4gA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		5 / 12 ASP A 313
GLY A 315
ASP A  80
GLY A  82
SER A  84
 EQG  A 504 (-2.1A)
EQG  A 504 (-3.5A)
EQG  A 504 (-2.5A)
EQG  A 504 (-3.0A)
EDO  A 506 (-3.1A)
 0.82A 2v0zO-6c4gA:
34.1		 2v0zO-6c4gA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		3 / 3 LEU A 440
MET A 310
MET A 191
 None
 1.01A 2vavF-6c4gA:
undetectable		 2vavF-6c4gA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		4 / 5 LEU A 311
ASP A 313
ILE A 439
GLY A  82
 EQG  A 504 ( 4.2A)
EQG  A 504 (-2.1A)
EQG  A 504 (-4.3A)
EQG  A 504 (-3.0A)
 0.53A 3bufA-6c4gA:
32.6		 3bufA-6c4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		5 / 9 THR A 218
VAL A 203
LEU A 189
ILE A  66
GLY A 231
 None
 1.25A 3cv9A-6c4gA:
undetectable		 3cv9A-6c4gA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		5 / 12 ASP A  80
GLY A  82
VAL A 188
LEU A 311
ASP A 313
 EQG  A 504 (-2.5A)
EQG  A 504 (-3.0A)
None
EQG  A 504 ( 4.2A)
EQG  A 504 (-2.1A)
 0.57A 3d91B-6c4gA:
33.8		 3d91B-6c4gA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		3 / 3 VAL A 129
LYS A 132
HIS A 173
 None
 0.91A 3elzA-6c4gA:
undetectable		 3elzA-6c4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		4 / 7 ILE A 229
PHE A 202
TYR A  50
GLY A 226
 None
 1.09A 3em0B-6c4gA:
undetectable		 3em0B-6c4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		5 / 8 GLY A  82
SER A  83
TYR A 139
ASP A 313
THR A 317
 EQG  A 504 (-3.0A)
EQG  A 504 (-4.3A)
EQG  A 504 (-3.2A)
EQG  A 504 (-2.1A)
EQG  A 504 (-2.9A)
 0.19A 3pwwA-6c4gA:
32.0		 3pwwA-6c4gA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		5 / 8 GLY A  82
TYR A 139
SER A 143
ASP A 313
THR A 317
 EQG  A 504 (-3.0A)
EQG  A 504 (-3.2A)
EQG  A 504 ( 4.3A)
EQG  A 504 (-2.1A)
EQG  A 504 (-2.9A)
 0.49A 3pwwA-6c4gA:
32.0		 3pwwA-6c4gA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		6 / 12 ILE A  78
ASP A  80
GLY A  82
SER A 143
ASP A 313
ILE A 439
 EQG  A 504 ( 3.8A)
EQG  A 504 (-2.5A)
EQG  A 504 (-3.0A)
EQG  A 504 ( 4.3A)
EQG  A 504 (-2.1A)
EQG  A 504 (-4.3A)
 0.45A 3q70A-6c4gA:
8.7		 3q70A-6c4gA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		6 / 12 ILE A  78
ASP A  80
GLY A  82
SER A 143
ASP A 313
ILE A 439
 EQG  A 504 ( 3.8A)
EQG  A 504 (-2.5A)
EQG  A 504 (-3.0A)
EQG  A 504 ( 4.3A)
EQG  A 504 (-2.1A)
EQG  A 504 (-4.3A)
 0.65A 3tneA-6c4gA:
30.7		 3tneA-6c4gA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		6 / 12 ILE A  78
ASP A  80
GLY A  82
SER A 143
ASP A 313
ILE A 439
 EQG  A 504 ( 3.8A)
EQG  A 504 (-2.5A)
EQG  A 504 (-3.0A)
EQG  A 504 ( 4.3A)
EQG  A 504 (-2.1A)
EQG  A 504 (-4.3A)
 0.68A 3tneB-6c4gA:
30.6		 3tneB-6c4gA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		4 / 7 GLY A 293
THR A 404
THR A 319
PHE A 444
 None
 1.02A 4ac9C-6c4gA:
undetectable		 4ac9C-6c4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		4 / 8 LEU A 206
VAL A 164
LEU A  79
LEU A  64
 None
 0.92A 4l1xA-6c4gA:
undetectable		 4l1xA-6c4gA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		5 / 11 ASN A 209
VAL A 164
TYR A  50
LEU A 193
ALA A 230
 None
 1.38A 4m83A-6c4gA:
undetectable		 4m83A-6c4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		5 / 12 GLY A 315
TYR A 135
TYR A 149
GLY A 198
THR A  81
 EQG  A 504 (-3.5A)
None
None
None
None
 1.14A 5eskA-6c4gA:
undetectable		 5eskA-6c4gA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		5 / 12 GLY A 315
TYR A 135
TYR A 149
GLY A 198
THR A  81
 EQG  A 504 (-3.5A)
None
None
None
None
 1.16A 5eslA-6c4gA:
undetectable		 5eslA-6c4gA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		4 / 5 VAL A 291
ASN A 300
ASP A 295
LEU A 294
 None
 1.23A 5m0iB-6c4gA:
undetectable		 5m0iB-6c4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		4 / 6 ILE A  68
LEU A 206
PHE A 166
PHE A 452
 None
 1.04A 5vkqA-6c4gA:
undetectable
5vkqB-6c4gA:
undetectable		 5vkqA-6c4gA:
undetectable
5vkqB-6c4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		4 / 6 PHE A 452
ILE A  68
LEU A 206
PHE A 166
 None
 1.05A 5vkqA-6c4gA:
undetectable
5vkqD-6c4gA:
undetectable		 5vkqA-6c4gA:
undetectable
5vkqD-6c4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		5 / 12 TYR A 286
VAL A 291
SER A 406
LEU A 311
VAL A 281
 EDO  A 506 (-4.2A)
None
None
EQG  A 504 ( 4.2A)
None
 1.34A 6a93B-6c4gA:
undetectable		 6a93B-6c4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		4 / 7 SER A  85
SER A  87
HIS A 173
GLY A 187
 EDO  A 506 ( 4.1A)
None
None
None
 1.09A 6btxA-6c4gA:
undetectable		 6btxA-6c4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		4 / 8 ASP A  67
ILE A  66
ARG A  74
TYR A  53
 None
 1.05A 6hisA-6c4gA:
undetectable
6hisB-6c4gA:
undetectable		 6hisA-6c4gA:
22.34
6hisB-6c4gA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		4 / 8 ASP A  67
ILE A  66
ARG A  74
TYR A  53
 None
 1.05A 6hisB-6c4gA:
undetectable
6hisC-6c4gA:
undetectable		 6hisB-6c4gA:
22.34
6hisC-6c4gA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		4 / 8 ASP A  67
ILE A  66
ARG A  74
TYR A  53
 None
 1.05A 6hisC-6c4gA:
undetectable
6hisD-6c4gA:
undetectable		 6hisC-6c4gA:
22.34
6hisD-6c4gA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		4 / 8 ASP A  67
ILE A  66
ARG A  74
TYR A  53
 None
 1.05A 6hisD-6c4gA:
undetectable
6hisE-6c4gA:
undetectable		 6hisD-6c4gA:
22.34
6hisE-6c4gA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 6c4g ASPARTIC PROTEASE
PM5
(Plasmodium
vivax) 		4 / 8 TYR A  53
ASP A  67
ILE A  66
ARG A  74
 None
 1.04A 6hisA-6c4gA:
undetectable
6hisE-6c4gA:
undetectable		 6hisA-6c4gA:
22.34
6hisE-6c4gA:
22.34