SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6c4m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 6c4m YERSINOPINE
DEHYDROGENASE
(Yersinia
pestis) 		5 / 12 ILE C 221
ALA C 152
ILE C 118
ARG C  89
LEU C 212
 None
 1.17A 1ddsB-6c4mC:
undetectable		 1ddsB-6c4mC:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 6c4m YERSINOPINE
DEHYDROGENASE
(Yersinia
pestis) 		5 / 7 PRO C 385
LEU C 265
THR C 251
LEU C 255
VAL C 389
 None
 1.05A 1jgsA-6c4mC:
1.5		 1jgsA-6c4mC:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 6c4m YERSINOPINE
DEHYDROGENASE
(Yersinia
pestis) 		5 / 12 VAL C 130
LEU C 119
LEU C 197
TRP C 211
GLU C 208
 None
 1.31A 1mmkA-6c4mC:
undetectable		 1mmkA-6c4mC:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 6c4m YERSINOPINE
DEHYDROGENASE
(Yersinia
pestis) 		5 / 11 LEU C 245
TYR C 266
VAL C 278
ILE C 279
LEU C 307
 None
 1.33A 1mrqA-6c4mC:
undetectable		 1mrqA-6c4mC:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 6c4m YERSINOPINE
DEHYDROGENASE
(Yersinia
pestis) 		5 / 10 LEU C  19
ILE C 118
ARG C  89
LEU C 212
THR C 154
 None
 1.49A 1tdrB-6c4mC:
undetectable		 1tdrB-6c4mC:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 6c4m YERSINOPINE
DEHYDROGENASE
(Yersinia
pestis) 		5 / 11 SER C 126
VAL C  94
ALA C  93
LEU C 119
ILE C  91
 None
NAP  C 501 (-3.7A)
NAP  C 501 (-4.8A)
None
None
 1.27A 1uduA-6c4mC:
undetectable		 1uduA-6c4mC:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 6c4m YERSINOPINE
DEHYDROGENASE
(Yersinia
pestis) 		5 / 10 LEU C 119
LEU C 114
LEU C 134
VAL C 130
ILE C 106
 None
 1.16A 2w9gA-6c4mC:
undetectable		 2w9gA-6c4mC:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 6c4m YERSINOPINE
DEHYDROGENASE
(Yersinia
pestis) 		4 / 6 HIS C 220
ALA C  64
ALA C  62
THR C 188
 None
 1.10A 2xfhA-6c4mC:
undetectable		 2xfhA-6c4mC:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 6c4m YERSINOPINE
DEHYDROGENASE
(Yersinia
pestis) 		4 / 8 GLN C  66
LEU C  19
LEU C  56
ARG C 218
 None
 1.05A 2xn3A-6c4mC:
undetectable
2xn3B-6c4mC:
undetectable		 2xn3A-6c4mC:
13.51
2xn3B-6c4mC:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6c4m YERSINOPINE
DEHYDROGENASE
(Yersinia
pestis) 		4 / 7 GLN C 182
ILE C  17
TYR C  47
TYR C  55
 None
 1.35A 2xz5D-6c4mC:
undetectable
2xz5E-6c4mC:
undetectable		 2xz5D-6c4mC:
undetectable
2xz5E-6c4mC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGR_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 6c4m YERSINOPINE
DEHYDROGENASE
(Yersinia
pestis) 		5 / 11 LEU C  33
ASN C  35
TYR C  55
TYR C 184
LEU C  48
 None
NAP  C 501 (-3.0A)
None
None
None
 1.36A 3bgrA-6c4mC:
undetectable
3bgrB-6c4mC:
undetectable		 3bgrA-6c4mC:
9.63
3bgrB-6c4mC:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 6c4m YERSINOPINE
DEHYDROGENASE
(Yersinia
pestis) 		5 / 11 LEU C 119
LEU C 114
LEU C 134
VAL C 130
ILE C 106
 None
 1.09A 3frbX-6c4mC:
undetectable		 3frbX-6c4mC:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 6c4m YERSINOPINE
DEHYDROGENASE
(Yersinia
pestis) 		5 / 12 PHE C 191
THR C 154
SER C 149
ILE C  91
LEU C  19
 None
 1.33A 3iv6C-6c4mC:
3.2		 3iv6C-6c4mC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 6c4m YERSINOPINE
DEHYDROGENASE
(Yersinia
pestis) 		3 / 3 ARG C 415
ASP C 288
GLN C 335
 None
 0.90A 3lcvB-6c4mC:
undetectable		 3lcvB-6c4mC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 6c4m YERSINOPINE
DEHYDROGENASE
(Yersinia
pestis) 		4 / 8 VAL C  71
ARG C 218
VAL C 215
ILE C  23
 None
 1.05A 3remA-6c4mC:
2.4		 3remA-6c4mC:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 6c4m YERSINOPINE
DEHYDROGENASE
(Yersinia
pestis) 		4 / 8 VAL C  71
ARG C 218
VAL C 215
ILE C  23
 None
 1.05A 3remB-6c4mC:
2.3		 3remB-6c4mC:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 6c4m YERSINOPINE
DEHYDROGENASE
(Yersinia
pestis) 		4 / 5 LEU C 147
ALA C 232
MET C 209
ASN C 199
 None
 1.36A 3uq6A-6c4mC:
3.4		 3uq6A-6c4mC:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 6c4m YERSINOPINE
DEHYDROGENASE
(Yersinia
pestis) 		3 / 3 LEU C 285
ASP C 288
TYR C 289
 None
 0.57A 4qc6B-6c4mC:
undetectable		 4qc6B-6c4mC:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 6c4m YERSINOPINE
DEHYDROGENASE
(Yersinia
pestis) 		5 / 12 LEU C 245
TYR C 266
VAL C 278
LEU C 307
LEU C 303
 None
 1.31A 4yvpB-6c4mC:
undetectable		 4yvpB-6c4mC:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 6c4m YERSINOPINE
DEHYDROGENASE
(Yersinia
pestis) 		5 / 9 ASP C  74
LEU C  31
GLY C  32
LEU C  54
ALA C  20
 None
 0.99A 5dqfA-6c4mC:
undetectable		 5dqfA-6c4mC:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_B_GLYB404_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 6c4m YERSINOPINE
DEHYDROGENASE
(Yersinia
pestis) 		4 / 4 GLN C 260
ALA C 254
GLN C 253
THR C 251
 None
 1.36A 5hhjB-6c4mC:
undetectable		 5hhjB-6c4mC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 6c4m YERSINOPINE
DEHYDROGENASE
(Yersinia
pestis) 		4 / 6 ARG C 411
GLY C 284
ASP C 281
ASP C 288
 None
 1.03A 5hp1A-6c4mC:
undetectable		 5hp1A-6c4mC:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 6c4m YERSINOPINE
DEHYDROGENASE
(Yersinia
pestis) 		5 / 11 ASP C  22
ILE C   9
ILE C  17
ILE C 195
ILE C 221
 None
 1.16A 5hw8A-6c4mC:
undetectable
5hw8D-6c4mC:
undetectable		 5hw8A-6c4mC:
20.49
5hw8D-6c4mC:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 6c4m YERSINOPINE
DEHYDROGENASE
(Yersinia
pestis) 		5 / 12 SER C 236
THR C 238
ILE C 237
LEU C  92
PHE C 306
 None
 1.44A 6a93A-6c4mC:
undetectable		 6a93A-6c4mC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 6c4m YERSINOPINE
DEHYDROGENASE
(Yersinia
pestis) 		4 / 6 MET C   1
THR C   4
LEU C   5
LEU C  31
 None
 1.13A 6mvxA-6c4mC:
undetectable
6mvxB-6c4mC:
2.2
6mvxC-6c4mC:
2.4		 6mvxA-6c4mC:
undetectable
6mvxB-6c4mC:
undetectable
6mvxC-6c4mC:
undetectable