SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6c4n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 6c4n PSEUDOPALINE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 7 THR A 188
GLY A   9
THR A 118
THR A  91
 None
 0.99A 1gtnJ-6c4nA:
undetectable
1gtnK-6c4nA:
undetectable		 1gtnJ-6c4nA:
undetectable
1gtnK-6c4nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 6c4n PSEUDOPALINE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 7 GLU A 352
PRO A 411
ARG A 357
GLY A 354
 None
 1.28A 2hs1B-6c4nA:
undetectable		 2hs1B-6c4nA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 6c4n PSEUDOPALINE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 8 MET A 259
LEU A 316
SER A 267
VAL A 214
 None
 1.21A 2qd2A-6c4nA:
undetectable		 2qd2A-6c4nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 6c4n PSEUDOPALINE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 5 VAL A 122
TYR A 150
VAL A  23
ASP A  26
 None
NAP  A 501 (-4.7A)
None
None
 1.20A 2x45C-6c4nA:
undetectable		 2x45C-6c4nA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 6c4n PSEUDOPALINE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 11 CYH A  95
LEU A  94
LEU A  13
LEU A 120
VAL A  19
 None
None
None
None
NAP  A 501 (-3.7A)
 1.20A 3e22D-6c4nA:
2.4		 3e22D-6c4nA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 6c4n PSEUDOPALINE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 8 SER A 100
GLU A 364
TYR A 101
PHE A 125
 NAP  A 501 (-3.4A)
NAP  A 501 (-2.6A)
None
None
 0.85A 3i45A-6c4nA:
2.4		 3i45A-6c4nA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 6c4n PSEUDOPALINE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 11 PRO A 362
ASP A 365
LEU A 369
ALA A 258
ARG A 231
 None
 1.34A 3n23C-6c4nA:
undetectable		 3n23C-6c4nA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 6c4n PSEUDOPALINE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 377
LEU A 269
MET A 273
ALA A 422
ILE A 126
 None
 1.21A 3ut5D-6c4nA:
3.0		 3ut5D-6c4nA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 6c4n PSEUDOPALINE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  17
SER A 196
VAL A 198
TYR A 151
VAL A 170
 NAP  A 501 (-3.3A)
None
None
None
None
 1.37A 4ffwA-6c4nA:
undetectable		 4ffwA-6c4nA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 6c4n PSEUDOPALINE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  17
SER A 196
VAL A 198
TYR A 151
VAL A 170
 NAP  A 501 (-3.3A)
None
None
None
None
 1.37A 4ffwB-6c4nA:
undetectable		 4ffwB-6c4nA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_B_DM5B601_1
(SERUM ALBUMIN)		 6c4n PSEUDOPALINE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 324
VAL A 325
PRO A 327
TYR A 320
ILE A 251
 None
 1.27A 4lb2B-6c4nA:
1.0		 4lb2B-6c4nA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 6c4n PSEUDOPALINE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 PRO A 250
GLY A 225
PHE A 345
ARG A 231
 None
 1.02A 5jcnB-6c4nA:
undetectable		 5jcnB-6c4nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 6c4n PSEUDOPALINE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 8 THR A 216
SER A 149
LYS A 368
ALA A 128
 None
None
NAP  A 501 ( 4.9A)
None
 0.98A 5l5fY-6c4nA:
undetectable
5l5fZ-6c4nA:
undetectable		 5l5fY-6c4nA:
15.64
5l5fZ-6c4nA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 6c4n PSEUDOPALINE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 174
LEU A  60
ASP A  26
SER A 149
GLN A  63
 None
 1.30A 5syfB-6c4nA:
3.5		 5syfB-6c4nA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 6c4n PSEUDOPALINE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 121
LEU A 108
ALA A 135
LEU A 102
GLU A 210
 None
 1.26A 5y7pG-6c4nA:
undetectable		 5y7pG-6c4nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H3D_A_DHIA601_0
(DUF2338
DOMAIN-CONTAINING
PROTEIN)		 6c4n PSEUDOPALINE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 5 TYR A 243
ASN A 288
TYR A 289
ARG A 319
 None
 0.77A 6h3dA-6c4nA:
47.9		 6h3dA-6c4nA:
undetectable